Enoyl-CoA hydratase, mitochondrial

AltitudeomicsDB
Protein Official symbol ECHS1
Aliases ECHS1
Chromosomal Location 10
Length 290
Uniprot ID P30084
EC number 4.2.1.17
Protein family Information(Pfam) PF00378;
PDB id 2HW5;
InterPro ID IPR029045;IPR018376;IPR001753;IPR014748;
dbSNP rs587776498 rs10466126 rs375266808 rs201865375 rs371063211 rs1049951 rs1426014295 rs1085307550 rs770931871 rs864309656 rs786204001 rs375032130 rs761989177 rs769429279 rs565090080

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MCCC2 MCCC1 0.999
HADH ECHS1 0.997
ACADM ACAA2 0.996
ECHS1 HSD17B10 0.992
IVD MCCC2 0.991
ECHS1 ACADS 0.99
HADH ACAA2 0.989
HADHA ACAA2 0.985
ACAA2 ACADS 0.984
ACADSB ECHS1 0.983
ACOX3 EHHADH 0.982
ACOX1 EHHADH 0.982
ACADM EHHADH 0.98
ACADVL ACAA2 0.979
ACADVL HADHA 0.979
HADHA ACADM 0.978
ECHS1 MCCC2 0.977
ACAA2 EHHADH 0.977
HADH ACADM 0.975
HADHA ACADS 0.972
ACAA2 HSD17B10 0.972
ACADM ECHS1 0.969
ACADVL ECHS1 0.969
ECHS1 ACADL 0.969
ECHS1 GCDH 0.965
HADHA ACADL 0.964
ACAA2 ACADL 0.964
ACADL EHHADH 0.964
ACADSB ACAA2 0.964
IVD MCCC1 0.962
ACADVL EHHADH 0.961
HADHA ACOX1 0.961
ACOX1 ACAA2 0.96
ACADS EHHADH 0.96
ECHS1 ECI1 0.959
ACADM ACOX1 0.956
HADHA ACOX3 0.956
IVD ECHS1 0.955
ECHS1 ACOX1 0.955
ACADSB EHHADH 0.955
ECHS1 ACAA2 0.95
ECHS1 ACOX3 0.949
ETFA ACADM 0.948
ECHS1 MCCC1 0.948
IVD HADHA 0.948
ACOX1 GCDH 0.948
HADHA ACADSB 0.947
HADHA GCDH 0.946
HADH HIBCH 0.945
HADHA MCCC2 0.944
ACADSB GCDH 0.944
EHHADH GCDH 0.942
HADHA HSD17B10 0.942
HADH HSD17B10 0.942
ACOX3 GCDH 0.941
ACOX3 ACAA2 0.939
ECHS1 HIBCH 0.938
ECHS1 ACAD8 0.936
HADH HADHA 0.934
ACADM MCCC1 0.933
HADH EHHADH 0.933
HADHA MCCC1 0.932
HADHA ECHS1 0.931
HADHA ACAD8 0.931
ACADM GCDH 0.93
ACAA2 MECR 0.929
ACOX3 ACOX1 0.929
IVD EHHADH 0.928
ACAD8 EHHADH 0.928
EHHADH HSD17B10 0.927
HADH ACADS 0.927
ACADVL ACOX1 0.927
ACOX1 ACADL 0.926
ACADS GCDH 0.923
HADHA EHHADH 0.922
MCCC1 EHHADH 0.92
ECHS1 EHHADH 0.92
ACADM MCCC2 0.919
MCCC2 EHHADH 0.918
ECHS1 MECR 0.916
ACADM ACADL 0.915
HADHA HIBCH 0.915
HADHA MECR 0.914
ETFA ECHS1 0.911
HIBCH EHHADH 0.908
Gene Ontology Semantic Similarity
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# 56922 (MCCC1) 1892 (ECHS1) 10449 (ACAA2) 3028 (HSD17B10) 64087 (MCCC2) 35 (ACADS) 1962 (EHHADH) 3030 (HADHA) 34 (ACADM) 33 (ACADL) 2639 (GCDH) 51 (ACOX1) 1632 (ECI1) 8310 (ACOX3) 36 (ACADSB) 26275 (HIBCH) 27034 (ACAD8) 51102 (MECR) 3033 (HADH) 3712 (IVD) 37 (ACADVL) 2108 (ETFA)
56922 (MCCC1) 1.00 0.48 0.43 0.41 0.77 0.21 0.50 0.39 0.40 0.30 0.24 0.51 0.24 0.46 0.27 0.21 0.27 0.24 0.24 0.48 0.29 0.56
1892 (ECHS1) 0.48 1.00 0.47 0.43 0.60 0.21 0.82 0.64 0.46 0.22 0.20 0.47 0.54 0.39 0.24 0.17 0.24 0.20 0.20 0.60 0.25 0.55
10449 (ACAA2) 0.43 0.47 1.00 0.57 0.47 0.17 0.48 0.62 0.38 0.23 0.17 0.43 0.20 0.36 0.21 0.15 0.21 0.17 0.17 0.47 0.22 0.49
3028 (HSD17B10) 0.41 0.43 0.57 1.00 0.43 0.28 0.66 0.64 0.45 0.34 0.34 0.46 0.21 0.41 0.40 0.17 0.40 0.34 1.00 0.50 0.31 0.56
64087 (MCCC2) 0.77 0.60 0.47 0.43 1.00 0.21 0.55 0.42 0.46 0.22 0.20 0.47 0.24 0.39 0.24 0.17 0.24 0.20 0.20 0.60 0.25 0.55
35 (ACADS) 0.21 0.21 0.17 0.28 0.21 1.00 0.26 0.29 0.72 0.68 0.86 0.32 0.28 0.37 1.00 0.21 1.00 0.60 0.40 0.60 0.72 0.41
1962 (EHHADH) 0.50 0.82 0.48 0.66 0.55 0.26 1.00 0.85 0.51 0.27 0.34 0.53 0.45 0.49 0.40 0.17 0.40 0.34 1.00 0.59 0.31 0.61
3030 (HADHA) 0.39 0.64 0.62 0.64 0.42 0.29 0.85 1.00 0.44 0.29 0.34 0.44 0.43 0.38 0.40 0.17 0.40 0.34 1.00 0.47 0.31 0.55
34 (ACADM) 0.40 0.46 0.38 0.45 0.46 0.72 0.51 0.44 1.00 0.66 0.86 0.52 0.26 0.50 1.00 0.21 1.00 0.60 0.40 0.82 0.71 0.58
33 (ACADL) 0.30 0.22 0.23 0.34 0.22 0.68 0.27 0.29 0.66 1.00 0.86 0.63 0.25 0.69 1.00 0.21 1.00 0.60 0.40 0.56 0.82 0.62
2639 (GCDH) 0.24 0.20 0.17 0.34 0.20 0.86 0.34 0.34 0.86 0.86 1.00 0.51 0.28 0.51 0.86 0.17 0.86 0.51 0.34 0.73 0.86 0.60
51 (ACOX1) 0.51 0.47 0.43 0.46 0.47 0.32 0.53 0.44 0.52 0.63 0.51 1.00 0.19 0.91 0.60 0.17 0.60 0.51 0.34 0.57 0.45 0.69
1632 (ECI1) 0.24 0.54 0.20 0.21 0.24 0.28 0.45 0.43 0.26 0.25 0.28 0.19 1.00 0.20 0.33 0.25 0.33 0.28 0.28 0.24 0.25 0.32
8310 (ACOX3) 0.46 0.39 0.36 0.41 0.39 0.37 0.49 0.38 0.50 0.69 0.51 0.91 0.20 1.00 0.60 0.17 0.60 0.51 0.34 0.52 0.50 0.67
36 (ACADSB) 0.27 0.24 0.21 0.40 0.24 1.00 0.40 0.40 1.00 1.00 0.86 0.60 0.33 0.60 1.00 0.21 1.00 0.60 0.40 0.86 1.00 0.69
26275 (HIBCH) 0.21 0.17 0.15 0.17 0.17 0.21 0.17 0.17 0.21 0.21 0.17 0.17 0.25 0.17 0.21 1.00 0.21 0.17 0.17 0.17 0.21 0.32
27034 (ACAD8) 0.27 0.24 0.21 0.40 0.24 1.00 0.40 0.40 1.00 1.00 0.86 0.60 0.33 0.60 1.00 0.21 1.00 0.60 0.40 0.86 1.00 0.69
51102 (MECR) 0.24 0.20 0.17 0.34 0.20 0.60 0.34 0.34 0.60 0.60 0.51 0.51 0.28 0.51 0.60 0.17 0.60 1.00 0.34 0.51 0.60 0.60
3033 (HADH) 0.24 0.20 0.17 1.00 0.20 0.40 1.00 1.00 0.40 0.40 0.34 0.34 0.28 0.34 0.40 0.17 0.40 0.34 1.00 0.34 0.40 0.60
3712 (IVD) 0.48 0.60 0.47 0.50 0.60 0.60 0.59 0.47 0.82 0.56 0.73 0.57 0.24 0.52 0.86 0.17 0.86 0.51 0.34 1.00 0.62 0.63
37 (ACADVL) 0.29 0.25 0.22 0.31 0.25 0.72 0.31 0.31 0.71 0.82 0.86 0.45 0.25 0.50 1.00 0.21 1.00 0.60 0.40 0.62 1.00 0.53
2108 (ETFA) 0.56 0.55 0.49 0.56 0.55 0.41 0.61 0.55 0.58 0.62 0.60 0.69 0.32 0.67 0.69 0.32 0.69 0.60 0.60 0.63 0.53 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ECHS1 Human Skeletal muscle - 4559 m 9 day downregulated -1.28 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
BRCA1 672 ECHS1 1892 proximal_filtered 22955619 TRANSFAC
ZBTB33 10009 ECHS1 1892 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023625 hsa-miR-1-3p Homo sapiens ECHS1 1892 Homo sapiens Proteomics;Microarray Functional MTI (Weak) 18668037
MIRT045094 hsa-miR-186-5p Homo sapiens ECHS1 1892 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT045819 hsa-miR-152-3p Homo sapiens ECHS1 1892 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046438 hsa-miR-15b-5p Homo sapiens ECHS1 1892 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT733811 hsa-miR-548a-3p Homo sapiens ECHS1 1892 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26297544
Gene Ontology
ID GO ID GO Term GO Type
1892 GO:0004300 serine-type endopeptidase activity GOTERM_MF_DIRECT
1892 GO:0005739 mitochondrion GOTERM_CC_DIRECT
1892 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
1892 GO:0006635 fatty acid beta-oxidation GOTERM_BP_DIRECT
1892 GO:0005515 protein binding GOTERM_MF_DIRECT
1892 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1892 hsa00071 Fatty acid degradation
1892 hsa00062 Fatty acid elongation
1892 hsa00410 beta-Alanine metabolism
1892 hsa00280 Valine
1892 hsa00380 Tryptophan metabolism
1892 hsa00310 Lysine degradation
1892 hsa00650 Butanoate metabolism
1892 hsa00640 Propanoate metabolism
1892 hsa01130 Biosynthesis of antibiotics
1892 hsa01200 Carbon metabolism
1892 hsa01100 Metabolic pathways
1892 hsa01212 Fatty acid metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ECHS1 1892 Leigh Disease C0023264 Disease or Syndrome 0.43 0.69 0.379 disease
ECHS1 1892 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.69 0.379 group
ECHS1 1892 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.3 0.69 0.379 disease
ECHS1 1892 Encephalopathy, Subacute Necrotizing, Juvenile C0751268 Disease or Syndrome 0.3 0.69 0.379 disease
ECHS1 1892 Obesity C0028754 Disease or Syndrome 0.3 0.69 0.379 disease
ECHS1 1892 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.69 0.379 disease
ECHS1 1892 Encephalopathy, Subacute Necrotizing, Infantile C0751267 Disease or Syndrome 0.3 0.69 0.379 disease
ECHS1 1892 MITOCHONDRIAL SHORT-CHAIN ENOYL-CoA HYDRATASE 1 DEFICIENCY C4225391 Disease or Syndrome 0.6 0.69 0.379 disease
ECHS1 1892 Mitochondrial Diseases C0751651 Disease or Syndrome 0.3 0.69 0.379 group
ECHS1 1892 Alcoholic Intoxication, Chronic C0001973 Mental or Behavioral Dysfunction 0.3 0.69 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types