Hydroxysteroid (17-beta) dehydrogenase 6

AltitudeomicsDB
Protein Official symbol HSD17B10
Aliases HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2
Chromosomal Location X
Length 261
Uniprot ID Q99714
EC number 1.1.1.35; 1.1.1.51; 1.1.1.178
Protein family Information(Pfam) PF00106;
PDB id 1F67;1SO8;1U7T;2O23;
InterPro ID IPR036291;IPR020904;IPR002347;
dbSNP rs104886492 rs587777651 rs28935476 rs28935475 rs886041974 rs1556894502 rs122461163 rs62626305

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
RPP21 RPP30 0.999
RPP21 POP5 0.999
POP4 RPP21 0.999
POP4 POP5 0.999
DICER1 TARBP2 0.999
DICER1 AGO2 0.999
RPP25 POP7 0.999
POP4 RPP30 0.999
RPP30 POP5 0.999
HADHA HADHB 0.999
RPP30 RPP25 0.998
POP4 RPP25 0.998
RPP14 RPP30 0.998
RPP14 RPP25 0.998
POP4 RPP14 0.998
RPP21 RPP25 0.997
HADH ECHS1 0.997
RPP14 RPP21 0.997
POP5 RPP25 0.997
POP4 POP7 0.996
TARBP2 AGO2 0.996
POP4 POP1 0.996
RPP14 POP5 0.995
RPP30 POP1 0.995
HADH ACAA1 0.995
POP1 POP5 0.995
HADH HADHB 0.995
TRMT10C HSD17B10 0.994
KIAA0391 TRMT10C 0.994
RPP30 POP7 0.994
ECHS1 HSD17B10 0.992
RPP21 POP7 0.991
HADH ACAT1 0.991
HADH ACAT2 0.991
HADHB HSD17B10 0.99
HADH ACAA2 0.989
KIAA0391 HSD17B10 0.987
POP5 POP7 0.986
HADHA ACAT1 0.986
HADHA ACAA2 0.985
RPP21 POP1 0.985
ACAA1 EHHADH 0.981
ACAA2 EHHADH 0.977
HADHA ACAA1 0.977
HADHB EHHADH 0.976
RPP14 POP7 0.974
DICER1 POP1 0.974
HADH SCP2 0.974
HADHA ACAT2 0.973
POP1 TARBP2 0.973
ACAA2 HSD17B10 0.972
ACAT2 EHHADH 0.971
POP1 RPP25 0.968
ACAT1 EHHADH 0.967
ACAA2 ACAT1 0.964
SCP2 EHHADH 0.963
RPP14 POP1 0.953
ECHS1 ACAA2 0.95
ACAT2 ACAT1 0.947
ACAA1 HSD17B10 0.944
HADH HSD17B10 0.942
HADHA HSD17B10 0.942
POP4 KIAA0391 0.942
HADHB ACAT1 0.94
KIAA0391 POP5 0.938
ACAT1 HSD17B10 0.936
SCP2 HSD17B10 0.934
HADH HADHA 0.934
HADH EHHADH 0.933
ACAA1 ACAT1 0.932
HADHA ECHS1 0.931
KIAA0391 RPP14 0.931
HUWE1 HSD17B10 0.93
KIAA0391 RPP25 0.928
EHHADH HSD17B10 0.927
ACAT2 HADHB 0.926
HADHB ACAA2 0.925
KIAA0391 RPP21 0.923
HADHA EHHADH 0.922
KIAA0391 POP1 0.92
ECHS1 EHHADH 0.92
ACAT2 HSD17B10 0.919
KIAA0391 RPP30 0.919
ACAT2 ACAA1 0.919
POP1 POP7 0.917
ACAT2 ACAA2 0.915
POP4 HSD17B10 0.913
POP5 HSD17B10 0.913
RPP21 HSD17B10 0.912
POP4 DICER1 0.912
DICER1 RPP30 0.911
CLP1 AGO2 0.911
POP1 HSD17B10 0.91
DICER1 RPP21 0.91
TARBP2 HSD17B10 0.91
KIAA0391 POP7 0.909
RPP30 HSD17B10 0.907
POP7 TARBP2 0.907
DICER1 POP5 0.907
DICER1 RPP14 0.907
DICER1 RPP25 0.906
CLP1 POP1 0.906
RPP14 HSD17B10 0.906
DICER1 CLP1 0.906
KIAA0391 CLP1 0.905
RPP25 HSD17B10 0.905
POP7 HSD17B10 0.904
CLP1 TARBP2 0.902
CLP1 HSD17B10 0.902
RPP25 TARBP2 0.902
CLP1 POP7 0.902
POP1 AGO2 0.902
DICER1 POP7 0.901
RPP14 AGO2 0.9
KIAA0391 AGO2 0.9
RPP30 AGO2 0.9
CLP1 POP5 0.9
DICER1 HSD17B10 0.9
CLP1 RPP30 0.9
POP5 AGO2 0.9
POP4 TARBP2 0.9
KIAA0391 DICER1 0.9
POP4 CLP1 0.9
RPP21 TARBP2 0.9
RPP21 AGO2 0.9
RPP25 AGO2 0.9
POP4 AGO2 0.9
RPP30 TARBP2 0.9
CLP1 RPP25 0.9
POP7 AGO2 0.9
KIAA0391 TARBP2 0.9
POP5 TARBP2 0.9
AGO2 HSD17B10 0.9
CLP1 RPP14 0.9
CLP1 RPP21 0.9
RPP14 TARBP2 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 79897 (RPP21) 10775 (POP4) 23405 (DICER1) 54913 (RPP25) 10556 (RPP30) 3030 (HADHA) 11102 (RPP14) 3033 (HADH) 51367 (POP5) 6895 (TARBP2) 10940 (POP1) 54931 (TRMT10C) 9692 (KIAA0391) 1892 (ECHS1) 3032 (HADHB) 30 (ACAA1) 10449 (ACAA2) 39 (ACAT2) 38 (ACAT1) 6342 (SCP2) 10075 (HUWE1) 1962 (EHHADH) 10978 (CLP1) 10248 (POP7) 27161 (AGO2) 3028 (HSD17B10)
79897 (RPP21) 1.00 1.00 0.73 1.00 1.00 0.12 1.00 0.12 1.00 0.09 1.00 0.09 1.00 0.12 0.12 0.12 0.10 0.10 0.17 0.12 0.14 0.12 0.09 1.00 0.77 0.12
10775 (POP4) 1.00 1.00 0.80 0.92 0.92 0.36 0.82 0.17 0.74 0.75 0.99 0.57 1.00 0.45 0.53 0.38 0.60 0.40 0.18 0.43 0.63 0.47 0.16 0.92 0.81 0.59
23405 (DICER1) 0.73 0.80 1.00 0.81 0.81 0.37 0.68 0.16 0.64 0.76 0.80 0.55 0.73 0.44 0.52 0.39 0.58 0.40 0.17 0.42 0.60 0.45 0.15 0.81 0.81 0.57
54913 (RPP25) 1.00 0.92 0.81 1.00 1.00 0.38 0.87 0.16 0.87 0.79 0.93 0.58 1.00 0.53 0.52 0.42 0.62 0.45 0.17 0.46 0.65 0.51 0.16 1.00 0.81 0.60
10556 (RPP30) 1.00 0.92 0.81 1.00 1.00 0.38 0.87 0.16 0.87 0.79 0.93 0.58 1.00 0.53 0.52 0.42 0.62 0.45 0.17 0.46 0.65 0.51 0.16 1.00 0.81 0.60
3030 (HADHA) 0.12 0.36 0.37 0.38 0.38 1.00 0.18 1.00 0.38 0.50 0.36 0.33 0.12 0.64 0.86 0.53 0.62 0.66 0.53 0.46 0.41 0.85 0.15 0.38 0.35 0.64
11102 (RPP14) 1.00 0.82 0.68 0.87 0.87 0.18 1.00 0.12 0.68 0.54 0.81 0.44 1.00 0.24 0.36 0.19 0.44 0.20 0.14 0.24 0.50 0.22 0.15 0.87 0.72 0.46
3033 (HADH) 0.12 0.17 0.16 0.16 0.16 1.00 0.12 1.00 0.16 0.16 0.17 0.16 0.12 0.20 0.87 0.29 0.17 0.17 0.28 0.20 0.24 1.00 0.15 0.16 0.16 1.00
51367 (POP5) 1.00 0.74 0.64 0.87 0.87 0.38 0.68 0.16 1.00 0.59 0.81 0.38 1.00 0.57 0.39 0.43 0.45 0.47 0.18 0.47 0.46 0.53 0.12 0.87 0.53 0.40
6895 (TARBP2) 0.09 0.75 0.76 0.79 0.79 0.50 0.54 0.16 0.59 1.00 0.74 0.70 0.09 0.59 0.67 0.52 0.75 0.55 0.15 0.53 0.74 0.59 0.16 0.79 0.72 0.71
10940 (POP1) 1.00 0.99 0.80 0.93 0.93 0.36 0.81 0.17 0.81 0.74 1.00 0.53 1.00 0.47 0.49 0.39 0.56 0.41 0.19 0.44 0.61 0.48 0.16 0.93 0.81 0.56
54931 (TRMT10C) 0.09 0.57 0.55 0.58 0.58 0.33 0.44 0.16 0.38 0.70 0.53 1.00 0.09 0.39 0.49 0.37 0.56 0.38 0.16 0.41 0.61 0.42 0.17 0.58 0.62 0.56
9692 (KIAA0391) 1.00 1.00 0.73 1.00 1.00 0.12 1.00 0.12 1.00 0.09 1.00 0.09 1.00 0.12 0.12 0.12 0.10 0.10 0.17 0.12 0.14 0.12 0.09 1.00 0.77 0.12
1892 (ECHS1) 0.12 0.45 0.44 0.53 0.53 0.64 0.24 0.20 0.57 0.59 0.47 0.39 0.12 1.00 0.68 0.46 0.47 0.50 0.29 0.49 0.48 0.82 0.15 0.53 0.39 0.43
3032 (HADHB) 0.12 0.53 0.52 0.52 0.52 0.86 0.36 0.87 0.39 0.67 0.49 0.49 0.12 0.68 1.00 0.56 0.72 0.62 0.51 0.48 0.58 0.83 0.19 0.52 0.60 0.69
30 (ACAA1) 0.12 0.38 0.39 0.42 0.42 0.53 0.19 0.29 0.43 0.52 0.39 0.37 0.12 0.46 0.56 1.00 0.69 0.74 0.51 0.52 0.49 0.50 0.20 0.42 0.36 0.42
10449 (ACAA2) 0.10 0.60 0.58 0.62 0.62 0.62 0.44 0.17 0.45 0.75 0.56 0.56 0.10 0.47 0.72 0.69 1.00 0.91 0.61 0.55 0.66 0.48 0.20 0.62 0.64 0.57
39 (ACAT2) 0.10 0.40 0.40 0.45 0.45 0.66 0.20 0.17 0.47 0.55 0.41 0.38 0.10 0.50 0.62 0.74 0.91 1.00 0.67 0.57 0.50 0.50 0.18 0.45 0.37 0.39
38 (ACAT1) 0.17 0.18 0.17 0.17 0.17 0.53 0.14 0.28 0.18 0.15 0.19 0.16 0.17 0.29 0.51 0.51 0.61 0.67 1.00 0.28 0.26 0.29 0.18 0.17 0.15 0.21
6342 (SCP2) 0.12 0.43 0.42 0.46 0.46 0.46 0.24 0.20 0.47 0.53 0.44 0.41 0.12 0.49 0.48 0.52 0.55 0.57 0.28 1.00 0.49 0.52 0.21 0.46 0.39 0.42
10075 (HUWE1) 0.14 0.63 0.60 0.65 0.65 0.41 0.50 0.24 0.46 0.74 0.61 0.61 0.14 0.48 0.58 0.49 0.66 0.50 0.26 0.49 1.00 0.50 0.25 0.65 0.67 0.61
1962 (EHHADH) 0.12 0.47 0.45 0.51 0.51 0.85 0.22 1.00 0.53 0.59 0.48 0.42 0.12 0.82 0.83 0.50 0.48 0.50 0.29 0.52 0.50 1.00 0.14 0.51 0.41 0.66
10978 (CLP1) 0.09 0.16 0.15 0.16 0.16 0.15 0.15 0.15 0.12 0.16 0.16 0.17 0.09 0.15 0.19 0.20 0.20 0.18 0.18 0.21 0.25 0.14 1.00 0.16 0.17 0.17
10248 (POP7) 1.00 0.92 0.81 1.00 1.00 0.38 0.87 0.16 0.87 0.79 0.93 0.58 1.00 0.53 0.52 0.42 0.62 0.45 0.17 0.46 0.65 0.51 0.16 1.00 0.81 0.60
27161 (AGO2) 0.77 0.81 0.81 0.81 0.81 0.35 0.72 0.16 0.53 0.72 0.81 0.62 0.77 0.39 0.60 0.36 0.64 0.37 0.15 0.39 0.67 0.41 0.17 0.81 1.00 0.63
3028 (HSD17B10) 0.12 0.59 0.57 0.60 0.60 0.64 0.46 1.00 0.40 0.71 0.56 0.56 0.12 0.43 0.69 0.42 0.57 0.39 0.21 0.42 0.61 0.66 0.17 0.60 0.63 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HSD17B10 Human Blood - 3650 m 48 hours downregulated 0.646 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT022995 hsa-miR-124-3p Homo sapiens HSD17B10 3028 Homo sapiens Proteomics;Microarray Non-Functional MTI (Weak) 18668037
MIRT025528 hsa-miR-34a-5p Homo sapiens HSD17B10 3028 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT036869 hsa-miR-877-3p Homo sapiens HSD17B10 3028 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042654 hsa-miR-196b-5p Homo sapiens HSD17B10 3028 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044743 hsa-miR-320a Homo sapiens HSD17B10 3028 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048950 hsa-miR-92a-3p Homo sapiens HSD17B10 3028 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
3028 GO:0003857 1 GOTERM_MF_DIRECT
3028 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
3028 GO:0005739 mitochondrion GOTERM_CC_DIRECT
3028 GO:0047015 protein dimerization activity GOTERM_MF_DIRECT
3028 GO:0005737 cytoplasm GOTERM_CC_DIRECT
3028 GO:0090646 mitochondrial tRNA processing GOTERM_BP_DIRECT
3028 GO:0006629 lipid metabolic process GOTERM_BP_DIRECT
3028 GO:0009083 branched-chain amino acid catabolic process GOTERM_BP_DIRECT
3028 GO:0008709 cAMP-dependent protein kinase regulator activity GOTERM_MF_DIRECT
3028 GO:0030283 5-formyltetrahydrofolate cyclo-ligase activity GOTERM_MF_DIRECT
3028 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
3028 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
3028 GO:0005515 protein binding GOTERM_MF_DIRECT
3028 GO:0070901 mitochondrial tRNA methylation GOTERM_BP_DIRECT
3028 GO:0044822 poly GOTERM_MF_DIRECT
3028 GO:0005886 plasma membrane GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3028 hsa00280 Valine
3028 hsa01100 Metabolic pathways
3028 hsa01130 Biosynthesis of antibiotics
3028 hsa05010 Alzheimer's disease
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HSD17B10 3028 Adenocarcinoma of lung (disorder) C0152013 Neoplastic Process 0.3 0.645 0.483 disease
HSD17B10 3028 2-methyl-3-hydroxybutyric aciduria C3266731 Disease or Syndrome 0.6 0.645 0.483 disease
HSD17B10 3028 Mitochondrial Diseases C0751651 Disease or Syndrome 0.3 0.645 0.483 group
HSD17B10 3028 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.42 0.645 0.483 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types