Hydroxyacyl-Coenzyme A dehydrogenase, a-subunit

AltitudeomicsDB
Protein Official symbol HADHA
Aliases HADHA HADH
Chromosomal Location 2
Length 763
Uniprot ID P40939
EC number 2.3.1.-; 4.2.1.17; 1.1.1.211
Protein family Information(Pfam) PF00725;PF02737;PF00378;
PDB id 5ZQZ;5ZRV;6DV2;
InterPro ID IPR006180;IPR006176;IPR006108;IPR008927;IPR029045;IPR018376;IPR001753;IPR012803;IPR036291;
dbSNP rs137852773 rs137852774 rs137852772 rs2229420 rs137852769

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
HADHA HADHB 0.999
MCCC2 MCCC1 0.999
HADH ECHS1 0.997
ACADM ACAA2 0.996
HADH ACAA1 0.995
HADH HADHB 0.995
ECHS1 HSD17B10 0.992
HADH ACAT2 0.991
HADH ACAT1 0.991
ACAA1 ACOX1 0.991
IVD MCCC2 0.991
ECHS1 ACADS 0.99
HADHB HSD17B10 0.99
HADH ACAA2 0.989
ACADM HADHB 0.989
HADHA ACAT1 0.986
HADHA ACAA2 0.985
ACAA2 ACADS 0.984
ACADSB ECHS1 0.983
ACOX3 EHHADH 0.982
ACOX1 EHHADH 0.982
ACAA1 EHHADH 0.981
ACADM EHHADH 0.98
ACAA1 ACADS 0.98
HADHB ACADS 0.98
ACADVL ACAA2 0.979
ACADVL HADHA 0.979
HADHA ACADM 0.978
ACAA2 EHHADH 0.977
ECHS1 MCCC2 0.977
HADHA ACAA1 0.977
HADHB EHHADH 0.976
ACADVL ACAA1 0.976
ACADM ACAA1 0.975
HADH ACADM 0.975
ACADVL HADHB 0.975
HADHA ACAT2 0.973
ACAA2 HSD17B10 0.972
HADHA ACADS 0.972
ACAT1 ACADS 0.972
ACAT2 EHHADH 0.971
ACADM ECHS1 0.969
ACADVL ECHS1 0.969
ACOX3 ACAA1 0.969
ECHS1 ACADL 0.969
ACAT1 EHHADH 0.967
ACADSB ACAA1 0.966
ECHS1 GCDH 0.965
HADHB ACADL 0.965
ACADSB ACAA2 0.964
ACAA2 ACAT1 0.964
ACADL EHHADH 0.964
HADHA ACADL 0.964
HADHB ACOX1 0.964
ACAA2 ACADL 0.964
IVD MCCC1 0.962
ACADVL EHHADH 0.961
HADHA ACOX1 0.961
ACOX1 ACAA2 0.96
ACADS EHHADH 0.96
ACADSB ACAT1 0.959
ACAT2 ACADS 0.958
ACADM ACAT1 0.958
ACADM ACOX1 0.956
HADHA ACOX3 0.956
ACADSB HADHB 0.956
IVD ECHS1 0.955
ECHS1 ACOX1 0.955
ACADSB EHHADH 0.955
ECHS1 ACAA2 0.95
ACADSB ACAT2 0.95
ACAA1 ACADL 0.95
ECHS1 ACOX3 0.949
IVD HADHA 0.948
ACOX1 GCDH 0.948
ECHS1 MCCC1 0.948
HADHA ACADSB 0.947
ACAT2 ACAT1 0.947
HADHA GCDH 0.946
HADH HIBCH 0.945
ACAT2 ACOX1 0.945
ACAA1 HSD17B10 0.944
HADHA MCCC2 0.944
ACADSB GCDH 0.944
HADHA HSD17B10 0.942
EHHADH GCDH 0.942
HADH HSD17B10 0.942
ACOX3 HADHB 0.941
ACOX3 GCDH 0.941
ACOX1 ACAT1 0.94
HADHB ACAT1 0.94
ACOX3 ACAA2 0.939
ECHS1 HIBCH 0.938
ACOX3 ACAT1 0.937
ACAT1 HSD17B10 0.936
ECHS1 ACAD8 0.936
HADH HADHA 0.934
HADH EHHADH 0.933
ACADM MCCC1 0.933
HADHA MCCC1 0.932
ACAA1 ACAT1 0.932
HADHA ACAD8 0.931
HADHA ECHS1 0.931
ACAT2 ACOX3 0.931
HADHB MECR 0.93
ACADM GCDH 0.93
ACOX3 ACOX1 0.929
ACAA2 MECR 0.929
IVD EHHADH 0.928
ACAD8 EHHADH 0.928
ACADVL ACOX1 0.927
HADH ACADS 0.927
EHHADH HSD17B10 0.927
ACAT2 HADHB 0.926
ACOX1 ACADL 0.926
HADHB ACAA2 0.925
ACADS GCDH 0.923
ACADM ACAT2 0.922
HADHA EHHADH 0.922
MCCC1 EHHADH 0.92
ECHS1 EHHADH 0.92
ACAT2 ACAA1 0.919
ACAT2 HSD17B10 0.919
ACADM MCCC2 0.919
MCCC2 EHHADH 0.918
ECHS1 MECR 0.916
ACADM ACADL 0.915
ACAT2 ACAA2 0.915
HADHA HIBCH 0.915
HADHA MECR 0.914
HIBCH EHHADH 0.908
Gene Ontology Semantic Similarity
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# 3032 (HADHB) 56922 (MCCC1) 1892 (ECHS1) 10449 (ACAA2) 30 (ACAA1) 3028 (HSD17B10) 39 (ACAT2) 38 (ACAT1) 51 (ACOX1) 64087 (MCCC2) 35 (ACADS) 1962 (EHHADH) 3030 (HADHA) 34 (ACADM) 33 (ACADL) 2639 (GCDH) 8310 (ACOX3) 36 (ACADSB) 26275 (HIBCH) 27034 (ACAD8) 51102 (MECR) 3033 (HADH) 3712 (IVD) 37 (ACADVL)
3032 (HADHB) 1.00 0.41 0.68 0.72 0.56 0.69 0.62 0.51 0.43 0.41 0.25 0.83 0.86 0.40 0.29 0.29 0.37 0.35 0.17 0.35 0.29 0.87 0.44 0.28
56922 (MCCC1) 0.41 1.00 0.48 0.43 0.41 0.41 0.42 0.38 0.51 0.77 0.21 0.50 0.39 0.40 0.30 0.24 0.46 0.27 0.21 0.27 0.24 0.24 0.48 0.29
1892 (ECHS1) 0.68 0.48 1.00 0.47 0.46 0.43 0.50 0.29 0.47 0.60 0.21 0.82 0.64 0.46 0.22 0.20 0.39 0.24 0.17 0.24 0.20 0.20 0.60 0.25
10449 (ACAA2) 0.72 0.43 0.47 1.00 0.69 0.57 0.91 0.61 0.43 0.47 0.17 0.48 0.62 0.38 0.23 0.17 0.36 0.21 0.15 0.21 0.17 0.17 0.47 0.22
30 (ACAA1) 0.56 0.41 0.46 0.69 1.00 0.42 0.74 0.51 0.63 0.46 0.36 0.50 0.53 0.51 0.48 0.45 0.56 0.53 0.17 0.53 0.45 0.29 0.54 0.37
3028 (HSD17B10) 0.69 0.41 0.43 0.57 0.42 1.00 0.39 0.21 0.46 0.43 0.28 0.66 0.64 0.45 0.34 0.34 0.41 0.40 0.17 0.40 0.34 1.00 0.50 0.31
39 (ACAT2) 0.62 0.42 0.50 0.91 0.74 0.39 1.00 0.67 0.43 0.50 0.19 0.50 0.66 0.40 0.19 0.17 0.35 0.21 0.15 0.21 0.17 0.17 0.50 0.22
38 (ACAT1) 0.51 0.38 0.29 0.61 0.51 0.21 0.67 1.00 0.19 0.38 0.27 0.29 0.53 0.26 0.25 0.28 0.20 0.33 0.25 0.33 0.28 0.28 0.23 0.25
51 (ACOX1) 0.43 0.51 0.47 0.43 0.63 0.46 0.43 0.19 1.00 0.47 0.32 0.53 0.44 0.52 0.63 0.51 0.91 0.60 0.17 0.60 0.51 0.34 0.57 0.45
64087 (MCCC2) 0.41 0.77 0.60 0.47 0.46 0.43 0.50 0.38 0.47 1.00 0.21 0.55 0.42 0.46 0.22 0.20 0.39 0.24 0.17 0.24 0.20 0.20 0.60 0.25
35 (ACADS) 0.25 0.21 0.21 0.17 0.36 0.28 0.19 0.27 0.32 0.21 1.00 0.26 0.29 0.72 0.68 0.86 0.37 1.00 0.21 1.00 0.60 0.40 0.60 0.72
1962 (EHHADH) 0.83 0.50 0.82 0.48 0.50 0.66 0.50 0.29 0.53 0.55 0.26 1.00 0.85 0.51 0.27 0.34 0.49 0.40 0.17 0.40 0.34 1.00 0.59 0.31
3030 (HADHA) 0.86 0.39 0.64 0.62 0.53 0.64 0.66 0.53 0.44 0.42 0.29 0.85 1.00 0.44 0.29 0.34 0.38 0.40 0.17 0.40 0.34 1.00 0.47 0.31
34 (ACADM) 0.40 0.40 0.46 0.38 0.51 0.45 0.40 0.26 0.52 0.46 0.72 0.51 0.44 1.00 0.66 0.86 0.50 1.00 0.21 1.00 0.60 0.40 0.82 0.71
33 (ACADL) 0.29 0.30 0.22 0.23 0.48 0.34 0.19 0.25 0.63 0.22 0.68 0.27 0.29 0.66 1.00 0.86 0.69 1.00 0.21 1.00 0.60 0.40 0.56 0.82
2639 (GCDH) 0.29 0.24 0.20 0.17 0.45 0.34 0.17 0.28 0.51 0.20 0.86 0.34 0.34 0.86 0.86 1.00 0.51 0.86 0.17 0.86 0.51 0.34 0.73 0.86
8310 (ACOX3) 0.37 0.46 0.39 0.36 0.56 0.41 0.35 0.20 0.91 0.39 0.37 0.49 0.38 0.50 0.69 0.51 1.00 0.60 0.17 0.60 0.51 0.34 0.52 0.50
36 (ACADSB) 0.35 0.27 0.24 0.21 0.53 0.40 0.21 0.33 0.60 0.24 1.00 0.40 0.40 1.00 1.00 0.86 0.60 1.00 0.21 1.00 0.60 0.40 0.86 1.00
26275 (HIBCH) 0.17 0.21 0.17 0.15 0.17 0.17 0.15 0.25 0.17 0.17 0.21 0.17 0.17 0.21 0.21 0.17 0.17 0.21 1.00 0.21 0.17 0.17 0.17 0.21
27034 (ACAD8) 0.35 0.27 0.24 0.21 0.53 0.40 0.21 0.33 0.60 0.24 1.00 0.40 0.40 1.00 1.00 0.86 0.60 1.00 0.21 1.00 0.60 0.40 0.86 1.00
51102 (MECR) 0.29 0.24 0.20 0.17 0.45 0.34 0.17 0.28 0.51 0.20 0.60 0.34 0.34 0.60 0.60 0.51 0.51 0.60 0.17 0.60 1.00 0.34 0.51 0.60
3033 (HADH) 0.87 0.24 0.20 0.17 0.29 1.00 0.17 0.28 0.34 0.20 0.40 1.00 1.00 0.40 0.40 0.34 0.34 0.40 0.17 0.40 0.34 1.00 0.34 0.40
3712 (IVD) 0.44 0.48 0.60 0.47 0.54 0.50 0.50 0.23 0.57 0.60 0.60 0.59 0.47 0.82 0.56 0.73 0.52 0.86 0.17 0.86 0.51 0.34 1.00 0.62
37 (ACADVL) 0.28 0.29 0.25 0.22 0.37 0.31 0.22 0.25 0.45 0.25 0.72 0.31 0.31 0.71 0.82 0.86 0.50 1.00 0.21 1.00 0.60 0.40 0.62 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HADHA Human Blood - 3250 m 4 day downregulated -1.5984 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
HADHA Rat Skeletal muscle - 4500 m 30 day downregulated - 2-DE Southeast Asia Male wistar rats - Adult male Wistar rats weighing 180–200 g at 300m 22401655
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
HNF4A 3172 HADHA 3030 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT022799 hsa-miR-124-3p Homo sapiens HADHA 3030 Homo sapiens Proteomics;Microarray Functional MTI (Weak) 18668037
MIRT037157 hsa-miR-877-3p Homo sapiens HADHA 3030 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039455 hsa-miR-421 Homo sapiens HADHA 3030 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040109 hsa-miR-615-3p Homo sapiens HADHA 3030 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042269 hsa-miR-484 Homo sapiens HADHA 3030 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049028 hsa-miR-92a-3p Homo sapiens HADHA 3030 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052018 hsa-let-7b-5p Homo sapiens HADHA 3030 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
3030 GO:0003988 NADH dehydrogenase activity GOTERM_MF_DIRECT
3030 GO:0005515 protein binding GOTERM_MF_DIRECT
3030 GO:0006631 fatty acid metabolic process GOTERM_BP_DIRECT
3030 GO:0004300 serine-type endopeptidase activity GOTERM_MF_DIRECT
3030 GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex GOTERM_CC_DIRECT
3030 GO:0042493 response to drug GOTERM_BP_DIRECT
3030 GO:0016509 C-C chemokine receptor activity GOTERM_MF_DIRECT
3030 GO:0005739 mitochondrion GOTERM_CC_DIRECT
3030 GO:0042645 mitochondrial nucleoid GOTERM_CC_DIRECT
3030 GO:0032868 response to insulin GOTERM_BP_DIRECT
3030 GO:0003857 1-acylglycerol-3-phosphate O-acyltransferase activity GOTERM_MF_DIRECT
3030 GO:0032403 protein complex binding GOTERM_MF_DIRECT
3030 GO:0000062 fatty-acyl-CoA binding GOTERM_MF_DIRECT
3030 GO:0006635 fatty acid beta-oxidation GOTERM_BP_DIRECT
3030 GO:0003985 N-acetyllactosamine synthase activity GOTERM_MF_DIRECT
3030 GO:0016508 oxidoreductase activity GOTERM_MF_DIRECT
3030 GO:0035965 cardiolipin acyl-chain remodeling GOTERM_BP_DIRECT
3030 GO:0031012 extracellular matrix GOTERM_CC_DIRECT
3030 GO:0051287 phosphoprotein binding GOTERM_MF_DIRECT
3030 GO:0005743 mitochondrial inner membrane GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3030 hsa00062 Fatty acid elongation
3030 hsa00071 Fatty acid degradation
3030 hsa00380 Tryptophan metabolism
3030 hsa00410 beta-Alanine metabolism
3030 hsa00280 Valine
3030 hsa00310 Lysine degradation
3030 hsa01040 Biosynthesis of unsaturated fatty acids
3030 hsa01100 Metabolic pathways
3030 hsa01130 Biosynthesis of antibiotics
3030 hsa00640 Propanoate metabolism
3030 hsa00650 Butanoate metabolism
3030 hsa01200 Carbon metabolism
3030 hsa01212 Fatty acid metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HADHA 3030 Osteoarthrosis Deformans C0086743 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Trifunctional Protein Deficiency, Type 2 C3714237 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.616 0.552 disease
HADHA 3030 Degenerative polyarthritis C0029408 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Trifunctional Protein Deficiency With Myopathy And Neuropathy C1969443 Disease or Syndrome 0.8 0.616 0.552 disease
HADHA 3030 Long chain 3-hydroxyacyl-CoA dehydrogenase deficiency C3711645 Disease or Syndrome 0.6 0.616 0.552 disease
HADHA 3030 Rhabdomyolysis C0035410 Pathologic Function 0.4 0.616 0.552 phenotype
HADHA 3030 Charcot-Marie-Tooth Disease C0007959 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.616 0.552 group
HADHA 3030 Arthrogryposis C0003886 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Cholestasis C0008370 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Cholestasis in newborn C1112213 Disease or Syndrome 0.3 0.616 0.552 disease
HADHA 3030 Hyperammonemia C0220994 Disease or Syndrome 0.4 0.616 0.552 phenotype
HADHA 3030 Hydrops Fetalis C0020305 Disease or Syndrome 0.41 0.616 0.552 disease
HADHA 3030 Acute fatty liver of pregnancy C1455728 Disease or Syndrome 0.36 0.616 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types