Trans-2-enoyl-CoA reductase, mitochondrial

AltitudeomicsDB
Protein Official symbol MECR
Aliases MECR NBRF1 CGI-63
Chromosomal Location  1
Length 373
Uniprot ID Q9BV79
EC number 1.3.1.104
Protein family Information(Pfam) PF08240;PF00107;
PDB id 1ZSY;2VCY;
InterPro ID IPR013149;IPR013154;IPR011032;IPR036291;IPR020843;
dbSNP rs1128400 rs11544658 rs762913101 rs34835902 rs145192716 rs759218713

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
HADHA HADHB 0.999
HADHA ACAA2 0.979
ECHS1 ACAA2 0.932
HADHA ECHS1 0.931
HADHB MECR 0.93
ACAA2 MECR 0.929
HADHB ACAA2 0.925
ECHS1 MECR 0.916
HADHA MECR 0.914
PPT1 MECR 0.905
PPT2 MECR 0.903
Gene Ontology Semantic Similarity
Download Tab separated file
# 3030 (HADHA) 1892 (ECHS1) 3032 (HADHB) 10449 (ACAA2) 5538 (PPT1) 9374 (PPT2)
3030 (HADHA) 1.00 0.64 0.86 0.62 0.38 0.25
1892 (ECHS1) 0.64 1.00 0.68 0.47 0.51 0.25
3032 (HADHB) 0.86 0.68 1.00 0.72 0.38 0.24
10449 (ACAA2) 0.62 0.47 0.72 1.00 0.43 0.21
5538 (PPT1) 0.38 0.51 0.38 0.43 1.00 0.63
9374 (PPT2) 0.25 0.25 0.24 0.21 0.63 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MECR Bird Cardiac muscle - 4000 m Native downregulated -2.58 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT020488 hsa-miR-155-5p Homo sapiens MECR 51102 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT023488 hsa-miR-1-3p Homo sapiens MECR 51102 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT038990 hsa-let-7f-1-3p Homo sapiens MECR 51102 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT043378 hsa-miR-331-3p Homo sapiens MECR 51102 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
51102 GO:0019166 GDP binding GOTERM_MF_DIRECT
51102 GO:0006631 fatty acid metabolic process GOTERM_BP_DIRECT
51102 GO:0005634 nucleus GOTERM_CC_DIRECT
51102 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
51102 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
51102 GO:0005739 mitochondrion GOTERM_CC_DIRECT
51102 GO:0006633 fatty acid biosynthetic process GOTERM_BP_DIRECT
51102 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
51102 hsa00062 Fatty acid elongation
51102 hsa01100 Metabolic pathways
51102 hsa01212 Fatty acid metabolism
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MECR 51102 DYSTONIA, CHILDHOOD-ONSET, WITH OPTIC ATROPHY AND BASAL GANGLIA ABNORMALITIES C4310634 Disease or Syndrome 0.6 0.735 0.207 disease
MECR 51102 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.735 0.207 group
MECR 51102 Mitochondrial Diseases C0751651 Disease or Syndrome 0.3 0.735 0.207 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types