Palmitoyl-protein thioesterase 1

AltitudeomicsDB
Protein Official symbol PPT1
Aliases PPT1 CLN1 PPT
Chromosomal Location  1 
Length 306
Uniprot ID P50897
EC number 3.1.2.22
Protein family Information(Pfam) PF02089;
PDB id 3GRO;
InterPro ID IPR029058;IPR002472;IPR030294;
dbSNP rs386833626 rs386833627 rs386833631 rs137852702 rs137852696 rs137852697 rs137852701 rs386833642 rs137852695 rs1800205 rs386833646 rs386833647 rs386833650 rs148412181 rs148412181 rs386833657 rs386833658 rs137852698 rs386833661 rs386833663 rs386833665 rs386833666 rs386833669 rs386833671

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PPT1 MECR 0.905
Gene Ontology Semantic Similarity
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# 5538 (PPT1) 51102 (MECR)
5538 (PPT1) 1.00 0.20
51102 (MECR) 0.20 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PPT1 Bird Flight muscle - 4000 m Native upregulated 5.47 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
PPT1 Bird Liver - 4000 m Native upregulated 6.75 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
PPT1 Bird Lungs - 4000 m Native upregulated 5.52 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
PPT1 Bird Kidney - 4000 m Native upregulated 7.29 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
PPT1 Bird Cardiac muscle - 4000 m Native upregulated 6.46 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT029493 hsa-miR-26b-5p Homo sapiens PPT1 5538 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT031707 hsa-miR-16-5p Homo sapiens PPT1 5538 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT042764 hsa-miR-339-5p Homo sapiens PPT1 5538 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044242 hsa-miR-29c-3p Homo sapiens PPT1 5538 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044818 hsa-miR-320a Homo sapiens PPT1 5538 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046542 hsa-miR-15b-5p Homo sapiens PPT1 5538 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049981 hsa-miR-29a-3p Homo sapiens PPT1 5538 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT654808 hsa-miR-501-5p Homo sapiens PPT1 5538 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT654807 hsa-miR-8055 Homo sapiens PPT1 5538 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT654809 hsa-miR-208b-5p Homo sapiens PPT1 5538 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT654810 hsa-miR-208a-5p Homo sapiens PPT1 5538 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
Gene Ontology
ID GO ID GO Term GO Type
5538 GO:0007601 visual perception GOTERM_BP_DIRECT
5538 GO:0005515 protein binding GOTERM_MF_DIRECT
5538 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
5538 GO:0015031 protein transport GOTERM_BP_DIRECT
5538 GO:0005576 extracellular region GOTERM_CC_DIRECT
5538 GO:0005829 cytosol GOTERM_CC_DIRECT
5538 GO:0002084 protein depalmitoylation GOTERM_BP_DIRECT
5538 GO:0007042 lysosomal lumen acidification GOTERM_BP_DIRECT
5538 GO:0007625 grooming behavior GOTERM_BP_DIRECT
5538 GO:0051186 cofactor metabolic process GOTERM_BP_DIRECT
5538 GO:0006907 pinocytosis GOTERM_BP_DIRECT
5538 GO:0008344 adult locomotory behavior GOTERM_BP_DIRECT
5538 GO:0030149 sphingolipid catabolic process GOTERM_BP_DIRECT
5538 GO:0030424 axon GOTERM_CC_DIRECT
5538 GO:0007269 neurotransmitter secretion GOTERM_BP_DIRECT
5538 GO:0031579 membrane raft organization GOTERM_BP_DIRECT
5538 GO:0032429 regulation of phospholipase A2 activity GOTERM_BP_DIRECT
5538 GO:0050896 response to stimulus GOTERM_BP_DIRECT
5538 GO:0045121 membrane raft GOTERM_CC_DIRECT
5538 GO:0007268 chemical synaptic transmission GOTERM_BP_DIRECT
5538 GO:0007420 brain development GOTERM_BP_DIRECT
5538 GO:0005764 lysosome GOTERM_CC_DIRECT
5538 GO:0008021 synaptic vesicle GOTERM_CC_DIRECT
5538 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
5538 GO:0008306 associative learning GOTERM_BP_DIRECT
5538 GO:0048260 positive regulation of receptor-mediated endocytosis GOTERM_BP_DIRECT
5538 GO:0030308 negative regulation of cell growth GOTERM_BP_DIRECT
5538 GO:0051181 cofactor transport GOTERM_BP_DIRECT
5538 GO:0008474 inositol-1 GOTERM_MF_DIRECT
5538 GO:0007399 nervous system development GOTERM_BP_DIRECT
5538 GO:0016042 lipid catabolic process GOTERM_BP_DIRECT
5538 GO:0043524 negative regulation of neuron apoptotic process GOTERM_BP_DIRECT
5538 GO:0044257 cellular protein catabolic process GOTERM_BP_DIRECT
5538 GO:0048549 positive regulation of pinocytosis GOTERM_BP_DIRECT
5538 GO:0016290 antioxidant activity GOTERM_MF_DIRECT
5538 GO:0005634 nucleus GOTERM_CC_DIRECT
5538 GO:0050803 regulation of synapse structure or activity GOTERM_BP_DIRECT
5538 GO:0006898 receptor-mediated endocytosis GOTERM_BP_DIRECT
5538 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GOTERM_BP_DIRECT
5538 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
5538 GO:0016020 membrane GOTERM_CC_DIRECT
5538 GO:0030425 dendrite GOTERM_CC_DIRECT
5538 GO:0043202 lysosomal lumen GOTERM_CC_DIRECT
5538 GO:0030163 protein catabolic process GOTERM_BP_DIRECT
5538 GO:0048666 neuron development GOTERM_BP_DIRECT
5538 GO:0005615 extracellular space GOTERM_CC_DIRECT
5538 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5538 hsa00062 Fatty acid elongation
5538 hsa01100 Metabolic pathways
5538 hsa01212 Fatty acid metabolism
5538 hsa04142 Lysosome
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PPT1 5538 CEROID LIPOFUSCINOSIS, NEURONAL, 1 C1850451 Disease or Syndrome 0.94 0.627 0.448 disease
PPT1 5538 Ceroid lipofuscinosis, neuronal 1, infantile C2931673 Disease or Syndrome 0.8 0.627 0.448 disease
PPT1 5538 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.627 0.448 group
PPT1 5538 Epileptic encephalopathy C0543888 Disease or Syndrome 0.3 0.627 0.448 disease
PPT1 5538 Hyperammonemia C0220994 Disease or Syndrome 0.3 0.627 0.448 phenotype
PPT1 5538 Leukodystrophy C0023520 Disease or Syndrome 0.3 0.627 0.448 disease
PPT1 5538 Infantile neuronal ceroid lipofuscinosis C0268281 Disease or Syndrome 0.6 0.627 0.448 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
PPT1 5538 LAMOTRIGINE LAMOTRIGINE CHEMBL741 None