Electron transfer flavoprotein subunit a, mitochondrial

AltitudeomicsDB
Protein Official symbol ETFA
Aliases ETFA
Chromosomal Location 15
Length 333
Uniprot ID P13804
EC number None
Protein family Information(Pfam) PF01012;PF00766;
PDB id 1EFV;1T9G;2A1T;2A1U;
InterPro ID IPR029035;IPR014730;IPR001308;IPR033947;IPR014731;IPR018206;IPR014729;
dbSNP rs119458971 rs119458969 rs1801591 rs119458970

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ETFDH ETFB 0.9990000000000001
ETFA ETFDH 0.9990000000000001
ETFA ETFB 0.9990000000000001
ACADM ECHS1 0.9690000000000001
ETFB CYCS 0.9570000000000001
ETFA ACADM 0.948
ETFA CYCS 0.9440000000000001
ETFA LYRM5 0.919
ETFA ECHS1 0.9109999999999999
Gene Ontology Semantic Similarity
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# 2110 (ETFDH) 2108 (ETFA) 34 (ACADM) 2109 (ETFB) 1892 (ECHS1) 54205 (CYCS) 144363 (LYRM5)
2110 (ETFDH) 1.00 0.76 0.43 0.48 0.35 0.41 0.48
2108 (ETFA) 0.76 1.00 0.58 0.76 0.55 0.60 1.00
34 (ACADM) 0.43 0.58 1.00 0.47 0.46 0.38 0.82
2109 (ETFB) 0.48 0.76 0.47 1.00 0.64 0.68 1.00
1892 (ECHS1) 0.35 0.55 0.46 0.64 1.00 0.49 1.00
54205 (CYCS) 0.41 0.60 0.38 0.68 0.49 1.00 1.00
144363 (LYRM5) 0.48 1.00 0.82 1.00 1.00 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ETFA Human Skeletal muscle - 4559 m 9 day downregulated -1.2 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
TAF1 6872 ETFA 2108 proximal_filtered 22955619 TRANSFAC
EBF1 1879 ETFA 2108 proximal_filtered 22955619 TRANSFAC
BRCA1 672 ETFA 2108 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT049145 hsa-miR-92a-3p Homo sapiens ETFA 2108 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050284 hsa-miR-25-3p Homo sapiens ETFA 2108 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050733 hsa-miR-18a-5p Homo sapiens ETFA 2108 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052043 hsa-let-7b-5p Homo sapiens ETFA 2108 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
2108 GO:0009055 electron carrier activity GOTERM_MF_DIRECT
2108 GO:0005739 mitochondrion GOTERM_CC_DIRECT
2108 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2108 GO:0022904 respiratory electron transport chain GOTERM_BP_DIRECT
2108 GO:0003995 acid phosphatase activity GOTERM_MF_DIRECT
2108 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
2108 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
2108 GO:0055088 lipid homeostasis GOTERM_BP_DIRECT
2108 GO:0052890 lysophosphatidic acid phosphatase activity GOTERM_MF_DIRECT
2108 GO:0050660 methylarsonate reductase activity GOTERM_MF_DIRECT
2108 GO:0000062 tRNA binding GOTERM_MF_DIRECT
2108 GO:0005515 protein binding GOTERM_MF_DIRECT
2108 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ETFA 2108 Liver carcinoma C2239176 Neoplastic Process 0.3 0.611 0.655 disease
ETFA 2108 Degenerative polyarthritis C0029408 Disease or Syndrome 0.3 0.611 0.655 disease
ETFA 2108 Osteoarthrosis Deformans C0086743 Disease or Syndrome 0.3 0.611 0.655 disease
ETFA 2108 Glutaric Aciduria IIA C1856401 Disease or Syndrome 0.5 0.611 0.655 disease
ETFA 2108 Glutaric Aciduria IIB C1856403 Disease or Syndrome 0.5 0.611 0.655 disease
ETFA 2108 Multiple Acyl Coenzyme A Dehydrogenase Deficiency C0268596 Disease or Syndrome 0.64 0.611 0.655 disease
ETFA 2108 Glutaric Aciduria IIC C1856405 Disease or Syndrome 0.5 0.611 0.655 disease
ETFA 2108 Hyperammonemia C0220994 Disease or Syndrome 0.3 0.611 0.655 phenotype
ETFA 2108 Arthrogryposis C0003886 Disease or Syndrome 0.3 0.611 0.655 disease
ETFA 2108 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.611 0.655 group
ETFA 2108 Rhabdomyolysis C0035410 Pathologic Function 0.3 0.611 0.655 phenotype
ETFA 2108 GLUTARIC ACIDEMIA IIB C3278155 Disease or Syndrome 0.3 0.611 0.655 disease
ETFA 2108 GLUTARIC ACIDEMIA IIA C3278154 Disease or Syndrome 0.4 0.611 0.655 disease
ETFA 2108 GLUTARIC ACIDEMIA IIC C3278156 Disease or Syndrome 0.3 0.611 0.655 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types