ALTITUDEOMICSDB

Serine/threonine-protein kinase ATR

AltitudeomicsDB

Protein Official symbol	ATR
Aliases	ATR FRP1
Chromosomal Location	16
Length	2644
Uniprot ID	Q13535
EC number	2.7.11.1
Protein family Information(Pfam)	PF02259;PF02260;PF00454;PF08064;
PDB id	5YZ0;
InterPro ID	IPR011989;IPR016024;IPR003152;IPR021133;IPR011009;IPR000403;IPR036940;IPR018936;IPR003151;IPR014009;IPR011990;IPR012993;
dbSNP	rs35306038 rs28897763 rs2227928 rs2229033 rs28897764 rs28910271 rs34253059 rs34766606 rs34124242 rs55724025 rs55894265 rs35134774 rs28910273 rs387906797 rs2229032 rs33972295

Protein Protein Interaction

Download Tab separated file

AltitudeomicsDB

Protein 1	Protein 2	Combine Score
CHEK2	ATM	0.999
MCM2	MCM4	0.999
CDC45	MCM4	0.999
MCM10	CDC45	0.999
CDC45	MCM2	0.999
FANCI	FANCD2	0.999
CDC7	DBF4	0.998
RAD51	RAD52	0.998
CHEK1	CDC25A	0.998
RAD50	MRE11A	0.998
CHEK1	ATM	0.998
MCM10	MCM2	0.998
ATM	TP53	0.998
RAD51	BRCA2	0.997
CDC45	CHEK1	0.997
CHEK1	EXO1	0.997
RPA2	RPA1	0.997
CHEK2	CDC25C	0.997
H2AFX	ATM	0.997
RAD9A	HUS1	0.997
CHEK1	RAD51	0.997
ATM	NBN	0.997
EXO1	DNA2	0.997
CHEK2	ATR	0.997
CHEK2	TP53	0.997
CHEK1	CDC25C	0.996
RAD17	CLSPN	0.996
MCM10	MCM4	0.996
FANCD2	ATM	0.996
CHEK1	CLSPN	0.996
FANCD2	FANCM	0.996
RAD51	EXO1	0.996
CDC7	MCM2	0.996
RAD17	HUS1	0.996
BRCA1	BRCA2	0.996
CDC7	MCM4	0.995
CHEK1	ATR	0.995
TOP3A	RMI1	0.995
BRCA2	FANCD2	0.995
CHEK1	TOPBP1	0.995
CDC45	CDC7	0.995
RAD9A	TOPBP1	0.995
RFC5	RFC3	0.995
RBBP8	ATM	0.994
ERCC2	ERCC1	0.994
CDC45	DBF4	0.994
FANCI	FANCM	0.994
TIMELESS	TIPIN	0.994
EXO1	BLM	0.994
CHEK1	MCM4	0.994
RFC3	MCM2	0.994
ATM	TOPBP1	0.994
EXO1	ATM	0.993
CHEK1	MCM2	0.993
CHEK2	CDC25A	0.993
RPA2	MCM2	0.993
RAD17	ATM	0.993
RFC5	MCM2	0.993
MCM10	CHEK1	0.993
RAD17	CHEK1	0.993
ERCC4	ERCC1	0.993
CHEK1	TP53	0.993
RAD17	RAD9A	0.993
CDC25A	CDK2	0.992
TP53	CDK2	0.992
CHEK1	RAD9A	0.992
RAD51	DNA2	0.992
CHEK1	TIPIN	0.992
EXO1	WRN	0.992
ATRIP	TOPBP1	0.992
RAD51	ATM	0.991
BRCA1	ATM	0.991
BRCA1	RAD51	0.991
MCM10	CDC7	0.991
BRCA2	RAD51C	0.991
EXO1	ATR	0.991
BRCA2	ATM	0.991
TOPBP1	HUS1	0.991
RAD51	BLM	0.991
MCM2	RPA1	0.99
DBF4	MCM4	0.99
ERCC2	ERCC4	0.99
RAD17	TOPBP1	0.99
BRCA2	FANCI	0.99
ATR	RAD9A	0.99
CDK2	MCM2	0.99
RAD52	ATM	0.99
TIMELESS	CHEK1	0.99
WRN	ATM	0.99
CDK2	MCM4	0.99
RBBP8	EXO1	0.99
TOP3A	BLM	0.99
MRE11A	ATM	0.989
CHEK1	HUS1	0.989
RAD17	ATR	0.989
CLSPN	TIPIN	0.989
DBF4	MCM2	0.989
MCM10	DBF4	0.989
BRCA1	TP53	0.989
ATRIP	ATM	0.989
DNA2	WRN	0.989
RAD9A	ATM	0.989
MCM4	RPA1	0.988
BRCA1	CHEK2	0.988
CLSPN	TOPBP1	0.988
RBBP8	DNA2	0.988
CDC7	CHEK1	0.988
TOP3A	EXO1	0.988
CHEK1	BLM	0.988
ATR	TOPBP1	0.988
MRE11A	NBN	0.988
EXO1	RAD52	0.988
ATRIP	HUS1	0.988
RPA2	ATM	0.988
CDC45	CDK2	0.987
RPA2	MCM4	0.987
CDC25C	TP53	0.987
RAD52	WRN	0.987
DNA2	BLM	0.987
BRCA1	EXO1	0.987
BRCA1	FANCD2	0.987
CHEK1	RPA1	0.987
H2AFX	CHEK2	0.987
BRCA1	CHEK1	0.987
CHEK1	RPA2	0.987
RAD50	SMC3	0.987
TOP3A	DNA2	0.986
DNA2	RMI1	0.986
RAD9B	HUS1	0.986
RAD17	ATRIP	0.986
ATM	HUS1	0.986
RAD51	RPA1	0.986
RAD51	ATR	0.986
DNA2	ATR	0.986
RAD52	ATR	0.986
DNA2	ATM	0.986
RAD51	TOPBP1	0.986
RAD51	ERCC1	0.986
TOP3A	WRN	0.986
CHEK1	ATRIP	0.985
BRCA1	RBBP8	0.985
RAD51	MRE11A	0.985
RAD51C	ATM	0.985
TOP3A	RAD51	0.985
RAD17	EXO1	0.985
CDC45	CLSPN	0.985
EXO1	RMI1	0.985
TOP3A	RAD52	0.985
RAD52	DNA2	0.985
RAD51	WRN	0.985
RAD51	RPA2	0.984
BRCA1	FANCI	0.984
TIPIN	TOPBP1	0.984
RAD51	RAD9A	0.984
RAD50	NBN	0.984
CLSPN	RAD9A	0.984
CHEK2	NBN	0.983
RAD52	ERCC1	0.983
ATRIP	CLSPN	0.983
EXO1	MRE11A	0.983
BRCA1	RAD51C	0.983
CDC7	CLSPN	0.983
FANCD2	ERCC1	0.983
EXO1	CLSPN	0.983
MCM2	TOPBP1	0.983
RMI1	FANCM	0.982
BRCA2	EXO1	0.982
H2AFX	ATR	0.982
BLM	RMI1	0.982
EXO1	ERCC1	0.982
CLSPN	HUS1	0.982
RAD52	RPA1	0.982
SMC3	ATM	0.982
RAD17	RAD9B	0.982
H2AFX	RAD51	0.982
CHEK1	BRCA2	0.981
CDC7	CDK2	0.981
RBBP8	BRCA2	0.981
RAD17	RAD51	0.981
FANCM	ERCC1	0.981
TOP3A	FANCM	0.981
ATRIP	RAD9A	0.981
TIMELESS	CLSPN	0.981
CHEK1	RBBP8	0.98
RMI1	WRN	0.98
RAD17	RAD52	0.98
ATM	ERCC1	0.98
H2AFX	BRCA1	0.98
RAD52	BLM	0.98
MCM10	CLSPN	0.98
RBBP8	TOPBP1	0.98
CHEK1	DNA2	0.98
ATR	HUS1	0.98
FANCD2	TOPBP1	0.979
CLSPN	ATM	0.979
FANCI	ERCC1	0.979
ATR	MCM4	0.979
RAD52	MRE11A	0.979
RFC3	TIPIN	0.979
TOPBP1	RPA1	0.979
CHEK2	MRE11A	0.979
DNA2	TOPBP1	0.979
ATR	ATRIP	0.979
BLM	ATM	0.978
RAD17	TIPIN	0.978
RBBP8	RAD51	0.978
BLM	ATR	0.978
RAD51	NBN	0.978
RPA2	RAD52	0.978
WRN	TP53	0.978
RAD51	ERCC4	0.978
RAD1	HUS1	0.978
TIMELESS	TOPBP1	0.978
RAD17	RFC3	0.978
RAD50	ATM	0.978
CDC45	RPA1	0.978
CLSPN	MCM2	0.977
BRCA2	ATR	0.977
WRN	TOPBP1	0.977
RAD51	RMI1	0.977
BRCA1	RAD52	0.977
RBBP8	CDK2	0.976
RAD52	RMI1	0.976
BLM	FANCM	0.976
ATR	FANCM	0.976
ATR	CLSPN	0.976
BRCA2	CDK2	0.975
ATR	MRE11A	0.975
RFC3	EXO1	0.975
RAD17	RAD1	0.975
ATR	RPA1	0.975
ATRIP	FANCD2	0.975
WRN	ERCC1	0.975
BRCA1	DNA2	0.975
RAD51C	MRE11A	0.975
CDC45	RPA2	0.975
EXO1	ERCC4	0.975
BRCA1	TOPBP1	0.975
EXO1	TOPBP1	0.975
CHEK1	DBF4	0.975
EXO1	RPA1	0.975
RPA2	DNA2	0.974
RPA2	TIPIN	0.974
RBBP8	ATR	0.974
RFC3	RPA1	0.974
ERCC4	FANCD2	0.974
ATM	RPA1	0.974
RAD9A	WRN	0.974
CDC45	ATR	0.974
ATR	DBF4	0.974
RPA2	EXO1	0.974
ATM	CDK2	0.973
BRCA1	CLSPN	0.973
ATR	NBN	0.973
TP53	TOPBP1	0.973
RPA2	ATR	0.973
BLM	TOPBP1	0.973
DNA2	RPA1	0.973
BRCA2	WRN	0.973
CHEK1	MRE11A	0.973
EXO1	RAD9A	0.972
TIPIN	HUS1	0.972
RAD51	HUS1	0.972
CHEK1	NBN	0.972
RAD51	RAD50	0.972
BLM	RPA1	0.972
BRCA2	DNA2	0.971
RFC5	RPA1	0.971
TOP3A	ATR	0.971
DNA2	MRE11A	0.971
RAD50	ATR	0.971
RAD9A	FANCD2	0.971
TIMELESS	ATR	0.971
BRCA1	NBN	0.971
RAD52	ERCC4	0.971
H2AFX	RPA2	0.971
BLM	ERCC1	0.97
RAD50	RAD52	0.97
TIMELESS	RFC5	0.97
RAD1	RAD9A	0.97
ATR	WRN	0.97
CHEK1	WRN	0.97
BRCA2	NBN	0.97
ATR	MCM2	0.97
RBBP8	NBN	0.97
BRCA1	ERCC1	0.97
CHEK1	RFC3	0.97
EXO1	NBN	0.97
BRCA2	MRE11A	0.97
BRCA1	ATR	0.97
RAD9A	TP53	0.97
TIMELESS	BLM	0.97
FANCI	TOPBP1	0.969
ATR	ERCC4	0.969
ATRIP	RPA1	0.969
RAD17	RPA1	0.969
BLM	ERCC4	0.969
BRCA1	WRN	0.969
RAD17	NBN	0.969
RAD1	ATR	0.969
CDC7	ATR	0.969
RPA2	ATRIP	0.969
H2AFX	BRCA2	0.968
RPA2	TOPBP1	0.968
ATR	TIPIN	0.968
BRCA1	ATRIP	0.968
CHEK1	ERCC2	0.968
BLM	MRE11A	0.968
RAD17	BLM	0.968
H2AFX	RBBP8	0.967
H2AFX	FANCD2	0.967
RFC5	MCM4	0.967
CLSPN	DBF4	0.967
RPA1	ERCC1	0.967
MRE11A	WRN	0.967
BRCA1	MRE11A	0.967
RAD17	WRN	0.967
RAD52	RAD9A	0.967
ATRIP	TIPIN	0.967
RAD9A	TIPIN	0.967
RBBP8	ATRIP	0.966
MRE11A	ERCC4	0.966
RAD1	ATM	0.966
CHEK1	RAD1	0.966
RAD17	RPA2	0.966
TIMELESS	ATM	0.966
TOP3A	ATM	0.966
RAD9B	TOPBP1	0.966
RBBP8	WRN	0.966
RAD50	EXO1	0.966
RFC5	TIPIN	0.965
RBBP8	RAD52	0.965
RAD51	RAD1	0.965
BLM	TIPIN	0.965
TIMELESS	RAD17	0.965
EXO1	HUS1	0.965
RAD1	TOPBP1	0.965
FANCI	ERCC4	0.965
ERCC4	ATM	0.965
RFC3	RPA2	0.965
ATM	TIPIN	0.965
BRCA2	BLM	0.964
TOP3A	ERCC1	0.964
HUS1	RPA1	0.964
ATR	TP53	0.964
TOP3A	BRCA2	0.964
TIMELESS	WRN	0.964
RBBP8	RPA2	0.964
EXO1	TIPIN	0.963
FANCD2	NBN	0.963
BRCA1	RAD9A	0.963
EXO1	RAD51C	0.963
RAD17	MRE11A	0.963
ATRIP	NBN	0.963
RFC5	EXO1	0.962
EXO1	ATRIP	0.962
BRCA1	CDK2	0.962
H2AFX	NBN	0.962
H2AFX	CDK2	0.962
TIMELESS	HUS1	0.962
NBN	TOPBP1	0.962
RAD17	BRCA1	0.962
WRN	RPA1	0.962
TP53	RPA1	0.962
ATRIP	CDK2	0.962
RPA2	ERCC1	0.961
DNA2	RAD9A	0.961
ATR	RMI1	0.961
TIMELESS	SMC3	0.961
CLSPN	MCM4	0.961
RPA2	BLM	0.961
RAD9A	NBN	0.961
RPA2	CDK2	0.961
ATRIP	FANCI	0.961
RAD1	ATRIP	0.961
RAD9A	RPA1	0.961
BRCA2	RAD9A	0.961
MRE11A	FANCD2	0.961
ATR	FANCD2	0.961
ATR	ERCC1	0.96
RAD51C	NBN	0.96
RAD17	FANCD2	0.96
RPA2	RAD9A	0.96
TOP3A	TP53	0.96
TIMELESS	DNA2	0.96
ERCC2	ATM	0.96
RFC3	TOPBP1	0.959
CDK2	DBF4	0.959
RAD17	BRCA2	0.959
TOP3A	ERCC4	0.959
DNA2	ATRIP	0.959
BRCA1	BLM	0.959
RAD17	DNA2	0.959
RPA2	TP53	0.959
ATR	CDC25A	0.959
RAD52	TOPBP1	0.959
DNA2	CLSPN	0.959
TIMELESS	EXO1	0.959
BRCA1	RPA2	0.959
TOP3A	MRE11A	0.959
BRCA2	TOPBP1	0.959
RAD51	RFC3	0.959
RPA2	WRN	0.958
ATR	CDC25C	0.958
FANCM	RPA1	0.958
RAD51	CDK2	0.958
WRN	HUS1	0.958
RMI1	RPA1	0.958
RFC3	DNA2	0.958
MCM10	CDK2	0.957
CDC25C	CDC25A	0.957
RMI1	ERCC4	0.957
MRE11A	HUS1	0.957
RAD51C	RMI1	0.957
RAD52	ATRIP	0.957
RAD51	ATRIP	0.957
H2AFX	FANCI	0.957
MCM10	TIPIN	0.957
RAD17	ERCC1	0.956
BRCA1	HUS1	0.956
RFC5	ATR	0.956
NBN	HUS1	0.956
RFC3	FANCI	0.956
ERCC4	WRN	0.956
RBBP8	RMI1	0.955
WRN	TIPIN	0.955
TIMELESS	RPA1	0.955
RBBP8	RAD9A	0.955
DNA2	ERCC1	0.955
ERCC2	ATR	0.955
TIMELESS	ATRIP	0.955
RFC3	MCM4	0.955
CLSPN	CDK2	0.955
TIMELESS	MCM2	0.955
DNA2	TIPIN	0.955
RFC3	MRE11A	0.955
RBBP8	RAD51C	0.955
TIPIN	RPA1	0.955
MRE11A	RPA1	0.955
CDC7	RPA2	0.954
CHEK1	RAD9B	0.954
RFC5	CHEK1	0.954
RPA2	FANCD2	0.954
RPA2	CLSPN	0.954
RAD50	BLM	0.954
RAD50	DNA2	0.954
RAD1	EXO1	0.954
TOP3A	RAD51C	0.954
TP53	NBN	0.954
CDC45	ATRIP	0.954
MCM10	ATR	0.954
RAD51C	RPA1	0.954
BRCA1	ERCC4	0.954
BLM	HUS1	0.953
ATRIP	CDC25A	0.953
ATR	RAD51C	0.953
SMC3	ATR	0.953
ERCC4	RPA1	0.953
MRE11A	ERCC1	0.953
H2AFX	MRE11A	0.953
MCM10	RPA1	0.953
ATR	CDK2	0.953
RAD17	TP53	0.953
TIMELESS	RFC3	0.953
RFC5	RPA2	0.953
RBBP8	CLSPN	0.953
NBN	ERCC1	0.953
ATRIP	FANCM	0.953
CDC25C	CDK2	0.952
BRCA1	ERCC2	0.952
CDC45	TIPIN	0.952
DNA2	ERCC4	0.952
CLSPN	WRN	0.952
RBBP8	TP53	0.952
RAD9B	RAD1	0.952
DNA2	HUS1	0.952
ERCC2	RPA1	0.952
RAD1	CLSPN	0.952
TOP3A	TOPBP1	0.952
RFC3	HUS1	0.952
RAD17	ERCC4	0.952
RAD17	RAD50	0.952
MRE11A	RMI1	0.951
RAD51C	WRN	0.951
MRE11A	TP53	0.951
BRCA2	ATRIP	0.951
BRCA1	RAD50	0.951
H2AFX	RPA1	0.951
CHEK1	CDK2	0.951
ATR	FANCI	0.951
RFC5	RAD51	0.951
ATR	ATM	0.951
CDC45	EXO1	0.951
WRN	NBN	0.951
BLM	WRN	0.95
TOP3A	RPA1	0.95
SMC3	MRE11A	0.95
RAD9B	ATR	0.95
RMI1	ATM	0.95
RFC3	ATR	0.95
CLSPN	RPA1	0.95
RAD9B	ATM	0.95
ATRIP	TP53	0.95
RMI1	TOPBP1	0.949
RAD50	RAD51C	0.949
BRCA2	RMI1	0.949
RBBP8	HUS1	0.949
RBBP8	RPA1	0.949
CLSPN	NBN	0.949
RPA2	HUS1	0.949
ATRIP	WRN	0.949
RBBP8	BLM	0.948
RMI1	ERCC1	0.948
H2AFX	BLM	0.948
TP53	HUS1	0.948
RFC5	TOPBP1	0.948
RFC3	WRN	0.948
RFC3	RAD9A	0.948
RAD17	RBBP8	0.948
RFC5	HUS1	0.947
TIMELESS	CDC45	0.947
FANCD2	HUS1	0.947
RFC5	RAD9A	0.947
BLM	NBN	0.947
BRCA2	HUS1	0.947
EXO1	TP53	0.947
RAD1	DNA2	0.946
ERCC4	TOPBP1	0.946
BRCA2	RPA1	0.946
RAD17	FANCI	0.946
BRCA1	RMI1	0.946
ERCC4	HUS1	0.946
ATRIP	MCM2	0.946
RBBP8	ERCC1	0.946
BRCA2	RPA2	0.946
TOP3A	RAD1	0.946
RBBP8	MRE11A	0.946
TOP3A	RAD50	0.945
RAD51	RAD51C	0.945
RAD17	MCM2	0.945
RPA2	ERCC4	0.945
CHEK1	RMI1	0.945
BLM	RAD51C	0.945
CHEK2	BRCA2	0.945
BRCA1	RPA1	0.945
RPA2	FANCM	0.945
CHEK2	RAD50	0.945
TOP3A	RAD17	0.945
RAD50	WRN	0.944
BLM	RAD9A	0.944
RAD9A	ERCC1	0.944
CDK2	RPA1	0.944
H2AFX	RAD51C	0.944
HUS1	ERCC1	0.944
RPA2	NBN	0.944
TIMELESS	TOP3A	0.944
TOPBP1	ERCC1	0.944
RFC3	ATM	0.944
CHEK2	EXO1	0.943
ERCC2	FANCD2	0.943
TOP3A	RBBP8	0.943
RAD9A	ERCC4	0.943
BRCA1	SMC3	0.943
RAD51C	TOPBP1	0.943
RAD52	HUS1	0.943
DNA2	NBN	0.943
ATRIP	CDC25C	0.942
RAD9B	NBN	0.942
RAD17	RAD51C	0.942
RAD9A	MCM2	0.942
MRE11A	TOPBP1	0.941
RAD50	RMI1	0.941
MCM10	RPA2	0.941
BRCA1	TIPIN	0.941
RAD52	NBN	0.941
RAD17	RFC5	0.941
ERCC4	NBN	0.941
CDC45	RAD51	0.94
TOP3A	BRCA1	0.94
TIMELESS	RAD9A	0.94
TOP3A	CHEK1	0.939
ATRIP	ERCC1	0.939
BLM	CLSPN	0.939
CDK2	NBN	0.939
BLM	CDK2	0.939
RFC3	BLM	0.939
RAD9B	BRCA2	0.939
H2AFX	SMC3	0.939
RAD9B	EXO1	0.939
RAD1	WRN	0.939
H2AFX	RAD50	0.939
RFC3	CLSPN	0.938
ERCC4	FANCM	0.938
FANCI	HUS1	0.938
DNA2	RAD51C	0.938
RAD50	ERCC1	0.938
MCM2	HUS1	0.938
RFC5	FANCD2	0.938
ATRIP	RMI1	0.937
RAD1	NBN	0.937
BRCA1	RFC3	0.936
BRCA1	RFC5	0.936
FANCD2	RPA1	0.936
TIMELESS	BRCA1	0.936
RAD1	ERCC4	0.936
RFC5	FANCI	0.936
RAD1	TIPIN	0.935
RAD1	BLM	0.935
RAD9B	RAD51	0.935
CDC7	ATRIP	0.935
RAD9B	TIPIN	0.935
MRE11A	RAD9A	0.935
RFC5	ATM	0.934
TIMELESS	RPA2	0.934
RPA2	RMI1	0.934
BRCA2	RAD50	0.934
RPA2	FANCI	0.933
RFC5	DNA2	0.933
RAD51C	ATRIP	0.933
RBBP8	RAD50	0.933
TIMELESS	MCM4	0.932
RAD51C	RAD9A	0.932
BRCA2	RFC3	0.932
RMI1	NBN	0.932
ERCC2	RPA2	0.932
RAD1	RPA1	0.932
RAD50	RPA1	0.932
RAD9A	FANCI	0.932
RBBP8	TIPIN	0.932
RAD1	RAD52	0.932
CHEK1	RAD50	0.931
RMI1	TIPIN	0.931
RAD17	RMI1	0.931
RAD51	FANCD2	0.931
FANCI	RPA1	0.931
RFC5	WRN	0.93
BLM	TP53	0.93
SMC3	MCM4	0.93
ATRIP	DBF4	0.93
RPA2	MRE11A	0.93
SMC3	NBN	0.93
RAD9B	BLM	0.93
RPA2	RAD51C	0.93
RMI1	RAD9A	0.929
RAD50	TP53	0.929
TOP3A	NBN	0.929
DNA2	TP53	0.929
RAD9B	CLSPN	0.929
RFC5	CLSPN	0.929
RFC5	RAD52	0.928
RFC3	ERCC4	0.928
RMI1	CLSPN	0.928
TOP3A	RPA2	0.928
TOP3A	TIPIN	0.928
TOP3A	RFC3	0.927
BLM	ATRIP	0.927
RFC3	RAD51C	0.927
RFC5	RAD51C	0.926
RFC5	RMI1	0.926
CDC7	RPA1	0.925
RFC3	FANCD2	0.925
RAD9B	ERCC4	0.925
RFC3	RAD52	0.925
RAD1	ERCC1	0.925
RFC5	BLM	0.925
RAD51C	HUS1	0.924
RAD50	RAD9A	0.924
RAD50	HUS1	0.924
TOP3A	RFC5	0.924
RFC3	ATRIP	0.924
NBN	RPA1	0.924
TOP3A	RAD9A	0.923
MRE11A	ATRIP	0.923
RFC5	BRCA2	0.923
MRE11A	CLSPN	0.923
TOP3A	CLSPN	0.923
RAD1	RMI1	0.923
TOP3A	H2AFX	0.922
RFC5	ERCC4	0.922
RFC5	RAD1	0.922
RBBP8	ERCC4	0.922
RAD1	FANCI	0.922
RAD1	RPA2	0.922
MRE11A	CDK2	0.921
RAD50	CDK2	0.921
ATRIP	MCM4	0.921
RAD1	RFC3	0.921
TOP3A	ATRIP	0.921
RAD1	BRCA2	0.92
RPA2	DBF4	0.92
RAD9B	DNA2	0.92
TIMELESS	RBBP8	0.919
RFC3	RAD50	0.919
TIMELESS	RAD1	0.919
TIMELESS	MRE11A	0.919
RAD9B	RAD51C	0.919
TOP3A	CDK2	0.918
RAD9B	RFC3	0.918
RAD50	ERCC4	0.918
RAD1	RAD51C	0.918
RAD50	TOPBP1	0.918
RFC3	TP53	0.918
RFC3	RMI1	0.918
RAD50	FANCD2	0.918
ATRIP	ERCC4	0.918
ERCC2	FANCI	0.917
RAD9B	RPA1	0.917
RAD1	MCM2	0.917
MCM10	ATRIP	0.917
RFC5	MRE11A	0.917
RFC5	TP53	0.917
RAD1	TP53	0.916
RMI1	TP53	0.916
RFC5	RAD9B	0.916
BRCA1	RAD1	0.916
NBN	TIPIN	0.916
RAD9B	RAD52	0.915
RAD9B	WRN	0.915
TIMELESS	RMI1	0.915
RMI1	HUS1	0.915
RFC5	ATRIP	0.914
DBF4	RPA1	0.914
RAD50	CLSPN	0.914
CHEK1	FANCD2	0.914
RFC5	ERCC2	0.914
RAD50	RPA2	0.914
MRE11A	TIPIN	0.914
ERCC2	RFC3	0.914
TOP3A	HUS1	0.913
BRCA1	RAD9B	0.913
RAD1	MRE11A	0.913
RFC5	RAD50	0.912
RBBP8	RFC3	0.912
RFC5	NBN	0.911
RFC3	ERCC1	0.911
TIMELESS	RAD9B	0.911
BRCA2	TP53	0.911
RAD51	CHEK2	0.911
RAD9B	ATRIP	0.911
RAD1	FANCD2	0.911
MCM10	EXO1	0.91
RFC3	NBN	0.91
RAD9B	RPA2	0.91
RFC5	ERCC1	0.91
RAD9B	RAD9A	0.909
CDC45	CHEK2	0.908
RBBP8	RAD1	0.908
EXO1	MCM2	0.908
TIMELESS	NBN	0.907
RAD9B	ERCC1	0.907
RAD50	ATRIP	0.906
TOP3A	RAD9B	0.906
RAD50	TIPIN	0.904
MCM10	DNA2	0.904
RAD9B	RMI1	0.904
RAD9B	RAD50	0.904
CHEK1	CHEK2	0.904
RAD9B	TP53	0.904
RFC5	RBBP8	0.903
TIMELESS	RAD50	0.903
RAD9B	MRE11A	0.903
RAD1	RAD50	0.902
RBBP8	RAD9B	0.901
CHEK2	DNA2	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	11200 (CHEK2)	4171 (MCM2)	8318 (CDC45)	55388 (MCM10)	55215 (FANCI)	8317 (CDC7)	5888 (RAD51)	1111 (CHEK1)	10111 (RAD50)	472 (ATM)	6118 (RPA2)	3014 (H2AFX)	5883 (RAD9A)	9156 (EXO1)	5884 (RAD17)	2177 (FANCD2)	672 (BRCA1)	7156 (TOP3A)	675 (BRCA2)	5985 (RFC5)	5932 (RBBP8)	2068 (ERCC2)	8914 (TIMELESS)	5983 (RFC3)	2072 (ERCC4)	993 (CDC25A)	7157 (TP53)	84126 (ATRIP)	11073 (TOPBP1)	10926 (DBF4)	545 (ATR)	1017 (CDK2)	5893 (RAD52)	7486 (WRN)	4361 (MRE11A)	63967 (CLSPN)	1763 (DNA2)	4173 (MCM4)	995 (CDC25C)	144715 (RAD9B)	5889 (RAD51C)	54962 (TIPIN)	80010 (RMI1)	641 (BLM)	9126 (SMC3)	57697 (FANCM)	5810 (RAD1)	6117 (RPA1)	3364 (HUS1)	4683 (NBN)	2067 (ERCC1)
11200 (CHEK2)	1.00	0.59	0.51	0.60	0.63	0.84	0.59	0.85	0.51	0.80	0.59	0.65	0.68	0.39	0.56	0.63	0.66	0.58	0.62	0.58	0.50	0.63	0.59	0.49	0.56	0.63	0.56	0.61	0.71	0.61	0.78	0.81	0.63	0.37	0.50	0.62	0.41	0.56	0.62	0.58	0.52	0.59	1.00	0.36	0.59	0.60	0.55	0.49	1.00	0.58	0.53
4171 (MCM2)	0.59	1.00	0.72	0.87	0.76	0.54	0.64	0.47	0.60	0.55	0.82	0.94	0.66	0.45	0.74	0.76	0.71	0.55	0.69	0.69	0.72	0.52	1.00	0.69	0.71	0.58	0.59	0.73	0.80	0.55	0.54	0.50	0.95	0.42	0.54	0.75	0.42	0.61	0.56	0.63	0.80	1.00	1.00	0.43	0.63	0.71	0.78	0.84	1.00	0.78	0.76
8318 (CDC45)	0.51	0.72	1.00	0.82	0.55	0.44	0.73	0.42	0.61	0.53	0.73	0.74	0.57	0.50	0.72	0.55	0.64	0.46	0.64	0.62	0.65	0.64	0.72	0.70	0.66	0.50	0.60	0.53	0.60	0.46	0.46	0.44	0.77	0.63	0.57	0.55	0.65	0.60	0.49	0.49	0.64	0.72	1.00	0.61	0.60	0.67	0.62	0.74	1.00	0.73	0.68
55388 (MCM10)	0.60	0.87	0.82	1.00	0.63	0.51	0.72	0.46	0.63	0.53	0.84	0.86	0.61	0.51	0.66	0.63	0.72	0.52	0.74	0.64	0.76	0.54	0.87	0.69	0.74	0.54	0.60	0.61	0.72	0.52	0.51	0.49	0.94	0.43	0.60	0.62	0.47	0.54	0.53	0.55	0.76	0.87	1.00	0.46	0.58	0.60	0.73	0.83	1.00	0.74	0.76
55215 (FANCI)	0.63	0.76	0.55	0.63	1.00	0.60	0.59	0.51	0.42	0.59	0.58	0.81	0.73	0.34	0.68	1.00	0.60	0.62	0.62	0.67	0.48	0.46	0.76	0.50	0.54	0.63	0.52	0.81	0.86	0.60	0.58	0.54	0.70	0.30	0.44	0.83	0.34	0.69	0.61	0.71	0.57	0.76	1.00	0.29	0.68	0.79	0.63	0.52	1.00	0.68	0.56
8317 (CDC7)	0.84	0.54	0.44	0.51	0.60	1.00	0.52	0.93	0.47	0.81	0.49	0.62	0.60	0.33	0.50	0.60	0.57	0.53	0.56	0.50	0.42	0.63	0.54	0.41	0.49	0.52	0.49	0.57	0.66	0.47	0.85	0.86	0.55	0.30	0.42	0.59	0.33	0.49	0.51	0.51	0.44	0.54	1.00	0.28	0.55	0.56	0.48	0.42	1.00	0.55	0.48
5888 (RAD51)	0.59	0.64	0.73	0.72	0.59	0.52	1.00	0.51	0.66	0.55	0.73	0.70	0.61	0.58	0.70	0.59	0.68	0.55	0.67	0.75	0.66	0.71	0.64	0.77	0.68	0.54	0.67	0.53	0.62	0.50	0.51	0.51	0.71	0.61	0.67	0.54	0.68	0.62	0.54	0.53	0.61	0.64	1.00	0.67	0.60	0.60	0.61	0.66	1.00	0.71	0.67
1111 (CHEK1)	0.85	0.47	0.42	0.46	0.51	0.93	0.51	1.00	0.48	0.84	0.46	0.54	0.55	0.33	0.45	0.51	0.55	0.49	0.52	0.45	0.41	0.66	0.47	0.39	0.46	0.48	0.48	0.49	0.56	0.43	0.86	0.90	0.49	0.31	0.42	0.50	0.34	0.43	0.48	0.45	0.42	0.47	1.00	0.29	0.50	0.48	0.44	0.40	1.00	0.49	0.48
10111 (RAD50)	0.51	0.60	0.61	0.63	0.42	0.47	0.66	0.48	1.00	0.48	0.68	0.63	0.59	0.68	0.50	0.42	0.62	0.39	0.56	0.55	0.71	0.72	0.60	0.65	0.78	0.46	0.55	0.40	0.46	0.37	0.45	0.47	0.64	0.66	0.84	0.41	0.71	0.52	0.46	0.55	0.67	0.60	1.00	0.63	0.47	0.40	0.69	0.69	1.00	0.68	0.77
472 (ATM)	0.80	0.55	0.53	0.53	0.59	0.81	0.55	0.84	0.48	1.00	0.51	0.60	0.58	0.38	0.58	0.59	0.57	0.53	0.55	0.52	0.45	0.65	0.55	0.45	0.52	0.52	0.53	0.57	0.62	0.50	0.81	0.84	0.55	0.36	0.43	0.58	0.36	0.52	0.51	0.53	0.48	0.55	1.00	0.31	0.57	0.63	0.51	0.46	1.00	0.58	0.50
6118 (RPA2)	0.59	0.82	0.73	0.84	0.58	0.49	0.73	0.46	0.68	0.51	1.00	0.87	0.63	0.55	0.63	0.58	0.77	0.50	0.72	0.66	0.75	0.59	0.82	0.70	0.74	0.53	0.67	0.55	0.60	0.51	0.50	0.48	0.85	0.46	0.61	0.56	0.53	0.51	0.52	0.52	0.75	0.82	1.00	0.48	0.54	0.55	0.74	0.91	1.00	0.75	0.77
3014 (H2AFX)	0.65	0.94	0.74	0.86	0.81	0.62	0.70	0.54	0.63	0.60	0.87	1.00	0.76	0.49	0.76	0.81	0.76	0.63	0.72	0.77	0.73	0.56	0.94	0.72	0.73	0.65	0.63	0.76	0.80	0.63	0.60	0.56	0.92	0.44	0.57	0.77	0.47	0.68	0.63	0.69	0.81	0.94	1.00	0.46	0.67	0.75	0.79	0.83	1.00	0.79	0.77
5883 (RAD9A)	0.68	0.66	0.57	0.61	0.73	0.60	0.61	0.55	0.59	0.58	0.63	0.76	1.00	0.61	0.63	0.73	0.64	0.61	0.61	0.68	0.53	0.50	0.66	0.54	0.63	0.74	0.59	0.68	0.73	0.67	0.58	0.56	0.65	0.43	0.69	0.70	0.53	0.63	0.73	0.85	0.62	0.66	1.00	0.35	0.65	0.68	0.79	0.53	1.00	0.64	0.64
9156 (EXO1)	0.39	0.45	0.50	0.51	0.34	0.33	0.58	0.33	0.68	0.38	0.55	0.49	0.61	1.00	0.44	0.34	0.53	0.35	0.45	0.39	0.68	0.41	0.45	0.46	0.74	0.46	0.54	0.33	0.38	0.31	0.33	0.33	0.50	0.57	0.81	0.34	0.66	0.30	0.45	0.59	0.63	0.45	1.00	0.41	0.39	0.40	0.67	0.49	1.00	0.45	0.71
5884 (RAD17)	0.56	0.74	0.72	0.66	0.68	0.50	0.70	0.45	0.50	0.58	0.63	0.76	0.63	0.44	1.00	0.68	0.61	0.52	0.61	0.83	0.54	0.57	0.74	0.77	0.58	0.55	0.57	0.65	0.72	0.52	0.51	0.48	0.72	0.46	0.49	0.67	0.48	0.68	0.53	0.57	0.61	0.74	1.00	0.45	0.64	0.84	0.62	0.60	1.00	0.70	0.60
2177 (FANCD2)	0.63	0.76	0.55	0.63	1.00	0.60	0.59	0.51	0.42	0.59	0.58	0.81	0.73	0.34	0.68	1.00	0.60	0.62	0.62	0.67	0.48	0.46	0.76	0.50	0.54	0.63	0.52	0.81	0.86	0.60	0.58	0.54	0.70	0.30	0.44	0.83	0.34	0.69	0.61	0.71	0.57	0.76	1.00	0.29	0.68	0.79	0.63	0.52	1.00	0.68	0.56
672 (BRCA1)	0.66	0.71	0.64	0.72	0.60	0.57	0.68	0.55	0.62	0.57	0.77	0.76	0.64	0.53	0.61	0.60	1.00	0.55	0.70	0.64	0.72	0.57	0.71	0.64	0.68	0.56	0.67	0.57	0.63	0.53	0.56	0.55	0.75	0.48	0.60	0.58	0.52	0.54	0.55	0.55	0.68	0.71	1.00	0.49	0.59	0.57	0.65	0.69	1.00	0.66	0.68
7156 (TOP3A)	0.58	0.55	0.46	0.52	0.62	0.53	0.55	0.49	0.39	0.53	0.50	0.63	0.61	0.35	0.52	0.62	0.55	1.00	0.55	0.52	0.43	0.45	0.55	0.43	0.50	0.54	0.49	0.59	0.67	0.48	0.51	0.49	0.56	0.32	0.45	0.60	0.36	0.51	0.53	0.54	0.46	0.55	1.00	0.30	0.57	0.58	0.51	0.43	1.00	0.56	0.50
675 (BRCA2)	0.62	0.69	0.64	0.74	0.62	0.56	0.67	0.52	0.56	0.55	0.72	0.72	0.61	0.45	0.61	0.62	0.70	0.55	1.00	0.61	0.66	0.54	0.69	0.59	0.68	0.55	0.59	0.60	0.71	0.53	0.54	0.52	0.77	0.42	0.56	0.61	0.44	0.55	0.54	0.56	0.63	0.69	1.00	0.44	0.60	0.59	0.62	0.71	1.00	0.64	0.69
5985 (RFC5)	0.58	0.69	0.62	0.64	0.67	0.50	0.75	0.45	0.55	0.52	0.66	0.77	0.68	0.39	0.83	0.67	0.64	0.52	0.61	1.00	0.54	0.66	0.69	0.91	0.58	0.56	0.57	0.61	0.68	0.53	0.50	0.48	0.69	0.48	0.53	0.63	0.62	0.75	0.55	0.56	0.59	0.69	1.00	0.53	0.67	0.60	0.60	0.58	1.00	0.75	0.59
5932 (RBBP8)	0.50	0.72	0.65	0.76	0.48	0.42	0.66	0.41	0.71	0.45	0.75	0.73	0.53	0.68	0.54	0.48	0.72	0.43	0.66	0.54	1.00	0.55	0.72	0.64	0.86	0.48	0.60	0.46	0.53	0.43	0.43	0.42	0.78	0.53	0.75	0.47	0.61	0.43	0.47	0.48	0.77	0.72	1.00	0.51	0.47	0.46	0.70	0.73	1.00	0.68	0.84
2068 (ERCC2)	0.63	0.52	0.64	0.54	0.46	0.63	0.71	0.66	0.72	0.65	0.59	0.56	0.50	0.41	0.57	0.46	0.57	0.45	0.54	0.66	0.55	1.00	0.52	0.71	0.59	0.46	0.53	0.45	0.52	0.42	0.62	0.66	0.55	0.62	0.63	0.46	0.69	0.70	0.45	0.44	0.50	0.52	1.00	0.67	0.57	0.44	0.53	0.56	1.00	0.80	0.58
8914 (TIMELESS)	0.59	1.00	0.72	0.87	0.76	0.54	0.64	0.47	0.60	0.55	0.82	0.94	0.66	0.45	0.74	0.76	0.71	0.55	0.69	0.69	0.72	0.52	1.00	0.69	0.71	0.58	0.59	0.73	0.80	0.55	0.54	0.50	0.95	0.42	0.54	0.75	0.42	0.61	0.56	0.63	0.80	1.00	1.00	0.43	0.63	0.71	0.78	0.84	1.00	0.78	0.76
5983 (RFC3)	0.49	0.69	0.70	0.69	0.50	0.41	0.77	0.39	0.65	0.45	0.70	0.72	0.54	0.46	0.77	0.50	0.64	0.43	0.59	0.91	0.64	0.71	0.69	1.00	0.65	0.48	0.56	0.48	0.56	0.42	0.42	0.41	0.73	0.60	0.60	0.49	0.75	0.66	0.47	0.46	0.64	0.69	1.00	0.66	0.64	0.47	0.61	0.68	1.00	0.77	0.67
2072 (ERCC4)	0.56	0.71	0.66	0.74	0.54	0.49	0.68	0.46	0.78	0.52	0.74	0.73	0.63	0.74	0.58	0.54	0.68	0.50	0.68	0.58	0.86	0.59	0.71	0.65	1.00	0.57	0.60	0.53	0.63	0.48	0.48	0.47	0.78	0.52	0.84	0.54	0.69	0.50	0.56	0.61	0.84	0.71	1.00	0.50	0.54	0.53	0.76	0.74	1.00	0.70	0.96
993 (CDC25A)	0.63	0.58	0.50	0.54	0.63	0.52	0.54	0.48	0.46	0.52	0.53	0.65	0.74	0.46	0.55	0.63	0.56	0.54	0.55	0.56	0.48	0.46	0.58	0.48	0.57	1.00	0.54	0.60	0.67	0.60	0.51	0.49	0.58	0.36	0.54	0.62	0.46	0.55	0.95	0.65	0.54	0.58	1.00	0.32	0.59	0.60	0.61	0.47	1.00	0.58	0.56
7157 (TP53)	0.56	0.59	0.60	0.60	0.52	0.49	0.67	0.48	0.55	0.53	0.67	0.63	0.59	0.54	0.57	0.52	0.67	0.49	0.59	0.57	0.60	0.53	0.59	0.56	0.60	0.54	1.00	0.51	0.54	0.52	0.49	0.49	0.61	0.54	0.55	0.51	0.50	0.50	0.52	0.50	0.58	0.59	1.00	0.55	0.53	0.55	0.56	0.59	1.00	0.59	0.59
84126 (ATRIP)	0.61	0.73	0.53	0.61	0.81	0.57	0.53	0.49	0.40	0.57	0.55	0.76	0.68	0.33	0.65	0.81	0.57	0.59	0.60	0.61	0.46	0.45	0.73	0.48	0.53	0.60	0.51	1.00	0.83	0.58	0.56	0.52	0.68	0.30	0.43	0.79	0.32	0.65	0.59	0.67	0.55	0.73	1.00	0.29	0.65	0.76	0.60	0.50	1.00	0.65	0.54
11073 (TOPBP1)	0.71	0.80	0.60	0.72	0.86	0.66	0.62	0.56	0.46	0.62	0.60	0.80	0.73	0.38	0.72	0.86	0.63	0.67	0.71	0.68	0.53	0.52	0.80	0.56	0.63	0.67	0.54	0.83	1.00	0.65	0.63	0.58	0.79	0.33	0.52	0.85	0.38	0.74	0.65	0.75	0.63	0.80	1.00	0.32	0.71	0.82	0.68	0.56	1.00	0.71	0.63
10926 (DBF4)	0.61	0.55	0.46	0.52	0.60	0.47	0.50	0.43	0.37	0.50	0.51	0.63	0.67	0.31	0.52	0.60	0.53	0.48	0.53	0.53	0.43	0.42	0.55	0.42	0.48	0.60	0.52	0.58	0.65	1.00	0.48	0.46	0.56	0.29	0.40	0.59	0.31	0.50	0.59	0.51	0.46	0.55	1.00	0.28	0.55	0.57	0.49	0.44	1.00	0.55	0.49
545 (ATR)	0.78	0.54	0.46	0.51	0.58	0.85	0.51	0.86	0.45	0.81	0.50	0.60	0.58	0.33	0.51	0.58	0.56	0.51	0.54	0.50	0.43	0.62	0.54	0.42	0.48	0.51	0.49	0.56	0.63	0.48	1.00	0.85	0.54	0.34	0.42	0.61	0.33	0.50	0.50	0.51	0.46	0.54	1.00	0.29	0.57	0.55	0.49	0.44	1.00	0.54	0.48
1017 (CDK2)	0.81	0.50	0.44	0.49	0.54	0.86	0.51	0.90	0.47	0.84	0.48	0.56	0.56	0.33	0.48	0.54	0.55	0.49	0.52	0.48	0.42	0.66	0.50	0.41	0.47	0.49	0.49	0.52	0.58	0.46	0.85	1.00	0.51	0.31	0.41	0.53	0.34	0.47	0.49	0.48	0.44	0.50	1.00	0.29	0.51	0.51	0.46	0.43	1.00	0.51	0.49
5893 (RAD52)	0.63	0.95	0.77	0.94	0.70	0.55	0.71	0.49	0.64	0.55	0.85	0.92	0.65	0.50	0.72	0.70	0.75	0.56	0.77	0.69	0.78	0.55	0.95	0.73	0.78	0.58	0.61	0.68	0.79	0.56	0.54	0.51	1.00	0.45	0.60	0.69	0.48	0.60	0.56	0.61	0.81	0.95	1.00	0.48	0.62	0.67	0.78	0.88	1.00	0.78	0.80
7486 (WRN)	0.37	0.42	0.63	0.43	0.30	0.30	0.61	0.31	0.66	0.36	0.46	0.44	0.43	0.57	0.46	0.30	0.48	0.32	0.42	0.48	0.53	0.62	0.42	0.60	0.52	0.36	0.54	0.30	0.33	0.29	0.34	0.31	0.45	1.00	0.68	0.31	0.71	0.48	0.36	0.39	0.47	0.42	1.00	0.88	0.46	0.34	0.48	0.43	1.00	0.58	0.50
4361 (MRE11A)	0.50	0.54	0.57	0.60	0.44	0.42	0.67	0.42	0.84	0.43	0.61	0.57	0.69	0.81	0.49	0.44	0.60	0.45	0.56	0.53	0.75	0.63	0.54	0.60	0.84	0.54	0.55	0.43	0.52	0.40	0.42	0.41	0.60	0.68	1.00	0.43	0.79	0.52	0.54	0.68	0.70	0.54	1.00	0.60	0.49	0.43	0.75	0.56	1.00	0.63	0.80
63967 (CLSPN)	0.62	0.75	0.55	0.62	0.83	0.59	0.54	0.50	0.41	0.58	0.56	0.77	0.70	0.34	0.67	0.83	0.58	0.60	0.61	0.63	0.47	0.46	0.75	0.49	0.54	0.62	0.51	0.79	0.85	0.59	0.61	0.53	0.69	0.31	0.43	1.00	0.33	0.67	0.60	0.69	0.56	0.75	1.00	0.29	0.70	0.78	0.62	0.51	1.00	0.67	0.55
1763 (DNA2)	0.41	0.42	0.65	0.47	0.34	0.33	0.68	0.34	0.71	0.36	0.53	0.47	0.53	0.66	0.48	0.34	0.52	0.36	0.44	0.62	0.61	0.69	0.42	0.75	0.69	0.46	0.50	0.32	0.38	0.31	0.33	0.34	0.48	0.71	0.79	0.33	1.00	0.53	0.45	0.47	0.55	0.42	1.00	0.69	0.56	0.32	0.54	0.48	1.00	0.62	0.65
4173 (MCM4)	0.56	0.61	0.60	0.54	0.69	0.49	0.62	0.43	0.52	0.52	0.51	0.68	0.63	0.30	0.68	0.69	0.54	0.51	0.55	0.75	0.43	0.70	0.61	0.66	0.50	0.55	0.50	0.65	0.74	0.50	0.50	0.47	0.60	0.48	0.52	0.67	0.53	1.00	0.53	0.57	0.47	0.61	1.00	0.51	0.67	0.64	0.52	0.44	1.00	0.85	0.50
995 (CDC25C)	0.62	0.56	0.49	0.53	0.61	0.51	0.54	0.48	0.46	0.51	0.52	0.63	0.73	0.45	0.53	0.61	0.55	0.53	0.54	0.55	0.47	0.45	0.56	0.47	0.56	0.95	0.52	0.59	0.65	0.59	0.50	0.49	0.56	0.36	0.54	0.60	0.45	0.53	1.00	0.63	0.52	0.56	1.00	0.32	0.58	0.58	0.59	0.45	1.00	0.57	0.56
144715 (RAD9B)	0.58	0.63	0.49	0.55	0.71	0.51	0.53	0.45	0.55	0.53	0.52	0.69	0.85	0.59	0.57	0.71	0.55	0.54	0.56	0.56	0.48	0.44	0.63	0.46	0.61	0.65	0.50	0.67	0.75	0.51	0.51	0.48	0.61	0.39	0.68	0.69	0.47	0.57	0.63	1.00	0.57	0.63	1.00	0.30	0.62	0.66	0.87	0.45	1.00	0.60	0.59
5889 (RAD51C)	0.52	0.80	0.64	0.76	0.57	0.44	0.61	0.42	0.67	0.48	0.75	0.81	0.62	0.63	0.61	0.57	0.68	0.46	0.63	0.59	0.77	0.50	0.80	0.64	0.84	0.54	0.58	0.55	0.63	0.46	0.46	0.44	0.81	0.47	0.70	0.56	0.55	0.47	0.52	0.57	1.00	0.80	1.00	0.46	0.54	0.54	0.73	0.74	1.00	0.69	0.84
54962 (TIPIN)	0.59	1.00	0.72	0.87	0.76	0.54	0.64	0.47	0.60	0.55	0.82	0.94	0.66	0.45	0.74	0.76	0.71	0.55	0.69	0.69	0.72	0.52	1.00	0.69	0.71	0.58	0.59	0.73	0.80	0.55	0.54	0.50	0.95	0.42	0.54	0.75	0.42	0.61	0.56	0.63	0.80	1.00	1.00	0.43	0.63	0.71	0.78	0.84	1.00	0.78	0.76
80010 (RMI1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
641 (BLM)	0.36	0.43	0.61	0.46	0.29	0.28	0.67	0.29	0.63	0.31	0.48	0.46	0.35	0.41	0.45	0.29	0.49	0.30	0.44	0.53	0.51	0.67	0.43	0.66	0.50	0.32	0.55	0.29	0.32	0.28	0.29	0.29	0.48	0.88	0.60	0.29	0.69	0.51	0.32	0.30	0.46	0.43	1.00	1.00	0.46	0.28	0.41	0.46	1.00	0.63	0.48
9126 (SMC3)	0.59	0.63	0.60	0.58	0.68	0.55	0.60	0.50	0.47	0.57	0.54	0.67	0.65	0.39	0.64	0.68	0.59	0.57	0.60	0.67	0.47	0.57	0.63	0.64	0.54	0.59	0.53	0.65	0.71	0.55	0.57	0.51	0.62	0.46	0.49	0.70	0.56	0.67	0.58	0.62	0.54	0.63	1.00	0.46	1.00	0.65	0.58	0.50	1.00	0.66	0.54
57697 (FANCM)	0.60	0.71	0.67	0.60	0.79	0.56	0.60	0.48	0.40	0.63	0.55	0.75	0.68	0.40	0.84	0.79	0.57	0.58	0.59	0.60	0.46	0.44	0.71	0.47	0.53	0.60	0.55	0.76	0.82	0.57	0.55	0.51	0.67	0.34	0.43	0.78	0.32	0.64	0.58	0.66	0.54	0.71	1.00	0.28	0.65	1.00	0.59	0.49	1.00	0.65	0.54
5810 (RAD1)	0.55	0.78	0.62	0.73	0.63	0.48	0.61	0.44	0.69	0.51	0.74	0.79	0.79	0.67	0.62	0.63	0.65	0.51	0.62	0.60	0.70	0.53	0.78	0.61	0.76	0.61	0.56	0.60	0.68	0.49	0.49	0.46	0.78	0.48	0.75	0.62	0.54	0.52	0.59	0.87	0.73	0.78	1.00	0.41	0.58	0.59	1.00	0.74	1.00	0.74	0.78
6117 (RPA1)	0.49	0.84	0.74	0.83	0.52	0.42	0.66	0.40	0.69	0.46	0.91	0.83	0.53	0.49	0.60	0.52	0.69	0.43	0.71	0.58	0.73	0.56	0.84	0.68	0.74	0.47	0.59	0.50	0.56	0.44	0.44	0.43	0.88	0.43	0.56	0.51	0.48	0.44	0.45	0.45	0.74	0.84	1.00	0.46	0.50	0.49	0.74	1.00	1.00	0.75	0.78
3364 (HUS1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
4683 (NBN)	0.58	0.78	0.73	0.74	0.68	0.55	0.71	0.49	0.68	0.58	0.75	0.79	0.64	0.45	0.70	0.68	0.66	0.56	0.64	0.75	0.68	0.80	0.78	0.77	0.70	0.58	0.59	0.65	0.71	0.55	0.54	0.51	0.78	0.58	0.63	0.67	0.62	0.85	0.57	0.60	0.69	0.78	1.00	0.63	0.66	0.65	0.74	0.75	1.00	1.00	0.71
2067 (ERCC1)	0.53	0.76	0.68	0.76	0.56	0.48	0.67	0.48	0.77	0.50	0.77	0.77	0.64	0.71	0.60	0.56	0.68	0.50	0.69	0.59	0.84	0.58	0.76	0.67	0.96	0.56	0.59	0.54	0.63	0.49	0.48	0.49	0.80	0.50	0.80	0.55	0.65	0.50	0.56	0.59	0.84	0.76	1.00	0.48	0.54	0.54	0.78	0.78	1.00	0.71	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
ATR	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	8.3	RT-qPCR	Western US	C57BL/6 mice	−1.1	7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
ATR	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	6.4	RT-qPCR	Western US	C57BL/6 mice	−1.1	7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
TCF4	6925	ATR	545	proximal_filtered	22955619	TRANSFAC
ELF1	1997	ATR	545	proximal_filtered	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT051394	hsa-let-7f-5p	Homo sapiens	ATR	545	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT053599	hsa-miR-185-5p	Homo sapiens	ATR	545	Homo sapiens	Flow//Microarray//qRT-PCR//Western blot	Functional MTI	23807228
MIRT441143	hsa-miR-218-5p	Homo sapiens	ATR	545	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	23212916
MIRT732600	hsa-miR-383-5p	Homo sapiens	ATR	545	Homo sapiens	Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26261078

Gene Ontology

ID	GO ID	GO Term	GO Type
545	GO:0006974	cellular response to DNA damage stimulus	GOTERM_BP_DIRECT
545	GO:0043517	positive regulation of DNA damage response	GOTERM_BP_DIRECT
545	GO:0005794	Golgi apparatus	GOTERM_CC_DIRECT
545	GO:0006260	DNA replication	GOTERM_BP_DIRECT
545	GO:0070198	protein localization to chromosome	GOTERM_BP_DIRECT
545	GO:0003677	nucleic acid binding	GOTERM_MF_DIRECT
545	GO:0032407	protein complex binding	GOTERM_MF_DIRECT
545	GO:0097695	establishment of macromolecular complex localization to telomere	GOTERM_BP_DIRECT
545	GO:1900034	regulation of cellular response to heat	GOTERM_BP_DIRECT
545	GO:0005515	protein binding	GOTERM_MF_DIRECT
545	telomericregion	None	GOTERM_CC_DIRECT
545	GO:0005694	chromosome	GOTERM_CC_DIRECT
545	GO:0071480	cellular response to gamma radiation	GOTERM_BP_DIRECT
545	GO:0016605	PML body	GOTERM_CC_DIRECT
545	GO:0006281	DNA repair	GOTERM_BP_DIRECT
545	GO:0007275	multicellular organism development	GOTERM_BP_DIRECT
545	GO:0036297	interstrand cross-link repair	GOTERM_BP_DIRECT
545	GO:1901796	regulation of signal transduction by p53 class mediator	GOTERM_BP_DIRECT
545	GO:0005524	ATP binding	GOTERM_MF_DIRECT
545	GO:0000784	nuclear chromosome	GOTERM_CC_DIRECT
545	GO:0000077	DNA damage checkpoint	GOTERM_BP_DIRECT
545	GO:1904884	positive regulation of telomerase catalytic core complex assembly	GOTERM_BP_DIRECT
545	GO:0004672	propionyl-CoA carboxylase activity	GOTERM_MF_DIRECT
545	GO:0034644	cellular response to UV	GOTERM_BP_DIRECT
545	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
545	GO:0018105	peptidyl-serine phosphorylation	GOTERM_BP_DIRECT
545	GO:0007049	cell cycle	GOTERM_BP_DIRECT
545	GO:0042493	response to drug	GOTERM_BP_DIRECT
545	GO:0032405	protein complex binding	GOTERM_MF_DIRECT
545	GO:0032212	positive regulation of telomere maintenance via telomerase	GOTERM_BP_DIRECT
545	GO:0046777	protein autophosphorylation	GOTERM_BP_DIRECT
545	GO:0090399	replicative senescence	GOTERM_BP_DIRECT
545	GO:0004674	protein histidine kinase activity	GOTERM_MF_DIRECT
545	GO:0008156	negative regulation of DNA replication	GOTERM_BP_DIRECT
545	GO:0097694	establishment of RNA localization to telomere	GOTERM_BP_DIRECT
545	GO:0016301	palmitoyl-CoA hydrolase activity	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
545	hsa03460	Fanconi anemia pathway
545	hsa04110	Cell cycle
545	hsa04115	p53 signaling pathway
545	hsa05166	HTLV-I infection

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
ATR	545	Stomach Neoplasms	C0038356	Neoplastic Process	0.3	0.486	0.759	group
ATR	545	Endometrial Carcinoma	C0476089	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Squamous cell carcinoma of oropharynx	C0280313	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Glioma	C0017638	Neoplastic Process	0.32	0.486	0.759	disease
ATR	545	Carcinoma in situ of endometrium	C0346191	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Ovarian Carcinoma	C0029925	Neoplastic Process	0.34	0.486	0.759	disease
ATR	545	Neoplasm of uncertain or unknown behavior of stomach	C0496905	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Neoplasm of uncertain or unknown behavior of ovary	C0496920	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	ovarian neoplasm	C0919267	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Carcinoma in situ of stomach	C0154060	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.33	0.486	0.759	disease
ATR	545	Benign neoplasm of stomach	C0153943	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Stomach Carcinoma	C0699791	Neoplastic Process	0.32	0.486	0.759	disease
ATR	545	Malignant Neoplasms	C0006826	Neoplastic Process	0.33	0.486	0.759	group
ATR	545	Malignant neoplasm of endometrium	C0007103	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Malignant neoplasm of ovary	C1140680	Neoplastic Process	0.34	0.486	0.759	disease
ATR	545	Urologic Neoplasms	C0042076	Neoplastic Process	0.3	0.486	0.759	group
ATR	545	Bagassosis	C0004681	Disease or Syndrome	0.3	0.486	0.759	disease
ATR	545	Prostatic Neoplasms	C0033578	Neoplastic Process	0.3	0.486	0.759	group
ATR	545	Cancer of Urinary Tract	C0751571	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Pneumoconiosis	C0032273	Disease or Syndrome	0.3	0.486	0.759	disease
ATR	545	Seckel syndrome	C0265202	Disease or Syndrome	0.8	0.486	0.759	disease
ATR	545	CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL	C3281203	Neoplastic Process	0.7	0.486	0.759	disease
ATR	545	Large cell carcinoma of lung	C0345958	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Squamous cell carcinoma of lung	C0149782	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Adenocarcinoma of lung (disorder)	C0152013	Neoplastic Process	0.3	0.486	0.759	disease
ATR	545	Infiltrating duct carcinoma of female breast	C3165106	Neoplastic Process	0.3	0.486	0.759	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
ATR	545	ATM/ATR KINASE INHIBITOR	CHEMBL1221601	CHEMBL1221601	inhibitor
ATR	545	AZ20	None	None	inhibitor
ATR	545	AZD6738	AZD-6738	CHEMBL3545178	inhibitor
ATR	545	AZD-6738	AZD-6738	CHEMBL3545178	inhibitor
ATR	545	BMN673	TALAZOPARIB	CHEMBL3137320	None
ATR	545	CISPLATIN	None	None	None
ATR	545	DACTOLISIB	DACTOLISIB	CHEMBL1879463	inhibitor
ATR	545	E7449	None	None	None
ATR	545	NIRAPARIB	NIRAPARIB	CHEMBL1094636	None
ATR	545	Olaparib	OLAPARIB	CHEMBL521686	None
ATR	545	OLAPARIB	OLAPARIB	CHEMBL521686	None
ATR	545	RUCAPARIB	RUCAPARIB	CHEMBL1173055	None
ATR	545	Temozolomide	TEMOZOLOMIDE	CHEMBL810	None
ATR	545	VE-822	None	None	inhibitor
ATR	545	VE-821	None	None	inhibitor
ATR	545	VELIPARIB	VELIPARIB	CHEMBL506871	None
ATR	545	VX-970	VX-970	CHEMBL3545202	inhibitor