Mitogen-activated protein kinase kinase 5

AltitudeomicsDB
Protein Official symbol MAP2K5
Aliases MAP2K5 MEK5 MKK5 PRKMK5
Chromosomal Location 15
Length 448
Uniprot ID Q13163
EC number 2.7.12.2
Protein family Information(Pfam) PF00564;PF00069;
PDB id 2NPT;2O2V;4IC7;
InterPro ID IPR011009;IPR000270;IPR034851;IPR000719;IPR017441;IPR008271;
dbSNP rs56241934 rs1226964455 rs55811347

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
NTRK1 NGF 0.997
NTRK1 NTF3 0.992
NTRK1 BDNF 0.99
MAPK7 MAP2K5 0.94
BDNF MAP2K5 0.932
MAP3K2 MAP2K5 0.931
MAP3K3 MAP2K5 0.927
MAP3K1 MAP2K5 0.926
NGF MAP2K5 0.923
MAP3K8 MAP2K5 0.923
BDNF NGF 0.92
NTF3 NGF 0.916
BDNF NTF3 0.916
NTF3 MAP2K5 0.904
NTRK1 MAP2K5 0.903
Gene Ontology Semantic Similarity
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# 4803 (NGF) 4908 (NTF3) 627 (BDNF) 5607 (MAP2K5) 4914 (NTRK1) 5598 (MAPK7) 10746 (MAP3K2) 4215 (MAP3K3) 4214 (MAP3K1) 1326 (MAP3K8)
4803 (NGF) 1.00 0.73 1.00 0.45 0.45 0.50 0.51 0.50 0.47 0.50
4908 (NTF3) 0.73 1.00 1.00 0.54 0.51 0.59 0.60 0.60 0.55 0.60
627 (BDNF) 1.00 1.00 1.00 0.69 0.69 0.69 0.69 0.69 0.69 0.69
5607 (MAP2K5) 0.45 0.54 0.69 1.00 0.64 0.85 0.91 0.96 0.89 0.90
4914 (NTRK1) 0.45 0.51 0.69 0.64 1.00 0.59 0.63 0.63 0.63 0.59
5598 (MAPK7) 0.50 0.59 0.69 0.85 0.59 1.00 0.92 0.88 0.92 0.89
10746 (MAP3K2) 0.51 0.60 0.69 0.91 0.63 0.92 1.00 0.94 0.97 0.89
4215 (MAP3K3) 0.50 0.60 0.69 0.96 0.63 0.88 0.94 1.00 0.92 0.94
4214 (MAP3K1) 0.47 0.55 0.69 0.89 0.63 0.92 0.97 0.92 1.00 0.94
1326 (MAP3K8) 0.50 0.60 0.69 0.90 0.59 0.89 0.89 0.94 0.94 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MAP2K5 Human Blood - 3250 m 4 day downregulated -1.63 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT018716 hsa-miR-335-5p Homo sapiens MAP2K5 5607 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT024959 hsa-miR-214-3p Homo sapiens MAP2K5 5607 Homo sapiens Microarray;Other Functional MTI (Weak) 19859982
MIRT438086 hsa-miR-330-3p Homo sapiens MAP2K5 5607 Homo sapiens Genotyping Functional MTI (Weak) 24436253
Gene Ontology
ID GO ID GO Term GO Type
5607 GO:0000122 negative regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
5607 GO:0004702 protein kinase C activity GOTERM_MF_DIRECT
5607 GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GOTERM_BP_DIRECT
5607 GO:0005515 protein binding GOTERM_MF_DIRECT
5607 GO:0005634 nucleus GOTERM_CC_DIRECT
5607 GO:0005819 spindle GOTERM_CC_DIRECT
5607 GO:0007165 signal transduction GOTERM_BP_DIRECT
5607 GO:0046872 metal ion binding GOTERM_MF_DIRECT
5607 GO:0000187 activation of MAPK activity GOTERM_BP_DIRECT
5607 GO:0005524 ATP binding GOTERM_MF_DIRECT
5607 GO:0005737 cytoplasm GOTERM_CC_DIRECT
5607 GO:0050679 positive regulation of epithelial cell proliferation GOTERM_BP_DIRECT
5607 GO:0071363 cellular response to growth factor stimulus GOTERM_BP_DIRECT
5607 GO:0071499 cellular response to laminar fluid shear stress GOTERM_BP_DIRECT
5607 GO:0004713 protein tyrosine kinase activity GOTERM_MF_DIRECT
5607 GO:0034115 negative regulation of heterotypic cell-cell adhesion GOTERM_BP_DIRECT
5607 GO:0004672 protein kinase activity GOTERM_MF_DIRECT
5607 GO:0007507 heart development GOTERM_BP_DIRECT
5607 GO:0045415 negative regulation of interleukin-8 biosynthetic process GOTERM_BP_DIRECT
5607 GO:0051247 positive regulation of protein metabolic process GOTERM_BP_DIRECT
5607 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GOTERM_BP_DIRECT
5607 GO:0030307 positive regulation of cell growth GOTERM_BP_DIRECT
5607 GO:0032088 negative regulation of NF-kappaB transcription factor activity GOTERM_BP_DIRECT
5607 GO:0060761 negative regulation of response to cytokine stimulus GOTERM_BP_DIRECT
5607 GO:0070375 ERK5 cascade GOTERM_BP_DIRECT
5607 GO:2000342 negative regulation of chemokine GOTERM_BP_DIRECT
5607 GO:0018108 peptidyl-tyrosine phosphorylation GOTERM_BP_DIRECT
5607 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GOTERM_BP_DIRECT
5607 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
5607 GO:0004674 protein serine/threonine kinase activity GOTERM_MF_DIRECT
5607 GO:0005829 cytosol GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5607 hsa04010 MAPK signaling pathway
5607 hsa04540 Gap junction
5607 hsa04722 Neurotrophin signaling pathway
5607 hsa04921 Oxytocin signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MAP2K5 5607 Body Weight C0005910 Organism Attribute 0.3 0.659 0.448 phenotype
MAP2K5 5607 Amphetamine Addiction C0236804 Mental or Behavioral Dysfunction 0.3 0.659 0.448 disease
MAP2K5 5607 Amphetamine-Related Disorders C0236733 Mental or Behavioral Dysfunction 0.3 0.659 0.448 group
MAP2K5 5607 Amphetamine Abuse C0236807 Mental or Behavioral Dysfunction 0.3 0.659 0.448 disease
MAP2K5 5607 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.31 0.659 0.448 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
MAP2K5 5607 AZD6244 SELUMETINIB CHEMBL1614701 inhibitor
MAP2K5 5607 BAY869766 Refametinib CHEMBL2138601 inhibitor
MAP2K5 5607 BIX02189 TRIHEXYPHENIDYL CHEMBL1490 inhibitor
MAP2K5 5607 BIX02188 1,4-BUTANEDIOL CHEMBL171623 inhibitor
MAP2K5 5607 DABRAFENIB MESYLATE DABRAFENIB MESYLATE CHEMBL2105729 inhibitor
MAP2K5 5607 GDC-0973 COBIMETINIB CHEMBL2146883 inhibitor
MAP2K5 5607 MEK162 BINIMETINIB CHEMBL3187723 inhibitor
MAP2K5 5607 PD 0325901 PD-0325901 CHEMBL507361 inhibitor
MAP2K5 5607 SELUMETINIB SELUMETINIB CHEMBL1614701 inhibitor
MAP2K5 5607 TRAMETINIB TRAMETINIB CHEMBL2103875 inhibitor
MAP2K5 5607 WX-554 WX-554 CHEMBL3545145 None