Mitogen-activated protein kinase kinase kinase 1

AltitudeomicsDB
Protein Official symbol MAP3K1
Aliases MAP3K1 MAPKKK1 MEKK MEKK1
Chromosomal Location  5 
Length 1512
Uniprot ID Q13233
EC number 2.7.11.25
Protein family Information(Pfam) PF00069;
PDB id None
InterPro ID IPR011989;IPR016024;IPR011009;IPR000719;IPR017441;IPR008271;IPR001841;IPR013083;IPR007527;
dbSNP rs387906788 rs387906788 rs143853590 rs702689 rs832582

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CD40 CD40LG 0.997
IKBKG IKBKB 0.996
TNF TNFRSF1A 0.995
TNF TNFRSF1B 0.995
TRADD FADD 0.994
TRAF6 MYD88 0.994
TRAF3 CD40 0.993
TRADD TNFRSF1A 0.993
TNFRSF1B TNFRSF1A 0.992
MYD88 IL1R1 0.991
IKBKB NFKBIA 0.99
MAP3K7 TAB1 0.989
MAPK14 TAB1 0.989
CHUK NFKB2 0.988
TNF NFKBIA 0.988
FADD TNFRSF1A 0.987
HRAS MAP2K1 0.986
IKBKB NFKB1 0.985
CDC42 MAPK8 0.985
IKBKB NFKBIB 0.984
TNF RELA 0.984
TNF MAPK14 0.984
TRAF6 MAPK8 0.983
TRAF1 CD40 0.982
IKBKB RELA 0.982
CASP3 FADD 0.981
TNF TRAF1 0.981
CHUK NFKBIA 0.981
TRAF2 TNFRSF1A 0.98
TRAF6 TLR4 0.98
TRAF6 TAB1 0.98
HRAS MAP2K2 0.98
IKBKG CHUK 0.98
TNF CD40LG 0.979
TRAF3 TANK 0.979
CASP3 MAPK14 0.978
CREB1 MAPK14 0.978
TRAF6 ECSIT 0.978
TRADD TRAF2 0.977
MYD88 NFKB1 0.977
RELA NFKBIA 0.977
IKBKB NFKB2 0.977
SOS1 MAP2K2 0.977
SOS1 MAP2K1 0.976
HRAS SOS1 0.976
TRAF6 IL1R1 0.976
IKBKG TRAF6 0.975
TNFRSF1B TRAF1 0.975
IKBKG RELA 0.975
CHUK NFKB1 0.974
IKBKG NFKB2 0.973
MYD88 NFKBIA 0.973
TRAF6 MAP3K7 0.973
CD40 TRAF2 0.973
RELA CD40 0.972
MYD88 NFKB2 0.972
TRAF6 TNF 0.972
TRAF1 TNFRSF1A 0.972
RELA CHUK 0.97
TNF TRAF2 0.97
TANK TRAF1 0.97
CDC42 MAP3K11 0.97
TNF TRADD 0.969
TNFRSF1B TRAF2 0.969
TRAF1 TRADD 0.969
TRAF6 TNFRSF1A 0.968
TRADD CASP3 0.968
CHUK NFKBIB 0.968
TRAF6 CD40 0.968
IKBKG TRADD 0.968
TNF NFKB1 0.968
IKBKG TAB1 0.967
TNF FADD 0.967
IKBKB TNF 0.967
IKBKG TNF 0.966
IKBKG NFKBIB 0.966
TRAF3 TLR4 0.966
IKBKG NFKBIA 0.965
IKBKG NFKB1 0.965
MAPK8 TRAF2 0.965
IKBKG TNFRSF1A 0.965
MAP2K3 TAB1 0.964
FADD TRAF2 0.964
MAPK9 CDC42 0.964
RELA NFKBIB 0.963
TRAF6 TANK 0.963
TRAF3 MAP3K1 0.962
TRAF6 NFKB2 0.961
MYD88 MAP3K7 0.961
TRAF6 RELA 0.961
TRAF6 MAPK9 0.961
IKBKG MYD88 0.961
MYD88 RELA 0.961
RELA TNFRSF1A 0.96
MYD88 TAB1 0.96
IKBKG FADD 0.96
TRAF6 TRADD 0.959
TRAF3 TNF 0.958
IKBKB MYD88 0.958
TRAF6 IKBKB 0.958
TNFRSF1B TRADD 0.958
TNF CHUK 0.958
TRAF3 MAPK8 0.958
IKBKB TNFRSF1A 0.957
TNF TLR4 0.957
IKBKG TRAF2 0.957
TRAF6 MAPK14 0.957
IKBKB TLR4 0.956
TNF MAP2K7 0.956
MAP3K7 NFKB1 0.956
MAPK8 CD40 0.956
IKBKG TLR4 0.956
TRAF6 CHUK 0.955
TRAF1 NFKBIA 0.955
TRAF6 NFKB1 0.955
TRAF6 NFKBIA 0.955
TRADD TAB1 0.955
NFKBIA TNFRSF1A 0.955
SOS1 CDC42 0.954
TRAF3 CD40LG 0.954
TRAF6 CD40LG 0.954
RELA TRAF1 0.953
MAP3K7 NFKBIA 0.953
MAP2K4 TAB1 0.953
NFKB1 TNFRSF1A 0.952
CDC42 MAPK14 0.952
TRAF6 FADD 0.952
IKBKG MAP3K1 0.952
MAP3K1 TANK 0.952
TRAF1 FADD 0.952
RELA MAPK8 0.952
IKBKG MAP3K7 0.951
TRAF6 MAPK10 0.951
RELA TRADD 0.951
TLR4 TAB1 0.951
TNFRSF1B CD40LG 0.951
CHUK TNFRSF1A 0.951
TRAF3 TNFRSF1B 0.951
MAP2K4 MAPK8 0.951
TANK TRADD 0.951
TANK TLR4 0.951
IL1R1 TAB1 0.951
TRAF1 NFKB1 0.95
TRAF2 MAP4K5 0.95
TAB1 TNFRSF1A 0.95
TRAF1 CD40LG 0.95
IKBKB TAB1 0.949
MAP2K7 MAPK8 0.949
TLR4 FADD 0.949
NCOR2 MAP2K1 0.949
NFKBIB TRAF2 0.949
TRAF6 MAP2K3 0.948
MYD88 CHUK 0.948
NFKB2 TRAF2 0.948
TNF TAB1 0.948
NCOR2 MAP3K1 0.948
CD40 NFKB1 0.948
CDC42 MAP3K1 0.948
MAP3K1 NFATC3 0.948
TNF MAP2K3 0.947
CD40 NFKBIA 0.947
IKBKB TRADD 0.947
MAP2K4 MAPK10 0.947
IKBKG TANK 0.947
CHUK TAB1 0.947
TRAF6 MAP2K4 0.947
MAP3K1 ECSIT 0.947
TRAF6 MAP2K7 0.947
RELA TRAF2 0.947
CHUK TRADD 0.946
MAPK9 MAP2K7 0.946
CDC42 MAPK10 0.946
MAPK14 NFKBIA 0.946
TANK TNFRSF1A 0.945
RELA CD40LG 0.945
HRAS MAP3K1 0.945
MAPK8 CD40LG 0.945
RELA TAB1 0.945
MAP2K4 MAPK9 0.945
IL1R1 RELA 0.945
TRADD NFKB1 0.944
IL1R1 NFKB1 0.944
MAP3K1 CD40 0.944
RELA MAPK14 0.944
TLR4 CHUK 0.944
CASP3 TRAF2 0.943
MAP2K7 MAPK10 0.943
TRAF2 NFKBIA 0.943
TLR4 MAP3K7 0.942
MAP2K4 TNF 0.942
MAP2K3 MAPK14 0.942
TNF MAP3K7 0.942
MAPK8 MAP2K3 0.941
TRAF6 MAP3K1 0.941
MYD88 TLR4 0.941
CHUK FADD 0.941
TRAF6 NFKBIB 0.941
TNF TANK 0.941
IL1R1 MAP3K7 0.94
IKBKB MAP3K7 0.94
RELA MAP3K7 0.94
IKBKB TRAF2 0.939
HRAS RELA 0.939
MAP3K7 TNFRSF1A 0.939
TNF MAP3K1 0.939
MAPK14 NFKB1 0.939
CDC42 MAP2K3 0.939
IKBKB FADD 0.939
MAP3K1 NFKBIA 0.939
MAP2K1 MAPK14 0.939
MAPK9 MAP2K3 0.938
CHUK TRAF2 0.938
NFKBIA TAB1 0.938
MAP3K1 TRAF1 0.938
CD40LG TRAF2 0.938
MAP3K1 TAB1 0.938
HRAS MAPK8 0.938
CD40 MAPK14 0.938
MAP2K4 MAPK14 0.938
MAP3K1 TRADD 0.937
MAP3K1 CASP3 0.937
MAPK8 MAP3K11 0.937
CD40LG NFKB1 0.937
MAP2K7 TNFRSF1A 0.937
MAP3K1 NFKB2 0.937
MAP3K1 TNFRSF1A 0.937
MYD88 FADD 0.937
MAP2K7 MAPK14 0.937
TRAF2 TAB1 0.936
MAPK9 TRAF2 0.936
MAP3K1 FADD 0.936
MAP2K1 NFKB1 0.936
MAP2K7 TAB1 0.935
MAPK10 TRAF2 0.935
NFKB1 TAB1 0.935
TANK TNFRSF1B 0.935
MAP2K7 FADD 0.934
NFKB1 NFKBIA 0.934
CREB1 MAP3K1 0.934
MAPK10 MAP2K3 0.933
IKBKG MAP2K7 0.933
MAP2K4 MAP3K11 0.933
MAP2K4 MAP3K1 0.933
TRAF2 MAPK14 0.932
HRAS NFKB1 0.932
MAP3K1 MAP2K7 0.932
IL1R1 CHUK 0.932
RELA MAP3K1 0.932
MAP3K1 MAP2K1 0.931
MAP3K1 NFKB1 0.931
NFKBIB NFKBIA 0.931
MAP3K7 TRADD 0.93
CD40LG NFKBIA 0.93
MAP3K1 TLR4 0.93
CDC42 MAP4K2 0.93
MAP2K7 MAP3K11 0.93
MAP3K1 MAPK8 0.93
TRAF3 TRADD 0.929
MAP3K7 MAP2K3 0.929
TRAF2 NFKB1 0.929
MAP2K3 MAP3K11 0.929
NFKB2 NFKBIA 0.929
TRAF3 MAPK10 0.929
TANK TRAF2 0.929
MAP2K4 TNFRSF1A 0.929
MAP2K4 TRAF2 0.928
SOS1 MAP3K1 0.928
MAPK9 MAP3K1 0.928
MAPK9 NFATC3 0.928
MAPK9 CD40 0.928
MAP3K7 NFKBIB 0.928
MAP3K1 NFKBIB 0.928
RELA TLR4 0.928
TNF CD40 0.928
CHUK MAP3K7 0.928
TRAF3 MAPK9 0.928
MAP3K1 TNFRSF1B 0.928
MAP3K7 TRAF2 0.927
CD40LG MAPK14 0.927
RELA NFKB1 0.927
RELA NFKB2 0.927
MAP2K7 MAP3K7 0.927
MAPK8 NFATC3 0.927
MAP3K1 MAP2K2 0.926
MAP2K4 TRADD 0.926
MAP3K1 MAP2K5 0.926
MAP2K1 TAB1 0.926
MAP2K4 FADD 0.926
MAP3K1 SMAD2 0.926
MAP2K3 TNFRSF1A 0.926
MYD88 MAP3K1 0.926
MAP3K1 TRAF2 0.926
TRAF3 TRAF6 0.925
IL1R1 MAP3K1 0.925
MAP3K1 MAP3K11 0.925
MAP2K4 MAP3K7 0.925
NFKB2 NFKBIB 0.924
IKBKB MAP3K1 0.923
NFKBIB NFKB1 0.923
NFKB2 NFKB1 0.923
MAP4K1 MAP3K11 0.923
MAP3K1 MAP2K3 0.923
MAP2K7 TRADD 0.923
CD40 MAPK10 0.923
HRAS MAP3K11 0.923
MAP3K7 MAP4K5 0.922
MAP3K1 CHUK 0.922
CSNK1A1 MAP3K1 0.922
MAP2K3 TRADD 0.922
MAP3K1 MAP3K7 0.921
MAP3K1 MAP4K2 0.921
MAP3K7 MAPK14 0.921
TNF MAP4K2 0.921
MAP2K4 MAP2K1 0.921
IKBKG MAP2K4 0.921
MAP3K1 MAPK10 0.92
MAP2K7 TRAF2 0.92
MAP3K1 MAP4K5 0.92
MAP3K1 MAPK14 0.92
IKBKG MAP2K3 0.92
MAP4K1 MAP3K1 0.92
MAP3K1 MAP4K3 0.92
MAP3K1 CD40LG 0.92
TNF MAP4K3 0.919
MAPK9 CD40LG 0.918
TLR4 NFKB1 0.918
SOS1 CREB1 0.918
MAP2K4 NFKB1 0.918
MAP2K7 TRAF1 0.918
NCOR2 SMAD2 0.918
MAP4K1 MAP3K7 0.917
TRAF3 TRAF1 0.916
MAPK8 NFKB1 0.916
CSNK1A1 NFATC3 0.916
MAP3K7 MAP2K1 0.915
MAP2K4 CD40 0.915
MAP4K2 TNFRSF1A 0.915
TRADD MAP4K2 0.915
TRAF6 TRAF2 0.914
MAP2K3 TRAF2 0.914
MAP2K4 MAP2K7 0.912
MAPK8 MAPK14 0.911
TRAF3 TRAF2 0.911
MAP4K2 TRAF2 0.911
CD40LG MAPK10 0.91
TNF MAPK8 0.91
CSNK1A1 CDC42 0.909
MAPK9 MAPK14 0.909
MAP3K11 MAP4K5 0.909
MAPK10 MAPK14 0.909
MAP4K3 TRAF2 0.908
TRAF1 TRAF2 0.907
MAP2K4 CD40LG 0.906
IKBKB CHUK 0.905
MAPK9 MAPK8 0.905
NCOR2 MAPK14 0.905
HRAS MAPK9 0.904
MAPK9 MAPK10 0.904
TNF MAP4K5 0.904
TANK MAP4K2 0.904
MAPK8 MAPK10 0.903
MAP2K1 MAP2K2 0.902
MAP4K3 TNFRSF1A 0.9
TRADD MAP4K3 0.9
TNFRSF1A MAP4K5 0.9
TRADD MAP4K5 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 958 (CD40) 8517 (IKBKG) 7124 (TNF) 8717 (TRADD) 7189 (TRAF6) 7187 (TRAF3) 7133 (TNFRSF1B) 4615 (MYD88) 3551 (IKBKB) 6885 (MAP3K7) 1432 (MAPK14) 1147 (CHUK) 8772 (FADD) 3265 (HRAS) 998 (CDC42) 7185 (TRAF1) 836 (CASP3) 7186 (TRAF2) 1385 (CREB1) 5970 (RELA) 6654 (SOS1) 10010 (TANK) 5599 (MAPK8) 5606 (MAP2K3) 5601 (MAPK9) 4792 (NFKBIA) 6416 (MAP2K4) 4790 (NFKB1) 4214 (MAP3K1) 7099 (TLR4) 3554 (IL1R1) 10454 (TAB1) 5609 (MAP2K7) 9612 (NCOR2) 4793 (NFKBIB) 4791 (NFKB2) 5604 (MAP2K1) 959 (CD40LG) 5602 (MAPK10) 11184 (MAP4K1) 1452 (CSNK1A1) 5871 (MAP4K2) 4296 (MAP3K11) 8491 (MAP4K3) 7132 (TNFRSF1A) 5605 (MAP2K2) 51295 (ECSIT) 11183 (MAP4K5) 4775 (NFATC3) 5607 (MAP2K5) 4087 (SMAD2)
958 (CD40) 1.00 0.80 0.68 0.80 0.78 0.79 0.92 0.78 0.62 0.60 0.65 0.59 0.79 0.59 0.59 0.88 0.40 0.78 0.49 0.53 0.53 0.73 0.58 0.63 0.64 0.87 0.49 0.50 0.57 0.61 0.62 0.73 0.63 0.60 0.72 0.49 0.54 0.79 0.54 0.49 0.55 0.56 0.59 0.49 0.71 0.54 0.73 0.49 0.52 0.55 0.55
8517 (IKBKG) 0.80 1.00 0.69 0.78 0.73 0.72 0.79 0.78 0.72 0.64 0.61 0.70 0.76 0.61 0.62 0.81 0.47 0.73 0.53 0.59 0.57 0.69 0.56 0.62 0.64 0.80 0.55 0.59 0.58 0.69 0.62 0.68 0.59 0.60 0.68 0.54 0.57 0.71 0.58 0.55 0.59 0.58 0.67 0.55 0.68 0.59 0.68 0.55 0.55 0.58 0.56
7124 (TNF) 0.68 0.69 1.00 0.70 0.69 0.67 0.65 0.74 0.60 0.58 0.56 0.56 0.80 0.54 0.56 0.76 0.41 0.71 0.65 0.65 0.50 0.55 0.51 0.55 0.57 0.70 0.48 0.73 0.52 0.61 0.55 0.60 0.54 0.68 0.60 0.60 0.52 0.68 0.51 0.48 0.51 0.51 0.57 0.48 0.60 0.51 0.60 0.48 0.61 0.51 0.62
8717 (TRADD) 0.80 0.78 0.70 1.00 0.74 0.68 0.76 0.80 0.69 0.65 0.63 0.62 0.78 0.61 0.64 0.78 0.44 0.72 0.52 0.54 0.56 0.63 0.56 0.67 0.65 0.79 0.53 0.54 0.62 0.65 0.63 0.71 0.62 0.61 0.71 0.52 0.56 0.76 0.57 0.53 0.58 0.60 0.66 0.53 0.70 0.57 0.71 0.53 0.54 0.58 0.53
7189 (TRAF6) 0.78 0.73 0.69 0.74 1.00 0.85 0.71 0.72 0.73 0.67 0.67 0.63 0.72 0.58 0.75 0.82 0.51 0.90 0.55 0.61 0.55 0.65 0.66 0.71 0.63 0.77 0.59 0.54 0.69 0.62 0.59 0.63 0.70 0.63 0.63 0.53 0.62 0.68 0.59 0.58 0.63 0.67 0.72 0.58 0.63 0.59 0.65 0.58 0.54 0.61 0.56
7187 (TRAF3) 0.79 0.72 0.67 0.68 0.85 1.00 0.75 0.72 0.62 0.60 0.67 0.60 0.72 0.54 0.67 0.87 0.44 0.91 0.47 0.51 0.49 0.64 0.60 0.60 0.60 0.75 0.55 0.49 0.58 0.57 0.55 0.60 0.65 0.56 0.60 0.46 0.58 0.70 0.55 0.53 0.60 0.55 0.59 0.53 0.60 0.56 0.64 0.53 0.49 0.57 0.55
7133 (TNFRSF1B) 0.92 0.79 0.65 0.76 0.71 0.75 1.00 0.77 0.60 0.58 0.58 0.58 0.74 0.57 0.56 0.84 0.39 0.71 0.46 0.52 0.51 0.71 0.52 0.59 0.62 0.82 0.48 0.50 0.54 0.59 0.60 0.70 0.56 0.58 0.70 0.47 0.53 0.77 0.52 0.48 0.53 0.53 0.56 0.48 0.79 0.53 0.70 0.48 0.50 0.53 0.54
4615 (MYD88) 0.78 0.78 0.74 0.80 0.72 0.72 0.77 1.00 0.66 0.65 0.60 0.63 0.84 0.61 0.61 0.83 0.45 0.73 0.51 0.53 0.57 0.64 0.55 0.64 0.66 0.78 0.54 0.55 0.59 0.66 0.64 0.73 0.59 0.61 0.72 0.53 0.57 0.83 0.58 0.54 0.59 0.58 0.64 0.54 0.71 0.58 0.73 0.54 0.55 0.58 0.53
3551 (IKBKB) 0.62 0.72 0.60 0.69 0.73 0.62 0.60 0.66 1.00 0.90 0.81 0.96 0.66 0.51 0.76 0.65 0.44 0.69 0.48 0.55 0.48 0.53 0.78 0.87 0.77 0.67 0.84 0.53 0.89 0.62 0.54 0.56 0.81 0.54 0.56 0.46 0.83 0.59 0.76 0.80 0.85 0.80 0.92 0.80 0.57 0.80 0.59 0.80 0.48 0.85 0.51
6885 (MAP3K7) 0.60 0.64 0.58 0.65 0.67 0.60 0.58 0.65 0.90 1.00 0.81 0.88 0.64 0.48 0.73 0.63 0.40 0.66 0.45 0.50 0.44 0.49 0.80 0.85 0.79 0.65 0.85 0.48 0.92 0.56 0.50 0.53 0.79 0.52 0.52 0.42 0.84 0.56 0.79 0.83 0.87 0.80 0.90 0.83 0.54 0.81 0.56 0.83 0.45 0.87 0.49
1432 (MAPK14) 0.65 0.61 0.56 0.63 0.67 0.67 0.58 0.60 0.81 0.81 1.00 0.79 0.62 0.48 0.69 0.61 0.40 0.70 0.45 0.50 0.45 0.50 0.83 0.86 0.82 0.67 0.86 0.47 0.84 0.54 0.51 0.52 0.89 0.52 0.52 0.42 0.80 0.55 0.85 0.77 0.80 0.76 0.80 0.77 0.54 0.78 0.55 0.77 0.46 0.85 0.53
1147 (CHUK) 0.59 0.70 0.56 0.62 0.63 0.60 0.58 0.63 0.96 0.88 0.79 1.00 0.62 0.48 0.70 0.61 0.40 0.63 0.43 0.51 0.44 0.49 0.78 0.83 0.78 0.62 0.86 0.50 0.86 0.59 0.51 0.53 0.77 0.52 0.52 0.42 0.84 0.56 0.77 0.82 0.88 0.77 0.88 0.82 0.54 0.81 0.56 0.82 0.45 0.87 0.50
8772 (FADD) 0.79 0.76 0.80 0.78 0.72 0.72 0.74 0.84 0.66 0.64 0.62 0.62 1.00 0.61 0.61 0.82 0.46 0.76 0.53 0.53 0.56 0.63 0.57 0.63 0.65 0.78 0.54 0.55 0.58 0.65 0.63 0.70 0.60 0.61 0.70 0.53 0.57 0.82 0.58 0.54 0.59 0.58 0.64 0.54 0.69 0.57 0.70 0.54 0.55 0.58 0.54
3265 (HRAS) 0.59 0.61 0.54 0.61 0.58 0.54 0.57 0.61 0.51 0.48 0.48 0.48 0.61 1.00 0.76 0.59 0.38 0.57 0.40 0.47 0.41 0.48 0.43 0.46 0.48 0.61 0.38 0.44 0.43 0.51 0.46 0.50 0.47 0.51 0.49 0.38 0.48 0.54 0.40 0.57 0.42 0.61 0.47 0.57 0.51 0.44 0.51 0.57 0.42 0.41 0.48
998 (CDC42) 0.59 0.62 0.56 0.64 0.75 0.67 0.56 0.61 0.76 0.73 0.69 0.70 0.61 0.76 1.00 0.64 0.44 0.72 0.46 0.51 0.45 0.50 0.68 0.71 0.63 0.63 0.67 0.48 0.73 0.54 0.49 0.51 0.69 0.52 0.51 0.43 0.68 0.54 0.61 0.74 0.69 0.75 0.74 0.74 0.52 0.65 0.54 0.74 0.46 0.68 0.49
7185 (TRAF1) 0.88 0.81 0.76 0.78 0.82 0.87 0.84 0.83 0.65 0.63 0.61 0.61 0.82 0.59 0.64 1.00 0.43 0.84 0.51 0.54 0.55 0.70 0.56 0.61 0.63 0.84 0.52 0.54 0.56 0.64 0.62 0.69 0.59 0.60 0.69 0.51 0.55 0.80 0.56 0.52 0.57 0.56 0.63 0.52 0.68 0.56 0.69 0.52 0.53 0.56 0.56
836 (CASP3) 0.40 0.47 0.41 0.44 0.51 0.44 0.39 0.45 0.44 0.40 0.40 0.40 0.46 0.38 0.44 0.43 1.00 0.49 0.33 0.42 0.34 0.60 0.41 0.35 0.36 0.47 0.32 0.36 0.34 0.41 0.34 0.40 0.39 0.40 0.32 0.28 0.42 0.35 0.31 0.31 0.35 0.32 0.39 0.31 0.36 0.39 0.40 0.31 0.33 0.32 0.42
7186 (TRAF2) 0.78 0.73 0.71 0.72 0.90 0.91 0.71 0.73 0.69 0.66 0.70 0.63 0.76 0.57 0.72 0.84 0.49 1.00 0.55 0.57 0.54 0.64 0.64 0.67 0.62 0.77 0.58 0.54 0.65 0.63 0.58 0.62 0.71 0.59 0.62 0.52 0.59 0.73 0.58 0.57 0.62 0.62 0.67 0.57 0.62 0.59 0.64 0.57 0.53 0.60 0.57
1385 (CREB1) 0.49 0.53 0.65 0.52 0.55 0.47 0.46 0.51 0.48 0.45 0.45 0.43 0.53 0.40 0.46 0.51 0.33 0.55 1.00 0.82 0.37 0.41 0.42 0.41 0.42 0.55 0.36 0.85 0.39 0.46 0.40 0.41 0.44 0.78 0.49 0.88 0.41 0.43 0.37 0.36 0.38 0.39 0.45 0.36 0.42 0.40 0.41 0.36 0.83 0.37 0.76
5970 (RELA) 0.53 0.59 0.65 0.54 0.61 0.51 0.52 0.53 0.55 0.50 0.50 0.51 0.53 0.47 0.51 0.54 0.42 0.57 0.82 1.00 0.45 0.49 0.48 0.49 0.50 0.60 0.44 0.87 0.48 0.51 0.46 0.47 0.50 0.77 0.47 0.74 0.47 0.48 0.45 0.44 0.45 0.47 0.52 0.44 0.48 0.46 0.47 0.44 0.82 0.45 0.80
6654 (SOS1) 0.53 0.57 0.50 0.56 0.55 0.49 0.51 0.57 0.48 0.44 0.45 0.44 0.56 0.41 0.45 0.55 0.34 0.54 0.37 0.45 1.00 0.50 0.48 0.41 0.43 0.57 0.33 0.41 0.38 0.47 0.41 0.65 0.43 0.47 0.43 0.34 0.46 0.48 0.35 0.33 0.36 0.37 0.43 0.33 0.45 0.45 0.43 0.33 0.39 0.36 0.46
10010 (TANK) 0.73 0.69 0.55 0.63 0.65 0.64 0.71 0.64 0.53 0.49 0.50 0.49 0.63 0.48 0.50 0.70 0.60 0.64 0.41 0.49 0.50 1.00 0.49 0.47 0.49 0.71 0.38 0.44 0.43 0.51 0.47 0.68 0.48 0.51 0.51 0.38 0.50 0.57 0.40 0.38 0.42 0.42 0.48 0.38 0.53 0.49 0.53 0.38 0.43 0.41 0.50
5599 (MAPK8) 0.58 0.56 0.51 0.56 0.66 0.60 0.52 0.55 0.78 0.80 0.83 0.78 0.57 0.43 0.68 0.56 0.41 0.64 0.42 0.48 0.48 0.49 1.00 0.76 0.82 0.60 0.77 0.42 0.81 0.49 0.44 0.54 0.76 0.51 0.44 0.37 0.77 0.48 0.81 0.76 0.83 0.74 0.78 0.76 0.47 0.75 0.50 0.76 0.41 0.78 0.49
5606 (MAP2K3) 0.63 0.62 0.55 0.67 0.71 0.60 0.59 0.64 0.87 0.85 0.86 0.83 0.63 0.46 0.71 0.61 0.35 0.67 0.41 0.49 0.41 0.47 0.76 1.00 0.77 0.64 0.94 0.44 0.92 0.53 0.49 0.51 0.89 0.51 0.51 0.38 0.83 0.57 0.84 0.79 0.86 0.81 0.86 0.79 0.54 0.82 0.55 0.79 0.43 0.94 0.49
5601 (MAPK9) 0.64 0.64 0.57 0.65 0.63 0.60 0.62 0.66 0.77 0.79 0.82 0.78 0.65 0.48 0.63 0.63 0.36 0.62 0.42 0.50 0.43 0.49 0.82 0.77 1.00 0.70 0.76 0.47 0.80 0.55 0.51 0.54 0.71 0.52 0.54 0.40 0.72 0.60 0.94 0.75 0.76 0.73 0.76 0.75 0.56 0.71 0.57 0.75 0.47 0.78 0.52
4792 (NFKBIA) 0.87 0.80 0.70 0.79 0.77 0.75 0.82 0.78 0.67 0.65 0.67 0.62 0.78 0.61 0.63 0.84 0.47 0.77 0.55 0.60 0.57 0.71 0.60 0.64 0.70 1.00 0.55 0.58 0.60 0.65 0.64 0.70 0.64 0.62 0.70 0.54 0.57 0.74 0.59 0.55 0.60 0.60 0.65 0.55 0.69 0.58 0.70 0.55 0.59 0.59 0.59
6416 (MAP2K4) 0.49 0.55 0.48 0.53 0.59 0.55 0.48 0.54 0.84 0.85 0.86 0.86 0.54 0.38 0.67 0.52 0.32 0.58 0.36 0.44 0.33 0.38 0.77 0.94 0.76 0.55 1.00 0.40 0.87 0.47 0.40 0.39 0.87 0.45 0.39 0.32 0.88 0.44 0.86 0.82 0.90 0.76 0.83 0.82 0.43 0.86 0.45 0.82 0.37 0.99 0.47
4790 (NFKB1) 0.50 0.59 0.73 0.54 0.54 0.49 0.50 0.55 0.53 0.48 0.47 0.50 0.55 0.44 0.48 0.54 0.36 0.54 0.85 0.87 0.41 0.44 0.42 0.44 0.47 0.58 0.40 1.00 0.42 0.52 0.44 0.46 0.45 0.75 0.45 0.79 0.44 0.48 0.41 0.40 0.42 0.42 0.47 0.40 0.47 0.43 0.46 0.40 0.84 0.41 0.75
4214 (MAP3K1) 0.57 0.58 0.52 0.62 0.69 0.58 0.54 0.59 0.89 0.92 0.84 0.86 0.58 0.43 0.73 0.56 0.34 0.65 0.39 0.48 0.38 0.43 0.81 0.92 0.80 0.60 0.87 0.42 1.00 0.50 0.44 0.46 0.83 0.48 0.45 0.36 0.82 0.50 0.79 0.84 0.90 0.85 0.92 0.84 0.48 0.79 0.51 0.84 0.40 0.89 0.47
7099 (TLR4) 0.61 0.69 0.61 0.65 0.62 0.57 0.59 0.66 0.62 0.56 0.54 0.59 0.65 0.51 0.54 0.64 0.41 0.63 0.46 0.51 0.47 0.51 0.49 0.53 0.55 0.65 0.47 0.52 0.50 1.00 0.80 0.55 0.52 0.55 0.54 0.44 0.51 0.59 0.51 0.46 0.47 0.49 0.55 0.46 0.74 0.50 0.55 0.46 0.47 0.49 0.51
3554 (IL1R1) 0.62 0.62 0.55 0.63 0.59 0.55 0.60 0.64 0.54 0.50 0.51 0.51 0.63 0.46 0.49 0.62 0.34 0.58 0.40 0.46 0.41 0.47 0.44 0.49 0.51 0.64 0.40 0.44 0.44 0.80 1.00 0.52 0.49 0.51 0.51 0.39 0.47 0.57 0.44 0.39 0.42 0.44 0.48 0.39 0.80 0.46 0.52 0.39 0.43 0.43 0.48
10454 (TAB1) 0.73 0.68 0.60 0.71 0.63 0.60 0.70 0.73 0.56 0.53 0.52 0.53 0.70 0.50 0.51 0.69 0.40 0.62 0.41 0.47 0.65 0.68 0.54 0.51 0.54 0.70 0.39 0.46 0.46 0.55 0.52 1.00 0.50 0.54 0.60 0.40 0.55 0.69 0.43 0.39 0.44 0.45 0.51 0.39 0.61 0.56 0.61 0.39 0.45 0.44 0.49
5609 (MAP2K7) 0.63 0.59 0.54 0.62 0.70 0.65 0.56 0.59 0.81 0.79 0.89 0.77 0.60 0.47 0.69 0.59 0.39 0.71 0.44 0.50 0.43 0.48 0.76 0.89 0.71 0.64 0.87 0.45 0.83 0.52 0.49 0.50 1.00 0.51 0.49 0.41 0.80 0.53 0.78 0.73 0.78 0.74 0.79 0.73 0.52 0.78 0.52 0.73 0.44 0.85 0.51
9612 (NCOR2) 0.60 0.60 0.68 0.61 0.63 0.56 0.58 0.61 0.54 0.52 0.52 0.52 0.61 0.51 0.52 0.60 0.40 0.59 0.78 0.77 0.47 0.51 0.51 0.51 0.52 0.62 0.45 0.75 0.48 0.55 0.51 0.54 0.51 1.00 0.62 0.74 0.51 0.57 0.47 0.46 0.48 0.48 0.51 0.46 0.55 0.49 0.54 0.46 0.77 0.48 0.69
4793 (NFKBIB) 0.72 0.68 0.60 0.71 0.63 0.60 0.70 0.72 0.56 0.52 0.52 0.52 0.70 0.49 0.51 0.69 0.32 0.62 0.49 0.47 0.43 0.51 0.44 0.51 0.54 0.70 0.39 0.45 0.45 0.54 0.51 0.60 0.49 0.62 1.00 0.60 0.48 0.68 0.42 0.39 0.44 0.45 0.50 0.39 0.60 0.47 0.60 0.39 0.44 0.43 0.48
4791 (NFKB2) 0.49 0.54 0.60 0.52 0.53 0.46 0.47 0.53 0.46 0.42 0.42 0.42 0.53 0.38 0.43 0.51 0.28 0.52 0.88 0.74 0.34 0.38 0.37 0.38 0.40 0.54 0.32 0.79 0.36 0.44 0.39 0.40 0.41 0.74 0.60 1.00 0.40 0.44 0.33 0.32 0.34 0.35 0.41 0.32 0.42 0.38 0.40 0.32 0.88 0.34 0.71
5604 (MAP2K1) 0.54 0.57 0.52 0.56 0.62 0.58 0.53 0.57 0.83 0.84 0.80 0.84 0.57 0.48 0.68 0.55 0.42 0.59 0.41 0.47 0.46 0.50 0.77 0.83 0.72 0.57 0.88 0.44 0.82 0.51 0.47 0.55 0.80 0.51 0.48 0.40 1.00 0.51 0.78 0.79 0.84 0.74 0.80 0.79 0.50 0.95 0.52 0.79 0.43 0.88 0.48
959 (CD40LG) 0.79 0.71 0.68 0.76 0.68 0.70 0.77 0.83 0.59 0.56 0.55 0.56 0.82 0.54 0.54 0.80 0.35 0.73 0.43 0.48 0.48 0.57 0.48 0.57 0.60 0.74 0.44 0.48 0.50 0.59 0.57 0.69 0.53 0.57 0.68 0.44 0.51 1.00 0.48 0.44 0.50 0.50 0.54 0.44 0.67 0.51 0.69 0.44 0.48 0.49 0.50
5602 (MAPK10) 0.54 0.58 0.51 0.57 0.59 0.55 0.52 0.58 0.76 0.79 0.85 0.77 0.58 0.40 0.61 0.56 0.31 0.58 0.37 0.45 0.35 0.40 0.81 0.84 0.94 0.59 0.86 0.41 0.79 0.51 0.44 0.43 0.78 0.47 0.42 0.33 0.78 0.48 1.00 0.74 0.76 0.72 0.75 0.74 0.47 0.77 0.47 0.74 0.39 0.85 0.48
11184 (MAP4K1) 0.49 0.55 0.48 0.53 0.58 0.53 0.48 0.54 0.80 0.83 0.77 0.82 0.54 0.57 0.74 0.52 0.31 0.57 0.36 0.44 0.33 0.38 0.76 0.79 0.75 0.55 0.82 0.40 0.84 0.46 0.39 0.39 0.73 0.46 0.39 0.32 0.79 0.44 0.74 1.00 0.85 0.94 0.80 1.00 0.43 0.75 0.44 1.00 0.37 0.84 0.46
1452 (CSNK1A1) 0.55 0.59 0.51 0.58 0.63 0.60 0.53 0.59 0.85 0.87 0.80 0.88 0.59 0.42 0.69 0.57 0.35 0.62 0.38 0.45 0.36 0.42 0.83 0.86 0.76 0.60 0.90 0.42 0.90 0.47 0.42 0.44 0.78 0.48 0.44 0.34 0.84 0.50 0.76 0.85 1.00 0.78 0.86 0.85 0.47 0.80 0.52 0.85 0.39 0.93 0.46
5871 (MAP4K2) 0.56 0.58 0.51 0.60 0.67 0.55 0.53 0.58 0.80 0.80 0.76 0.77 0.58 0.61 0.75 0.56 0.32 0.62 0.39 0.47 0.37 0.42 0.74 0.81 0.73 0.60 0.76 0.42 0.85 0.49 0.44 0.45 0.74 0.48 0.45 0.35 0.74 0.50 0.72 0.94 0.78 1.00 0.83 0.94 0.48 0.71 0.48 0.94 0.40 0.77 0.48
4296 (MAP3K11) 0.59 0.67 0.57 0.66 0.72 0.59 0.56 0.64 0.92 0.90 0.80 0.88 0.64 0.47 0.74 0.63 0.39 0.67 0.45 0.52 0.43 0.48 0.78 0.86 0.76 0.65 0.83 0.47 0.92 0.55 0.48 0.51 0.79 0.51 0.50 0.41 0.80 0.54 0.75 0.80 0.86 0.83 1.00 0.80 0.52 0.77 0.54 0.80 0.44 0.85 0.49
8491 (MAP4K3) 0.49 0.55 0.48 0.53 0.58 0.53 0.48 0.54 0.80 0.83 0.77 0.82 0.54 0.57 0.74 0.52 0.31 0.57 0.36 0.44 0.33 0.38 0.76 0.79 0.75 0.55 0.82 0.40 0.84 0.46 0.39 0.39 0.73 0.46 0.39 0.32 0.79 0.44 0.74 1.00 0.85 0.94 0.80 1.00 0.43 0.75 0.44 1.00 0.37 0.84 0.46
7132 (TNFRSF1A) 0.71 0.68 0.60 0.70 0.63 0.60 0.79 0.71 0.57 0.54 0.54 0.54 0.69 0.51 0.52 0.68 0.36 0.62 0.42 0.48 0.45 0.53 0.47 0.54 0.56 0.69 0.43 0.47 0.48 0.74 0.80 0.61 0.52 0.55 0.60 0.42 0.50 0.67 0.47 0.43 0.47 0.48 0.52 0.43 1.00 0.49 0.61 0.43 0.46 0.47 0.49
5605 (MAP2K2) 0.54 0.59 0.51 0.57 0.59 0.56 0.53 0.58 0.80 0.81 0.78 0.81 0.57 0.44 0.65 0.56 0.39 0.59 0.40 0.46 0.45 0.49 0.75 0.82 0.71 0.58 0.86 0.43 0.79 0.50 0.46 0.56 0.78 0.49 0.47 0.38 0.95 0.51 0.77 0.75 0.80 0.71 0.77 0.75 0.49 1.00 0.50 0.75 0.42 0.86 0.48
51295 (ECSIT) 0.73 0.68 0.60 0.71 0.65 0.64 0.70 0.73 0.59 0.56 0.55 0.56 0.70 0.51 0.54 0.69 0.40 0.64 0.41 0.47 0.43 0.53 0.50 0.55 0.57 0.70 0.45 0.46 0.51 0.55 0.52 0.61 0.52 0.54 0.60 0.40 0.52 0.69 0.47 0.44 0.52 0.48 0.54 0.44 0.61 0.50 1.00 0.44 0.45 0.49 0.49
11183 (MAP4K5) 0.49 0.55 0.48 0.53 0.58 0.53 0.48 0.54 0.80 0.83 0.77 0.82 0.54 0.57 0.74 0.52 0.31 0.57 0.36 0.44 0.33 0.38 0.76 0.79 0.75 0.55 0.82 0.40 0.84 0.46 0.39 0.39 0.73 0.46 0.39 0.32 0.79 0.44 0.74 1.00 0.85 0.94 0.80 1.00 0.43 0.75 0.44 1.00 0.37 0.84 0.46
4775 (NFATC3) 0.52 0.55 0.61 0.54 0.54 0.49 0.50 0.55 0.48 0.45 0.46 0.45 0.55 0.42 0.46 0.53 0.33 0.53 0.83 0.82 0.39 0.43 0.41 0.43 0.47 0.59 0.37 0.84 0.40 0.47 0.43 0.45 0.44 0.77 0.44 0.88 0.43 0.48 0.39 0.37 0.39 0.40 0.44 0.37 0.46 0.42 0.45 0.37 1.00 0.39 0.74
5607 (MAP2K5) 0.55 0.58 0.51 0.58 0.61 0.57 0.53 0.58 0.85 0.87 0.85 0.87 0.58 0.41 0.68 0.56 0.32 0.60 0.37 0.45 0.36 0.41 0.78 0.94 0.78 0.59 0.99 0.41 0.89 0.49 0.43 0.44 0.85 0.48 0.43 0.34 0.88 0.49 0.85 0.84 0.93 0.77 0.85 0.84 0.47 0.86 0.49 0.84 0.39 1.00 0.47
4087 (SMAD2) 0.55 0.56 0.62 0.53 0.56 0.55 0.54 0.53 0.51 0.49 0.53 0.50 0.54 0.48 0.49 0.56 0.42 0.57 0.76 0.80 0.46 0.50 0.49 0.49 0.52 0.59 0.47 0.75 0.47 0.51 0.48 0.49 0.51 0.69 0.48 0.71 0.48 0.50 0.48 0.46 0.46 0.48 0.49 0.46 0.49 0.48 0.49 0.46 0.74 0.47 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MAP3K1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 1.3 RT-qPCR Western US C57BL/6 mice –3.5 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
MAP3K1 Human Blood - 4000 m 24 hours upregulated 3.7 RT-qPCR The South Atlantic States, USA Americans 1 Soldier exposed to high altitude compared to their low altitude profile 24183776
MAP3K1 Toad Heart - 3464 m 33 day upregulated 2.198938632 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
MAP3K1 Human Blood - 3500 m 24 hours upregulated 4 RT-qPCR The South Atlantic States, USA Americans 1 Soldier exposed to high altitude compared to their low altitude profile 24183776
MAP3K1 Human Blood - 3000m 24 hours upregulated 2 RT-qPCR The South Atlantic States, USA Americans 1 Soldier exposed to high altitude compared to their low altitude profile 24183776
MAP3K1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 5.7 RT-qPCR Western US C57BL/6 mice –3.5 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
ATF2 1386 MAP3K1 4214 Unknown 19479051 TRUSST
JUN 3725 MAP3K1 4214 Activation 21278380 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT004142 hsa-miR-192-5p Homo sapiens MAP3K1 4214 Homo sapiens Microarray Functional MTI (Weak) 16822819
MIRT031009 hsa-miR-21-5p Homo sapiens MAP3K1 4214 Homo sapiens Microarray Functional MTI (Weak) 18591254
MIRT042622 hsa-miR-423-3p Homo sapiens MAP3K1 4214 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT045762 hsa-miR-125a-5p Homo sapiens MAP3K1 4214 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046560 hsa-let-7g-5p Homo sapiens MAP3K1 4214 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047383 hsa-miR-34a-5p Homo sapiens MAP3K1 4214 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052565 hsa-let-7a-5p Homo sapiens MAP3K1 4214 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT166402 hsa-miR-153-5p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT166342 hsa-miR-193b-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT166399 hsa-miR-19a-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT166400 hsa-miR-19b-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT166338 hsa-miR-193a-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT166417 hsa-miR-3646 Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656511 hsa-miR-4762-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656512 hsa-miR-4539 Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT656513 hsa-miR-1252-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT702158 hsa-miR-548ac Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702154 hsa-miR-548z Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702157 hsa-miR-548bb-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702143 hsa-miR-892c-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702148 hsa-miR-548j-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702149 hsa-miR-548aq-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702155 hsa-miR-548h-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702145 hsa-miR-452-5p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702151 hsa-miR-548aj-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702152 hsa-miR-548ah-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702153 hsa-miR-548ae-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702150 hsa-miR-548am-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702147 hsa-miR-548x-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702141 hsa-miR-4703-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702140 hsa-miR-5585-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702142 hsa-miR-509-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702146 hsa-miR-323a-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702144 hsa-miR-4676-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT702156 hsa-miR-548d-3p Homo sapiens MAP3K1 4214 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT731313 hsa-miR-302a-3p Homo sapiens MAP3K1 4214 Homo sapiens Luciferase reporter assay Functional MTI 26842910
MIRT731315 hsa-miR-302c-3p Homo sapiens MAP3K1 4214 Homo sapiens Luciferase reporter assay Functional MTI 26842910
MIRT731314 hsa-miR-302b-3p Homo sapiens MAP3K1 4214 Homo sapiens Luciferase reporter assay Functional MTI 26842910
MIRT731316 hsa-miR-302d-3p Homo sapiens MAP3K1 4214 Homo sapiens Luciferase reporter assay Functional MTI 26842910
MIRT734394 hsa-miR-451a Homo sapiens MAP3K1 4214 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 26019450
Gene Ontology
ID GO ID GO Term GO Type
4214 GO:0004674 protein serine/threonine kinase activity GOTERM_MF_DIRECT
4214 GO:0000186 activation of MAPKK activity GOTERM_BP_DIRECT
4214 GO:0004702 receptor signaling protein serine/threonine kinase activity GOTERM_MF_DIRECT
4214 GO:0071260 cellular response to mechanical stimulus GOTERM_BP_DIRECT
4214 GO:0005737 cytoplasm GOTERM_CC_DIRECT
4214 GO:0000165 MAPK cascade GOTERM_BP_DIRECT
4214 GO:0005515 protein binding GOTERM_MF_DIRECT
4214 GO:0002755 MyD88-dependent toll-like receptor signaling pathway GOTERM_BP_DIRECT
4214 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
4214 GO:0004672 protein kinase activity GOTERM_MF_DIRECT
4214 GO:0006915 apoptotic process GOTERM_BP_DIRECT
4214 GO:0038095 Fc-epsilon receptor signaling pathway GOTERM_BP_DIRECT
4214 GO:0019901 protein kinase binding GOTERM_MF_DIRECT
4214 GO:0004709 MAP kinase kinase activity GOTERM_MF_DIRECT
4214 GO:0005829 cytosol GOTERM_CC_DIRECT
4214 GO:0006468 protein phosphorylation GOTERM_BP_DIRECT
4214 GO:0005524 ATP binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4214 hsa04010 MAPK signaling pathway
4214 hsa04120 Ubiquitin mediated proteolysis
4214 hsa04622 RIG-I-like receptor signaling pathway
4214 hsa04722 Neurotrophin signaling pathway
4214 hsa04912 GnRH signaling pathway
4214 hsa05166 HTLV-I infection
4214 hsa05161 Hepatitis B
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MAP3K1 4214 Mammary Neoplasms C1458155 Neoplastic Process 0.53 0.569 0.586 group
MAP3K1 4214 Prostatic Neoplasms C0033578 Neoplastic Process 0.31 0.569 0.586 group
MAP3K1 4214 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.32 0.569 0.586 disease
MAP3K1 4214 Breast Carcinoma C0678222 Neoplastic Process 0.5 0.569 0.586 disease
MAP3K1 4214 Malignant neoplasm of breast C0006142 Neoplastic Process 0.4 0.569 0.586 disease
MAP3K1 4214 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.569 0.586 group
MAP3K1 4214 46,XY SEX REVERSAL 6 C3151064 Disease or Syndrome 0.6 0.569 0.586 disease
MAP3K1 4214 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.569 0.586 group
MAP3K1 4214 Disorders of Sex Development C0036875 Congenital Abnormality 0.3 0.569 0.586 group
MAP3K1 4214 Gonadal Dysgenesis, 46,XY C0018054 Disease or Syndrome 0.31 0.569 0.586 disease
MAP3K1 4214 46,XY partial gonadal dysgenesis C4510744 Disease or Syndrome 0.3 0.569 0.586 phenotype
MAP3K1 4214 Swyer Syndrome C2936694 Disease or Syndrome 0.3 0.569 0.586 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
MAP3K1 4214 E6201 E-6201 CHEMBL1097999 inhibitor
MAP3K1 4214 E-6201 E-6201 CHEMBL1097999 inhibitor