Mitogen-activated protein kinase kinase 7
AltitudeomicsDB
Protein Official symbol |
MAP2K7 |
Aliases |
MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 |
Chromosomal Location |
19 |
Length |
419 |
Uniprot ID |
O14733 |
EC number |
2.7.12.2 |
Protein family Information(Pfam) |
PF00069; |
PDB id |
2DYL;3WZU;4UX9;5B2K;5B2L;5B2M;5Y8U;5Y90;5Z1D;5Z1E;6IB0;6IB2;6QFL;6QFR;6QFT;6QG4;6QG7;6QHO;6QHR; |
InterPro ID |
IPR011009;IPR000719;IPR008271; |
dbSNP |
rs56316660 rs56106612 rs55800262 rs1053566 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
CASP8 |
FADD |
0.997 |
TRAF6 |
IRAK1 |
0.996 |
NOD1 |
RIPK2 |
0.996 |
TNF |
TNFRSF1A |
0.995 |
TRADD |
FADD |
0.994 |
UBE2V1 |
UBE2N |
0.994 |
TRADD |
TNFRSF1A |
0.993 |
TAB2 |
TAB1 |
0.992 |
CASP8 |
TRADD |
0.991 |
CASP8 |
RIPK1 |
0.991 |
FASLG |
CASP8 |
0.99 |
FASLG |
FAS |
0.99 |
MAPK14 |
TAB1 |
0.989 |
FADD |
RIPK1 |
0.989 |
MAP3K7 |
TAB1 |
0.989 |
BIRC3 |
RIPK2 |
0.988 |
NOD2 |
RIPK2 |
0.988 |
TRADD |
RIPK1 |
0.988 |
TRAF6 |
TAB2 |
0.987 |
MAP3K7 |
TAB2 |
0.987 |
FADD |
TNFRSF1A |
0.987 |
CASP8 |
FAS |
0.986 |
FASLG |
FADD |
0.986 |
MAPK8 |
MAPK8IP1 |
0.984 |
TNF |
MAPK14 |
0.984 |
TRAF6 |
MAPK8 |
0.983 |
TRAF1 |
BIRC3 |
0.982 |
DAXX |
MAP3K5 |
0.982 |
IKBKG |
RIPK1 |
0.981 |
CASP8 |
TNFRSF1A |
0.981 |
TNF |
TRAF1 |
0.981 |
TRAF6 |
TAB1 |
0.98 |
TRAF2 |
TNFRSF1A |
0.98 |
FAS |
FADD |
0.979 |
TRAF6 |
UBE2N |
0.978 |
TAB3 |
TAB1 |
0.978 |
TNF |
CASP8 |
0.978 |
BIRC3 |
RIPK1 |
0.978 |
TNF |
BIRC3 |
0.978 |
TRAF6 |
IRAK2 |
0.977 |
TRADD |
TRAF2 |
0.977 |
TNF |
RIPK1 |
0.977 |
IKBKG |
IRAK1 |
0.977 |
IKBKG |
TRAF6 |
0.975 |
BIRC3 |
TRAF2 |
0.975 |
RIPK1 |
TRAF2 |
0.974 |
TAB2 |
UBE2N |
0.973 |
TRAF6 |
MAP3K7 |
0.973 |
RIPK1 |
TNFRSF1A |
0.973 |
MAP3K5 |
TRAF2 |
0.972 |
IKBKG |
UBE2V1 |
0.972 |
TRAF1 |
TNFRSF1A |
0.972 |
TRAF6 |
TNF |
0.972 |
IRAK1 |
TAB2 |
0.971 |
TNF |
MAP3K5 |
0.971 |
CASP8 |
BIRC3 |
0.971 |
TNF |
TRAF2 |
0.97 |
TAB2 |
UBE2V1 |
0.97 |
IKBKG |
TAB2 |
0.97 |
TNF |
TRADD |
0.969 |
MAPK10 |
MAPK8IP1 |
0.969 |
IKBKG |
BIRC3 |
0.969 |
TRAF1 |
TRADD |
0.969 |
IRAK1 |
TAB1 |
0.969 |
TRAF6 |
TNFRSF1A |
0.968 |
IKBKG |
TRADD |
0.968 |
IKBKG |
TAB3 |
0.968 |
TRAF6 |
TAB3 |
0.967 |
MAPK9 |
MAPK8IP1 |
0.967 |
TNF |
FADD |
0.967 |
IKBKG |
TAB1 |
0.967 |
IKBKG |
TNF |
0.966 |
TRAF6 |
UBE2V1 |
0.966 |
IKBKG |
TNFRSF1A |
0.965 |
MAPK8 |
TRAF2 |
0.965 |
TAB3 |
UBE2V1 |
0.965 |
RAC1 |
PAK1 |
0.965 |
TAB3 |
MAP3K7 |
0.965 |
IKBKG |
UBE2N |
0.965 |
UBE2V1 |
TAB1 |
0.964 |
TRAF6 |
RIPK1 |
0.964 |
FADD |
TRAF2 |
0.964 |
TNF |
MAPK11 |
0.964 |
TAB2 |
RIPK1 |
0.963 |
TAB3 |
UBE2N |
0.962 |
FAS |
TRADD |
0.962 |
TAB2 |
TRADD |
0.962 |
TRAF1 |
MAP3K5 |
0.962 |
TRADD |
BIRC3 |
0.962 |
FADD |
BIRC3 |
0.962 |
FASLG |
TRADD |
0.961 |
TRAF6 |
MAP3K5 |
0.961 |
TRAF6 |
MAPK9 |
0.961 |
CASP8 |
TRAF2 |
0.96 |
UBE2N |
TAB1 |
0.96 |
BIRC3 |
TNFRSF1A |
0.96 |
IKBKG |
FADD |
0.96 |
TAB3 |
IRAK1 |
0.959 |
TRAF6 |
TRADD |
0.959 |
TRAF6 |
NOD2 |
0.958 |
CASP2 |
FADD |
0.958 |
CASP2 |
BIRC3 |
0.957 |
IKBKG |
TRAF2 |
0.957 |
TRAF6 |
MAPK14 |
0.957 |
TAB3 |
TRADD |
0.956 |
MAP3K5 |
CASP8 |
0.956 |
TRAF1 |
CASP8 |
0.956 |
TAB2 |
IRAK2 |
0.956 |
TNF |
MAP2K7 |
0.956 |
IKBKG |
CASP8 |
0.956 |
TAB2 |
BIRC3 |
0.955 |
IRAK1 |
UBE2N |
0.955 |
IRAK1 |
UBE2V1 |
0.955 |
TRAF6 |
NOD1 |
0.955 |
TRADD |
TAB1 |
0.955 |
TAB2 |
TNFRSF1A |
0.954 |
IKBKG |
NOD2 |
0.954 |
MAP2K4 |
TAB1 |
0.953 |
TRAF6 |
RIPK2 |
0.953 |
IKBKG |
RIPK2 |
0.953 |
FASLG |
RIPK1 |
0.953 |
MAP3K3 |
TAB1 |
0.952 |
IKBKG |
MAP3K1 |
0.952 |
TRAF6 |
FADD |
0.952 |
TRAF1 |
FADD |
0.952 |
TAB3 |
RIPK1 |
0.952 |
MAP3K7 |
UBE2N |
0.952 |
TRAF1 |
RIPK1 |
0.952 |
RAC1 |
PAK2 |
0.952 |
MAP2K4 |
MAPK8 |
0.951 |
DAXX |
FADD |
0.951 |
IKBKG |
IRAK2 |
0.951 |
TRAF6 |
MAPK10 |
0.951 |
IKBKG |
MAP3K7 |
0.951 |
FAS |
RIPK1 |
0.95 |
MAP3K5 |
FADD |
0.95 |
TRAF6 |
MAP3K3 |
0.95 |
TNF |
TAB2 |
0.95 |
TAB1 |
TNFRSF1A |
0.95 |
MAP2K7 |
CASP8 |
0.95 |
MAP2K7 |
MAPK8 |
0.949 |
IKBKG |
NOD1 |
0.949 |
IRAK2 |
TAB1 |
0.949 |
MAPK8 |
RAC1 |
0.948 |
FASLG |
RIPK2 |
0.948 |
TRAF1 |
CASP2 |
0.948 |
TNF |
TAB1 |
0.948 |
FASLG |
BIRC3 |
0.948 |
MAP3K5 |
TNFRSF1A |
0.948 |
MAP2K4 |
MAPK10 |
0.947 |
MAP3K5 |
TRADD |
0.947 |
RIPK1 |
TAB1 |
0.947 |
TRAF6 |
MAP2K4 |
0.947 |
TRAF6 |
MAP2K7 |
0.947 |
MAP3K3 |
RAC1 |
0.947 |
IKBKG |
MAP3K3 |
0.946 |
TRADD |
CASP2 |
0.946 |
MAPK9 |
MAP2K7 |
0.946 |
FAS |
BIRC3 |
0.946 |
TAB2 |
TRAF2 |
0.946 |
FAS |
TNFRSF1A |
0.946 |
MAP2K7 |
MAPK8IP1 |
0.945 |
MAP2K4 |
MAPK9 |
0.945 |
DAXX |
CASP8 |
0.945 |
CASP2 |
TNFRSF1A |
0.945 |
RAC1 |
FYN |
0.943 |
RIPK2 |
TAB1 |
0.943 |
MAP2K7 |
MAPK10 |
0.943 |
TAB3 |
IRAK2 |
0.943 |
NOD2 |
BIRC3 |
0.942 |
TAB3 |
TNFRSF1A |
0.942 |
CASP2 |
RIPK1 |
0.942 |
TNF |
MAP3K7 |
0.942 |
MAP2K4 |
TNF |
0.942 |
TAB2 |
MAP3K3 |
0.941 |
TRAF6 |
MAP3K1 |
0.941 |
MAP3K7 |
BIRC3 |
0.941 |
BIRC3 |
NOD1 |
0.941 |
MAP2K7 |
FASLG |
0.94 |
MAP3K7 |
UBE2V1 |
0.94 |
MAP2K7 |
MAP3K8 |
0.94 |
TNF |
CASP2 |
0.939 |
TNF |
MAP3K1 |
0.939 |
MAP2K4 |
TAB2 |
0.939 |
TNF |
TAB3 |
0.939 |
MAP3K7 |
TNFRSF1A |
0.939 |
TAB3 |
TRAF2 |
0.939 |
NOD1 |
TAB1 |
0.939 |
MAP3K3 |
TRADD |
0.938 |
MAP2K7 |
BIRC3 |
0.938 |
ARHGEF2 |
RAC1 |
0.938 |
TAB2 |
NOD2 |
0.938 |
MAP2K4 |
MAPK14 |
0.938 |
MAP3K1 |
TRAF1 |
0.938 |
MAP2K7 |
TAB2 |
0.938 |
MAP3K1 |
TAB1 |
0.938 |
TAB2 |
NOD1 |
0.938 |
MAPK8 |
FYN |
0.938 |
MAP3K1 |
TRADD |
0.937 |
MAP2K7 |
MAPK14 |
0.937 |
MAPK11 |
TAB1 |
0.937 |
FASLG |
MAP3K5 |
0.937 |
UBE2N |
RIPK1 |
0.937 |
TAB2 |
RIPK2 |
0.937 |
MAP2K7 |
TNFRSF1A |
0.937 |
DAXX |
FAS |
0.937 |
MAP3K1 |
TNFRSF1A |
0.937 |
MAPK8 |
MAP3K11 |
0.937 |
MAP3K1 |
FADD |
0.936 |
TRAF2 |
TAB1 |
0.936 |
BIRC3 |
TAB1 |
0.936 |
FASLG |
TRAF2 |
0.936 |
MAP2K4 |
MAP3K5 |
0.936 |
MAPK9 |
TRAF2 |
0.936 |
DAXX |
FASLG |
0.936 |
MAP3K5 |
FAS |
0.936 |
FADD |
RIPK2 |
0.936 |
MAP2K4 |
MAPK11 |
0.936 |
MAPK14 |
NOD1 |
0.935 |
MAP2K7 |
TAB1 |
0.935 |
IKBKG |
MAP3K8 |
0.935 |
MAPK10 |
TRAF2 |
0.935 |
MAP3K3 |
TNFRSF1A |
0.934 |
CASP8 |
NOD1 |
0.934 |
TAB3 |
BIRC3 |
0.934 |
CASP8 |
RIPK2 |
0.934 |
MAP2K7 |
FADD |
0.934 |
IKBKG |
MAP2K7 |
0.933 |
MAP2K4 |
MAP3K1 |
0.933 |
MAP2K4 |
MAP3K11 |
0.933 |
MAP3K1 |
MAP2K7 |
0.932 |
TRAF2 |
MAPK14 |
0.932 |
TRAF6 |
MAPK11 |
0.931 |
MAP2K7 |
RAC1 |
0.931 |
TAB2 |
MAPK14 |
0.931 |
MAP2K4 |
TAB3 |
0.931 |
MAP2K4 |
MAPK12 |
0.931 |
MAP2K7 |
MAP3K5 |
0.93 |
TAB3 |
NOD1 |
0.93 |
MAP3K1 |
MAPK8 |
0.93 |
MAPK14 |
RIPK2 |
0.93 |
MAP3K5 |
CASP2 |
0.93 |
MAP2K7 |
PAK1 |
0.93 |
TAB3 |
NOD2 |
0.93 |
MAP2K7 |
MAP3K11 |
0.93 |
RAC1 |
MAPK14 |
0.93 |
NOD2 |
TAB1 |
0.93 |
TNF |
MAP3K3 |
0.93 |
MAP3K7 |
TRADD |
0.93 |
MAP3K12 |
MAP2K4 |
0.93 |
IRAK1 |
MAP3K7 |
0.93 |
MAP2K4 |
TNFRSF1A |
0.929 |
FAS |
TRAF2 |
0.929 |
MAP2K4 |
MAPK13 |
0.929 |
UBE2V1 |
RIPK1 |
0.929 |
MAP2K4 |
TRAF2 |
0.928 |
MAPK9 |
RAC1 |
0.928 |
IKBKG |
FASLG |
0.928 |
NOD2 |
MAPK14 |
0.928 |
MAP2K7 |
FAS |
0.928 |
MAPK9 |
MAP3K1 |
0.928 |
MAP2K7 |
MAP3K13 |
0.927 |
MAPK8 |
PAK1 |
0.927 |
MAP2K7 |
MAP3K7 |
0.927 |
TAB3 |
RIPK2 |
0.927 |
MAP3K7 |
TRAF2 |
0.927 |
MAP2K4 |
DAXX |
0.926 |
MAP3K1 |
TRAF2 |
0.926 |
MAP2K4 |
MAP3K4 |
0.926 |
MAP2K4 |
MAP3K8 |
0.926 |
MAP2K4 |
FADD |
0.926 |
MAP2K7 |
MAPK11 |
0.926 |
MAP2K4 |
TRADD |
0.926 |
MAP3K1 |
MAP3K11 |
0.925 |
MAP2K4 |
MAP3K7 |
0.925 |
UBE2V1 |
RIPK2 |
0.925 |
MAP3K5 |
BIRC3 |
0.924 |
MAP3K12 |
MAP2K7 |
0.924 |
FYN |
MAPK14 |
0.924 |
MAP2K7 |
CASP2 |
0.924 |
TAB2 |
MAPK11 |
0.924 |
MAP2K7 |
TRADD |
0.923 |
MAP2K4 |
RAC1 |
0.923 |
MAP3K7 |
NOD1 |
0.923 |
MAP2K7 |
MAP3K4 |
0.923 |
TAB3 |
TAB2 |
0.923 |
MAP2K7 |
DAXX |
0.923 |
NOD2 |
NOD1 |
0.922 |
TAB3 |
MAPK14 |
0.922 |
MAP2K4 |
FASLG |
0.922 |
PAK1 |
MAPK14 |
0.922 |
UBE2N |
RIPK2 |
0.921 |
MAP2K4 |
UBE2N |
0.921 |
MAP3K7 |
NOD2 |
0.921 |
ARHGEF2 |
FYN |
0.921 |
CASP2 |
NOD1 |
0.921 |
IKBKG |
MAP2K4 |
0.921 |
MAP2K4 |
UBE2V1 |
0.921 |
TAB1 |
MAPK12 |
0.921 |
MAP3K1 |
MAP3K7 |
0.921 |
CASP2 |
TRAF2 |
0.921 |
MAP3K7 |
MAPK14 |
0.921 |
MAP2K7 |
UBE2N |
0.921 |
MAP2K7 |
TAB3 |
0.921 |
FYN |
PAK1 |
0.921 |
IKBKG |
FAS |
0.921 |
MAP3K7 |
MAP3K3 |
0.921 |
IRAK1 |
IRAK2 |
0.921 |
PAK2 |
MAPK14 |
0.92 |
FYN |
PAK2 |
0.92 |
MAP3K1 |
MAPK14 |
0.92 |
MAP2K7 |
FYN |
0.92 |
MAP2K7 |
TRAF2 |
0.92 |
MAP2K7 |
MAPK13 |
0.92 |
MAP3K3 |
RIPK1 |
0.92 |
MAP3K3 |
MAPK14 |
0.92 |
IRAK1 |
MAP3K3 |
0.92 |
MAP3K1 |
MAPK10 |
0.92 |
MAP2K4 |
MAP3K2 |
0.919 |
TAB2 |
MAPK12 |
0.919 |
MAP3K5 |
RIPK1 |
0.919 |
UBE2N |
NOD1 |
0.919 |
MAP3K12 |
MAPK14 |
0.919 |
MAP3K2 |
MAP2K7 |
0.919 |
UBE2N |
NOD2 |
0.919 |
MAP3K7 |
IRAK2 |
0.919 |
RAC1 |
MAP3K11 |
0.919 |
MAP2K7 |
MAP3K3 |
0.918 |
MAP2K4 |
PAK1 |
0.918 |
PAK1 |
MAPK12 |
0.918 |
MAP2K7 |
TRAF1 |
0.918 |
MAP2K7 |
MAPK12 |
0.918 |
MAP2K4 |
FAS |
0.918 |
MAP3K12 |
MAPK11 |
0.917 |
MAP2K7 |
ARHGEF2 |
0.917 |
FYN |
MAPK11 |
0.917 |
MAPK11 |
PAK1 |
0.917 |
MAP2K4 |
MAP3K3 |
0.917 |
TAB3 |
MAPK12 |
0.917 |
MAP2K4 |
IRAK1 |
0.916 |
PAK2 |
MAPK12 |
0.916 |
IRAK1 |
RIPK2 |
0.916 |
MAP2K4 |
BIRC3 |
0.916 |
MAP3K7 |
RIPK1 |
0.916 |
MAPK11 |
PAK2 |
0.916 |
MAP2K7 |
MAPK8IP2 |
0.916 |
MAPK10 |
RAC1 |
0.915 |
UBE2V1 |
NOD1 |
0.915 |
MAP3K1 |
IRAK1 |
0.915 |
RAC1 |
MAPK13 |
0.915 |
PAK2 |
MAPK13 |
0.915 |
TAB1 |
MAPK13 |
0.915 |
MAP3K3 |
TRAF2 |
0.915 |
RAC1 |
MAPK12 |
0.915 |
RAC1 |
MAPK11 |
0.915 |
FAS |
RIPK2 |
0.915 |
MAP2K4 |
PAK2 |
0.915 |
PAK1 |
MAPK13 |
0.914 |
MAP3K3 |
MAPK11 |
0.914 |
TRAF6 |
TRAF2 |
0.914 |
MAP2K7 |
UBE2V1 |
0.914 |
MAP3K1 |
MAPK11 |
0.913 |
MAP3K7 |
MAPK11 |
0.913 |
MAP2K4 |
IRAK2 |
0.913 |
MAP3K1 |
RIPK1 |
0.913 |
UBE2V1 |
NOD2 |
0.913 |
MAP2K7 |
NOD1 |
0.913 |
MAP3K7 |
MAPK12 |
0.913 |
MAP3K1 |
RAC1 |
0.913 |
MAP2K4 |
MAP2K7 |
0.912 |
MAP3K7 |
RIPK2 |
0.912 |
MAP2K7 |
IRAK1 |
0.912 |
TAB2 |
MAPK13 |
0.912 |
NOD2 |
MAPK13 |
0.912 |
MAPK11 |
MAPK12 |
0.911 |
MAP3K7 |
MAPK13 |
0.911 |
MAPK8 |
MAPK14 |
0.911 |
FYN |
MAPK13 |
0.911 |
MAP2K7 |
PAK2 |
0.911 |
MAPK8 |
ARHGEF2 |
0.911 |
TNF |
MAPK8 |
0.91 |
DAXX |
RIPK2 |
0.91 |
FYN |
MAPK12 |
0.91 |
RIPK1 |
MAPK14 |
0.91 |
MAP3K1 |
PAK2 |
0.91 |
NOD1 |
MAPK13 |
0.91 |
MAPK11 |
RIPK2 |
0.91 |
MAP2K4 |
NOD1 |
0.91 |
MAPK11 |
NOD1 |
0.91 |
MAP2K4 |
RIPK1 |
0.91 |
MAPK11 |
TRAF2 |
0.91 |
MAP2K7 |
RIPK1 |
0.91 |
MAPK8 |
MAPK11 |
0.909 |
MAPK9 |
MAPK11 |
0.909 |
MAPK10 |
MAPK14 |
0.909 |
MAPK10 |
MAPK11 |
0.909 |
MAPK9 |
MAPK14 |
0.909 |
MAPK11 |
NOD2 |
0.909 |
TAB3 |
MAPK13 |
0.908 |
MAP3K1 |
PAK1 |
0.908 |
MAP2K7 |
NOD2 |
0.908 |
MAP2K7 |
IRAK2 |
0.907 |
MAP3K4 |
PAK2 |
0.907 |
MAP2K4 |
NOD2 |
0.907 |
TRAF1 |
TRAF2 |
0.907 |
MAPK11 |
MAPK13 |
0.906 |
TAB3 |
MAPK11 |
0.906 |
MAP2K7 |
RIPK2 |
0.906 |
MAPK14 |
MAPK13 |
0.906 |
MAP2K4 |
RIPK2 |
0.906 |
MAPK9 |
MAPK8 |
0.905 |
RIPK2 |
MAPK12 |
0.905 |
MAPK14 |
MAPK12 |
0.905 |
MAP3K4 |
PAK1 |
0.905 |
RIPK2 |
MAPK13 |
0.905 |
FYN |
MAP3K11 |
0.905 |
NOD2 |
MAPK12 |
0.905 |
NOD1 |
MAPK12 |
0.905 |
MAPK9 |
MAPK10 |
0.904 |
MAPK12 |
MAPK13 |
0.904 |
MAPK8 |
MAPK10 |
0.903 |
PAK2 |
PAK1 |
0.902 |
MAP3K11 |
MAPK8IP1 |
0.902 |
MAPK11 |
MAPK14 |
0.902 |
MAP3K12 |
PAK1 |
0.902 |
ARHGEF2 |
MAP3K11 |
0.902 |
MAP3K12 |
PAK2 |
0.902 |
MAPK8IP2 |
MAP3K11 |
0.901 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
8772 (FADD) |
3654 (IRAK1) |
8767 (RIPK2) |
7132 (TNFRSF1A) |
7334 (UBE2N) |
10454 (TAB1) |
8717 (TRADD) |
8737 (RIPK1) |
841 (CASP8) |
355 (FAS) |
23118 (TAB2) |
9479 (MAPK8IP1) |
1432 (MAPK14) |
5599 (MAPK8) |
330 (BIRC3) |
4217 (MAP3K5) |
7185 (TRAF1) |
3656 (IRAK2) |
7186 (TRAF2) |
7189 (TRAF6) |
6885 (MAP3K7) |
7335 (UBE2V1) |
7124 (TNF) |
257397 (TAB3) |
5058 (PAK1) |
5600 (MAPK11) |
5601 (MAPK9) |
64127 (NOD2) |
5609 (MAP2K7) |
10392 (NOD1) |
4214 (MAP3K1) |
5062 (PAK2) |
5602 (MAPK10) |
4215 (MAP3K3) |
5879 (RAC1) |
835 (CASP2) |
6416 (MAP2K4) |
2534 (FYN) |
356 (FASLG) |
1326 (MAP3K8) |
4296 (MAP3K11) |
6300 (MAPK12) |
5603 (MAPK13) |
9175 (MAP3K13) |
1616 (DAXX) |
4216 (MAP3K4) |
10746 (MAP3K2) |
9181 (ARHGEF2) |
23542 (MAPK8IP2) |
8517 (IKBKG) |
7786 (MAP3K12) |
8772 (FADD)
|
1.00
|
0.57
|
0.77
|
0.69
|
0.62
|
0.70
|
0.78
|
0.67
|
0.63
|
0.76
|
0.74
|
0.67
|
0.62
|
0.57
|
0.55
|
0.61
|
0.82
|
0.70
|
0.76
|
0.72
|
0.64
|
0.69
|
0.80
|
1.00
|
0.61
|
0.63
|
0.65
|
0.71
|
0.60
|
0.71
|
0.58
|
0.62
|
0.58
|
0.63
|
0.64
|
0.75
|
0.54
|
0.62
|
0.79
|
0.63
|
0.64
|
0.60
|
0.63
|
0.59
|
0.67
|
0.63
|
0.63
|
0.57
|
0.66
|
0.76
|
0.59
|
3654 (IRAK1)
|
0.57
|
1.00
|
0.84
|
0.47
|
0.55
|
0.45
|
0.57
|
0.81
|
0.50
|
0.56
|
0.49
|
0.47
|
0.79
|
0.82
|
0.59
|
0.82
|
0.55
|
0.94
|
0.61
|
0.62
|
0.86
|
0.53
|
0.51
|
1.00
|
0.82
|
0.86
|
0.76
|
0.55
|
0.76
|
0.56
|
0.86
|
0.76
|
0.76
|
0.88
|
0.72
|
0.53
|
0.85
|
0.69
|
0.52
|
0.86
|
0.88
|
0.81
|
0.86
|
0.81
|
0.58
|
0.86
|
0.85
|
0.44
|
0.50
|
0.66
|
0.89
|
8767 (RIPK2)
|
0.77
|
0.84
|
1.00
|
0.61
|
0.60
|
0.61
|
0.70
|
0.83
|
0.58
|
0.69
|
0.64
|
0.59
|
0.77
|
0.76
|
0.59
|
0.83
|
0.70
|
0.85
|
0.68
|
0.67
|
0.86
|
0.63
|
0.68
|
1.00
|
0.78
|
0.81
|
0.76
|
0.67
|
0.74
|
0.72
|
0.83
|
0.76
|
0.75
|
0.82
|
0.71
|
0.68
|
0.78
|
0.73
|
0.70
|
0.84
|
0.89
|
0.78
|
0.81
|
0.84
|
0.62
|
0.84
|
0.80
|
0.54
|
0.60
|
0.74
|
0.87
|
7132 (TNFRSF1A)
|
0.69
|
0.47
|
0.61
|
1.00
|
0.53
|
0.61
|
0.70
|
0.54
|
0.51
|
0.79
|
0.67
|
0.58
|
0.54
|
0.47
|
0.44
|
0.51
|
0.68
|
0.61
|
0.62
|
0.63
|
0.54
|
0.59
|
0.60
|
1.00
|
0.52
|
0.52
|
0.56
|
0.64
|
0.52
|
0.61
|
0.48
|
0.53
|
0.47
|
0.52
|
0.55
|
0.61
|
0.43
|
0.53
|
0.73
|
0.52
|
0.52
|
0.50
|
0.52
|
0.48
|
0.62
|
0.52
|
0.53
|
0.50
|
0.59
|
0.68
|
0.49
|
7334 (UBE2N)
|
0.62
|
0.55
|
0.60
|
0.53
|
1.00
|
0.52
|
0.62
|
0.62
|
0.57
|
0.59
|
0.60
|
0.52
|
0.56
|
0.54
|
0.73
|
0.54
|
0.68
|
0.59
|
0.76
|
0.76
|
0.57
|
0.80
|
0.60
|
1.00
|
0.55
|
0.53
|
0.54
|
0.60
|
0.54
|
0.56
|
0.53
|
0.55
|
0.49
|
0.55
|
0.56
|
0.58
|
0.50
|
0.55
|
0.60
|
0.53
|
0.55
|
0.52
|
0.53
|
0.51
|
0.62
|
0.53
|
0.56
|
0.48
|
0.55
|
0.71
|
0.54
|
10454 (TAB1)
|
0.70
|
0.45
|
0.61
|
0.61
|
0.52
|
1.00
|
0.71
|
0.53
|
0.49
|
0.68
|
0.69
|
0.65
|
0.52
|
0.54
|
0.47
|
0.50
|
0.69
|
0.61
|
0.62
|
0.63
|
0.53
|
0.59
|
0.60
|
1.00
|
0.51
|
0.49
|
0.54
|
0.65
|
0.50
|
0.70
|
0.46
|
0.60
|
0.43
|
0.50
|
0.54
|
0.61
|
0.39
|
0.55
|
0.76
|
0.49
|
0.51
|
0.47
|
0.49
|
0.46
|
0.67
|
0.49
|
0.51
|
0.56
|
0.59
|
0.68
|
0.48
|
8717 (TRADD)
|
0.78
|
0.57
|
0.70
|
0.70
|
0.62
|
0.71
|
1.00
|
0.67
|
0.59
|
0.83
|
0.76
|
0.69
|
0.63
|
0.56
|
0.55
|
0.61
|
0.78
|
0.71
|
0.72
|
0.74
|
0.65
|
0.70
|
0.70
|
1.00
|
0.61
|
0.63
|
0.65
|
0.72
|
0.62
|
0.71
|
0.62
|
0.65
|
0.57
|
0.63
|
0.65
|
0.75
|
0.53
|
0.61
|
0.80
|
0.63
|
0.66
|
0.60
|
0.63
|
0.62
|
0.68
|
0.63
|
0.68
|
0.57
|
0.72
|
0.78
|
0.63
|
8737 (RIPK1)
|
0.67
|
0.81
|
0.83
|
0.54
|
0.62
|
0.53
|
0.67
|
1.00
|
0.58
|
0.62
|
0.56
|
0.53
|
0.77
|
0.76
|
0.57
|
0.80
|
0.70
|
0.79
|
0.70
|
0.69
|
0.85
|
0.57
|
0.60
|
1.00
|
0.79
|
0.81
|
0.74
|
0.64
|
0.75
|
0.64
|
0.83
|
0.75
|
0.73
|
0.83
|
0.71
|
0.60
|
0.81
|
0.70
|
0.60
|
0.83
|
0.86
|
0.77
|
0.81
|
0.80
|
0.61
|
0.83
|
0.81
|
0.49
|
0.55
|
0.69
|
0.84
|
841 (CASP8)
|
0.63
|
0.50
|
0.58
|
0.51
|
0.57
|
0.49
|
0.59
|
0.58
|
1.00
|
0.59
|
0.52
|
0.50
|
0.51
|
0.50
|
0.52
|
0.53
|
0.63
|
0.53
|
0.63
|
0.63
|
0.56
|
0.50
|
0.54
|
1.00
|
0.49
|
0.48
|
0.50
|
0.57
|
0.50
|
0.56
|
0.48
|
0.52
|
0.46
|
0.48
|
0.55
|
0.89
|
0.46
|
0.53
|
0.54
|
0.48
|
0.53
|
0.47
|
0.48
|
0.50
|
0.59
|
0.48
|
0.49
|
0.47
|
0.52
|
0.65
|
0.49
|
355 (FAS)
|
0.76
|
0.56
|
0.69
|
0.79
|
0.59
|
0.68
|
0.83
|
0.62
|
0.59
|
1.00
|
0.72
|
0.66
|
0.63
|
0.56
|
0.52
|
0.59
|
0.76
|
0.68
|
0.70
|
0.73
|
0.64
|
0.67
|
0.68
|
1.00
|
0.59
|
0.62
|
0.65
|
0.70
|
0.62
|
0.69
|
0.61
|
0.63
|
0.59
|
0.60
|
0.63
|
0.71
|
0.53
|
0.59
|
0.76
|
0.62
|
0.65
|
0.59
|
0.62
|
0.62
|
0.66
|
0.62
|
0.65
|
0.55
|
0.70
|
0.74
|
0.62
|
23118 (TAB2)
|
0.74
|
0.49
|
0.64
|
0.67
|
0.60
|
0.69
|
0.76
|
0.56
|
0.52
|
0.72
|
1.00
|
0.63
|
0.55
|
0.48
|
0.46
|
0.52
|
0.74
|
0.66
|
0.65
|
0.65
|
0.56
|
0.67
|
0.64
|
1.00
|
0.56
|
0.56
|
0.60
|
0.67
|
0.53
|
0.64
|
0.50
|
0.55
|
0.48
|
0.56
|
0.57
|
0.65
|
0.44
|
0.55
|
0.84
|
0.56
|
0.54
|
0.52
|
0.56
|
0.49
|
0.64
|
0.56
|
0.57
|
0.52
|
0.63
|
0.83
|
0.52
|
9479 (MAPK8IP1)
|
0.67
|
0.47
|
0.59
|
0.58
|
0.52
|
0.65
|
0.69
|
0.53
|
0.50
|
0.66
|
0.63
|
1.00
|
0.53
|
0.51
|
0.49
|
0.50
|
0.66
|
0.59
|
0.62
|
0.62
|
0.52
|
0.57
|
0.59
|
1.00
|
0.51
|
0.50
|
0.54
|
0.64
|
0.51
|
0.61
|
0.48
|
0.59
|
0.45
|
0.50
|
0.55
|
0.60
|
0.42
|
0.54
|
0.68
|
0.50
|
0.51
|
0.48
|
0.50
|
0.48
|
0.66
|
0.50
|
0.53
|
0.51
|
0.75
|
0.66
|
0.50
|
1432 (MAPK14)
|
0.62
|
0.79
|
0.77
|
0.54
|
0.56
|
0.52
|
0.63
|
0.77
|
0.51
|
0.63
|
0.55
|
0.53
|
1.00
|
0.83
|
0.54
|
0.78
|
0.61
|
0.77
|
0.70
|
0.67
|
0.81
|
0.55
|
0.56
|
1.00
|
0.78
|
0.84
|
0.82
|
0.64
|
0.89
|
0.55
|
0.84
|
0.76
|
0.85
|
0.81
|
0.76
|
0.59
|
0.86
|
0.68
|
0.58
|
0.81
|
0.80
|
0.80
|
0.84
|
0.76
|
0.62
|
0.81
|
0.83
|
0.50
|
0.58
|
0.61
|
0.81
|
5599 (MAPK8)
|
0.57
|
0.82
|
0.76
|
0.47
|
0.54
|
0.54
|
0.56
|
0.76
|
0.50
|
0.56
|
0.48
|
0.51
|
0.83
|
1.00
|
0.59
|
0.74
|
0.56
|
0.76
|
0.64
|
0.66
|
0.80
|
0.51
|
0.51
|
1.00
|
0.76
|
0.84
|
0.82
|
0.58
|
0.76
|
0.53
|
0.81
|
0.75
|
0.81
|
0.80
|
0.73
|
0.54
|
0.77
|
0.69
|
0.51
|
0.80
|
0.78
|
0.80
|
0.84
|
0.73
|
0.60
|
0.80
|
0.79
|
0.49
|
0.51
|
0.56
|
0.78
|
330 (BIRC3)
|
0.55
|
0.59
|
0.59
|
0.44
|
0.73
|
0.47
|
0.55
|
0.57
|
0.52
|
0.52
|
0.46
|
0.49
|
0.54
|
0.59
|
1.00
|
0.54
|
0.53
|
0.55
|
0.70
|
0.71
|
0.57
|
0.68
|
0.49
|
1.00
|
0.54
|
0.51
|
0.50
|
0.55
|
0.53
|
0.55
|
0.53
|
0.56
|
0.46
|
0.54
|
0.53
|
0.52
|
0.51
|
0.55
|
0.50
|
0.51
|
0.55
|
0.49
|
0.51
|
0.50
|
0.56
|
0.51
|
0.55
|
0.43
|
0.49
|
0.56
|
0.54
|
4217 (MAP3K5)
|
0.61
|
0.82
|
0.83
|
0.51
|
0.54
|
0.50
|
0.61
|
0.80
|
0.53
|
0.59
|
0.52
|
0.50
|
0.78
|
0.74
|
0.54
|
1.00
|
0.59
|
0.79
|
0.65
|
0.62
|
0.82
|
0.53
|
0.56
|
1.00
|
0.74
|
0.76
|
0.71
|
0.58
|
0.82
|
0.61
|
0.80
|
0.73
|
0.70
|
0.77
|
0.75
|
0.59
|
0.76
|
0.68
|
0.55
|
0.79
|
0.84
|
0.83
|
0.76
|
0.80
|
0.56
|
0.79
|
0.76
|
0.50
|
0.52
|
0.66
|
0.82
|
7185 (TRAF1)
|
0.82
|
0.55
|
0.70
|
0.68
|
0.68
|
0.69
|
0.78
|
0.70
|
0.63
|
0.76
|
0.74
|
0.66
|
0.61
|
0.56
|
0.53
|
0.59
|
1.00
|
0.69
|
0.84
|
0.82
|
0.63
|
0.68
|
0.76
|
1.00
|
0.60
|
0.61
|
0.63
|
0.70
|
0.59
|
0.70
|
0.56
|
0.61
|
0.56
|
0.61
|
0.66
|
0.73
|
0.52
|
0.61
|
0.80
|
0.61
|
0.63
|
0.58
|
0.61
|
0.58
|
0.70
|
0.61
|
0.61
|
0.56
|
0.65
|
0.81
|
0.58
|
3656 (IRAK2)
|
0.70
|
0.94
|
0.85
|
0.61
|
0.59
|
0.61
|
0.71
|
0.79
|
0.53
|
0.68
|
0.66
|
0.59
|
0.77
|
0.76
|
0.55
|
0.79
|
0.69
|
1.00
|
0.65
|
0.66
|
0.83
|
0.63
|
0.61
|
1.00
|
0.81
|
0.86
|
0.78
|
0.64
|
0.74
|
0.68
|
0.84
|
0.74
|
0.75
|
0.88
|
0.70
|
0.63
|
0.82
|
0.67
|
0.71
|
0.86
|
0.87
|
0.80
|
0.86
|
0.79
|
0.65
|
0.86
|
0.85
|
0.51
|
0.59
|
0.79
|
0.89
|
7186 (TRAF2)
|
0.76
|
0.61
|
0.68
|
0.62
|
0.76
|
0.62
|
0.72
|
0.70
|
0.63
|
0.70
|
0.65
|
0.62
|
0.70
|
0.64
|
0.70
|
0.65
|
0.84
|
0.65
|
1.00
|
0.90
|
0.66
|
0.71
|
0.71
|
1.00
|
0.62
|
0.61
|
0.62
|
0.71
|
0.71
|
0.65
|
0.65
|
0.67
|
0.58
|
0.62
|
0.71
|
0.70
|
0.58
|
0.65
|
0.68
|
0.61
|
0.67
|
0.60
|
0.61
|
0.64
|
0.71
|
0.61
|
0.68
|
0.56
|
0.66
|
0.73
|
0.65
|
7189 (TRAF6)
|
0.72
|
0.62
|
0.67
|
0.63
|
0.76
|
0.63
|
0.74
|
0.69
|
0.63
|
0.73
|
0.65
|
0.62
|
0.67
|
0.66
|
0.71
|
0.62
|
0.82
|
0.66
|
0.90
|
1.00
|
0.67
|
0.71
|
0.69
|
1.00
|
0.62
|
0.62
|
0.63
|
0.74
|
0.70
|
0.65
|
0.69
|
0.69
|
0.59
|
0.63
|
0.74
|
0.71
|
0.59
|
0.65
|
0.68
|
0.62
|
0.72
|
0.61
|
0.62
|
0.68
|
0.74
|
0.62
|
0.72
|
0.56
|
0.71
|
0.73
|
0.70
|
6885 (MAP3K7)
|
0.64
|
0.86
|
0.86
|
0.54
|
0.57
|
0.53
|
0.65
|
0.85
|
0.56
|
0.64
|
0.56
|
0.52
|
0.81
|
0.80
|
0.57
|
0.82
|
0.63
|
0.83
|
0.66
|
0.67
|
1.00
|
0.57
|
0.58
|
1.00
|
0.83
|
0.87
|
0.79
|
0.61
|
0.79
|
0.59
|
0.92
|
0.80
|
0.79
|
0.88
|
0.75
|
0.59
|
0.85
|
0.72
|
0.61
|
0.90
|
0.90
|
0.82
|
0.87
|
0.85
|
0.60
|
0.90
|
0.89
|
0.48
|
0.57
|
0.64
|
0.90
|
7335 (UBE2V1)
|
0.69
|
0.53
|
0.63
|
0.59
|
0.80
|
0.59
|
0.70
|
0.57
|
0.50
|
0.67
|
0.67
|
0.57
|
0.55
|
0.51
|
0.68
|
0.53
|
0.68
|
0.63
|
0.71
|
0.71
|
0.57
|
1.00
|
0.59
|
1.00
|
0.55
|
0.54
|
0.57
|
0.64
|
0.53
|
0.60
|
0.52
|
0.55
|
0.47
|
0.56
|
0.56
|
0.61
|
0.46
|
0.55
|
0.74
|
0.54
|
0.55
|
0.51
|
0.54
|
0.49
|
0.61
|
0.54
|
0.57
|
0.48
|
0.58
|
0.67
|
0.53
|
7124 (TNF)
|
0.80
|
0.51
|
0.68
|
0.60
|
0.60
|
0.60
|
0.70
|
0.60
|
0.54
|
0.68
|
0.64
|
0.59
|
0.56
|
0.51
|
0.49
|
0.56
|
0.76
|
0.61
|
0.71
|
0.69
|
0.58
|
0.59
|
1.00
|
1.00
|
0.54
|
0.54
|
0.57
|
0.64
|
0.54
|
0.64
|
0.52
|
0.57
|
0.51
|
0.55
|
0.58
|
0.65
|
0.48
|
0.58
|
0.70
|
0.54
|
0.57
|
0.53
|
0.54
|
0.54
|
0.62
|
0.54
|
0.55
|
0.52
|
0.59
|
0.69
|
0.53
|
257397 (TAB3)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
5058 (PAK1)
|
0.61
|
0.82
|
0.78
|
0.52
|
0.55
|
0.51
|
0.61
|
0.79
|
0.49
|
0.59
|
0.56
|
0.51
|
0.78
|
0.76
|
0.54
|
0.74
|
0.60
|
0.81
|
0.62
|
0.62
|
0.83
|
0.55
|
0.54
|
1.00
|
1.00
|
0.84
|
0.74
|
0.60
|
0.75
|
0.55
|
0.84
|
0.83
|
0.73
|
0.88
|
0.70
|
0.56
|
0.84
|
0.68
|
0.59
|
0.84
|
0.81
|
0.78
|
0.84
|
0.72
|
0.58
|
0.84
|
0.85
|
0.58
|
0.54
|
0.61
|
0.82
|
5600 (MAPK11)
|
0.63
|
0.86
|
0.81
|
0.52
|
0.53
|
0.49
|
0.63
|
0.81
|
0.48
|
0.62
|
0.56
|
0.50
|
0.84
|
0.84
|
0.51
|
0.76
|
0.61
|
0.86
|
0.61
|
0.62
|
0.87
|
0.54
|
0.54
|
1.00
|
0.84
|
1.00
|
0.91
|
0.60
|
0.76
|
0.55
|
0.90
|
0.74
|
0.89
|
0.94
|
0.71
|
0.55
|
0.86
|
0.66
|
0.61
|
0.95
|
0.84
|
0.91
|
1.00
|
0.77
|
0.58
|
0.95
|
0.89
|
0.45
|
0.53
|
0.62
|
0.85
|
5601 (MAPK9)
|
0.65
|
0.76
|
0.76
|
0.56
|
0.54
|
0.54
|
0.65
|
0.74
|
0.50
|
0.65
|
0.60
|
0.54
|
0.82
|
0.82
|
0.50
|
0.71
|
0.63
|
0.78
|
0.62
|
0.63
|
0.79
|
0.57
|
0.57
|
1.00
|
0.74
|
0.91
|
1.00
|
0.61
|
0.71
|
0.57
|
0.80
|
0.68
|
0.94
|
0.80
|
0.67
|
0.57
|
0.76
|
0.62
|
0.64
|
0.85
|
0.76
|
0.84
|
0.91
|
0.73
|
0.59
|
0.85
|
0.77
|
0.51
|
0.56
|
0.64
|
0.76
|
64127 (NOD2)
|
0.71
|
0.55
|
0.67
|
0.64
|
0.60
|
0.65
|
0.72
|
0.64
|
0.57
|
0.70
|
0.67
|
0.64
|
0.64
|
0.58
|
0.55
|
0.58
|
0.70
|
0.64
|
0.71
|
0.74
|
0.61
|
0.64
|
0.64
|
1.00
|
0.60
|
0.60
|
0.61
|
1.00
|
0.64
|
0.79
|
0.62
|
0.64
|
0.57
|
0.60
|
0.67
|
0.68
|
0.54
|
0.59
|
0.70
|
0.60
|
0.62
|
0.58
|
0.60
|
0.60
|
0.70
|
0.60
|
0.66
|
0.58
|
0.72
|
0.69
|
0.62
|
5609 (MAP2K7)
|
0.60
|
0.76
|
0.74
|
0.52
|
0.54
|
0.50
|
0.62
|
0.75
|
0.50
|
0.62
|
0.53
|
0.51
|
0.89
|
0.76
|
0.53
|
0.82
|
0.59
|
0.74
|
0.71
|
0.70
|
0.79
|
0.53
|
0.54
|
1.00
|
0.75
|
0.76
|
0.71
|
0.64
|
1.00
|
0.53
|
0.83
|
0.76
|
0.78
|
0.78
|
0.76
|
0.58
|
0.87
|
0.67
|
0.56
|
0.76
|
0.79
|
0.83
|
0.76
|
0.74
|
0.63
|
0.76
|
0.84
|
0.51
|
0.59
|
0.59
|
0.81
|
10392 (NOD1)
|
0.71
|
0.56
|
0.72
|
0.61
|
0.56
|
0.70
|
0.71
|
0.64
|
0.56
|
0.69
|
0.64
|
0.61
|
0.55
|
0.53
|
0.55
|
0.61
|
0.70
|
0.68
|
0.65
|
0.65
|
0.59
|
0.60
|
0.64
|
1.00
|
0.55
|
0.55
|
0.57
|
0.79
|
0.53
|
1.00
|
0.52
|
0.61
|
0.51
|
0.55
|
0.56
|
0.66
|
0.48
|
0.57
|
0.67
|
0.55
|
0.62
|
0.53
|
0.55
|
0.59
|
0.64
|
0.55
|
0.56
|
0.54
|
0.60
|
0.75
|
0.59
|
4214 (MAP3K1)
|
0.58
|
0.86
|
0.83
|
0.48
|
0.53
|
0.46
|
0.62
|
0.83
|
0.48
|
0.61
|
0.50
|
0.48
|
0.84
|
0.81
|
0.53
|
0.80
|
0.56
|
0.84
|
0.65
|
0.69
|
0.92
|
0.52
|
0.52
|
1.00
|
0.84
|
0.90
|
0.80
|
0.62
|
0.83
|
0.52
|
1.00
|
0.82
|
0.79
|
0.92
|
0.78
|
0.53
|
0.87
|
0.69
|
0.54
|
0.94
|
0.92
|
0.84
|
0.90
|
0.86
|
0.60
|
0.94
|
0.97
|
0.44
|
0.59
|
0.58
|
0.95
|
5062 (PAK2)
|
0.62
|
0.76
|
0.76
|
0.53
|
0.55
|
0.60
|
0.65
|
0.75
|
0.52
|
0.63
|
0.55
|
0.59
|
0.76
|
0.75
|
0.56
|
0.73
|
0.61
|
0.74
|
0.67
|
0.69
|
0.80
|
0.55
|
0.57
|
1.00
|
0.83
|
0.74
|
0.68
|
0.64
|
0.76
|
0.61
|
0.82
|
1.00
|
0.68
|
0.77
|
0.72
|
0.60
|
0.76
|
0.69
|
0.58
|
0.74
|
0.81
|
0.71
|
0.74
|
0.76
|
0.69
|
0.74
|
0.82
|
0.59
|
0.60
|
0.63
|
0.81
|
5602 (MAPK10)
|
0.58
|
0.76
|
0.75
|
0.47
|
0.49
|
0.43
|
0.57
|
0.73
|
0.46
|
0.59
|
0.48
|
0.45
|
0.85
|
0.81
|
0.46
|
0.70
|
0.56
|
0.75
|
0.58
|
0.59
|
0.79
|
0.47
|
0.51
|
1.00
|
0.73
|
0.89
|
0.94
|
0.57
|
0.78
|
0.51
|
0.79
|
0.68
|
1.00
|
0.79
|
0.65
|
0.51
|
0.86
|
0.62
|
0.53
|
0.82
|
0.75
|
0.82
|
0.89
|
0.71
|
0.56
|
0.82
|
0.76
|
0.43
|
0.49
|
0.58
|
0.75
|
4215 (MAP3K3)
|
0.63
|
0.88
|
0.82
|
0.52
|
0.55
|
0.50
|
0.63
|
0.83
|
0.48
|
0.60
|
0.56
|
0.50
|
0.81
|
0.80
|
0.54
|
0.77
|
0.61
|
0.88
|
0.62
|
0.63
|
0.88
|
0.56
|
0.55
|
1.00
|
0.88
|
0.94
|
0.80
|
0.60
|
0.78
|
0.55
|
0.92
|
0.77
|
0.79
|
1.00
|
0.73
|
0.56
|
0.92
|
0.70
|
0.62
|
0.94
|
0.86
|
0.85
|
0.94
|
0.76
|
0.58
|
0.94
|
0.94
|
0.46
|
0.54
|
0.63
|
0.88
|
5879 (RAC1)
|
0.64
|
0.72
|
0.71
|
0.55
|
0.56
|
0.54
|
0.65
|
0.71
|
0.55
|
0.63
|
0.57
|
0.55
|
0.76
|
0.73
|
0.53
|
0.75
|
0.66
|
0.70
|
0.71
|
0.74
|
0.75
|
0.56
|
0.58
|
1.00
|
0.70
|
0.71
|
0.67
|
0.67
|
0.76
|
0.56
|
0.78
|
0.72
|
0.65
|
0.73
|
1.00
|
0.63
|
0.71
|
0.65
|
0.60
|
0.71
|
0.75
|
0.68
|
0.71
|
0.71
|
0.65
|
0.71
|
0.78
|
0.50
|
0.62
|
0.62
|
0.76
|
835 (CASP2)
|
0.75
|
0.53
|
0.68
|
0.61
|
0.58
|
0.61
|
0.75
|
0.60
|
0.89
|
0.71
|
0.65
|
0.60
|
0.59
|
0.54
|
0.52
|
0.59
|
0.73
|
0.63
|
0.70
|
0.71
|
0.59
|
0.61
|
0.65
|
1.00
|
0.56
|
0.55
|
0.57
|
0.68
|
0.58
|
0.66
|
0.53
|
0.60
|
0.51
|
0.56
|
0.63
|
1.00
|
0.48
|
0.58
|
0.69
|
0.55
|
0.59
|
0.53
|
0.55
|
0.55
|
0.65
|
0.55
|
0.57
|
0.54
|
0.62
|
0.74
|
0.55
|
6416 (MAP2K4)
|
0.54
|
0.85
|
0.78
|
0.43
|
0.50
|
0.39
|
0.53
|
0.81
|
0.46
|
0.53
|
0.44
|
0.42
|
0.86
|
0.77
|
0.51
|
0.76
|
0.52
|
0.82
|
0.58
|
0.59
|
0.85
|
0.46
|
0.48
|
1.00
|
0.84
|
0.86
|
0.76
|
0.54
|
0.87
|
0.48
|
0.87
|
0.76
|
0.86
|
0.92
|
0.71
|
0.48
|
1.00
|
0.69
|
0.48
|
0.86
|
0.83
|
0.80
|
0.86
|
0.74
|
0.54
|
0.86
|
0.89
|
0.41
|
0.47
|
0.55
|
0.84
|
2534 (FYN)
|
0.62
|
0.69
|
0.73
|
0.53
|
0.55
|
0.55
|
0.61
|
0.70
|
0.53
|
0.59
|
0.55
|
0.54
|
0.68
|
0.69
|
0.55
|
0.68
|
0.61
|
0.67
|
0.65
|
0.65
|
0.72
|
0.55
|
0.58
|
1.00
|
0.68
|
0.66
|
0.62
|
0.59
|
0.67
|
0.57
|
0.69
|
0.69
|
0.62
|
0.70
|
0.65
|
0.58
|
0.69
|
1.00
|
0.61
|
0.66
|
0.71
|
0.64
|
0.66
|
0.66
|
0.60
|
0.66
|
0.70
|
0.61
|
0.55
|
0.61
|
0.69
|
356 (FASLG)
|
0.79
|
0.52
|
0.70
|
0.73
|
0.60
|
0.76
|
0.80
|
0.60
|
0.54
|
0.76
|
0.84
|
0.68
|
0.58
|
0.51
|
0.50
|
0.55
|
0.80
|
0.71
|
0.68
|
0.68
|
0.61
|
0.74
|
0.70
|
1.00
|
0.59
|
0.61
|
0.64
|
0.70
|
0.56
|
0.67
|
0.54
|
0.58
|
0.53
|
0.62
|
0.60
|
0.69
|
0.48
|
0.61
|
1.00
|
0.61
|
0.57
|
0.57
|
0.61
|
0.52
|
0.66
|
0.61
|
0.61
|
0.55
|
0.66
|
0.74
|
0.55
|
1326 (MAP3K8)
|
0.63
|
0.86
|
0.84
|
0.52
|
0.53
|
0.49
|
0.63
|
0.83
|
0.48
|
0.62
|
0.56
|
0.50
|
0.81
|
0.80
|
0.51
|
0.79
|
0.61
|
0.86
|
0.61
|
0.62
|
0.90
|
0.54
|
0.54
|
1.00
|
0.84
|
0.95
|
0.85
|
0.60
|
0.76
|
0.55
|
0.94
|
0.74
|
0.82
|
0.94
|
0.71
|
0.55
|
0.86
|
0.66
|
0.61
|
1.00
|
0.87
|
0.86
|
0.95
|
0.81
|
0.58
|
1.00
|
0.89
|
0.45
|
0.53
|
0.62
|
0.88
|
4296 (MAP3K11)
|
0.64
|
0.88
|
0.89
|
0.52
|
0.55
|
0.51
|
0.66
|
0.86
|
0.53
|
0.65
|
0.54
|
0.51
|
0.80
|
0.78
|
0.55
|
0.84
|
0.63
|
0.87
|
0.67
|
0.72
|
0.90
|
0.55
|
0.57
|
1.00
|
0.81
|
0.84
|
0.76
|
0.62
|
0.79
|
0.62
|
0.92
|
0.81
|
0.75
|
0.86
|
0.75
|
0.59
|
0.83
|
0.71
|
0.57
|
0.87
|
1.00
|
0.79
|
0.84
|
0.90
|
0.60
|
0.87
|
0.89
|
0.47
|
0.58
|
0.67
|
0.97
|
6300 (MAPK12)
|
0.60
|
0.81
|
0.78
|
0.50
|
0.52
|
0.47
|
0.60
|
0.77
|
0.47
|
0.59
|
0.52
|
0.48
|
0.80
|
0.80
|
0.49
|
0.83
|
0.58
|
0.80
|
0.60
|
0.61
|
0.82
|
0.51
|
0.53
|
1.00
|
0.78
|
0.91
|
0.84
|
0.58
|
0.83
|
0.53
|
0.84
|
0.71
|
0.82
|
0.85
|
0.68
|
0.53
|
0.80
|
0.64
|
0.57
|
0.86
|
0.79
|
1.00
|
0.91
|
0.74
|
0.57
|
0.86
|
0.82
|
0.49
|
0.52
|
0.60
|
0.80
|
5603 (MAPK13)
|
0.63
|
0.86
|
0.81
|
0.52
|
0.53
|
0.49
|
0.63
|
0.81
|
0.48
|
0.62
|
0.56
|
0.50
|
0.84
|
0.84
|
0.51
|
0.76
|
0.61
|
0.86
|
0.61
|
0.62
|
0.87
|
0.54
|
0.54
|
1.00
|
0.84
|
1.00
|
0.91
|
0.60
|
0.76
|
0.55
|
0.90
|
0.74
|
0.89
|
0.94
|
0.71
|
0.55
|
0.86
|
0.66
|
0.61
|
0.95
|
0.84
|
0.91
|
1.00
|
0.77
|
0.58
|
0.95
|
0.89
|
0.45
|
0.53
|
0.62
|
0.85
|
9175 (MAP3K13)
|
0.59
|
0.81
|
0.84
|
0.48
|
0.51
|
0.46
|
0.62
|
0.80
|
0.50
|
0.62
|
0.49
|
0.48
|
0.76
|
0.73
|
0.50
|
0.80
|
0.58
|
0.79
|
0.64
|
0.68
|
0.85
|
0.49
|
0.54
|
1.00
|
0.72
|
0.77
|
0.73
|
0.60
|
0.74
|
0.59
|
0.86
|
0.76
|
0.71
|
0.76
|
0.71
|
0.55
|
0.74
|
0.66
|
0.52
|
0.81
|
0.90
|
0.74
|
0.77
|
1.00
|
0.58
|
0.81
|
0.81
|
0.45
|
0.56
|
0.63
|
0.90
|
1616 (DAXX)
|
0.67
|
0.58
|
0.62
|
0.62
|
0.62
|
0.67
|
0.68
|
0.61
|
0.59
|
0.66
|
0.64
|
0.66
|
0.62
|
0.60
|
0.56
|
0.56
|
0.70
|
0.65
|
0.71
|
0.74
|
0.60
|
0.61
|
0.62
|
1.00
|
0.58
|
0.58
|
0.59
|
0.70
|
0.63
|
0.64
|
0.60
|
0.69
|
0.56
|
0.58
|
0.65
|
0.65
|
0.54
|
0.60
|
0.66
|
0.58
|
0.60
|
0.57
|
0.58
|
0.58
|
1.00
|
0.58
|
0.63
|
0.58
|
0.66
|
0.71
|
0.60
|
4216 (MAP3K4)
|
0.63
|
0.86
|
0.84
|
0.52
|
0.53
|
0.49
|
0.63
|
0.83
|
0.48
|
0.62
|
0.56
|
0.50
|
0.81
|
0.80
|
0.51
|
0.79
|
0.61
|
0.86
|
0.61
|
0.62
|
0.90
|
0.54
|
0.54
|
1.00
|
0.84
|
0.95
|
0.85
|
0.60
|
0.76
|
0.55
|
0.94
|
0.74
|
0.82
|
0.94
|
0.71
|
0.55
|
0.86
|
0.66
|
0.61
|
1.00
|
0.87
|
0.86
|
0.95
|
0.81
|
0.58
|
1.00
|
0.89
|
0.45
|
0.53
|
0.62
|
0.88
|
10746 (MAP3K2)
|
0.63
|
0.85
|
0.80
|
0.53
|
0.56
|
0.51
|
0.68
|
0.81
|
0.49
|
0.65
|
0.57
|
0.53
|
0.83
|
0.79
|
0.55
|
0.76
|
0.61
|
0.85
|
0.68
|
0.72
|
0.89
|
0.57
|
0.55
|
1.00
|
0.85
|
0.89
|
0.77
|
0.66
|
0.84
|
0.56
|
0.97
|
0.82
|
0.76
|
0.94
|
0.78
|
0.57
|
0.89
|
0.70
|
0.61
|
0.89
|
0.89
|
0.82
|
0.89
|
0.81
|
0.63
|
0.89
|
1.00
|
0.47
|
0.63
|
0.62
|
0.93
|
9181 (ARHGEF2)
|
0.57
|
0.44
|
0.54
|
0.50
|
0.48
|
0.56
|
0.57
|
0.49
|
0.47
|
0.55
|
0.52
|
0.51
|
0.50
|
0.49
|
0.43
|
0.50
|
0.56
|
0.51
|
0.56
|
0.56
|
0.48
|
0.48
|
0.52
|
1.00
|
0.58
|
0.45
|
0.51
|
0.58
|
0.51
|
0.54
|
0.44
|
0.59
|
0.43
|
0.46
|
0.50
|
0.54
|
0.41
|
0.61
|
0.55
|
0.45
|
0.47
|
0.49
|
0.45
|
0.45
|
0.58
|
0.45
|
0.47
|
1.00
|
0.52
|
0.58
|
0.45
|
23542 (MAPK8IP2)
|
0.66
|
0.50
|
0.60
|
0.59
|
0.55
|
0.59
|
0.72
|
0.55
|
0.52
|
0.70
|
0.63
|
0.75
|
0.58
|
0.51
|
0.49
|
0.52
|
0.65
|
0.59
|
0.66
|
0.71
|
0.57
|
0.58
|
0.59
|
1.00
|
0.54
|
0.53
|
0.56
|
0.72
|
0.59
|
0.60
|
0.59
|
0.60
|
0.49
|
0.54
|
0.62
|
0.62
|
0.47
|
0.55
|
0.66
|
0.53
|
0.58
|
0.52
|
0.53
|
0.56
|
0.66
|
0.53
|
0.63
|
0.52
|
1.00
|
0.65
|
0.59
|
8517 (IKBKG)
|
0.76
|
0.66
|
0.74
|
0.68
|
0.71
|
0.68
|
0.78
|
0.69
|
0.65
|
0.74
|
0.83
|
0.66
|
0.61
|
0.56
|
0.56
|
0.66
|
0.81
|
0.79
|
0.73
|
0.73
|
0.64
|
0.67
|
0.69
|
1.00
|
0.61
|
0.62
|
0.64
|
0.69
|
0.59
|
0.75
|
0.58
|
0.63
|
0.58
|
0.63
|
0.62
|
0.74
|
0.55
|
0.61
|
0.74
|
0.62
|
0.67
|
0.60
|
0.62
|
0.63
|
0.71
|
0.62
|
0.62
|
0.58
|
0.65
|
1.00
|
0.64
|
7786 (MAP3K12)
|
0.59
|
0.89
|
0.87
|
0.49
|
0.54
|
0.48
|
0.63
|
0.84
|
0.49
|
0.62
|
0.52
|
0.50
|
0.81
|
0.78
|
0.54
|
0.82
|
0.58
|
0.89
|
0.65
|
0.70
|
0.90
|
0.53
|
0.53
|
1.00
|
0.82
|
0.85
|
0.76
|
0.62
|
0.81
|
0.59
|
0.95
|
0.81
|
0.75
|
0.88
|
0.76
|
0.55
|
0.84
|
0.69
|
0.55
|
0.88
|
0.97
|
0.80
|
0.85
|
0.90
|
0.60
|
0.88
|
0.93
|
0.45
|
0.59
|
0.64
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
MAP2K7 |
Human |
Blood |
- |
3250 m |
4 day |
upregulated |
1.8723 |
Microarray |
Himalayas |
Indians |
1 |
Sea level healthy individuals |
24465776 |
MAP2K7 |
Human |
Blood |
- |
3250 m |
4 day |
upregulated |
1.8723 |
Microarray |
Himalayas |
Indians |
1 |
Sea level healthy individuals |
24465776 |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
5609 |
GO:0004708 |
MAP kinase activity |
GOTERM_MF_DIRECT |
5609 |
GO:0009411 |
response to UV |
GOTERM_BP_DIRECT |
5609 |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
GOTERM_BP_DIRECT |
5609 |
GO:0051403 |
stress-activated MAPK cascade |
GOTERM_BP_DIRECT |
5609 |
GO:0004672 |
protein kinase activity |
GOTERM_MF_DIRECT |
5609 |
GO:0005737 |
cytoplasm |
GOTERM_CC_DIRECT |
5609 |
GO:0006970 |
response to osmotic stress |
GOTERM_BP_DIRECT |
5609 |
GO:0032212 |
positive regulation of telomere maintenance via telomerase |
GOTERM_BP_DIRECT |
5609 |
GO:0038095 |
Fc-epsilon receptor signaling pathway |
GOTERM_BP_DIRECT |
5609 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
5609 |
GO:0035897 |
proteolysis in other organism |
GOTERM_BP_DIRECT |
5609 |
GO:0007254 |
JNK cascade |
GOTERM_BP_DIRECT |
5609 |
GO:0004713 |
protein tyrosine kinase activity |
GOTERM_MF_DIRECT |
5609 |
GO:0006915 |
apoptotic process |
GOTERM_BP_DIRECT |
5609 |
GO:0051973 |
positive regulation of telomerase activity |
GOTERM_BP_DIRECT |
5609 |
GO:0019903 |
protein phosphatase binding |
GOTERM_MF_DIRECT |
5609 |
GO:0019901 |
protein kinase binding |
GOTERM_MF_DIRECT |
5609 |
GO:0019899 |
enzyme binding |
GOTERM_MF_DIRECT |
5609 |
GO:1904355 |
positive regulation of telomere capping |
GOTERM_BP_DIRECT |
5609 |
GO:0000287 |
magnesium ion binding |
GOTERM_MF_DIRECT |
5609 |
GO:0004702 |
calcium-independent protein kinase C activity |
GOTERM_MF_DIRECT |
5609 |
GO:0007165 |
signal transduction |
GOTERM_BP_DIRECT |
5609 |
GO:0009408 |
response to heat |
GOTERM_BP_DIRECT |
5609 |
GO:0034612 |
response to tumor necrosis factor |
GOTERM_BP_DIRECT |
5609 |
GO:0007257 |
activation of JUN kinase activity |
GOTERM_BP_DIRECT |
5609 |
GO:0005524 |
ATP binding |
GOTERM_MF_DIRECT |
5609 |
GO:0005634 |
nucleus |
GOTERM_CC_DIRECT |
5609 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
5609 |
hsa04012 |
ErbB signaling pathway |
5609 |
hsa04010 |
MAPK signaling pathway |
5609 |
hsa04141 |
Protein processing in endoplasmic reticulum |
5609 |
hsa04620 |
Toll-like receptor signaling pathway |
5609 |
hsa04660 |
T cell receptor signaling pathway |
5609 |
hsa04380 |
Osteoclast differentiation |
5609 |
hsa04664 |
Fc epsilon RI signaling pathway |
5609 |
hsa04668 |
TNF signaling pathway |
5609 |
hsa04722 |
Neurotrophin signaling pathway |
5609 |
hsa04912 |
GnRH signaling pathway |
5609 |
hsa05164 |
Influenza A |
5609 |
hsa05169 |
Epstein-Barr virus infection |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
MAP2K7 |
5609 |
Malignant neoplasm of lung |
C0242379 |
Neoplastic Process |
0.4 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Breast Carcinoma |
C0678222 |
Neoplastic Process |
0.4 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Precancerous Conditions |
C0032927 |
Neoplastic Process |
0.3 |
0.462 |
0.759 |
group |
MAP2K7 |
5609 |
Heart Failure, Right-Sided |
C0235527 |
Disease or Syndrome |
0.3 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Heart failure |
C0018801 |
Disease or Syndrome |
0.3 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Heart Decompensation |
C1961112 |
Pathologic Function |
0.3 |
0.462 |
0.759 |
phenotype |
MAP2K7 |
5609 |
Cirrhosis |
C1623038 |
Disease or Syndrome |
0.3 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Left-Sided Heart Failure |
C0023212 |
Disease or Syndrome |
0.3 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Mammary Neoplasms |
C1458155 |
Neoplastic Process |
0.32 |
0.462 |
0.759 |
group |
MAP2K7 |
5609 |
Myocardial Failure |
C1959583 |
Disease or Syndrome |
0.3 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Condition, Preneoplastic |
C0282313 |
Neoplastic Process |
0.3 |
0.462 |
0.759 |
phenotype |
MAP2K7 |
5609 |
Lung Neoplasms |
C0024121 |
Neoplastic Process |
0.31 |
0.462 |
0.759 |
group |
MAP2K7 |
5609 |
Mammary Neoplasms, Human |
C1257931 |
Neoplastic Process |
0.3 |
0.462 |
0.759 |
group |
MAP2K7 |
5609 |
Malignant neoplasm of breast |
C0006142 |
Neoplastic Process |
0.4 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Fibrosis |
C0016059 |
Pathologic Function |
0.3 |
0.462 |
0.759 |
phenotype |
MAP2K7 |
5609 |
Congestive heart failure |
C0018802 |
Disease or Syndrome |
0.3 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Mammary Neoplasms, Experimental |
C0024668 |
Experimental Model of Disease; Neoplastic Process |
0.3 |
0.462 |
0.759 |
group |
MAP2K7 |
5609 |
Schizophrenia |
C0036341 |
Mental or Behavioral Dysfunction |
0.31 |
0.462 |
0.759 |
disease |
MAP2K7 |
5609 |
Adenocarcinoma of large intestine |
C1319315 |
Neoplastic Process |
0.3 |
0.462 |
0.759 |
disease |