α-1,4 glucan phosphorylase

AltitudeomicsDB
Protein Official symbol PYGM
Aliases PYGM
Chromosomal Location 11
Length 842
Uniprot ID P11217
EC number 2.4.1.1
Protein family Information(Pfam) PF00343;
PDB id 1Z8D;
InterPro ID IPR011833;IPR000811;IPR035090;
dbSNP rs776680924 rs376581557 rs119103251 rs780375860 rs1005687078 rs11231866 rs1555134900 rs119103252 rs750195683 rs119103253 rs119103256 rs144081869 rs1483102315 rs119103258

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
GBE1 AGL 0.998
PGM2 PGM1 0.997
GBE1 GYG1 0.997
GBE1 PYGL 0.9940000000000001
GBE1 PYGB 0.993
GBE1 PYGM 0.993
AGL PYGB 0.992
AGL PYGL 0.992
AGL PYGM 0.992
PGM1 UGP2 0.988
PHKG1 PHKB 0.985
PHKG1 PHKA1 0.981
PGM1 PYGL 0.98
PYGB PYGM 0.98
PGM1 PYGM 0.978
GYG1 AGL 0.976
PHKG1 PYGM 0.975
PGM1 PYGB 0.972
GYG2 GYG1 0.968
UGP2 PYGL 0.9670000000000001
PGM1 AGL 0.966
UGP2 PYGB 0.965
GBE1 GYG2 0.9640000000000001
PGM2 UGP2 0.963
PYGB PYGL 0.9620000000000001
UGP2 AGL 0.961
GYG1 UGP2 0.961
PYGL PYGM 0.961
UGP2 PYGM 0.96
PGM1 PGM2L1 0.9590000000000001
PHKA1 PYGM 0.9590000000000001
PHKG1 PYGB 0.956
PHKB PYGM 0.955
PHKB PYGL 0.955
GYG1 PYGB 0.9540000000000001
MGAM AGL 0.9520000000000001
LOC93432 GBE1 0.951
GYG2 AGL 0.948
PHKB PYGB 0.9470000000000001
GYG1 PYGM 0.946
MGAM GBE1 0.946
LOC93432 PYGB 0.945
UGP2 PGM2L1 0.945
LOC93432 PYGM 0.94
PGM2L1 PYGL 0.94
GYG2 UGP2 0.9390000000000001
LOC93432 AGL 0.9390000000000001
LOC93432 PYGL 0.938
PHKA1 PYGB 0.9359999999999999
GYG1 PYGL 0.935
MGAM PYGB 0.9329999999999999
PGM2 PYGM 0.93
PHKA1 PHKB 0.9279999999999999
PGM2 PYGB 0.9259999999999999
PGM2 AGL 0.9259999999999999
GYG2 PYGB 0.9259999999999999
GYG2 PYGM 0.925
MGAM PYGM 0.925
PGM2L1 PYGB 0.9229999999999999
PGM2L1 PYGM 0.922
GYG2 PYGL 0.922
PGM2 PYGL 0.922
MGAM PYGL 0.9209999999999999
PGM2L1 AGL 0.914
ENPP3 AGL 0.9129999999999999
ENPP1 AGL 0.9129999999999999
PGM2 ENPP1 0.909
GBE1 PGM1 0.9059999999999999
ENPP3 PYGL 0.9059999999999999
PGM2 PGM2L1 0.904
ENPP3 PGM2L1 0.903
ENPP3 PGM2 0.903
ENPP1 PYGL 0.903
ENPP3 PGM1 0.903
PGM1 ENPP1 0.903
ENPP1 PGM2L1 0.903
ENPP3 GYG2 0.902
ENPP3 GYG1 0.902
GYG2 ENPP1 0.902
ENPP1 GYG1 0.902
ENPP1 PYGB 0.9
ENPP3 PYGB 0.9
ENPP1 PYGM 0.9
ENPP3 PYGM 0.9
LOC93432 MGAM 0.9
Gene Ontology Semantic Similarity
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# 2632 (GBE1) 55276 (PGM2) 178 (AGL) 5236 (PGM1) 5260 (PHKG1) 5834 (PYGB) 2992 (GYG1) 8908 (GYG2) 7360 (UGP2) 5836 (PYGL) 5255 (PHKA1) 5257 (PHKB) 8972 (MGAM) 283209 (PGM2L1) 5169 (ENPP3) 5167 (ENPP1) 5837 (PYGM)
2632 (GBE1) 1.00 0.52 0.65 0.55 0.22 0.72 0.77 0.54 0.67 0.50 0.22 0.61 0.36 0.31 0.17 0.40 0.72
55276 (PGM2) 0.52 1.00 0.50 0.85 0.13 0.47 0.49 0.15 0.55 0.41 0.13 0.49 0.38 0.18 0.17 0.38 0.47
178 (AGL) 0.65 0.50 1.00 0.50 0.25 0.57 0.58 0.51 0.55 0.46 0.25 0.48 0.62 0.31 0.26 0.42 0.57
5236 (PGM1) 0.55 0.85 0.50 1.00 0.13 0.50 0.53 0.15 0.58 0.43 0.13 0.53 0.33 0.18 0.15 0.48 0.50
5260 (PHKG1) 0.22 0.13 0.25 0.13 1.00 0.19 0.17 0.17 0.25 0.19 1.00 1.00 0.33 0.57 0.11 0.11 0.19
5834 (PYGB) 0.72 0.47 0.57 0.50 0.19 1.00 0.65 0.46 0.59 0.70 0.19 0.54 0.29 0.27 0.13 0.43 1.00
2992 (GYG1) 0.77 0.49 0.58 0.53 0.17 0.65 1.00 1.00 0.64 0.47 0.17 0.58 0.29 0.23 0.14 0.39 0.65
8908 (GYG2) 0.54 0.15 0.51 0.15 0.17 0.46 1.00 1.00 0.19 0.46 0.17 0.17 0.35 0.23 0.13 0.13 0.46
7360 (UGP2) 0.67 0.55 0.55 0.58 0.25 0.59 0.64 0.19 1.00 0.47 0.25 0.66 0.30 0.36 0.13 0.43 0.59
5836 (PYGL) 0.50 0.41 0.46 0.43 0.19 0.70 0.47 0.46 0.47 1.00 0.19 0.43 0.23 0.27 0.10 0.57 0.70
5255 (PHKA1) 0.22 0.13 0.25 0.13 1.00 0.19 0.17 0.17 0.25 0.19 1.00 1.00 0.33 0.57 0.11 0.11 0.19
5257 (PHKB) 0.61 0.49 0.48 0.53 1.00 0.54 0.58 0.17 0.66 0.43 1.00 1.00 0.29 0.57 0.13 0.39 0.54
8972 (MGAM) 0.36 0.38 0.62 0.33 0.33 0.29 0.29 0.35 0.30 0.23 0.33 0.29 1.00 0.40 0.37 0.26 0.29
283209 (PGM2L1) 0.31 0.18 0.31 0.18 0.57 0.27 0.23 0.23 0.36 0.27 0.57 0.57 0.40 1.00 0.16 0.16 0.27
5169 (ENPP3) 0.17 0.17 0.26 0.15 0.11 0.13 0.14 0.13 0.13 0.10 0.11 0.13 0.37 0.16 1.00 0.40 0.13
5167 (ENPP1) 0.40 0.38 0.42 0.48 0.11 0.43 0.39 0.13 0.43 0.57 0.11 0.39 0.26 0.16 0.40 1.00 0.43
5837 (PYGM) 0.72 0.47 0.57 0.50 0.19 1.00 0.65 0.46 0.59 0.70 0.19 0.54 0.29 0.27 0.13 0.43 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PYGM Rat Left brain cortices 300hPa 9144 m 1 hour downregulated 0.80±0.2 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT017225 hsa-miR-335-5p Homo sapiens PYGM 5837 Homo sapiens Microarray Functional MTI (Weak) 18185580
Gene Ontology
ID GO ID GO Term GO Type
5837 GO:0005737 cytoplasm GOTERM_CC_DIRECT
5837 GO:0000166 nucleotide binding GOTERM_MF_DIRECT
5837 GO:0005977 glycogen metabolic process GOTERM_BP_DIRECT
5837 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
5837 GO:0008184 protein tyrosine phosphatase activator activity GOTERM_MF_DIRECT
5837 GO:0005975 carbohydrate metabolic process GOTERM_BP_DIRECT
5837 GO:0005980 glycogen catabolic process GOTERM_BP_DIRECT
5837 GO:0005515 protein binding GOTERM_MF_DIRECT
5837 GO:0030170 pyridoxal phosphate binding GOTERM_MF_DIRECT
5837 GO:0005829 cytosol GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5837 hsa00500 Starch and sucrose metabolism
5837 hsa01100 Metabolic pathways
5837 hsa04922 Glucagon signaling pathway
5837 hsa04910 Insulin signaling pathway
5837 hsa04931 Insulin resistance
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PYGM 5837 Myopathy C0026848 Disease or Syndrome 0.4 0.707 0.414 group
PYGM 5837 Glycogen Storage Disease Type V C0017924 Disease or Syndrome 1 0.707 0.414 disease
PYGM 5837 Arthrogryposis C0003886 Disease or Syndrome 0.3 0.707 0.414 disease
PYGM 5837 Rhabdomyolysis C0035410 Pathologic Function 0.4 0.707 0.414 phenotype
PYGM 5837 Ketotic hypoglycemia C0271713 Disease or Syndrome 0.3 0.707 0.414 phenotype
PYGM 5837 Hyperammonemia C0220994 Disease or Syndrome 0.3 0.707 0.414 phenotype
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
PYGM 5837 PSN357 SIVELESTAT CHEMBL76688 None
PYGM 5837 RU 486 MIFEPRISTONE CHEMBL1276308 None