ALTITUDEOMICSDB

Synapsin II

AltitudeomicsDB

Protein Official symbol	SYN2
Aliases	SYN2
Chromosomal Location	3
Length	582
Uniprot ID	Q92777
EC number	None
Protein family Information(Pfam)	PF02078;PF02750;PF10581;
PDB id	None
InterPro ID	IPR013815;IPR016185;IPR028712;IPR001359;IPR020898;IPR019735;IPR019736;IPR020897;
dbSNP	rs794999

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
SYT1	STX1A	0.999
SYT1	SNAP25	0.999
SNAP25	STX1A	0.999
VAMP2	SNAP25	0.999
VAMP2	STX1A	0.998
CPLX1	SNAP25	0.998
LIN7A	CASK	0.998
CASK	LIN7B	0.998
CPLX1	SYT1	0.998
RIMS1	UNC13B	0.997
RIMS1	RAB3A	0.996
CPLX1	STX1A	0.996
CASK	APBA1	0.995
CASK	LIN7C	0.995
VAMP2	SYT1	0.994
SNAP25	RAB3A	0.991
UNC13B	STX1A	0.988
VAMP2	CPLX1	0.988
PPFIA2	CASK	0.987
SYN1	SNAP25	0.986
RIMS1	SNAP25	0.984
SYN1	SYT1	0.984
UNC13B	SNAP25	0.984
RIMS1	BZRAP1	0.983
LIN7C	APBA1	0.982
UNC13B	SYT1	0.982
APBA1	LIN7B	0.982
SYN1	RAB3A	0.981
SYN2	SYT1	0.981
SYT1	RAB3A	0.981
SYN2	SNAP25	0.979
UNC13B	RAB3A	0.979
UNC13B	VAMP2	0.978
LIN7A	APBA1	0.977
UNC13B	PPFIA3	0.977
UNC13B	PPFIA1	0.976
RIMS1	PPFIA3	0.976
VAMP2	RAB3A	0.974
RIMS1	PPFIA1	0.974
SYN3	SYT1	0.973
UNC13B	BZRAP1	0.973
VAMP2	SYN1	0.972
SYN2	RAB3A	0.971
SYN3	SNAP25	0.971
CPLX1	RAB3A	0.97
RIMS1	STX1A	0.969
BZRAP1	RAB3A	0.969
STX1A	RAB3A	0.969
SYN2	CPLX1	0.968
CASK	PPFIA3	0.966
CASK	PPFIA1	0.965
PPFIA2	RIMS1	0.965
UNC13B	CPLX1	0.962
SYN1	STX1A	0.962
CPLX1	SYN1	0.962
RIMS1	SYT1	0.962
APBA1	STX1A	0.961
RIMS1	SYN1	0.961
PPFIA2	LIN7A	0.96
SYN3	RAB3A	0.96
SYN2	VAMP2	0.959
PPFIA3	APBA1	0.957
APBA1	SNAP25	0.955
APBA1	PPFIA1	0.954
SYN2	STX1A	0.954
PPFIA3	RAB3A	0.952
SYN2	SYN1	0.952
SYN3	VAMP2	0.951
RIMS1	VAMP2	0.95
SYN2	RIMS1	0.949
LIN7A	PPFIA3	0.949
LIN7A	PPFIA4	0.949
CASK	RAB3A	0.948
PPFIA3	SYN1	0.947
PPFIA2	LIN7B	0.947
RIMS1	APBA1	0.947
LIN7A	PPFIA1	0.946
SYN3	STX1A	0.946
PPFIA3	SNAP25	0.944
RIMS1	CPLX1	0.944
UNC13B	SYN1	0.944
SLC18A2	SNAP25	0.943
PPFIA3	SYT1	0.943
PPFIA3	CPLX1	0.941
RIMS1	SYN3	0.941
VAMP2	SLC18A2	0.94
CASK	SNAP25	0.94
PPFIA1	RAB3A	0.939
BZRAP1	SYT1	0.938
SLC18A2	SYT1	0.938
RIMS1	PPFIA4	0.938
SYN2	PPFIA3	0.938
CASK	PPFIA4	0.938
PPFIA2	SNAP25	0.938
SLC18A2	SYN1	0.937
PPFIA2	APBA1	0.937
SYT1	PPFIA1	0.937
SYN3	CPLX1	0.936
PPFIA3	STX1A	0.936
SYN1	PPFIA1	0.936
PPFIA2	SYN1	0.936
PPFIA3	VAMP2	0.936
PPFIA2	UNC13B	0.935
SNAP25	PPFIA1	0.935
PPFIA2	SYT1	0.935
UNC13B	SYN3	0.935
BZRAP1	PPFIA3	0.935
PPFIA2	RAB3A	0.935
SYN2	UNC13B	0.935
PPFIA3	LIN7B	0.934
PPFIA4	LIN7B	0.933
PPFIA2	CPLX1	0.933
SYN2	PPFIA2	0.933
PPFIA4	RAB3A	0.933
BZRAP1	PPFIA1	0.933
PPFIA2	LIN7C	0.932
VAMP2	PPFIA1	0.932
LIN7C	PPFIA4	0.932
SYN3	SYN1	0.932
SYN2	SYN3	0.931
PPFIA3	LIN7C	0.931
SLC18A2	STX1A	0.931
LIN7C	PPFIA1	0.931
UNC13B	PPFIA4	0.931
CASK	SYN1	0.93
SYN2	PPFIA4	0.93
SYN2	PPFIA1	0.93
RIMS1	CASK	0.929
SYN3	SLC18A2	0.929
PPFIA2	PPFIA3	0.928
UNC13B	CASK	0.928
BZRAP1	SNAP25	0.927
SYN1	PPFIA4	0.927
APBA1	RAB3A	0.927
APBA1	SYT1	0.927
PPFIA1	STX1A	0.926
CPLX1	PPFIA4	0.926
LIN7A	SYT1	0.925
SYN3	PPFIA3	0.925
PPFIA1	LIN7B	0.924
UNC13B	LIN7C	0.924
LIN7A	SNAP25	0.924
SLC18A2	RAB3A	0.923
UNC13B	APBA1	0.923
SYN2	SLC18A2	0.923
PPFIA2	BZRAP1	0.923
BZRAP1	PPFIA4	0.923
PPFIA3	PPFIA1	0.923
SYN3	PPFIA1	0.922
PPFIA4	SYT1	0.922
PPFIA2	PPFIA1	0.922
SYN3	BZRAP1	0.921
SYN2	BZRAP1	0.921
BZRAP1	APBA1	0.921
BZRAP1	SYN1	0.921
PPFIA4	APBA1	0.921
CPLX1	LIN7C	0.92
PPFIA4	STX1A	0.92
BZRAP1	LIN7B	0.92
LIN7A	UNC13B	0.919
SNAP25	LIN7B	0.919
PPFIA4	SNAP25	0.919
CASK	STX1A	0.918
LIN7A	SYN3	0.918
CPLX1	PPFIA1	0.918
CASK	SYN3	0.917
SYN2	LIN7A	0.917
SYN2	APBA1	0.916
LIN7A	STX1A	0.916
SLC18A2	APBA1	0.916
UNC13B	SLC18A2	0.916
PPFIA2	SYN3	0.916
LIN7C	LIN7B	0.916
SYN2	CASK	0.915
CPLX1	SLC18A2	0.915
PPFIA3	PPFIA4	0.915
SYN1	APBA1	0.915
CPLX1	APBA1	0.915
BZRAP1	LIN7C	0.914
VAMP2	PPFIA4	0.914
PPFIA2	VAMP2	0.914
LIN7A	RIMS1	0.913
BZRAP1	CPLX1	0.913
LIN7C	SNAP25	0.913
SYN3	PPFIA4	0.913
PPFIA2	STX1A	0.913
VAMP2	APBA1	0.913
LIN7A	RAB3A	0.913
BZRAP1	STX1A	0.912
RIMS1	LIN7B	0.912
LIN7C	RAB3A	0.911
CASK	SYT1	0.911
RIMS1	LIN7C	0.911
LIN7A	SYN1	0.909
LIN7A	CPLX1	0.908
PPFIA2	PPFIA4	0.908
LIN7C	SYT1	0.908
CPLX1	LIN7B	0.908
SYT1	LIN7B	0.907
PPFIA2	SLC18A2	0.907
RIMS1	SLC18A2	0.906
CASK	BZRAP1	0.906
SYN2	LIN7B	0.906
RAB3A	LIN7B	0.906
VAMP2	LIN7C	0.906
STX1A	LIN7B	0.905
VAMP2	LIN7B	0.905
CASK	VAMP2	0.905
BZRAP1	VAMP2	0.905
UNC13B	LIN7B	0.904
LIN7C	STX1A	0.904
SYN1	LIN7B	0.904
LIN7A	VAMP2	0.903
PPFIA4	PPFIA1	0.903
LIN7A	BZRAP1	0.903
SYN3	LIN7B	0.903
SYN3	APBA1	0.903
PPFIA3	SLC18A2	0.903
CASK	CPLX1	0.903
SYN2	LIN7C	0.902
SYN3	LIN7C	0.902
BZRAP1	SLC18A2	0.902
SYN1	LIN7C	0.902
CASK	SLC18A2	0.901
SLC18A2	PPFIA1	0.901
SLC18A2	PPFIA4	0.9
SLC18A2	LIN7C	0.9
SLC18A2	LIN7B	0.9
LIN7A	SLC18A2	0.9

Gene Ontology Semantic Similarity

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#	6857 (SYT1)	6616 (SNAP25)	6844 (VAMP2)	10815 (CPLX1)	8825 (LIN7A)	8573 (CASK)	22999 (RIMS1)	10497 (UNC13B)	8499 (PPFIA2)	6853 (SYN1)	55327 (LIN7C)	320 (APBA1)	6854 (SYN2)	8224 (SYN3)	9256 (BZRAP1)	6804 (STX1A)	8541 (PPFIA3)	6571 (SLC18A2)	8500 (PPFIA1)	8497 (PPFIA4)	5864 (RAB3A)	64130 (LIN7B)
6857 (SYT1)	1.00	0.74	0.86	0.69	0.62	0.57	0.57	0.70	1.00	0.58	0.54	0.60	0.30	0.30	0.62	0.66	1.00	0.10	1.00	1.00	0.58	0.51
6616 (SNAP25)	0.74	1.00	0.90	0.86	0.80	0.72	0.68	0.83	1.00	0.67	0.69	0.76	0.15	0.15	0.80	0.81	1.00	0.11	1.00	1.00	0.71	0.67
6844 (VAMP2)	0.86	0.90	1.00	0.84	0.76	0.71	0.68	0.83	1.00	0.68	0.65	0.73	0.27	0.27	0.76	0.77	1.00	0.11	1.00	1.00	0.70	0.63
10815 (CPLX1)	0.69	0.86	0.84	1.00	0.88	0.73	0.67	0.77	1.00	0.65	0.76	0.81	0.15	0.15	0.88	0.81	1.00	0.12	1.00	1.00	0.71	0.75
8825 (LIN7A)	0.62	0.80	0.76	0.88	1.00	0.70	0.65	0.74	1.00	0.63	0.89	0.77	0.15	0.15	0.85	0.74	1.00	0.12	1.00	1.00	0.68	0.91
8573 (CASK)	0.57	0.72	0.71	0.73	0.70	1.00	0.57	0.67	1.00	0.54	0.65	0.63	0.15	0.15	0.70	0.66	1.00	0.11	1.00	1.00	0.57	0.60
22999 (RIMS1)	0.57	0.68	0.68	0.67	0.65	0.57	1.00	0.73	1.00	0.57	0.58	0.61	0.24	0.24	0.65	0.65	1.00	0.11	1.00	1.00	0.57	0.55
10497 (UNC13B)	0.70	0.83	0.83	0.77	0.74	0.67	0.73	1.00	1.00	0.63	0.64	0.70	0.15	0.15	0.74	0.71	1.00	0.11	1.00	1.00	0.66	0.61
8499 (PPFIA2)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	0.15	0.15	1.00	1.00	1.00	0.15	1.00	1.00	1.00	0.82
6853 (SYN1)	0.58	0.67	0.68	0.65	0.63	0.54	0.57	0.63	1.00	1.00	0.57	0.58	1.00	1.00	0.63	0.67	1.00	0.22	1.00	1.00	0.55	0.53
55327 (LIN7C)	0.54	0.69	0.65	0.76	0.89	0.65	0.58	0.64	0.82	0.57	1.00	0.69	0.12	0.12	0.74	0.64	0.82	0.10	0.82	0.82	0.66	0.93
320 (APBA1)	0.60	0.76	0.73	0.81	0.77	0.63	0.61	0.70	1.00	0.58	0.69	1.00	0.15	0.15	0.77	0.70	1.00	0.12	1.00	1.00	0.63	0.66
6854 (SYN2)	0.30	0.15	0.27	0.15	0.15	0.15	0.24	0.15	0.15	1.00	0.12	0.15	1.00	1.00	0.15	0.15	0.15	0.04	0.15	0.15	0.15	0.12
8224 (SYN3)	0.30	0.15	0.27	0.15	0.15	0.15	0.24	0.15	0.15	1.00	0.12	0.15	1.00	1.00	0.15	0.15	0.15	0.04	0.15	0.15	0.15	0.12
9256 (BZRAP1)	0.62	0.80	0.76	0.88	0.85	0.70	0.65	0.74	1.00	0.63	0.74	0.77	0.15	0.15	1.00	0.74	1.00	0.12	1.00	1.00	0.68	0.72
6804 (STX1A)	0.66	0.81	0.77	0.81	0.74	0.66	0.65	0.71	1.00	0.67	0.64	0.70	0.15	0.15	0.74	1.00	1.00	0.11	1.00	1.00	0.65	0.62
8541 (PPFIA3)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	0.15	0.15	1.00	1.00	1.00	0.15	1.00	1.00	1.00	0.82
6571 (SLC18A2)	0.10	0.11	0.11	0.12	0.12	0.11	0.11	0.11	0.15	0.22	0.10	0.12	0.04	0.04	0.12	0.11	0.15	1.00	0.15	0.15	0.10	0.10
8500 (PPFIA1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	0.15	0.15	1.00	1.00	1.00	0.15	1.00	1.00	1.00	0.82
8497 (PPFIA4)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	0.15	0.15	1.00	1.00	1.00	0.15	1.00	1.00	1.00	0.82
5864 (RAB3A)	0.58	0.71	0.70	0.71	0.68	0.57	0.57	0.66	1.00	0.55	0.66	0.63	0.15	0.15	0.68	0.65	1.00	0.10	1.00	1.00	1.00	0.58
64130 (LIN7B)	0.51	0.67	0.63	0.75	0.91	0.60	0.55	0.61	0.82	0.53	0.93	0.66	0.12	0.12	0.72	0.62	0.82	0.10	0.82	0.82	0.58	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
SYN2	Human	Blood	-	3650 m	48 hours	downregulated	0.631	Microarray	Himalayas	Indians	1	HAPE Pateints Vs Normal	http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
EGR1	1958	SYN2	6854	Unknown	19846662	TRUSST
ETV4	2118	SYN2	6854	Activation	12471036	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)

Gene Ontology

ID	GO ID	GO Term	GO Type
6854	GO:0005524	ATP binding	GOTERM_MF_DIRECT
6854	GO:0003824	catalytic activity	GOTERM_MF_DIRECT
6854	GO:0007269	neurotransmitter secretion	GOTERM_BP_DIRECT
6854	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
6854	GO:0031201	SNARE complex	GOTERM_CC_DIRECT
6854	GO:0007268	chemical synaptic transmission	GOTERM_BP_DIRECT
6854	GO:0030054	cell junction	GOTERM_CC_DIRECT
6854	GO:0045202	synapse	GOTERM_CC_DIRECT
6854	GO:0008021	synaptic vesicle	GOTERM_CC_DIRECT
6854	GO:0043209	myelin sheath	GOTERM_CC_DIRECT
6854	GO:0030672	synaptic vesicle membrane	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
SYN2	6854	Hyperalgesia	C0020429	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Jacksonian Seizure	C0022333	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Seizures, Clonic	C0234535	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Seizures, Auditory	C0422852	Pathologic Function	0.3	0.681	0.276	phenotype
SYN2	6854	Single Seizure	C0751110	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Complex partial seizures	C0149958	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Gustatory seizure	C0422854	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Tactile Allodynia	C0751213	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Atonic Absence Seizures	C0751123	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Visual seizure	C0270824	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Tonic Seizures	C0270844	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Hyperalgesia, Primary	C0751211	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Convulsions	C4048158	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Generalized seizures	C0234533	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Generalized Absence Seizures	C4505436	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Tonic - clonic seizures	C0494475	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Hyperalgesia, Thermal	C0751214	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Seizures, Somatosensory	C0422850	Pathologic Function	0.3	0.681	0.276	phenotype
SYN2	6854	Vertiginous seizure	C0422855	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Seizures, Sensory	C0751496	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Nonepileptic Seizures	C3495874	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Seizures	C0036572	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Olfactory seizure	C0422853	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Allodynia	C0458247	Finding	0.3	0.681	0.276	phenotype
SYN2	6854	Absence Seizures	C4316903	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Hyperalgesia, Secondary	C0751212	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Mechanical Allodynia	C2936719	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Convulsive Seizures	C0751494	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Seizures, Focal	C0751495	Disease or Syndrome	0.3	0.681	0.276	phenotype
SYN2	6854	Myoclonic Seizures	C4317123	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Non-epileptic convulsion	C0751056	Sign or Symptom	0.3	0.681	0.276	phenotype
SYN2	6854	Epileptic Seizures	C4317109	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.37	0.681	0.276	disease
SYN2	6854	Epileptic drop attack	C0270846	Disease or Syndrome	0.3	0.681	0.276	disease
SYN2	6854	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.02	0.681	0.276	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types