Actin, alpha cardiac muscle 1

AltitudeomicsDB
Protein Official symbol ACTC1
Aliases ACTC1 ACTC
Chromosomal Location  15
Length 377
Uniprot ID P68032
EC number None
Protein family Information(Pfam) PF00022;
PDB id None
InterPro ID IPR004000;IPR020902;IPR004001;IPR043129;
dbSNP rs121912676 rs759495229 rs193922680 rs121912677 rs267606628 rs121912675 rs121912673 rs267606629 rs121912674

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CFL1 ACTB 0.999
TNNI3 TNNT2 0.998
TPM1 ACTC1 0.997
MYH6 TPM1 0.996
MYL3 MYH7 0.996
MYH7 MYL2 0.996
TPM1 TNNT2 0.993
MYL3 MYL2 0.991
MYH6 MYL2 0.991
MYH6 TNNT2 0.991
MYH6 MYL3 0.99
MYH6 TNNI3 0.987
TPM1 TNNI3 0.986
TPM3 TPM1 0.986
MYL3 TNNI3 0.985
TPM1 MYL2 0.985
TNNT2 MYL2 0.985
ACTB ACTC1 0.984
TNNI3 MYL2 0.983
MYL3 TNNT2 0.983
MYH6 MYL4 0.982
MYH6 MYH7 0.981
MYL3 TPM1 0.979
TPM3 ACTC1 0.979
TPM3 TNNT2 0.977
MYH6 ACTC1 0.97
MYL4 TNNI3 0.97
MYL4 TNNT2 0.968
MYH7 ACTC1 0.968
ACTC1 TNNT2 0.967
MYH7 MYL4 0.963
ACTC1 MYL2 0.963
MYL3 MYH10 0.963
TNNI3 ACTC1 0.962
MYL3 TPM3 0.962
MYH6 TPM3 0.961
MYL3 ACTC1 0.961
TPM3 TNNI3 0.961
TPM3 MYL2 0.959
TPM3 MYL4 0.956
TPM1 MYL4 0.955
ACTBL2 ACTB 0.946
ACTBL2 ACTC1 0.939
MYH10 ACTC1 0.936
MYL4 MYL2 0.923
MYH10 MYL2 0.919
MYH6 MYH10 0.918
MYH10 ACTB 0.917
MYH10 MYH7 0.917
MYH7 TNNT2 0.91
MYL4 ACTC1 0.91
CFL1 ACTC1 0.908
MYL3 MYL4 0.903
Gene Ontology Semantic Similarity
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# 1072 (CFL1) 7137 (TNNI3) 7168 (TPM1) 4624 (MYH6) 4634 (MYL3) 4625 (MYH7) 7170 (TPM3) 7139 (TNNT2) 60 (ACTB) 4635 (MYL4) 70 (ACTC1) 345651 (ACTBL2) 4628 (MYH10) 4633 (MYL2)
1072 (CFL1) 1.00 0.77 0.74 0.28 0.52 0.48 0.90 0.67 0.54 0.74 0.44 0.75 0.50 0.64
7137 (TNNI3) 0.77 1.00 0.75 0.40 0.53 0.56 0.76 0.73 0.61 0.62 0.49 0.69 0.58 0.67
7168 (TPM1) 0.74 0.75 1.00 0.32 0.67 0.54 0.76 0.70 0.68 0.60 0.47 0.69 0.57 0.78
4624 (MYH6) 0.28 0.40 0.32 1.00 0.20 0.82 0.33 0.50 0.34 0.19 0.57 0.34 0.58 0.27
4634 (MYL3) 0.52 0.53 0.67 0.20 1.00 0.33 0.55 0.52 0.39 0.80 0.39 0.53 0.35 0.80
4625 (MYH7) 0.48 0.56 0.54 0.82 0.33 1.00 0.52 0.73 0.45 0.34 0.71 0.52 0.72 0.47
7170 (TPM3) 0.90 0.76 0.76 0.33 0.55 0.52 1.00 0.66 0.55 0.66 0.43 0.90 0.52 0.65
7139 (TNNT2) 0.67 0.73 0.70 0.50 0.52 0.73 0.66 1.00 0.54 0.56 0.62 0.64 0.65 0.73
60 (ACTB) 0.54 0.61 0.68 0.34 0.39 0.45 0.55 0.54 1.00 0.37 0.35 0.55 0.44 0.56
4635 (MYL4) 0.74 0.62 0.60 0.19 0.80 0.34 0.66 0.56 0.37 1.00 0.44 0.50 0.43 0.65
70 (ACTC1) 0.44 0.49 0.47 0.57 0.39 0.71 0.43 0.62 0.35 0.44 1.00 0.42 0.72 0.46
345651 (ACTBL2) 0.75 0.69 0.69 0.34 0.53 0.52 0.90 0.64 0.55 0.50 0.42 1.00 0.44 0.65
4628 (MYH10) 0.50 0.58 0.57 0.58 0.35 0.72 0.52 0.65 0.44 0.43 0.72 0.44 1.00 0.46
4633 (MYL2) 0.64 0.67 0.78 0.27 0.80 0.47 0.65 0.73 0.56 0.65 0.46 0.65 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ACTC1 Toad Heart - 3464 m 33 day downregulated -5.642882515 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
NANOG 79923 ACTC1 70 distal 22955619 TRANSFAC
MAX 4149 ACTC1 70 distal 22955619 TRANSFAC
EP300 2033 ACTC1 70 distal 22955619 TRANSFAC
YY1 7528 ACTC1 70 Unknown 15623502 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023839 hsa-miR-1-3p Homo sapiens ACTC1 70 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT731629 hsa-miR-139-5p Homo sapiens ACTC1 70 Homo sapiens Luciferase reporter assay Functional MTI 27139165
MIRT783026 hsa-let-7c-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783791 hsa-miR-142-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784317 hsa-miR-25-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784406 hsa-miR-29b-1-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784400 hsa-miR-299-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784500 hsa-miR-30a-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784558 hsa-miR-3119 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784653 hsa-miR-3145-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784546 hsa-miR-30d-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784595 hsa-miR-3126-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784539 hsa-miR-30c-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784513 hsa-miR-30b-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784553 hsa-miR-30e-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784763 hsa-miR-3188 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784842 hsa-miR-3202 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784897 hsa-miR-340-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784852 hsa-miR-32-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784983 hsa-miR-363-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785064 hsa-miR-3663-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785175 hsa-miR-367-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785286 hsa-miR-369-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785479 hsa-miR-3942-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785380 hsa-miR-378a-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785457 hsa-miR-3927-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785847 hsa-miR-4432 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786191 hsa-miR-4533 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785795 hsa-miR-4422 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786404 hsa-miR-4684-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785781 hsa-miR-4419a Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786602 hsa-miR-4747-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786170 hsa-miR-4527 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786071 hsa-miR-4510 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786457 hsa-miR-4703-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786804 hsa-miR-4793-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786908 hsa-miR-495-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787063 hsa-miR-5087 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787223 hsa-miR-5196-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787222 hsa-miR-5196-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787528 hsa-miR-548g-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787796 hsa-miR-5695 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787740 hsa-miR-5688 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787701 hsa-miR-5590-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787996 hsa-miR-6079 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787990 hsa-miR-6077 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788073 hsa-miR-6130 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787924 hsa-miR-580-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788059 hsa-miR-6127 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788066 hsa-miR-6129 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788081 hsa-miR-6133 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788234 hsa-miR-6503-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788566 hsa-miR-6753-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789256 hsa-miR-6875-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788990 hsa-miR-6831-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789394 hsa-miR-7107-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789424 hsa-miR-7-1-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789506 hsa-miR-7-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789470 hsa-miR-7-2-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789016 hsa-miR-6834-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789031 hsa-miR-6838-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789018 hsa-miR-6835-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789881 hsa-miR-876-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789960 hsa-miR-92b-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT790013 hsa-miR-9500 Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT790018 hsa-miR-95-5p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789958 hsa-miR-92a-3p Homo sapiens ACTC1 70 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
Gene Ontology
ID GO ID GO Term GO Type
70 GO:0090131 mesenchyme migration GOTERM_BP_DIRECT
70 GO:0030049 muscle filament sliding GOTERM_BP_DIRECT
70 GO:0042643 actomyosin GOTERM_CC_DIRECT
70 GO:0030175 filopodium GOTERM_CC_DIRECT
70 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
70 GO:0016887 ATPase activity GOTERM_MF_DIRECT
70 GO:0042493 response to drug GOTERM_BP_DIRECT
70 GO:0017022 thiol oxidase activity GOTERM_MF_DIRECT
70 GO:0044297 cell body GOTERM_CC_DIRECT
70 GO:0005737 cytoplasm GOTERM_CC_DIRECT
70 actinportion None GOTERM_CC_DIRECT
70 GO:0031032 actomyosin structure organization GOTERM_BP_DIRECT
70 GO:0033275 actin-myosin filament sliding GOTERM_BP_DIRECT
70 GO:0060047 heart contraction GOTERM_BP_DIRECT
70 GO:0016020 membrane GOTERM_CC_DIRECT
70 GO:0060048 cardiac muscle contraction GOTERM_BP_DIRECT
70 GO:0030240 skeletal muscle thin filament assembly GOTERM_BP_DIRECT
70 GO:0005524 ATP binding GOTERM_MF_DIRECT
70 GO:0006915 apoptotic process GOTERM_BP_DIRECT
70 GO:0005884 actin filament GOTERM_CC_DIRECT
70 GO:0030027 lamellipodium GOTERM_CC_DIRECT
70 GO:0031674 I band GOTERM_CC_DIRECT
70 GO:0005829 cytosol GOTERM_CC_DIRECT
70 GO:0005925 focal adhesion GOTERM_CC_DIRECT
70 GO:0055003 cardiac myofibril assembly GOTERM_BP_DIRECT
70 GO:0043066 negative regulation of apoptotic process GOTERM_BP_DIRECT
70 GO:0030017 sarcomere GOTERM_CC_DIRECT
70 GO:0072562 blood microparticle GOTERM_CC_DIRECT
70 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
70 GO:0045471 response to ethanol GOTERM_BP_DIRECT
70 GO:0030048 actin filament-based movement GOTERM_BP_DIRECT
70 GO:0055008 cardiac muscle tissue morphogenesis GOTERM_BP_DIRECT
70 GO:0005615 extracellular space GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
70 hsa04260 Cardiac muscle contraction
70 hsa04261 Adrenergic signaling in cardiomyocytes
70 hsa05410 Hypertrophic cardiomyopathy
70 hsa05414 Dilated cardiomyopathy
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ACTC1 70 Cardiomyopathy, Hypertrophic, Familial C0949658 Disease or Syndrome 0.42 0.656 0.414 disease
ACTC1 70 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.656 0.414 group
ACTC1 70 Refractive Errors C0034951 Disease or Syndrome 0.3 0.656 0.414 group
ACTC1 70 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.3 0.656 0.414 disease
ACTC1 70 Hypertrophic Cardiomyopathy C0007194 Disease or Syndrome 0.66 0.656 0.414 disease
ACTC1 70 Precancerous Conditions C0032927 Neoplastic Process 0.3 0.656 0.414 group
ACTC1 70 Ametropia C1527310 Disease or Syndrome 0.3 0.656 0.414 disease
ACTC1 70 Cardiomyopathy, Familial Idiopathic C1449563 Disease or Syndrome 0.33 0.656 0.414 disease
ACTC1 70 Condition, Preneoplastic C0282313 Neoplastic Process 0.3 0.656 0.414 phenotype
ACTC1 70 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.656 0.414 disease
ACTC1 70 Cardiomyopathy, Dilated C0007193 Disease or Syndrome 0.84 0.656 0.414 group
ACTC1 70 Atrial Septal Defect 5 C2748552 Congenital Abnormality; Disease or Syndrome 0.6 0.656 0.414 disease
ACTC1 70 Cardiomyopathy, Familial Hypertrophic, 11 C2677506 Disease or Syndrome 0.6 0.656 0.414 disease
ACTC1 70 Left ventricular noncompaction cardiomyopathy C4021133 Disease or Syndrome 0.3 0.656 0.414 disease
ACTC1 70 Charcot-Marie-Tooth Disease C0007959 Disease or Syndrome 0.3 0.656 0.414 disease
ACTC1 70 Conduction disorder of the heart C0264886 Disease or Syndrome 0.3 0.656 0.414 group
ACTC1 70 Familial dilated cardiomyopathy C0340427 Disease or Syndrome 0.3 0.656 0.414 disease
ACTC1 70 Ostium secundum atrial septal defect C0344724 Congenital Abnormality 0.3 0.656 0.414 disease
ACTC1 70 Left ventricular noncompaction C1960469 Disease or Syndrome 0.3 0.656 0.414 disease
ACTC1 70 LEFT VENTRICULAR NONCOMPACTION 4 C3150682 Disease or Syndrome 0.6 0.656 0.414 disease
ACTC1 70 CARDIOMYOPATHY, DILATED, 1R C3150681 Disease or Syndrome 0.6 0.656 0.414 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ACTC1 70 DEXAMETHASONE DEXAMETHASONE CHEMBL384467 None
ACTC1 70 GLUCOCORTICOID None None None