Probable tRNA pseudouridine synthase 1

AltitudeomicsDB
Protein Official symbol PUS1
Aliases PUS1 PP8985
Chromosomal Location 12
Length 427
Uniprot ID Q9Y606
EC number 5.4.99.12
Protein family Information(Pfam) PF01416;
PDB id 4IQM;4ITS;4J37;4NZ6;4NZ7;
InterPro ID IPR020103;IPR001406;IPR020097;IPR020095;IPR041708;
dbSNP rs76655496 rs104894371

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PUS1 YARS2 0.96
PUS1 TRUB1 0.94
PUS1 TSFM 0.933
PUS7 TRUB1 0.931
PUS1 PUS7 0.915
Gene Ontology Semantic Similarity
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# 80324 (PUS1) 54517 (PUS7) 51067 (YARS2) 142940 (TRUB1) 10102 (TSFM)
80324 (PUS1) 1.00 0.85 0.58 1.00 0.71
54517 (PUS7) 0.85 1.00 0.60 1.00 0.77
51067 (YARS2) 0.58 0.60 1.00 0.21 0.70
142940 (TRUB1) 1.00 1.00 0.21 1.00 0.18
10102 (TSFM) 0.71 0.77 0.70 0.18 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PUS1 Rat Lungs - 7600 m 24 hours upregulated 3.7 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MYC 4609 PUS1 80324 proximal_filtered 22955619 TRANSFAC
ELF1 1997 PUS1 80324 proximal_filtered 22955619 TRANSFAC
PAX5 5079 PUS1 80324 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT022192 hsa-miR-124-3p Homo sapiens PUS1 80324 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT027453 hsa-miR-98-5p Homo sapiens PUS1 80324 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT032213 hsa-let-7b-5p Homo sapiens PUS1 80324 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT041439 hsa-miR-193b-3p Homo sapiens PUS1 80324 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PUS1 80324 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.3 0.676 0.483 disease
PUS1 80324 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.676 0.483 disease
PUS1 80324 Disease Exacerbation C0235874 Finding 0.3 0.676 0.483 phenotype
PUS1 80324 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.676 0.483 group
PUS1 80324 MITOCHONDRIAL MYOPATHY AND SIDEROBLASTIC ANEMIA C1838103 Disease or Syndrome 0.95 0.676 0.483 disease
PUS1 80324 Congenital anemia C0158995 Disease or Syndrome 0.3 0.676 0.483 disease
PUS1 80324 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.676 0.483 group
PUS1 80324 Congenital myopathy (disorder) C0270960 Congenital Abnormality 0.3 0.676 0.483 group
PUS1 80324 Cytopenia C0010828 Pathologic Function 0.3 0.676 0.483 phenotype
PUS1 80324 Arthrogryposis C0003886 Disease or Syndrome 0.3 0.676 0.483 disease
PUS1 80324 Mitochondrial Diseases C0751651 Disease or Syndrome 0.31 0.676 0.483 group
PUS1 80324 Malignant neoplasm of breast C0006142 Neoplastic Process 0.3 0.676 0.483 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types