ATPase inhibitor, mitochondrial

AltitudeomicsDB
Protein Official symbol ATPIF1
Aliases ATP5IF1 ATPI ATPIF1
Chromosomal Location  1
Length 106
Uniprot ID Q9UII2
EC number None
Protein family Information(Pfam) PF04568;
PDB id None
InterPro ID IPR007648;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ATP5C1 ATP5B 0.9990000000000001
ATP5C1 ATP5E 0.998
ATP5B ATP5E 0.995
ATPIF1 ATP5B 0.958
ATP5C1 ATPIF1 0.958
ATPIF1 ATP5E 0.9279999999999999
Gene Ontology Semantic Similarity
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# 509 (ATP5C1) 506 (ATP5B) 93974 (ATPIF1) 514 (ATP5E)
509 (ATP5C1) 1.00 0.61 0.23 0.83
506 (ATP5B) 0.61 1.00 0.49 0.61
93974 (ATPIF1) 0.23 0.49 1.00 0.18
514 (ATP5E) 0.83 0.61 0.18 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ATPIF1 Rat Left brain cortices 300hPa 9144 m 1 hour downregulated 1.44±0.2 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
NFYB 4801 ATPIF1 93974 proximal_filtered 22955619 TRANSFAC
FOS 2353 ATPIF1 93974 proximal_filtered 22955619 TRANSFAC
NFYA 4800 ATPIF1 93974 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT040414 hsa-miR-615-3p Homo sapiens ATPIF1 93974 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042994 hsa-miR-324-3p Homo sapiens ATPIF1 93974 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
93974 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GOTERM_BP_DIRECT
93974 GO:0043532 ADP binding GOTERM_MF_DIRECT
93974 GO:0001937 negative regulation of endothelial cell proliferation GOTERM_BP_DIRECT
93974 GO:1903214 regulation of protein targeting to mitochondrion GOTERM_BP_DIRECT
93974 GO:0030272 carbohydrate binding GOTERM_MF_DIRECT
93974 GO:0005739 mitochondrion GOTERM_CC_DIRECT
93974 GO:0001525 angiogenesis GOTERM_BP_DIRECT
93974 GO:0006783 heme biosynthetic process GOTERM_BP_DIRECT
93974 GO:0004857 thiol-dependent ubiquitin-specific protease activity GOTERM_MF_DIRECT
93974 GO:0009986 cell surface GOTERM_CC_DIRECT
93974 GO:0042030 tyrosine 3-monooxygenase activator activity GOTERM_MF_DIRECT
93974 GO:0051117 chaperone binding GOTERM_MF_DIRECT
93974 GO:0006091 generation of precursor metabolites and energy GOTERM_BP_DIRECT
93974 GO:0051289 protein homotetramerization GOTERM_BP_DIRECT
93974 GO:0009396 folic acid-containing compound biosynthetic process GOTERM_BP_DIRECT
93974 GO:1903578 regulation of ATP metabolic process GOTERM_BP_DIRECT
93974 GO:0005516 protein binding GOTERM_MF_DIRECT
93974 GO:0051346 negative regulation of hydrolase activity GOTERM_BP_DIRECT
93974 GO:0005753 mitochondrial proton-transporting ATP synthase complex GOTERM_CC_DIRECT
93974 GO:0030218 erythrocyte differentiation GOTERM_BP_DIRECT
93974 GO:0035999 tetrahydrofolate interconversion GOTERM_BP_DIRECT
93974 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
93974 GO:0051260 protein homooligomerization GOTERM_BP_DIRECT
93974 GO:0051882 mitochondrial depolarization GOTERM_BP_DIRECT
93974 GO:0072593 reactive oxygen species metabolic process GOTERM_BP_DIRECT
93974 GO:0032780 negative regulation of ATPase activity GOTERM_BP_DIRECT
93974 GO:0098779 mitophagy in response to mitochondrial depolarization GOTERM_BP_DIRECT
93974 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types