Rho guanine nucleotide exchange factor 11

AltitudeomicsDB
Protein Official symbol ARHGEF11
Aliases ARHGEF11 KIAA0380
Chromosomal Location 1
Length 1522
Uniprot ID O15085
EC number None
Protein family Information(Pfam) PF00595;PF17838;PF09128;PF00621;
PDB id 1HTJ;1XCG;2DLS;3KZ1;3T06;5E6P;5JHG;5JHH;5TYT;
InterPro ID IPR035899;IPR000219;IPR001478;IPR032919;IPR036034;IPR037889;IPR011993;IPR041020;IPR001849;IPR037803;IPR016137;IPR015212;IPR036305;
dbSNP rs868188 rs945508

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SEMA4D PLXNB1 0.994
RHOA ROCK1 0.991
RHOA ROCK2 0.991
RHOA ARHGEF12 0.98
RHOA ARHGEF11 0.978
ROCK1 RHOC 0.977
PLXNB1 RND1 0.976
CDC42 ROCK1 0.976
ROCK2 RHOC 0.973
SEMA4D RND1 0.973
ARHGEF12 PLXNB1 0.973
CDC42 RHOC 0.972
PLXNB1 ERBB2 0.97
RHOA PLXNB1 0.969
CDC42 ROCK2 0.966
ARHGEF12 RHOC 0.963
CDC42 ARHGEF12 0.963
CDC42 ARHGEF11 0.961
ARHGEF11 PLXNB1 0.96
ROCK1 RHOB 0.96
ARHGEF11 RHOC 0.96
SEMA4D ERBB2 0.959
RHOA ERBB2 0.959
ROCK2 RHOB 0.956
ARHGEF12 RHOB 0.955
ARHGEF11 RHOB 0.952
RHOC ERBB2 0.952
SEMA4D RHOA 0.951
ROCK1 ARHGEF12 0.947
ROCK1 ARHGEF11 0.947
SEMA4D ARHGEF11 0.947
SEMA4D ARHGEF12 0.946
RHOBTB2 RHOT1 0.945
RHOT1 RHOBTB1 0.945
RHOBTB2 RHOT2 0.945
ARHGEF11 ERBB2 0.945
ROCK1 RND1 0.945
RHOBTB1 RHOT2 0.943
ARHGEF11 ROCK2 0.943
ARHGEF11 RND1 0.941
RHOB ERBB2 0.939
ARHGEF11 RHOD 0.938
ARHGEF12 ROCK2 0.936
ARHGEF12 RND1 0.935
ARHGEF12 RHOD 0.933
ROCK1 ERBB2 0.931
ARHGEF12 RHOG 0.93
RAC1 ROCK2 0.93
ARHGEF11 RAC2 0.929
SEMA4D RAC1 0.929
ARHGEF12 RAC2 0.929
RHOA CDC42 0.928
PLXNB1 RAC1 0.928
ARHGEF12 RAC1 0.928
ARHGEF11 RHOG 0.927
CDC42 RAC2 0.924
ROCK2 ERBB2 0.923
ARHGEF11 RAC1 0.923
SEMA4D RHOC 0.921
PLXNB1 RHOC 0.921
RHOA RHOC 0.92
RND1 ERBB2 0.92
ARHGEF12 ARHGEF11 0.92
RHOG RAC2 0.919
RHOC RAC2 0.918
ARHGEF12 ERBB2 0.918
RHOBTB2 RHOF 0.917
RHOH RHOT1 0.916
SEMA4D RHOB 0.916
RHOBTB1 RHOF 0.916
ROCK2 RND1 0.916
PLXNB1 RHOB 0.915
RHOT1 RHOQ 0.915
RHOT1 RHOF 0.915
RHOT1 RAC2 0.914
RHOT1 RHOG 0.914
RHOH RAC2 0.914
RHOBTB2 ARHGEF11 0.914
RHOH RHOBTB1 0.914
RHOD RHOV 0.913
RHOBTB2 RHOU 0.913
RHOBTB2 RHOH 0.913
RHOA RAC2 0.913
RHOA RAC1 0.913
RHOT1 RHOC 0.913
RHOU RHOBTB1 0.913
RHOH RHOF 0.913
RHOBTB1 RHOV 0.912
SEMA4D ROCK1 0.912
CDC42 RHOT1 0.912
RHOT1 RAC1 0.912
ROCK1 PLXNB1 0.912
ARHGEF11 RAC3 0.912
SEMA4D ROCK2 0.912
RHOH RHOT2 0.912
RHOH RHOD 0.912
RHOT2 RHOD 0.912
RHOBTB1 RHOD 0.912
ARHGEF11 RHOBTB1 0.911
RHOT2 RHOC 0.911
RHOBTB2 RHOD 0.911
RHOT1 RHOB 0.911
RHOBTB2 ARHGEF12 0.911
RHOH RHOG 0.911
RHOD RHOC 0.91
RHOT1 RHOJ 0.91
ARHGEF12 RHOH 0.91
RHOG RHOT2 0.91
RHOU RHOT2 0.91
RHOT1 RHOV 0.91
ARHGEF12 RHOV 0.91
RHOA RHOT1 0.91
ARHGEF12 RHOBTB1 0.91
RHOU RHOT1 0.91
ARHGEF12 RHOF 0.91
RHOT2 RHOQ 0.91
RHOT1 RHOD 0.91
CDC42 RHOB 0.91
RHOT2 RHOJ 0.909
RHOT2 RHOB 0.909
RHOF RHOV 0.909
RHOT2 RHOF 0.909
RHOH RHOQ 0.909
RAC1 RHOB 0.909
RHOB RAC2 0.909
RHOBTB2 RHOV 0.909
RHOBTB1 RHOJ 0.909
RAC1 RHOC 0.909
RHOU RHOD 0.909
RHOJ RHOD 0.909
ARHGEF12 RAC3 0.909
RHOH RAC1 0.909
RHOBTB2 CDC42 0.908
RHOBTB1 RHOB 0.908
RHOF RAC2 0.908
RAC3 RHOV 0.908
RND1 RHOB 0.908
CDC42 RHOH 0.908
RHOH RAC3 0.908
RHOH RHOV 0.908
CDC42 RHOBTB1 0.908
RAC1 RND1 0.908
RHOH RHOJ 0.908
RHOH RHOU 0.908
RHOA RAC3 0.908
RHOBTB2 RHOJ 0.908
RAC1 RHOBTB1 0.907
RHOJ RHOV 0.907
ARHGEF11 RHOU 0.907
RHOG RHOC 0.907
RAC3 RHOB 0.907
RHOJ RHOF 0.907
RHOG RHOF 0.907
RHOA RND1 0.907
RHOT2 RHOV 0.907
RHOBTB2 RAC1 0.907
RHOH RHOC 0.907
RAC3 RHOC 0.907
RHOBTB2 RHOB 0.907
RHOA RHOD 0.907
RHOA RHOT2 0.907
ROCK1 ROCK2 0.907
RHOA RHOH 0.907
RHOH RHOB 0.907
RHOC RHOV 0.907
RHOF RHOQ 0.906
RHOA RHOJ 0.906
RAC1 RHOD 0.906
RAC1 RAC2 0.906
RHOBTB1 RHOC 0.906
ARHGEF11 RHOV 0.906
CDC42 RHOG 0.906
RHOA RHOG 0.906
RHOB RHOV 0.906
RHOU RHOF 0.906
RHOA RHOBTB1 0.906
RHOA RHOV 0.906
RND1 RHOC 0.906
RHOJ RHOC 0.906
RHOBTB1 RHOQ 0.906
CDC42 RAC3 0.906
CDC42 RHOT2 0.906
CDC42 RHOD 0.906
ARHGEF12 RHOJ 0.906
RHOU RHOB 0.906
RHOT2 RAC3 0.906
CDC42 RAC1 0.906
RHOT2 RAC2 0.906
RHOC RHOQ 0.906
RHOD RHOQ 0.906
RHOG RHOD 0.906
RHOJ RHOB 0.906
RHOD RAC3 0.906
ARHGEF11 RHOF 0.906
RHOU RHOJ 0.905
RHOBTB1 RAC2 0.905
RAC1 RHOV 0.905
RHOQ RHOV 0.905
RHOD RAC2 0.905
RHOG RHOBTB1 0.905
RHOG RHOB 0.905
RHOG RHOJ 0.905
RAC1 RHOF 0.905
RHOBTB2 RHOG 0.905
RHOG RHOV 0.905
RHOBTB2 RHOQ 0.905
RHOU RAC1 0.905
RHOD RHOB 0.905
RHOBTB2 RHOA 0.905
RHOBTB1 RAC3 0.905
CDC42 RHOU 0.905
RAC1 RHOG 0.905
ARHGEF11 RHOT1 0.905
RHOBTB2 RHOC 0.905
CDC42 RHOF 0.905
RHOB RHOF 0.905
RHOBTB2 RAC3 0.905
RHOH ARHGEF11 0.905
RHOU RHOV 0.904
RHOU RHOG 0.904
RAC1 RHOJ 0.904
RHOU RHOQ 0.904
RHOD RHOF 0.904
RHOJ RHOQ 0.904
RHOU RAC2 0.904
RHOBTB2 RAC2 0.904
RHOC RHOF 0.904
CDC42 RHOV 0.904
RHOC RHOB 0.904
RHOB RHOQ 0.904
RHOA RHOF 0.904
RHOG RAC3 0.904
RHOA RHOQ 0.904
RHOA RHOU 0.904
RHOG RHOQ 0.904
RHOT1 RHOT2 0.903
RAC2 RHOV 0.903
RHOJ RAC2 0.903
RHOU RHOC 0.903
RHOU RAC3 0.903
PLXNB1 ROCK2 0.903
ARHGEF11 RHOQ 0.903
ARHGEF11 RHOT2 0.903
RAC1 RHOQ 0.903
CDC42 RHOJ 0.903
ARHGEF12 RHOU 0.903
RHOT1 RAC3 0.902
RHOJ RAC3 0.902
CDC42 RHOQ 0.902
RHOA RHOB 0.902
RAC3 RHOQ 0.902
RAC3 RHOF 0.902
RAC2 RHOQ 0.902
RAC1 RHOT2 0.902
RHOBTB2 RHOBTB1 0.902
RAC3 RAC2 0.901
RAC1 RAC3 0.901
ARHGEF11 RHOJ 0.901
ARHGEF12 RHOT1 0.9
ARHGEF12 RHOT2 0.9
ARHGEF12 RHOQ 0.9
Gene Ontology Semantic Similarity
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# 5364 (PLXNB1) 6093 (ROCK1) 9475 (ROCK2) 23365 (ARHGEF12) 9826 (ARHGEF11) 389 (RHOC) 27289 (RND1) 2064 (ERBB2) 388 (RHOB) 387 (RHOA) 55288 (RHOT1) 9886 (RHOBTB1) 89941 (RHOT2) 29984 (RHOD) 391 (RHOG) 5880 (RAC2) 5879 (RAC1) 998 (CDC42) 54509 (RHOF) 23433 (RHOQ) 171177 (RHOV) 58480 (RHOU) 399 (RHOH) 5881 (RAC3) 57381 (RHOJ) 10507 (SEMA4D) 23221 (RHOBTB2)
5364 (PLXNB1) 1.00 0.44 0.44 0.51 0.51 0.46 0.50 0.69 0.46 0.48 0.49 0.28 0.44 0.28 0.46 0.44 0.49 0.48 0.28 0.41 0.46 0.46 0.50 0.49 0.46 0.84 0.46
6093 (ROCK1) 0.44 1.00 0.81 0.49 0.49 0.45 0.50 0.70 0.45 0.48 0.46 0.29 0.43 0.29 0.45 0.43 0.73 0.68 0.29 0.43 0.45 0.45 0.40 0.50 0.45 0.52 0.45
9475 (ROCK2) 0.44 0.81 1.00 0.47 0.47 0.44 0.48 0.65 0.44 0.47 0.50 0.29 0.42 0.29 0.44 0.42 0.68 0.64 0.29 0.41 0.44 0.44 0.40 0.48 0.44 0.52 0.44
23365 (ARHGEF12) 0.51 0.49 0.47 1.00 1.00 0.50 0.56 0.64 0.50 0.52 0.53 0.31 0.49 0.31 0.50 0.49 0.53 0.51 0.31 0.46 0.50 0.50 0.49 0.54 0.50 0.58 0.50
9826 (ARHGEF11) 0.51 0.49 0.47 1.00 1.00 0.50 0.56 0.64 0.50 0.52 0.53 0.31 0.49 0.31 0.50 0.49 0.53 0.51 0.31 0.46 0.50 0.50 0.49 0.54 0.50 0.58 0.50
389 (RHOC) 0.46 0.45 0.44 0.50 0.50 1.00 0.98 0.52 1.00 0.97 0.89 0.94 0.94 0.94 1.00 0.94 0.86 0.79 0.94 0.92 1.00 1.00 0.80 0.98 1.00 0.53 1.00
27289 (RND1) 0.50 0.50 0.48 0.56 0.56 0.98 1.00 0.55 0.98 0.95 0.88 0.89 0.93 0.89 0.98 0.93 0.86 0.80 0.89 0.90 0.98 0.98 0.80 0.96 0.98 0.61 0.98
2064 (ERBB2) 0.69 0.70 0.65 0.64 0.64 0.52 0.55 1.00 0.52 0.53 0.54 0.34 0.52 0.34 0.52 0.52 0.64 0.63 0.34 0.45 0.52 0.52 0.50 0.54 0.52 0.69 0.52
388 (RHOB) 0.46 0.45 0.44 0.50 0.50 1.00 0.98 0.52 1.00 0.97 0.89 0.94 0.94 0.94 1.00 0.94 0.86 0.79 0.94 0.92 1.00 1.00 0.80 0.98 1.00 0.53 1.00
387 (RHOA) 0.48 0.48 0.47 0.52 0.52 0.97 0.95 0.53 0.97 1.00 0.86 0.88 0.91 0.88 0.97 0.91 0.85 0.78 0.88 0.89 0.97 0.97 0.79 0.95 0.97 0.54 0.97
55288 (RHOT1) 0.49 0.46 0.50 0.53 0.53 0.89 0.88 0.54 0.89 0.86 1.00 0.78 0.93 0.78 0.89 0.93 0.79 0.74 0.78 0.81 0.89 0.89 0.74 0.88 0.89 0.58 0.89
9886 (RHOBTB1) 0.28 0.29 0.29 0.31 0.31 0.94 0.89 0.34 0.94 0.88 0.78 1.00 0.87 1.00 0.94 0.87 0.77 0.67 1.00 0.86 0.94 0.94 0.72 0.89 0.94 0.32 0.94
89941 (RHOT2) 0.44 0.43 0.42 0.49 0.49 0.94 0.93 0.52 0.94 0.91 0.93 0.87 1.00 0.87 0.94 1.00 0.81 0.74 0.87 0.87 0.94 0.94 0.74 0.93 0.94 0.52 0.94
29984 (RHOD) 0.28 0.29 0.29 0.31 0.31 0.94 0.89 0.34 0.94 0.88 0.78 1.00 0.87 1.00 0.94 0.87 0.77 0.67 1.00 0.86 0.94 0.94 0.72 0.89 0.94 0.32 0.94
391 (RHOG) 0.46 0.45 0.44 0.50 0.50 1.00 0.98 0.52 1.00 0.97 0.89 0.94 0.94 0.94 1.00 0.94 0.86 0.79 0.94 0.92 1.00 1.00 0.80 0.98 1.00 0.53 1.00
5880 (RAC2) 0.44 0.43 0.42 0.49 0.49 0.94 0.93 0.52 0.94 0.91 0.93 0.87 1.00 0.87 0.94 1.00 0.81 0.74 0.87 0.87 0.94 0.94 0.74 0.93 0.94 0.52 0.94
5879 (RAC1) 0.49 0.73 0.68 0.53 0.53 0.86 0.86 0.64 0.86 0.85 0.79 0.77 0.81 0.77 0.86 0.81 1.00 0.88 0.77 0.80 0.86 0.86 0.75 0.86 0.86 0.55 0.86
998 (CDC42) 0.48 0.68 0.64 0.51 0.51 0.79 0.80 0.63 0.79 0.78 0.74 0.67 0.74 0.67 0.79 0.74 0.88 1.00 0.67 0.78 0.79 0.79 0.70 0.79 0.79 0.53 0.79
54509 (RHOF) 0.28 0.29 0.29 0.31 0.31 0.94 0.89 0.34 0.94 0.88 0.78 1.00 0.87 1.00 0.94 0.87 0.77 0.67 1.00 0.86 0.94 0.94 0.72 0.89 0.94 0.32 0.94
23433 (RHOQ) 0.41 0.43 0.41 0.46 0.46 0.92 0.90 0.45 0.92 0.89 0.81 0.86 0.87 0.86 0.92 0.87 0.80 0.78 0.86 1.00 0.92 0.92 0.75 0.90 0.92 0.47 0.92
171177 (RHOV) 0.46 0.45 0.44 0.50 0.50 1.00 0.98 0.52 1.00 0.97 0.89 0.94 0.94 0.94 1.00 0.94 0.86 0.79 0.94 0.92 1.00 1.00 0.80 0.98 1.00 0.53 1.00
58480 (RHOU) 0.46 0.45 0.44 0.50 0.50 1.00 0.98 0.52 1.00 0.97 0.89 0.94 0.94 0.94 1.00 0.94 0.86 0.79 0.94 0.92 1.00 1.00 0.80 0.98 1.00 0.53 1.00
399 (RHOH) 0.50 0.40 0.40 0.49 0.49 0.80 0.80 0.50 0.80 0.79 0.74 0.72 0.74 0.72 0.80 0.74 0.75 0.70 0.72 0.75 0.80 0.80 1.00 0.80 0.80 0.48 0.80
5881 (RAC3) 0.49 0.50 0.48 0.54 0.54 0.98 0.96 0.54 0.98 0.95 0.88 0.89 0.93 0.89 0.98 0.93 0.86 0.79 0.89 0.90 0.98 0.98 0.80 1.00 0.98 0.55 0.98
57381 (RHOJ) 0.46 0.45 0.44 0.50 0.50 1.00 0.98 0.52 1.00 0.97 0.89 0.94 0.94 0.94 1.00 0.94 0.86 0.79 0.94 0.92 1.00 1.00 0.80 0.98 1.00 0.53 1.00
10507 (SEMA4D) 0.84 0.52 0.52 0.58 0.58 0.53 0.61 0.69 0.53 0.54 0.58 0.32 0.52 0.32 0.53 0.52 0.55 0.53 0.32 0.47 0.53 0.53 0.48 0.55 0.53 1.00 0.53
23221 (RHOBTB2) 0.46 0.45 0.44 0.50 0.50 1.00 0.98 0.52 1.00 0.97 0.89 0.94 0.94 0.94 1.00 0.94 0.86 0.79 0.94 0.92 1.00 1.00 0.80 0.98 1.00 0.53 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ARHGEF11 Human Blood - 3250 m 4 day upregulated 2.1961 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT707298 hsa-miR-1277-5p Homo sapiens ARHGEF11 9826 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707300 hsa-miR-3924 Homo sapiens ARHGEF11 9826 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707302 hsa-miR-4789-5p Homo sapiens ARHGEF11 9826 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707303 hsa-miR-5011-5p Homo sapiens ARHGEF11 9826 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707299 hsa-miR-6083 Homo sapiens ARHGEF11 9826 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707301 hsa-miR-190a-3p Homo sapiens ARHGEF11 9826 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
Gene Ontology
ID GO ID GO Term GO Type
9826 GO:0007186 G-protein coupled receptor signaling pathway GOTERM_BP_DIRECT
9826 GO:0007266 Rho protein signal transduction GOTERM_BP_DIRECT
9826 GO:0005622 intracellular GOTERM_CC_DIRECT
9826 GO:0000910 cytokinesis GOTERM_BP_DIRECT
9826 GO:0030036 actin cytoskeleton organization GOTERM_BP_DIRECT
9826 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
9826 GO:0043547 positive regulation of GTPase activity GOTERM_BP_DIRECT
9826 GO:0045893 positive regulation of transcription GOTERM_BP_DIRECT
9826 GO:0001558 regulation of cell growth GOTERM_BP_DIRECT
9826 GO:0006928 movement of cell or subcellular component GOTERM_BP_DIRECT
9826 GO:0006941 striated muscle contraction GOTERM_BP_DIRECT
9826 GO:0005829 cytosol GOTERM_CC_DIRECT
9826 GO:0005085 guanyl-nucleotide exchange factor activity GOTERM_MF_DIRECT
9826 GO:0005737 cytoplasm GOTERM_CC_DIRECT
9826 GO:0001664 G-protein coupled adenosine receptor activity GOTERM_MF_DIRECT
9826 GO:0016020 membrane GOTERM_CC_DIRECT
9826 GO:0051056 regulation of small GTPase mediated signal transduction GOTERM_BP_DIRECT
9826 GO:0030010 establishment of cell polarity GOTERM_BP_DIRECT
9826 GO:0035023 regulation of Rho protein signal transduction GOTERM_BP_DIRECT
9826 GO:0005089 Ras guanyl-nucleotide exchange factor activity GOTERM_MF_DIRECT
9826 GO:0005096 GTPase activator activity GOTERM_MF_DIRECT
9826 GO:0005515 protein binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
9826 hsa04270 Vascular smooth muscle contraction
9826 hsa05200 Pathways in cancer
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ARHGEF11 9826 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.33 0.799 0.276 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types