Heat shock protein 105 kDa

AltitudeomicsDB
Protein Official symbol HSPH1
Aliases HSPH1 HSP105 HSP110 KIAA0201
Chromosomal Location 13
Length 858
Uniprot ID Q92598
EC number None
Protein family Information(Pfam) PF00012;
PDB id 6GFA;
InterPro ID IPR043129;IPR018181;IPR029048;IPR029047;IPR013126;IPR042053;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
HSPA9 GRPEL1 0.999
STIP1 HSP90AA1 0.999
HSPA8 HSP90AA1 0.999
HSPA8 DNAJB1 0.999
HSPA4 DNAJB1 0.999
HSP90AA1 HSPA4 0.997
HSPA1A HSP90AA1 0.997
HSPA8 DNAJA2 0.997
HSPA8 DNAJA1 0.996
STIP1 DNAJB1 0.996
HSPA1A DNAJB1 0.996
HSP90AA1 DNAJB1 0.995
HSPA8 STIP1 0.995
HSP90AA1 DNAJA2 0.994
DNAJA1 HSP90AA1 0.993
HSPA8 HSPA4 0.993
HSPA8 HSPH1 0.992
HSPA2 HSPH1 0.991
HSPA6 DNAJB1 0.991
HSPA5 DNAJB1 0.99
HSPA1A STIP1 0.989
STIP1 HSPA4 0.989
HSPA8 DNAJA4 0.989
DNAJA1 HSPA1A 0.989
HSPA9 DNAJB1 0.989
HSPH1 HSPA4 0.987
HSPA1L HSP90AA1 0.987
HSPA4L DNAJB1 0.987
HSPA2 HSP90AA1 0.986
DNAJA4 HSPA1A 0.986
DNAJA1 HSPH1 0.986
HSPA4 HSPA9 0.986
HSPA1B HSP90AA1 0.985
DNAJB4 HSPA4 0.985
HSPA1A HSPA5 0.984
DNAJC3 HSPA5 0.984
HSPA4 GRPEL1 0.984
HSPA1A DNAJA2 0.983
HSPA2 HSPA9 0.982
HSPA1L DNAJB1 0.982
HSPA2 STIP1 0.982
HSPA1B DNAJB1 0.982
HSPH1 HSPA9 0.982
HSPA1L HSPA6 0.982
HSPA1A HSPA6 0.982
HSPA5 HSPA6 0.982
HSPH1 DNAJB1 0.981
HSPA8 HSPA2 0.981
HSPA1A HSPA1B 0.981
HSPA2 HSPA1A 0.98
STIP1 DNAJA2 0.98
HSPA2 DNAJB1 0.98
DNAJA1 STIP1 0.979
HSPA4 HSPBP1 0.979
HSPA1B STIP1 0.979
HSPA9 HSPA4L 0.978
DNAJC3 HSPA8 0.978
DNAJA1 HSPA1L 0.977
GRPEL1 DNAJB1 0.976
HSPA12A HSPA4L 0.976
HSPA12A HSPA4 0.975
DNAJB4 HSPH1 0.974
HSPA14 DNAJB1 0.974
HSPA12A HSPA9 0.974
HSPA12A HSPA13 0.974
DNAJA4 HSPA1B 0.974
DNAJA4 HSPA1L 0.974
DNAJA1 HSPA1B 0.973
DNAJA4 HSPA2 0.97
HSPA2 DNAJA1 0.969
HSPA1L STIP1 0.969
HSPA14 HSPA12A 0.968
HSPA8 DNAJB4 0.968
HSPA2 DNAJA2 0.967
DNAJA4 STIP1 0.966
HSPA5 HSPA4 0.966
HSPA4 HSPA12B 0.966
HSP90AA1 HSPA5 0.965
DNAJA4 HSP90AA1 0.965
HSPA1B DNAJA2 0.965
HSPA1L DNAJA2 0.964
HSPA8 HSPA4L 0.964
DNAJA2 HSPA4 0.963
HSPA1A HSPA12A 0.962
DNAJA2 DNAJB1 0.962
HSPA1A HSPA12B 0.962
HSPA13 DNAJB1 0.961
HSPA12A HSPH1 0.956
HSPH1 GRPEL1 0.954
HSPA9 HSPA12B 0.954
HSPA8 HSPA9 0.954
HSPA8 GRPEL1 0.953
HSPA5 HSPH1 0.953
HSPH1 HSPA12B 0.952
DNAJA1 DNAJB1 0.951
HSPA8 HSPA5 0.95
HSPA5 HSPA4L 0.949
HSP90AA1 HSPA9 0.949
HSPA1A HSPBP1 0.949
HSPA6 HSPA4 0.949
HSPA14 HSPA12B 0.949
HSPA1A HSPA4 0.948
HSP90AA1 HSPH1 0.947
DNAJC3 HSPA4 0.947
HSPA2 HSPA4 0.947
DNAJA1 HSPA4 0.946
HSPA1A HSPH1 0.946
HSPA1L HSPA4 0.946
HSPA12A HSPA5 0.945
HSPA1B HSPA4 0.945
HSPA1L HSPA4L 0.945
HSPA4L HSPA12B 0.944
HSPA1A HSPA4L 0.944
HSPA1L HSPH1 0.943
HSPA13 HSPA12B 0.943
HSPH1 HSPBP1 0.943
HSPA5 HSPA12B 0.943
HSPA2 HSPA4L 0.943
DNAJA4 DNAJB1 0.942
DNAJA4 HSPH1 0.942
HSPA1B HSPA4L 0.942
HSPA14 HSPA4 0.941
HSPA6 HSPA12B 0.941
HSPA1B HSPH1 0.941
HSPA12B DNAJB1 0.94
HSPA14 HSPH1 0.94
HSPA12A DNAJB1 0.94
HSPA8 HSPA6 0.939
HSPA12A HSPA6 0.939
HSPA1L HSPA1A 0.939
HSPA14 HSPA4L 0.938
HSPA8 HSPA1A 0.938
HSPA4 HSPA13 0.938
HSPA1L HSPA5 0.938
HSPA6 HSPA4L 0.937
DNAJA4 DNAJA1 0.937
HSPA1L HSPA12A 0.937
HSPA4L HSPA13 0.937
HSPA8 HSPA12A 0.936
HSPA2 GRPEL1 0.935
HSPH1 HSPA6 0.934
HSPH1 HSPA13 0.933
HSPA14 HSPA9 0.932
STIP1 HSPH1 0.931
HSPA2 HSPA12A 0.929
HSPA5 HSPA9 0.929
HSPA6 HSPA9 0.927
HSPA14 HSPA13 0.926
DNAJC3 HSPA1A 0.924
HSPA9 HSPA13 0.924
HSPA2 HSPA5 0.924
HSPA12A HSPA12B 0.924
DNAJA4 DNAJA2 0.924
HSPA1B HSPA5 0.923
HSPA8 HSPBP1 0.923
HSPA1L HSPA12B 0.922
HSPA5 HSPA13 0.922
HSPA8 HSPA12B 0.922
DNAJA1 DNAJA2 0.921
HSPA14 HSPA5 0.92
DNAJB4 GRPEL1 0.918
HSPA1A HSPA9 0.918
HSPA14 HSPA6 0.917
HSPA4L HSPBP1 0.917
HSPA1L HSPA9 0.917
HSPA8 HSPA14 0.916
HSPA1B HSPA9 0.916
DNAJC3 HSPH1 0.915
DNAJA4 GRPEL1 0.913
HSPA14 HSPA1L 0.913
HSPA2 HSPA14 0.912
HSPA14 HSPA1A 0.912
HSPA8 HSPA13 0.911
HSPA1L HSPA13 0.91
DNAJC3 DNAJB1 0.91
DNAJC3 GRPEL1 0.91
HSPA8 HSPA1L 0.91
DNAJA1 HSPA4L 0.909
HSPA6 HSPA13 0.909
HSPA14 HSPA1B 0.909
DNAJA4 HSPA4 0.908
HSPA1A HSPA13 0.908
HSPH1 HSPA4L 0.908
HSPA4 HSPA4L 0.907
HSPA2 HSPA13 0.906
HSPA1B HSPA6 0.906
HSPA1B HSPA13 0.906
HSPA2 HSPA1L 0.904
HSPA8 HSPA1B 0.903
HSPA2 HSPA12B 0.903
HSPA2 HSPA6 0.902
HSPA1B HSPA12A 0.902
DNAJB4 STIP1 0.902
HSPA2 HSPA1B 0.901
HSPA1L HSPA1B 0.901
HSPA1B HSPA12B 0.9
HSPA1A DNAJB4 0.9
HSPH1 DNAJA2 0.9
Gene Ontology Semantic Similarity
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# 3313 (HSPA9) 10963 (STIP1) 3312 (HSPA8) 3308 (HSPA4) 3320 (HSP90AA1) 3303 (HSPA1A) 3301 (DNAJA1) 3306 (HSPA2) 3310 (HSPA6) 3309 (HSPA5) 10808 (HSPH1) 3305 (HSPA1L) 22824 (HSPA4L) 55466 (DNAJA4) 3304 (HSPA1B) 11080 (DNAJB4) 5611 (DNAJC3) 80273 (GRPEL1) 259217 (HSPA12A) 51182 (HSPA14) 10294 (DNAJA2) 6782 (HSPA13) 116835 (HSPA12B) 3337 (DNAJB1)
3313 (HSPA9) 1.00 0.71 0.92 0.71 0.78 0.87 0.66 0.90 0.94 0.91 0.61 0.97 1.00 0.66 0.94 0.63 0.59 0.55 0.48 0.94 0.63 0.94 1.00 0.62
10963 (STIP1) 0.71 1.00 0.68 0.66 0.59 0.67 0.67 0.60 0.65 0.65 0.67 0.63 0.24 0.78 0.72 0.69 0.61 0.56 0.48 0.64 0.69 0.64 1.00 0.65
3312 (HSPA8) 0.92 0.68 1.00 0.68 0.81 0.91 0.71 0.86 0.89 0.91 0.62 0.90 1.00 0.67 0.95 0.65 0.59 0.54 0.48 0.88 0.65 0.88 1.00 0.67
3308 (HSPA4) 0.71 0.66 0.68 1.00 0.59 0.67 0.64 0.69 0.76 0.73 0.71 0.74 1.00 0.76 0.72 0.65 0.59 0.62 0.48 0.75 0.65 0.75 1.00 0.62
3320 (HSP90AA1) 0.78 0.59 0.81 0.59 1.00 0.81 0.60 0.79 0.75 0.76 0.56 0.75 1.00 0.57 0.80 0.57 0.53 0.49 0.48 0.72 0.57 0.72 1.00 0.57
3303 (HSPA1A) 0.87 0.67 0.91 0.67 0.81 1.00 0.69 0.89 0.85 0.86 0.62 0.85 1.00 0.65 0.94 0.62 0.56 0.53 0.48 0.83 0.62 0.83 1.00 0.71
3301 (DNAJA1) 0.66 0.67 0.71 0.64 0.60 0.69 1.00 0.62 0.65 0.70 0.70 0.68 0.15 0.74 0.74 0.83 0.63 0.58 0.48 0.63 0.83 0.63 1.00 0.80
3306 (HSPA2) 0.90 0.60 0.86 0.69 0.79 0.89 0.62 1.00 0.95 0.89 0.60 0.92 1.00 0.65 0.88 0.62 0.59 0.54 0.48 0.93 0.62 0.93 1.00 0.62
3310 (HSPA6) 0.94 0.65 0.89 0.76 0.75 0.85 0.65 0.95 1.00 0.93 0.65 0.98 1.00 0.71 0.92 0.66 0.63 0.59 0.48 0.99 0.66 0.99 1.00 0.66
3309 (HSPA5) 0.91 0.65 0.91 0.73 0.76 0.86 0.70 0.89 0.93 1.00 0.65 0.93 1.00 0.71 0.90 0.68 0.63 0.57 0.48 0.91 0.68 0.91 1.00 0.70
10808 (HSPH1) 0.61 0.67 0.62 0.71 0.56 0.62 0.70 0.60 0.65 0.65 1.00 0.63 0.43 0.77 0.66 0.76 0.61 0.91 0.48 0.64 0.76 0.64 1.00 0.68
3305 (HSPA1L) 0.97 0.63 0.90 0.74 0.75 0.85 0.68 0.92 0.98 0.93 0.63 1.00 1.00 0.69 0.92 0.65 0.61 0.58 0.48 0.98 0.65 0.98 1.00 0.64
22824 (HSPA4L) 1.00 0.24 1.00 1.00 1.00 1.00 0.15 1.00 1.00 1.00 0.43 1.00 1.00 0.15 1.00 0.15 0.12 0.43 0.10 1.00 0.15 1.00 0.15 0.15
55466 (DNAJA4) 0.66 0.78 0.67 0.76 0.57 0.65 0.74 0.65 0.71 0.71 0.77 0.69 0.15 1.00 0.69 0.88 0.80 0.74 0.48 0.70 0.88 0.70 1.00 0.76
3304 (HSPA1B) 0.94 0.72 0.95 0.72 0.80 0.94 0.74 0.88 0.92 0.90 0.66 0.92 1.00 0.69 1.00 0.66 0.61 0.57 0.48 0.90 0.66 0.90 1.00 0.66
11080 (DNAJB4) 0.63 0.69 0.65 0.65 0.57 0.62 0.83 0.62 0.66 0.68 0.76 0.65 0.15 0.88 0.66 1.00 0.76 0.73 0.48 0.65 1.00 0.65 1.00 0.85
5611 (DNAJC3) 0.59 0.61 0.59 0.59 0.53 0.56 0.63 0.59 0.63 0.63 0.61 0.61 0.12 0.80 0.61 0.76 1.00 0.60 0.38 0.62 0.76 0.62 0.82 0.67
80273 (GRPEL1) 0.55 0.56 0.54 0.62 0.49 0.53 0.58 0.54 0.59 0.57 0.91 0.58 0.43 0.74 0.57 0.73 0.60 1.00 0.38 0.59 0.73 0.59 0.82 0.62
259217 (HSPA12A) 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.10 0.48 0.48 0.48 0.38 0.38 1.00 0.48 0.48 0.48 0.48 0.48
51182 (HSPA14) 0.94 0.64 0.88 0.75 0.72 0.83 0.63 0.93 0.99 0.91 0.64 0.98 1.00 0.70 0.90 0.65 0.62 0.59 0.48 1.00 0.65 1.00 1.00 0.64
10294 (DNAJA2) 0.63 0.69 0.65 0.65 0.57 0.62 0.83 0.62 0.66 0.68 0.76 0.65 0.15 0.88 0.66 1.00 0.76 0.73 0.48 0.65 1.00 0.65 1.00 0.85
6782 (HSPA13) 0.94 0.64 0.88 0.75 0.72 0.83 0.63 0.93 0.99 0.91 0.64 0.98 1.00 0.70 0.90 0.65 0.62 0.59 0.48 1.00 0.65 1.00 1.00 0.64
116835 (HSPA12B) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.15 1.00 1.00 1.00 0.82 0.82 0.48 1.00 1.00 1.00 1.00 1.00
3337 (DNAJB1) 0.62 0.65 0.67 0.62 0.57 0.71 0.80 0.62 0.66 0.70 0.68 0.64 0.15 0.76 0.66 0.85 0.67 0.62 0.48 0.64 0.85 0.64 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HSPH1 Toad Liver - 3464 m 33 day upregulated 2.629595252 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
HSF1 3297 HSPH1 10808 proximal_filtered 22955619 TRANSFAC
FOS 2353 HSPH1 10808 Activation 20145154 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT031808 hsa-miR-16-5p Homo sapiens HSPH1 10808 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT041390 hsa-miR-193b-3p Homo sapiens HSPH1 10808 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048010 hsa-miR-30c-5p Homo sapiens HSPH1 10808 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049463 hsa-miR-92a-3p Homo sapiens HSPH1 10808 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
10808 GO:0005515 protein binding GOTERM_MF_DIRECT
10808 GO:0005524 ATP binding GOTERM_MF_DIRECT
10808 GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide GOTERM_BP_DIRECT
10808 GO:0045345 positive regulation of MHC class I biosynthetic process GOTERM_BP_DIRECT
10808 GO:0051085 chaperone mediated protein folding requiring cofactor GOTERM_BP_DIRECT
10808 GO:1903748 negative regulation of establishment of protein localization to mitochondrion GOTERM_BP_DIRECT
10808 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
10808 GO:0043014 ATP-dependent protein binding GOTERM_MF_DIRECT
10808 GO:0051135 positive regulation of NK T cell activation GOTERM_BP_DIRECT
10808 GO:0005829 cytosol GOTERM_CC_DIRECT
10808 GO:0006898 receptor-mediated endocytosis GOTERM_BP_DIRECT
10808 GO:0006986 response to unfolded protein GOTERM_BP_DIRECT
10808 GO:1903753 negative regulation of p38MAPK cascade GOTERM_BP_DIRECT
10808 GO:0005874 microtubule GOTERM_CC_DIRECT
10808 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
10808 GO:0071682 endocytic vesicle lumen GOTERM_CC_DIRECT
10808 GO:0061098 positive regulation of protein tyrosine kinase activity GOTERM_BP_DIRECT
10808 GO:0005576 extracellular region GOTERM_CC_DIRECT
10808 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
10808 GO:1900034 regulation of cellular response to heat GOTERM_BP_DIRECT
10808 GO:0000774 RNA cap binding GOTERM_MF_DIRECT
10808 GO:0005737 cytoplasm GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
10808 hsa04141 Protein processing in endoplasmic reticulum
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HSPH1 10808 HIV Infections C0019693 Disease or Syndrome 0.3 0.696 0.483 group
HSPH1 10808 HIV Coinfection C4505456 Disease or Syndrome 0.3 0.696 0.483 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types