Apolipoprotein H (beta-2-glycoprotein I)
AltitudeomicsDB
Protein Official symbol |
APOH |
Aliases |
APOH B2G1 |
Chromosomal Location |
17 |
Length |
345 |
Uniprot ID |
P02749 |
EC number |
None |
Protein family Information(Pfam) |
PF00084;PF09014; |
PDB id |
1C1Z;1G4F;1G4G;1QUB;2KRI;3OP8;4JHS; |
InterPro ID |
IPR035976;IPR015104;IPR000436; |
dbSNP |
rs3826358 rs1801692 rs8178847 rs4581 rs1801689 rs1801690 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
APOA1 |
APOB |
0.999 |
APOA2 |
APOA1 |
0.999 |
APOA1 |
APOC3 |
0.999 |
SERPINC1 |
F2 |
0.999 |
FGG |
F2 |
0.998 |
APOA2 |
APOB |
0.997 |
APOB |
APOC3 |
0.996 |
APOA2 |
APOC3 |
0.996 |
AHSG |
APOA1 |
0.996 |
AHSG |
APOA2 |
0.995 |
SERPINC1 |
FGG |
0.995 |
LPA |
APOB |
0.994 |
AHSG |
FGG |
0.991 |
AHSG |
SERPINC1 |
0.987 |
AHSG |
APOB |
0.987 |
AHSG |
SPP2 |
0.986 |
LPA |
APOA1 |
0.985 |
FGG |
APOA1 |
0.984 |
APOA2 |
LPA |
0.981 |
APOA1 |
APOH |
0.981 |
FGG |
APOB |
0.98 |
AHSG |
AMBP |
0.979 |
HP |
APOA1 |
0.979 |
APOC3 |
APOH |
0.978 |
SERPINC1 |
APOA1 |
0.978 |
FGG |
AMBP |
0.975 |
SERPINC1 |
APOB |
0.974 |
AHSG |
F2 |
0.973 |
APOB |
APOH |
0.973 |
APOA2 |
APOH |
0.97 |
AHSG |
APOH |
0.97 |
APOA2 |
FGG |
0.97 |
FGG |
SPP2 |
0.969 |
F2 |
AMBP |
0.968 |
LPA |
APOC3 |
0.967 |
APOA2 |
SERPINC1 |
0.963 |
F2 |
APOH |
0.962 |
SERPINC1 |
SPP2 |
0.957 |
ITIH3 |
APOH |
0.956 |
ITIH3 |
SPP2 |
0.955 |
AMBP |
APOH |
0.954 |
SERPINA4 |
ITIH3 |
0.952 |
ITIH4 |
APOH |
0.949 |
FGG |
APOH |
0.948 |
APOB |
SPP2 |
0.947 |
SERPINC1 |
APOH |
0.937 |
SERPINA4 |
APOH |
0.936 |
ECM1 |
LGALS3BP |
0.936 |
SERPINA4 |
ITIH4 |
0.935 |
CLEC3B |
SPP2 |
0.933 |
SEPP1 |
CLEC3B |
0.933 |
ECM1 |
CLEC3B |
0.933 |
ECM1 |
TIMP3 |
0.932 |
LPA |
APOH |
0.93 |
ITIH4 |
LGALS3BP |
0.93 |
APOA2 |
HP |
0.927 |
ITIH3 |
ECM1 |
0.927 |
ITIH3 |
ITIH4 |
0.92 |
SEPP1 |
ITIH3 |
0.92 |
ITIH3 |
LGALS3BP |
0.918 |
APOA1 |
SPP2 |
0.918 |
ECM1 |
SPP2 |
0.917 |
SEPP1 |
ITIH4 |
0.917 |
ITIH4 |
SPP2 |
0.917 |
APOH |
SPP2 |
0.915 |
CLEC3B |
TIMP3 |
0.913 |
SERPINC1 |
AMBP |
0.913 |
SERPINA4 |
CTSW |
0.912 |
APOA2 |
SPP2 |
0.911 |
SEPP1 |
ECM1 |
0.911 |
CLEC3B |
ITIH4 |
0.911 |
CLEC3B |
APOH |
0.91 |
SERPINA4 |
SPP2 |
0.91 |
ECM1 |
CTSW |
0.908 |
RARRES2 |
TIMP3 |
0.908 |
SEPP1 |
RARRES2 |
0.908 |
SERPINA4 |
LGALS3BP |
0.908 |
RARRES2 |
ITIH3 |
0.908 |
ECM1 |
ITIH4 |
0.907 |
FAM3C |
CLEC3B |
0.907 |
SEPP1 |
LGALS3BP |
0.906 |
SEPP1 |
TIMP3 |
0.906 |
FAM3C |
APOH |
0.906 |
AMBP |
APOA1 |
0.906 |
LGALS3BP |
APOH |
0.905 |
SERPINA4 |
RARRES2 |
0.905 |
CTSW |
TIMP3 |
0.904 |
RARRES2 |
CLEC3B |
0.904 |
SERPINA4 |
SEPP1 |
0.904 |
ITIH3 |
CLEC3B |
0.904 |
SEPP1 |
APOH |
0.904 |
FAM3C |
TIMP3 |
0.903 |
TIMP3 |
LGALS3BP |
0.903 |
SEPP1 |
CTSW |
0.903 |
RARRES2 |
APOH |
0.903 |
SEPP1 |
FAM3C |
0.903 |
CTSW |
LGALS3BP |
0.902 |
RARRES2 |
SPP2 |
0.902 |
CLEC3B |
LGALS3BP |
0.902 |
ITIH3 |
TIMP3 |
0.902 |
RARRES2 |
ITIH4 |
0.902 |
TIMP3 |
ITIH4 |
0.902 |
RARRES2 |
ECM1 |
0.902 |
SEPP1 |
SPP2 |
0.902 |
ECM1 |
APOH |
0.902 |
FAM3C |
SPP2 |
0.902 |
RARRES2 |
LGALS3BP |
0.902 |
SERPINA4 |
FAM3C |
0.901 |
CDC37L1 |
FAM3C |
0.901 |
SERPINC1 |
LPA |
0.901 |
SERPINA4 |
TIMP3 |
0.901 |
SEPP1 |
CDC37L1 |
0.9 |
CDC37L1 |
CTSW |
0.9 |
CTSW |
ITIH4 |
0.9 |
ITIH3 |
FAM3C |
0.9 |
ITIH3 |
CDC37L1 |
0.9 |
CDC37L1 |
CLEC3B |
0.9 |
SERPINA4 |
ECM1 |
0.9 |
FAM3C |
ITIH4 |
0.9 |
CDC37L1 |
TIMP3 |
0.9 |
ITIH3 |
AMBP |
0.9 |
RARRES2 |
CTSW |
0.9 |
CDC37L1 |
APOH |
0.9 |
CDC37L1 |
LGALS3BP |
0.9 |
SERPINA4 |
CLEC3B |
0.9 |
TIMP3 |
APOH |
0.9 |
FAM3C |
LGALS3BP |
0.9 |
SERPINA4 |
CDC37L1 |
0.9 |
TIMP3 |
SPP2 |
0.9 |
ECM1 |
FAM3C |
0.9 |
FAM3C |
CTSW |
0.9 |
CTSW |
SPP2 |
0.9 |
CTSW |
APOH |
0.9 |
CTSW |
CLEC3B |
0.9 |
LGALS3BP |
SPP2 |
0.9 |
ITIH3 |
CTSW |
0.9 |
CDC37L1 |
SPP2 |
0.9 |
CDC37L1 |
ITIH4 |
0.9 |
RARRES2 |
CDC37L1 |
0.9 |
CDC37L1 |
ECM1 |
0.9 |
RARRES2 |
FAM3C |
0.9 |
HP |
APOH |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
335 (APOA1) |
336 (APOA2) |
462 (SERPINC1) |
2266 (FGG) |
197 (AHSG) |
338 (APOB) |
4018 (LPA) |
3240 (HP) |
345 (APOC3) |
2147 (F2) |
3699 (ITIH3) |
259 (AMBP) |
5267 (SERPINA4) |
3700 (ITIH4) |
1893 (ECM1) |
7123 (CLEC3B) |
350 (APOH) |
5919 (RARRES2) |
10447 (FAM3C) |
1521 (CTSW) |
7078 (TIMP3) |
55664 (CDC37L1) |
6694 (SPP2) |
335 (APOA1)
|
1.00
|
0.88
|
0.57
|
0.61
|
0.17
|
0.72
|
0.57
|
0.57
|
0.65
|
0.56
|
0.33
|
0.54
|
0.30
|
0.55
|
0.63
|
0.41
|
0.71
|
0.60
|
0.57
|
0.12
|
0.56
|
0.62
|
0.33
|
336 (APOA2)
|
0.88
|
1.00
|
0.54
|
0.56
|
0.22
|
0.71
|
0.55
|
0.53
|
0.71
|
0.51
|
0.50
|
0.55
|
0.46
|
0.54
|
0.56
|
0.38
|
0.71
|
0.55
|
0.52
|
0.11
|
0.53
|
0.58
|
0.50
|
462 (SERPINC1)
|
0.57
|
0.54
|
1.00
|
0.69
|
0.50
|
0.55
|
0.73
|
0.73
|
0.45
|
0.58
|
0.90
|
0.70
|
1.00
|
0.90
|
0.76
|
0.43
|
0.63
|
0.73
|
0.70
|
0.12
|
0.91
|
0.75
|
0.90
|
2266 (FGG)
|
0.61
|
0.56
|
0.69
|
1.00
|
0.16
|
0.63
|
0.62
|
0.80
|
0.46
|
0.71
|
0.16
|
0.58
|
0.15
|
0.69
|
0.76
|
0.49
|
0.67
|
0.86
|
0.81
|
0.16
|
0.68
|
0.80
|
0.16
|
197 (AHSG)
|
0.17
|
0.22
|
0.50
|
0.16
|
1.00
|
0.12
|
0.38
|
0.14
|
0.38
|
0.12
|
1.00
|
0.34
|
0.90
|
0.65
|
0.15
|
0.10
|
0.21
|
0.14
|
0.14
|
0.08
|
0.45
|
0.14
|
1.00
|
338 (APOB)
|
0.72
|
0.71
|
0.55
|
0.63
|
0.12
|
1.00
|
0.65
|
0.62
|
0.54
|
0.55
|
0.13
|
0.50
|
0.12
|
0.53
|
0.65
|
0.58
|
0.69
|
0.64
|
0.60
|
0.11
|
0.55
|
0.66
|
0.13
|
4018 (LPA)
|
0.57
|
0.55
|
0.73
|
0.62
|
0.38
|
0.65
|
1.00
|
0.63
|
0.46
|
0.71
|
1.00
|
0.63
|
0.90
|
0.76
|
0.64
|
0.56
|
0.62
|
0.63
|
0.61
|
0.29
|
0.71
|
0.66
|
1.00
|
3240 (HP)
|
0.57
|
0.53
|
0.73
|
0.80
|
0.14
|
0.62
|
0.63
|
1.00
|
0.40
|
0.66
|
0.13
|
0.58
|
0.12
|
0.74
|
0.77
|
0.52
|
0.68
|
0.91
|
0.88
|
0.14
|
0.72
|
0.88
|
0.13
|
345 (APOC3)
|
0.65
|
0.71
|
0.45
|
0.46
|
0.38
|
0.54
|
0.46
|
0.40
|
1.00
|
0.41
|
0.50
|
0.41
|
0.46
|
0.48
|
0.42
|
0.34
|
0.62
|
0.45
|
0.42
|
0.12
|
0.44
|
0.42
|
0.50
|
2147 (F2)
|
0.56
|
0.51
|
0.58
|
0.71
|
0.12
|
0.55
|
0.71
|
0.66
|
0.41
|
1.00
|
0.13
|
0.52
|
0.12
|
0.56
|
0.70
|
0.41
|
0.59
|
0.73
|
0.67
|
0.32
|
0.57
|
0.69
|
0.13
|
3699 (ITIH3)
|
0.33
|
0.50
|
0.90
|
0.16
|
1.00
|
0.13
|
1.00
|
0.13
|
0.50
|
0.13
|
1.00
|
0.90
|
0.90
|
1.00
|
0.16
|
0.09
|
0.28
|
0.13
|
0.13
|
0.07
|
0.80
|
0.13
|
1.00
|
259 (AMBP)
|
0.54
|
0.55
|
0.70
|
0.58
|
0.34
|
0.50
|
0.63
|
0.58
|
0.41
|
0.52
|
0.90
|
1.00
|
1.00
|
0.68
|
0.60
|
0.37
|
0.57
|
0.58
|
0.56
|
0.11
|
0.64
|
0.62
|
0.90
|
5267 (SERPINA4)
|
0.30
|
0.46
|
1.00
|
0.15
|
0.90
|
0.12
|
0.90
|
0.12
|
0.46
|
0.12
|
0.90
|
1.00
|
1.00
|
0.90
|
0.15
|
0.08
|
0.26
|
0.12
|
0.12
|
0.07
|
0.71
|
0.12
|
0.90
|
3700 (ITIH4)
|
0.55
|
0.54
|
0.90
|
0.69
|
0.65
|
0.53
|
0.76
|
0.74
|
0.48
|
0.56
|
1.00
|
0.68
|
0.90
|
1.00
|
0.69
|
0.43
|
0.63
|
0.74
|
0.70
|
0.13
|
0.86
|
0.76
|
1.00
|
1893 (ECM1)
|
0.63
|
0.56
|
0.76
|
0.76
|
0.15
|
0.65
|
0.64
|
0.77
|
0.42
|
0.70
|
0.16
|
0.60
|
0.15
|
0.69
|
1.00
|
0.48
|
0.67
|
0.77
|
0.76
|
0.15
|
0.76
|
0.78
|
0.16
|
7123 (CLEC3B)
|
0.41
|
0.38
|
0.43
|
0.49
|
0.10
|
0.58
|
0.56
|
0.52
|
0.34
|
0.41
|
0.09
|
0.37
|
0.08
|
0.43
|
0.48
|
1.00
|
0.48
|
0.52
|
0.50
|
0.09
|
0.43
|
0.53
|
0.09
|
350 (APOH)
|
0.71
|
0.71
|
0.63
|
0.67
|
0.21
|
0.69
|
0.62
|
0.68
|
0.62
|
0.59
|
0.28
|
0.57
|
0.26
|
0.63
|
0.67
|
0.48
|
1.00
|
0.68
|
0.67
|
0.13
|
0.63
|
0.71
|
0.28
|
5919 (RARRES2)
|
0.60
|
0.55
|
0.73
|
0.86
|
0.14
|
0.64
|
0.63
|
0.91
|
0.45
|
0.73
|
0.13
|
0.58
|
0.12
|
0.74
|
0.77
|
0.52
|
0.68
|
1.00
|
0.92
|
0.14
|
0.72
|
0.88
|
0.13
|
10447 (FAM3C)
|
0.57
|
0.52
|
0.70
|
0.81
|
0.14
|
0.60
|
0.61
|
0.88
|
0.42
|
0.67
|
0.13
|
0.56
|
0.12
|
0.70
|
0.76
|
0.50
|
0.67
|
0.92
|
1.00
|
0.14
|
0.70
|
0.86
|
0.13
|
1521 (CTSW)
|
0.12
|
0.11
|
0.12
|
0.16
|
0.08
|
0.11
|
0.29
|
0.14
|
0.12
|
0.32
|
0.07
|
0.11
|
0.07
|
0.13
|
0.15
|
0.09
|
0.13
|
0.14
|
0.14
|
1.00
|
0.12
|
0.14
|
0.07
|
7078 (TIMP3)
|
0.56
|
0.53
|
0.91
|
0.68
|
0.45
|
0.55
|
0.71
|
0.72
|
0.44
|
0.57
|
0.80
|
0.64
|
0.71
|
0.86
|
0.76
|
0.43
|
0.63
|
0.72
|
0.70
|
0.12
|
1.00
|
0.75
|
0.80
|
55664 (CDC37L1)
|
0.62
|
0.58
|
0.75
|
0.80
|
0.14
|
0.66
|
0.66
|
0.88
|
0.42
|
0.69
|
0.13
|
0.62
|
0.12
|
0.76
|
0.78
|
0.53
|
0.71
|
0.88
|
0.86
|
0.14
|
0.75
|
1.00
|
0.13
|
6694 (SPP2)
|
0.33
|
0.50
|
0.90
|
0.16
|
1.00
|
0.13
|
1.00
|
0.13
|
0.50
|
0.13
|
1.00
|
0.90
|
0.90
|
1.00
|
0.16
|
0.09
|
0.28
|
0.13
|
0.13
|
0.07
|
0.80
|
0.13
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
APOH |
Human |
Blood |
- |
3650 m |
48 hours |
downregulated |
0.595 |
Microarray |
Himalayas |
Indians |
1 |
HAPE Pateints Vs Normal |
http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf |
APOH |
Rat |
Plasma |
- |
7620 m |
12 hours |
downregulated |
0.56 |
2-DE |
Northern indo-australian plate |
Sprague-dawley rats |
1 |
Male SD rats weighing 220g |
24842778 |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
350 |
GO:0010596 |
negative regulation of endothelial cell migration |
GOTERM_BP_DIRECT |
350 |
GO:0030194 |
positive regulation of blood coagulation |
GOTERM_BP_DIRECT |
350 |
GO:0051917 |
regulation of fibrinolysis |
GOTERM_BP_DIRECT |
350 |
GO:0070062 |
extracellular exosome |
GOTERM_CC_DIRECT |
350 |
GO:0006641 |
triglyceride metabolic process |
GOTERM_BP_DIRECT |
350 |
GO:0031639 |
plasminogen activation |
GOTERM_BP_DIRECT |
350 |
GO:0008201 |
heparin binding |
GOTERM_MF_DIRECT |
350 |
GO:0005543 |
phospholipid binding |
GOTERM_MF_DIRECT |
350 |
GO:0031012 |
extracellular matrix |
GOTERM_CC_DIRECT |
350 |
GO:0042627 |
chylomicron |
GOTERM_CC_DIRECT |
350 |
GO:0030195 |
negative regulation of blood coagulation |
GOTERM_BP_DIRECT |
350 |
GO:0005576 |
extracellular region |
GOTERM_CC_DIRECT |
350 |
GO:0001937 |
negative regulation of endothelial cell proliferation |
GOTERM_BP_DIRECT |
350 |
GO:0007597 |
blood coagulation |
GOTERM_BP_DIRECT |
350 |
GO:0008289 |
lipid binding |
GOTERM_MF_DIRECT |
350 |
GO:0051918 |
negative regulation of fibrinolysis |
GOTERM_BP_DIRECT |
350 |
GO:0005615 |
extracellular space |
GOTERM_CC_DIRECT |
350 |
GO:0060230 |
phosphatidylcholine-sterol O-acyltransferase activator activity |
GOTERM_MF_DIRECT |
350 |
GO:0009986 |
cell surface |
GOTERM_CC_DIRECT |
350 |
GO:0034392 |
negative regulation of smooth muscle cell apoptotic process |
GOTERM_BP_DIRECT |
350 |
GO:0031089 |
platelet dense granule lumen |
GOTERM_CC_DIRECT |
350 |
GO:0034361 |
very-low-density lipoprotein particle |
GOTERM_CC_DIRECT |
350 |
GO:0033033 |
negative regulation of myeloid cell apoptotic process |
GOTERM_BP_DIRECT |
350 |
GO:0034197 |
triglyceride transport |
GOTERM_BP_DIRECT |
350 |
GO:0051006 |
positive regulation of lipoprotein lipase activity |
GOTERM_BP_DIRECT |
350 |
GO:0001948 |
glycoprotein binding |
GOTERM_MF_DIRECT |
350 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
350 |
GO:0002576 |
platelet degranulation |
GOTERM_BP_DIRECT |
350 |
GO:0016525 |
negative regulation of angiogenesis |
GOTERM_BP_DIRECT |
350 |
GO:0042802 |
identical protein binding |
GOTERM_MF_DIRECT |
350 |
GO:0034364 |
high-density lipoprotein particle |
GOTERM_CC_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
APOH |
350 |
Chemically-Induced Liver Toxicity |
C4279912 |
Disease or Syndrome |
0.3 |
0.611 |
0.724 |
disease |
APOH |
350 |
Chemical and Drug Induced Liver Injury |
C4277682 |
Disease or Syndrome |
0.3 |
0.611 |
0.724 |
disease |
APOH |
350 |
Drug-Induced Liver Disease |
C0860207 |
Disease or Syndrome |
0.3 |
0.611 |
0.724 |
disease |
APOH |
350 |
Hepatitis, Toxic |
C0019193 |
Injury or Poisoning |
0.3 |
0.611 |
0.724 |
disease |
APOH |
350 |
Drug-Induced Acute Liver Injury |
C3658290 |
Disease or Syndrome |
0.3 |
0.611 |
0.724 |
disease |
APOH |
350 |
Hepatitis, Drug-Induced |
C1262760 |
Disease or Syndrome |
0.3 |
0.611 |
0.724 |
disease |
APOH |
350 |
Schizophrenia |
C0036341 |
Mental or Behavioral Dysfunction |
0.3 |
0.611 |
0.724 |
disease |
Association with Drug
Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |
APOH |
350 |
LJP-1082 |
None |
None |
inhibitor |