Inter-alpha-inhibitor H4 heavy

AltitudeomicsDB
Protein Official symbol ITIH4
Aliases ITIH4 IHRP ITIHL1 PK120 PRO1851
Chromosomal Location  14
Length 930
Uniprot ID Q14624
EC number None
Protein family Information(Pfam) PF06668;PF08487;PF00092;
PDB id None
InterPro ID IPR010600;IPR013694;IPR002035;IPR036465;
dbSNP rs13072536 rs2276814 rs4687657 rs2256734 rs2535621

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CXCR4 CD4 0.974
CCR5 ITIH4 0.959
ITIH3 APOH 0.956
ITIH3 SPP2 0.955
ERVW-1 ITIH4 0.953
SERPINA4 ITIH3 0.952
ITIH4 APOH 0.949
ITIH4 CD4 0.937
SERPINA4 APOH 0.936
ECM1 LGALS3BP 0.936
SERPINA4 ITIH4 0.935
CLEC3B SPP2 0.933
ECM1 CLEC3B 0.933
SEPP1 CLEC3B 0.933
ECM1 TIMP3 0.932
ITIH4 LGALS3BP 0.93
ITIH3 ECM1 0.927
CXCR4 CCR5 0.922
SEPP1 ITIH3 0.92
ITIH3 ITIH4 0.92
ITIH3 LGALS3BP 0.918
ECM1 SPP2 0.917
ITIH4 SPP2 0.917
SEPP1 ITIH4 0.917
APOH SPP2 0.915
ITIH4 ENPEP 0.915
CLEC3B TIMP3 0.913
CXCR4 ITIH4 0.912
CLEC3B ITIH4 0.911
SEPP1 ECM1 0.911
SERPINA4 SPP2 0.91
CLEC3B APOH 0.91
RARRES2 TIMP3 0.908
RARRES2 ITIH3 0.908
SERPINA4 LGALS3BP 0.908
SEPP1 RARRES2 0.908
ECM1 CTSW 0.908
FAM3C CLEC3B 0.907
ECM1 ITIH4 0.907
SEPP1 TIMP3 0.906
FAM3C APOH 0.906
SEPP1 LGALS3BP 0.906
LGALS3BP APOH 0.905
SERPINA4 RARRES2 0.905
CTSW TIMP3 0.904
RARRES2 CLEC3B 0.904
ITIH3 CLEC3B 0.904
SERPINA4 SEPP1 0.904
SEPP1 APOH 0.904
SEPP1 CTSW 0.903
TIMP3 LGALS3BP 0.903
FAM3C TIMP3 0.903
SEPP1 FAM3C 0.903
RARRES2 APOH 0.903
FAM3C SPP2 0.902
CTSW LGALS3BP 0.902
TIMP3 ITIH4 0.902
ITIH3 TIMP3 0.902
RARRES2 ECM1 0.902
SEPP1 SPP2 0.902
CLEC3B LGALS3BP 0.902
RARRES2 LGALS3BP 0.902
RARRES2 ITIH4 0.902
ECM1 APOH 0.902
RARRES2 SPP2 0.902
SERPINA4 TIMP3 0.901
CDC37L1 FAM3C 0.901
SERPINA4 FAM3C 0.901
CTSW APOH 0.9
SERPINA4 CDC37L1 0.9
CDC37L1 CTSW 0.9
CDC37L1 ITIH4 0.9
FAM3C LGALS3BP 0.9
TIMP3 APOH 0.9
SERPINA4 ECM1 0.9
CTSW SPP2 0.9
FAM3C CTSW 0.9
FAM3C ITIH4 0.9
RARRES2 FAM3C 0.9
RARRES2 CDC37L1 0.9
CDC37L1 SPP2 0.9
CTSW ITIH4 0.9
ITIH3 FAM3C 0.9
CDC37L1 LGALS3BP 0.9
SERPINA4 CTSW 0.9
CDC37L1 ECM1 0.9
CDC37L1 APOH 0.9
SERPINA4 CLEC3B 0.9
CTSW CLEC3B 0.9
ITIH3 CTSW 0.9
RARRES2 CTSW 0.9
CDC37L1 CLEC3B 0.9
CDC37L1 TIMP3 0.9
SEPP1 CDC37L1 0.9
TIMP3 SPP2 0.9
ITIH3 CDC37L1 0.9
ECM1 FAM3C 0.9
LGALS3BP SPP2 0.9
Gene Ontology Semantic Similarity
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# 7852 (CXCR4) 1234 (CCR5) 3699 (ITIH3) 5267 (SERPINA4) 3700 (ITIH4) 1893 (ECM1) 7123 (CLEC3B) 350 (APOH) 5919 (RARRES2) 10447 (FAM3C) 1521 (CTSW) 7078 (TIMP3) 55664 (CDC37L1) 920 (CD4) 6694 (SPP2) 2028 (ENPEP)
7852 (CXCR4) 1.00 0.84 0.13 0.12 0.52 0.67 0.37 0.55 0.58 0.57 0.11 0.53 0.62 0.71 0.13 0.25
1234 (CCR5) 0.84 1.00 0.13 0.12 0.44 0.61 0.33 0.50 0.51 0.50 0.13 0.46 0.56 0.66 0.13 0.25
3699 (ITIH3) 0.13 0.13 1.00 0.90 1.00 0.16 0.09 0.28 0.13 0.13 0.07 0.80 0.13 0.13 1.00 0.10
5267 (SERPINA4) 0.12 0.12 0.90 1.00 0.90 0.15 0.08 0.26 0.12 0.12 0.07 0.71 0.12 0.12 0.90 0.10
3700 (ITIH4) 0.52 0.44 1.00 0.90 1.00 0.69 0.43 0.63 0.74 0.70 0.13 0.86 0.76 0.50 1.00 0.26
1893 (ECM1) 0.67 0.61 0.16 0.15 0.69 1.00 0.48 0.67 0.77 0.76 0.15 0.76 0.78 0.66 0.16 0.32
7123 (CLEC3B) 0.37 0.33 0.09 0.08 0.43 0.48 1.00 0.48 0.52 0.50 0.09 0.43 0.53 0.40 0.09 0.31
350 (APOH) 0.55 0.50 0.28 0.26 0.63 0.67 0.48 1.00 0.68 0.67 0.13 0.63 0.71 0.56 0.28 0.31
5919 (RARRES2) 0.58 0.51 0.13 0.12 0.74 0.77 0.52 0.68 1.00 0.92 0.14 0.72 0.88 0.55 0.13 0.30
10447 (FAM3C) 0.57 0.50 0.13 0.12 0.70 0.76 0.50 0.67 0.92 1.00 0.14 0.70 0.86 0.54 0.13 0.29
1521 (CTSW) 0.11 0.13 0.07 0.07 0.13 0.15 0.09 0.13 0.14 0.14 1.00 0.12 0.14 0.12 0.07 0.48
7078 (TIMP3) 0.53 0.46 0.80 0.71 0.86 0.76 0.43 0.63 0.72 0.70 0.12 1.00 0.75 0.52 0.80 0.26
55664 (CDC37L1) 0.62 0.56 0.13 0.12 0.76 0.78 0.53 0.71 0.88 0.86 0.14 0.75 1.00 0.58 0.13 0.32
920 (CD4) 0.71 0.66 0.13 0.12 0.50 0.66 0.40 0.56 0.55 0.54 0.12 0.52 0.58 1.00 0.13 0.34
6694 (SPP2) 0.13 0.13 1.00 0.90 1.00 0.16 0.09 0.28 0.13 0.13 0.07 0.80 0.13 0.13 1.00 0.10
2028 (ENPEP) 0.25 0.25 0.10 0.10 0.26 0.32 0.31 0.31 0.30 0.29 0.48 0.26 0.32 0.34 0.10 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ITIH4 Rat Plasma - 7619 m 24 hours upregulated 1.08 2-DE Northern indo-australian plate Male sprague-dawley 1 8 weeks old male SD rats kept at standard conditions 26882918
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT019901 hsa-miR-375 Homo sapiens ITIH4 3700 Homo sapiens Microarray Functional MTI (Weak) 20215506
Gene Ontology
ID GO ID GO Term GO Type
3700 GO:0005576 extracellular region GOTERM_CC_DIRECT
3700 GO:0005515 protein binding GOTERM_MF_DIRECT
3700 GO:0006953 acute-phase response GOTERM_BP_DIRECT
3700 GO:0005886 plasma membrane GOTERM_CC_DIRECT
3700 GO:0034097 response to cytokine GOTERM_BP_DIRECT
3700 GO:0004866 endopeptidase inhibitor activity GOTERM_MF_DIRECT
3700 GO:0002576 platelet degranulation GOTERM_BP_DIRECT
3700 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3700 GO:0010951 negative regulation of endopeptidase activity GOTERM_BP_DIRECT
3700 GO:0004867 serine-type endopeptidase inhibitor activity GOTERM_MF_DIRECT
3700 GO:0030212 hyaluronan metabolic process GOTERM_BP_DIRECT
3700 GO:0031089 platelet dense granule lumen GOTERM_CC_DIRECT
3700 GO:0072562 blood microparticle GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ITIH4 3700 Adenomatous Polyposis Coli C0032580 Neoplastic Process 0.3 0.6 0.621 disease
ITIH4 3700 Polyposis, Adenomatous Intestinal C2713442 Disease or Syndrome 0.3 0.6 0.621 disease
ITIH4 3700 LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 2 C3276941 Finding 0.3 0.6 0.621 phenotype
ITIH4 3700 Hyperlipoproteinemia Type IIa C0745103 Disease or Syndrome 0.3 0.6 0.621 disease
ITIH4 3700 Familial Intestinal Polyposis C2713443 Disease or Syndrome 0.3 0.6 0.621 disease
ITIH4 3700 Malignant tumor of colon C0007102 Neoplastic Process 0.3 0.6 0.621 disease
ITIH4 3700 Colonic Neoplasms C0009375 Neoplastic Process 0.3 0.6 0.621 group
ITIH4 3700 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.32 0.6 0.621 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types