Inter-α (globulin) inhibitor H3

AltitudeomicsDB
Protein Official symbol ITIH3
Aliases ITIH3
Chromosomal Location  3
Length 890
Uniprot ID Q06033
EC number None
Protein family Information(Pfam) PF06668;PF08487;PF00092;
PDB id None
InterPro ID IPR010600;IPR013694;IPR002035;IPR036465;
dbSNP rs3617 rs35271262 rs60805548 rs9883888 rs2710330 rs2710329

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ITIH3 APOH 0.956
ITIH3 SPP2 0.955
AMBP APOH 0.954
SERPINA4 ITIH3 0.952
ITIH4 APOH 0.949
SERPINA4 APOH 0.936
ECM1 LGALS3BP 0.936
SERPINA4 ITIH4 0.935
SEPP1 CLEC3B 0.933
ECM1 CLEC3B 0.933
CLEC3B SPP2 0.933
ECM1 TIMP3 0.932
ITIH4 LGALS3BP 0.93
ITIH3 ECM1 0.927
ITIH3 ITIH4 0.92
SEPP1 ITIH3 0.92
ITIH3 LGALS3BP 0.918
SEPP1 ITIH4 0.917
ECM1 SPP2 0.917
ITIH4 SPP2 0.917
APOH SPP2 0.915
CLEC3B TIMP3 0.913
SERPINA4 CTSW 0.912
CLEC3B ITIH4 0.911
SEPP1 ECM1 0.911
CLEC3B APOH 0.91
SERPINA4 SPP2 0.91
SEPP1 RARRES2 0.908
SERPINA4 LGALS3BP 0.908
RARRES2 TIMP3 0.908
RARRES2 ITIH3 0.908
ECM1 CTSW 0.908
ECM1 ITIH4 0.907
FAM3C CLEC3B 0.907
SEPP1 TIMP3 0.906
SEPP1 LGALS3BP 0.906
FAM3C APOH 0.906
SERPINA4 RARRES2 0.905
LGALS3BP APOH 0.905
RARRES2 CLEC3B 0.904
SEPP1 APOH 0.904
CTSW TIMP3 0.904
ITIH3 CLEC3B 0.904
SERPINA4 SEPP1 0.904
SEPP1 FAM3C 0.903
RARRES2 APOH 0.903
FAM3C TIMP3 0.903
SEPP1 CTSW 0.903
TIMP3 LGALS3BP 0.903
ECM1 APOH 0.902
CLEC3B LGALS3BP 0.902
RARRES2 ITIH4 0.902
RARRES2 SPP2 0.902
ITIH3 TIMP3 0.902
RARRES2 LGALS3BP 0.902
CTSW LGALS3BP 0.902
SEPP1 SPP2 0.902
TIMP3 ITIH4 0.902
FAM3C SPP2 0.902
RARRES2 ECM1 0.902
SERPINA4 FAM3C 0.901
CDC37L1 FAM3C 0.901
SERPINA4 TIMP3 0.901
FAM3C LGALS3BP 0.9
SERPINA4 CDC37L1 0.9
LGALS3BP SPP2 0.9
CTSW APOH 0.9
ITIH3 CDC37L1 0.9
SERPINA4 ECM1 0.9
ECM1 FAM3C 0.9
TIMP3 SPP2 0.9
RARRES2 FAM3C 0.9
CDC37L1 LGALS3BP 0.9
ITIH3 CTSW 0.9
CDC37L1 TIMP3 0.9
FAM3C CTSW 0.9
ITIH3 AMBP 0.9
CDC37L1 ECM1 0.9
CTSW SPP2 0.9
SEPP1 CDC37L1 0.9
CDC37L1 CTSW 0.9
TIMP3 APOH 0.9
ITIH3 FAM3C 0.9
RARRES2 CDC37L1 0.9
CDC37L1 APOH 0.9
CDC37L1 ITIH4 0.9
CDC37L1 CLEC3B 0.9
FAM3C ITIH4 0.9
CTSW CLEC3B 0.9
RARRES2 CTSW 0.9
SERPINA4 CLEC3B 0.9
CTSW ITIH4 0.9
CDC37L1 SPP2 0.9
Gene Ontology Semantic Similarity
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# 3699 (ITIH3) 259 (AMBP) 5267 (SERPINA4) 3700 (ITIH4) 1893 (ECM1) 6414 (SEPP1) 7123 (CLEC3B) 350 (APOH) 5919 (RARRES2) 10447 (FAM3C) 3959 (LGALS3BP) 1521 (CTSW) 7078 (TIMP3) 55664 (CDC37L1) 6694 (SPP2)
3699 (ITIH3) 1.00 0.68 0.90 1.00 0.68 0.59 0.43 0.62 0.74 0.70 1.00 0.13 0.86 0.76 1.00
259 (AMBP) 0.68 1.00 1.00 0.68 0.59 0.59 0.37 0.56 0.58 0.56 1.00 0.11 0.64 0.62 0.90
5267 (SERPINA4) 0.90 1.00 1.00 0.90 0.12 0.12 0.08 0.26 0.12 0.12 0.12 0.07 0.71 0.12 0.90
3700 (ITIH4) 1.00 0.68 0.90 1.00 0.68 0.59 0.43 0.62 0.74 0.70 1.00 0.13 0.86 0.76 1.00
1893 (ECM1) 0.68 0.59 0.12 0.68 1.00 0.59 0.48 0.66 0.76 0.75 1.00 0.13 0.75 0.77 0.13
6414 (SEPP1) 0.59 0.59 0.12 0.59 0.59 1.00 0.41 0.59 0.59 0.59 0.59 0.16 0.59 0.59 0.13
7123 (CLEC3B) 0.43 0.37 0.08 0.43 0.48 0.41 1.00 0.48 0.52 0.50 0.69 0.09 0.43 0.53 0.09
350 (APOH) 0.62 0.56 0.26 0.62 0.66 0.59 0.48 1.00 0.68 0.66 1.00 0.13 0.62 0.71 0.28
5919 (RARRES2) 0.74 0.58 0.12 0.74 0.76 0.59 0.52 0.68 1.00 0.92 1.00 0.14 0.72 0.88 0.13
10447 (FAM3C) 0.70 0.56 0.12 0.70 0.75 0.59 0.50 0.66 0.92 1.00 1.00 0.14 0.70 0.86 0.13
3959 (LGALS3BP) 1.00 1.00 0.12 1.00 1.00 0.59 0.69 1.00 1.00 1.00 1.00 0.16 1.00 1.00 0.13
1521 (CTSW) 0.13 0.11 0.07 0.13 0.13 0.16 0.09 0.13 0.14 0.14 0.16 1.00 0.12 0.14 0.07
7078 (TIMP3) 0.86 0.64 0.71 0.86 0.75 0.59 0.43 0.62 0.72 0.70 1.00 0.12 1.00 0.75 0.80
55664 (CDC37L1) 0.76 0.62 0.12 0.76 0.77 0.59 0.53 0.71 0.88 0.86 1.00 0.14 0.75 1.00 0.13
6694 (SPP2) 1.00 0.90 0.90 1.00 0.13 0.13 0.09 0.28 0.13 0.13 0.13 0.07 0.80 0.13 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ITIH3 Human Plasma - 3760 m 1-3 day upregulated 2 2-DE Southeast Asia Han-Chinese 1 Lowland Han-Chinese individuals from Xining, China (2,260 m above sea level) 24940404
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
3699 GO:0004866 endopeptidase inhibitor activity GOTERM_MF_DIRECT
3699 GO:0004867 serine-type endopeptidase inhibitor activity GOTERM_MF_DIRECT
3699 GO:0002576 platelet degranulation GOTERM_BP_DIRECT
3699 GO:0010951 negative regulation of endopeptidase activity GOTERM_BP_DIRECT
3699 GO:0030212 hyaluronan metabolic process GOTERM_BP_DIRECT
3699 GO:0031089 platelet dense granule lumen GOTERM_CC_DIRECT
3699 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3699 GO:0005576 extracellular region GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ITIH3 3699 Liver carcinoma C2239176 Neoplastic Process 0.3 0.785 0.138 disease
ITIH3 3699 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.43 0.785 0.138 disease
ITIH3 3699 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.44 0.785 0.138 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types