ALTITUDEOMICSDB

Protein kinas C epsilon

AltitudeomicsDB

Protein Official symbol	PRKCE
Aliases	PRKCE PKCE
Chromosomal Location	2
Length	737
Uniprot ID	Q02156
EC number	2.7.11.13
Protein family Information(Pfam)	PF00130;PF00168;PF00069;PF00433;
PDB id	2WH0;5LIH;
InterPro ID	IPR000961;IPR000008;IPR035892;IPR020454;IPR011009;IPR034669;IPR002219;IPR027274;IPR017892;IPR014376;IPR000719;IPR017441;IPR008271;
dbSNP	rs772834505 rs55989965 rs55767130 rs34077350 rs35777875

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
IL2RA	IL2	0.996
CDC42	PARD6A	0.993
GNB1	GNG2	0.988
CDC42	SRC	0.986
PRKACB	PRKAR2B	0.984
PAK4	CDC42	0.983
HRAS	SRC	0.983
PRKACB	PRKAR2A	0.983
HRAS	MAPK3	0.981
MAPK3	KRAS	0.979
HRAS	MAPK1	0.979
MARCKS	PRKCA	0.977
GNB1	GNGT1	0.977
IL2RA	IL2RG	0.974
KRAS	MAPK1	0.973
IL2RG	IL2	0.972
GNG2	GNB2	0.971
SRC	KRAS	0.971
GNB1	GNGT2	0.971
GNGT1	GNB4	0.97
GNG5	GNB2	0.97
GNGT2	GNB4	0.969
LCK	IL2	0.969
GNB2	GNG3	0.968
PRKCE	VDAC1	0.967
LCK	PLCG1	0.966
HRAS	IL2	0.965
GNG4	GNGT1	0.965
GNG4	GNB4	0.964
GNGT2	GNB2	0.963
GNGT2	GNG4	0.962
GNGT2	GNB3	0.961
GNB1	GNG12	0.961
GNG5	GNGT1	0.961
GNG3	GNGT1	0.959
GNG2	GNB4	0.959
GNB1	GNG5	0.958
GNG2	GNB5	0.958
GNG5	GNB5	0.958
MARCKS	PRKCB	0.958
GNGT1	GNB3	0.958
MAPK3	PLCG1	0.956
GNG5	GNB4	0.956
GNAZ	GNB5	0.956
MAPK3	IL2	0.955
GNG12	GNB5	0.955
GNB1	GNG3	0.955
GNG3	GNB4	0.955
GNG3	GNB5	0.954
IL2	MAPK1	0.954
PRKACB	ADCY9	0.954
GNGT2	GNG5	0.954
IL2RA	LCK	0.954
GNG12	GNB4	0.953
GNG4	GNB3	0.953
GNB1	GNAZ	0.953
GNG7	GNGT1	0.952
GNG8	GNGT1	0.952
GNAZ	GNG3	0.952
GNG12	GNB2	0.952
GNG7	GNB3	0.951
GNAZ	GNG4	0.951
GNG4	GNB5	0.951
GNAZ	GNB2	0.95
GNAZ	GNB4	0.95
CDC42	LCK	0.95
HRAS	LCK	0.949
GNB5	GNGT1	0.949
GNG7	GNB2	0.948
ADCY5	ADRA2A	0.948
PRKACB	ADCY6	0.948
GNG7	GNB4	0.947
GNAZ	GNGT1	0.947
PRKCA	PLCG1	0.946
GNAZ	GNGT2	0.946
GNG2	GNB3	0.945
GNG7	GNB5	0.945
ADCY9	PRKAR2B	0.945
GNG5	GNB3	0.945
GNB1	GNG7	0.945
GNGT2	GNB5	0.945
GNB1	GNG4	0.945
IL2RG	LCK	0.945
GNB1	CDC42	0.945
GNG4	GNB2	0.943
GNAZ	GNG5	0.943
GNG12	GNB3	0.943
GNG3	GNB3	0.943
PRKACB	ADCY2	0.943
SRC	MAPK3	0.941
ADRA2A	GNB3	0.941
KRAS	IL2	0.94
GNB2	GNGT1	0.94
GNAZ	GNG8	0.94
SRC	MAPK1	0.94
ADRA2C	GNB3	0.939
LCK	KRAS	0.939
ADCY9	PRKAR2A	0.939
ADCY5	PRKAR2B	0.939
GNAZ	GNB3	0.938
ADCY2	PRKAR2B	0.938
PRKCA	HRAS	0.938
ADCY5	GNG7	0.938
GNB1	PRKAR2B	0.937
GNAZ	GNG7	0.937
ADCY6	PRKAR2B	0.937
GNG8	GNB5	0.937
SRC	PLCG1	0.936
GNAZ	ADCY6	0.935
PRKCB	PLCG1	0.934
GNG8	GNB4	0.934
PRKCE	PLCG1	0.933
GNAZ	GNG12	0.933
PRKCD	SRC	0.933
HRAS	PRKCD	0.932
ADRA2C	GNG7	0.931
HRAS	PRKCB	0.931
ADRA2C	ADCY6	0.931
LCK	MAPK3	0.93
ADCY5	ADRA2C	0.93
GNG3	PRKCG	0.93
PRKCA	SRC	0.93
ADCY5	PRKACB	0.93
GNG2	PRKCE	0.929
VR1	SRC	0.929
GNB1	PRKACB	0.929
PRKCE	GNG3	0.929
GNGT2	GNG8	0.929
CDC42	PLCG1	0.928
PRKCA	GNB2	0.928
LCK	MAPK1	0.928
ADCY5	ADCY9	0.928
PPP1CA	PRKAR2B	0.928
PTK2B	SRC	0.928
PRKCE	GNB5	0.928
GNAZ	ADCY5	0.928
ADCY6	ADRA2A	0.928
SRC	PDPK1	0.927
HRAS	PRKCE	0.927
ADRA2B	ADCY6	0.927
SRC	PARD6A	0.927
ADCY6	ADCY9	0.927
GNB1	PRKAR2A	0.927
PRKCD	PLCG1	0.926
PRKCA	MAPK3	0.926
PPP1CA	PRKAR2A	0.926
PRKAR2B	MAPK3	0.925
ADCY2	PRKAR2A	0.925
PRKACB	MAPK1	0.925
ADRA2B	ADCY5	0.925
CDC42	PRKCE	0.925
ADRA2C	ADCY2	0.925
GNG12	ADCY6	0.925
PRKCD	KRAS	0.925
PAK4	SRC	0.924
GNG7	ADCY9	0.924
GNAZ	GNG2	0.924
PRKCD	MAPK3	0.924
VR1	PRKCE	0.924
GNG7	ADCY2	0.924
ADRA2B	GNB3	0.924
IL2RA	MAPK3	0.924
MARCKS	PRKCE	0.923
ADCY2	ADCY9	0.923
PTK2B	IL2	0.923
PTK2B	IL2RG	0.923
PRKCA	MAPK1	0.923
GNB1	SRC	0.923
PRKCA	ADRA2C	0.922
ADCY5	GNG8	0.922
PRKCD	MAPK1	0.922
CDC42	GNG2	0.922
ADRA2C	ADCY9	0.922
ADCY6	PRKAR2A	0.922
PRKACB	PPP1CA	0.922
HRAS	IL2RA	0.922
ADCY2	ADRA2A	0.921
ADCY5	PRKAR2A	0.921
GNGT2	GNGT1	0.921
PRKCA	KRAS	0.921
PRKAR2A	MAPK1	0.921
HRAS	IL2RG	0.921
PRKCE	KRAS	0.921
PRKACB	MAPK3	0.921
ADCY9	GNB3	0.921
PRKCE	MAPK3	0.921
PRKCE	PRKAR2B	0.92
IL2RA	KRAS	0.92
PRKCD	GNG8	0.92
PRKCB	MAPK3	0.92
GNB1	ADCY6	0.92
PRKCG	PLCG1	0.92
PRKCB	KRAS	0.92
IL2RA	MAPK1	0.92
GNAZ	ADRA2A	0.92
PRKCE	GNB4	0.919
ADRA2B	PRKCA	0.919
PRKCD	GNG4	0.919
GNB1	LCK	0.919
ADCY9	ADRA2A	0.919
PRKCB	IL2	0.919
PRKCA	ADRA2A	0.919
GNB1	GNG8	0.919
GNB1	GNB2	0.919
GNB1	HRAS	0.919
ADRA2B	ADCY9	0.919
PRKCA	GNG8	0.918
GNG4	ADCY9	0.918
PRKAR2B	MAPK1	0.918
PTK2B	LCK	0.918
SRC	GNG2	0.918
PRKCE	GNB3	0.918
ADRA2B	ADCY2	0.917
ADCY5	GNG5	0.917
PRKCE	MAPK1	0.917
GNG7	PRKCG	0.917
PRKCB	MAPK1	0.917
GNG7	ADCY6	0.917
GNG2	PRKCG	0.917
GNB1	ADCY2	0.916
PRKCA	GNB5	0.916
GNB1	PRKCA	0.916
HRAS	PRKCG	0.916
ADCY5	GNB2	0.916
ADCY5	PRKCE	0.915
GNGT2	PRKCD	0.915
IL2RG	MAPK3	0.915
IL2RG	MAPK1	0.915
PRKAR2A	MAPK3	0.915
GNB1	ADCY5	0.915
ADRA2B	PRKCD	0.915
ADCY5	GNG3	0.915
ADCY2	GNG2	0.915
ADCY5	ADCY2	0.915
PTK2B	PRKCB	0.914
ADCY9	GNB5	0.914
ADCY2	GNG3	0.914
LCK	PRKCB	0.914
GNGT2	PRKCA	0.914
ADCY6	PRKCE	0.914
PTK2B	PRKCD	0.914
GNG7	ADRA2A	0.914
IKBKB	PRKCE	0.914
IL2RG	PRKCB	0.914
ADCY5	GNG2	0.913
ADCY5	GNG12	0.913
ADCY6	GNB3	0.913
GNB1	PRKCE	0.913
GNGT2	ADCY5	0.913
SRC	PRKCE	0.913
PRKCD	GNG7	0.912
PAK4	PARD6A	0.912
ADCY2	GNB5	0.912
PRKCA	CHUK	0.912
GNG5	PRKCE	0.912
SRC	PRKCB	0.912
GNAZ	MAPK3	0.912
GNAZ	MAPK1	0.912
GNAZ	PLCG1	0.912
PRKCE	GNGT1	0.911
IKBKB	PRKCB	0.911
ADCY2	GNB3	0.911
GNB2	ADCY9	0.911
ADCY2	GNB2	0.911
ADRA2B	GNG7	0.911
GNAZ	PRKCE	0.911
PRKCG	GNB3	0.911
GNG12	ADCY9	0.911
GNG2	ADCY9	0.911
PRKCB	GNG3	0.91
PRKCE	ADRA2A	0.91
PRKCA	GNG5	0.91
PRKCE	GNG8	0.91
IKBKB	PRKCA	0.91
CHUK	PDPK1	0.91
PRKCA	PTK2B	0.91
PRKCE	PRKCG	0.91
SRC	PRKCG	0.91
ADCY2	GNG8	0.91
GNG7	PRKCE	0.91
PRKCD	PDPK1	0.91
PRKCE	GNB2	0.91
CHUK	PRKCE	0.91
ADCY5	GNB3	0.91
ADCY6	GNG8	0.91
PRKCD	ADRA2A	0.91
PRKCD	GNG2	0.909
PRKCA	GNB4	0.909
PRKCD	GNG5	0.909
ADRA2B	PRKCB	0.909
GNG12	PRKCB	0.909
GNAZ	PRKCD	0.909
PRKCB	GNG8	0.909
ADCY5	GNG4	0.909
PTK2B	PRKCE	0.909
IKBKB	PDPK1	0.909
PDPK1	LCK	0.909
ADCY6	GNB2	0.909
GNG4	PRKCE	0.909
CHUK	PRKCB	0.909
PDPK1	PRKCE	0.909
PRKCA	GNB3	0.909
GNGT2	GNG2	0.909
GNGT2	PRKCB	0.909
ADCY2	ADCY6	0.908
ADRA2C	PRKCD	0.908
GNG8	ADCY9	0.908
GNG5	ADCY9	0.908
PRKCD	GNG3	0.908
GNG12	PRKCE	0.908
GNG4	PRKCG	0.908
GNG7	GNG3	0.908
ADRA2B	PRKCE	0.908
PRKCD	PRKCG	0.908
GNGT2	GNG3	0.908
PPP1CA	PRKCE	0.908
PRKCE	IL2	0.908
GNG2	GNGT1	0.908
GNB1	ADCY9	0.908
ADRA2C	PRKCE	0.908
GNGT2	ADCY2	0.907
GNAZ	ADCY2	0.907
ADCY9	GNB4	0.907
GNB1	GNB5	0.907
GNG4	PRKCB	0.907
PRKCA	PRKCD	0.907
GNAZ	PRKCA	0.907
GNB5	GNB3	0.907
PRKCE	PRKAR2A	0.907
GNAZ	PRKCB	0.907
IL2RG	KRAS	0.907
PRKCD	LCK	0.907
GNAZ	PRKCG	0.907
GNB5	GNB4	0.907
GNG4	ADCY2	0.907
ADCY6	GNB4	0.907
PRKACB	PRKCE	0.907
GNGT2	PRKCE	0.907
GNB2	GNB5	0.907
PRKCA	GNGT1	0.907
PRKCE	ADCY9	0.906
PRKCG	GNB5	0.906
GNB1	PRKCB	0.906
ADRA2C	ADRA2A	0.906
PRKCB	GNB4	0.906
GNB2	GNG8	0.906
PRKCA	PRKCE	0.906
PRKCE	PRKCB	0.906
PDPK1	PRKCB	0.906
ADRA2C	PRKCB	0.906
GNGT2	ADCY9	0.906
SRC	LCK	0.906
ADCY2	GNB4	0.906
GNG12	ADCY2	0.906
PRKCD	GNB4	0.906
GNB1	PRKCG	0.906
PRKCB	PRKCG	0.906
PRKCD	PRKCE	0.906
GNG5	PRKCB	0.906
ADCY6	GNB5	0.906
PAK4	PRKCE	0.906
ADCY5	GNB4	0.906
PRKCD	PRKCB	0.906
ADCY5	ADCY6	0.906
GNG4	GNG3	0.906
PRKCA	PDPK1	0.906
PRKCB	GNB5	0.906
IL2RA	PRKCE	0.906
PRKCD	GNB5	0.906
PRKCA	GNG3	0.906
ADCY5	GNB5	0.906
IL2RG	PRKCE	0.906
GNG3	ADCY9	0.906
PRKCD	GNB2	0.905
GNGT2	ADCY6	0.905
GNG12	GNG5	0.905
GNG7	PRKCB	0.905
GNGT2	GNG7	0.905
PRKCA	GNG4	0.905
PRKCD	GNGT1	0.905
GNG8	GNG3	0.905
PRKCA	GNG2	0.905
PRKCA	GNG7	0.905
GNAZ	HRAS	0.905
ADRA2B	ADRA2A	0.905
ADRA2B	ADRA2C	0.905
PRKCE	PARD6A	0.905
ADCY2	PRKCE	0.905
IKBKB	CHUK	0.905
PRKCG	GNGT1	0.905
LCK	PRKCE	0.905
GNB1	PLCG1	0.905
SRC	GNGT1	0.905
GNG5	GNG3	0.905
ADCY6	GNG3	0.905
GNG12	GNG3	0.904
GNG4	GNG5	0.904
GNG8	PRKCG	0.904
GNG7	GNG8	0.904
PRKCB	ADRA2A	0.904
PRKCB	GNGT1	0.904
GNG5	GNG2	0.904
PRKCA	GNG12	0.904
GNG2	PRKCB	0.904
GNGT2	GNG12	0.904
GNGT1	PLCG1	0.904
PRKCG	GNB4	0.904
GNG4	GNG7	0.904
GNG2	GNG3	0.904
GNAZ	CDC42	0.904
ADRA2B	GNG4	0.904
GNB1	PDPK1	0.904
PTK2B	PRKCG	0.904
GNG4	ADCY6	0.904
GNAZ	ADCY9	0.904
GNG8	GNB3	0.904
PRKCB	GNB2	0.904
GNG5	GNG8	0.904
GNB2	PRKCG	0.903
ADRA2A	GNB5	0.903
GNG12	GNG8	0.903
GNG12	GNG2	0.903
GNG4	GNG2	0.903
GNG7	GNG2	0.903
GNG5	PRKCG	0.903
GNG12	GNGT1	0.903
ADRA2C	GNG3	0.903
GNG7	GNG12	0.903
PRKCB	GNB3	0.902
ADRA2C	GNG4	0.902
PRKAR2B	PRKAR2A	0.902
GNG2	GNG8	0.902
ADRA2B	GNB5	0.902
GNG2	ADCY6	0.902
ADRA2A	PRKCG	0.902
ADRA2B	GNAZ	0.902
ADRA2C	GNG12	0.902
ADCY6	GNGT1	0.902
ADRA2C	PRKCG	0.902
GNG4	ADRA2A	0.902
GNB1	PRKCD	0.902
GNB4	GNB3	0.902
ADRA2C	GNB5	0.902
ADRA2A	GNB4	0.902
PRKCA	PRKCG	0.902
PRKCD	GNG12	0.902
GNG12	PDPK1	0.902
GNG7	GNG5	0.902
GNAZ	ADRA2C	0.902
HRAS	KRAS	0.902
ADRA2B	PRKCG	0.902
MAPK3	MAPK1	0.902
ADCY5	GNGT1	0.902
GNGT2	PRKCG	0.902
GNG4	GNG12	0.902
ADRA2B	GNG3	0.901
GNAZ	SRC	0.901
GNG4	GNG8	0.901
GNG12	PRKCG	0.901
ADCY9	GNGT1	0.901
ADCY2	GNGT1	0.901
ADRA2C	GNG2	0.901
PRKCD	GNB3	0.901
PRKCA	PRKCB	0.901
GNB1	GNB4	0.901
GNB2	GNB3	0.901
PTK2B	IL2RA	0.901
GNB2	GNB4	0.901
GNB1	GNB3	0.901
GNG3	ADRA2A	0.901
GNG5	PDPK1	0.901
GNG8	ADRA2A	0.9
ADRA2C	GNGT1	0.9
ADRA2B	GNG12	0.9
GNG4	PDPK1	0.9
PDPK1	GNGT1	0.9
GNGT2	ADRA2C	0.9
GNB2	ADRA2A	0.9
ADRA2B	GNG8	0.9
ADRA2C	GNG5	0.9
ADRA2A	GNGT1	0.9
PDPK1	GNB5	0.9
PDPK1	GNB2	0.9
GNG2	ADRA2A	0.9
ADRA2B	GNB2	0.9
HRAS	GNGT1	0.9
ADRA2B	GNGT1	0.9
PDPK1	GNG2	0.9
ADRA2C	GNB4	0.9
PDPK1	GNB3	0.9
PDPK1	GNG8	0.9
GNG5	ADCY2	0.9
PRKAR2A	GNGT1	0.9
GNB1	ADRA2A	0.9
PRKACB	GNGT1	0.9
GNAZ	LCK	0.9
GNB1	ADRA2C	0.9
ADRA2B	GNB4	0.9
PDPK1	GNG3	0.9
HRAS	GNG2	0.9
ADRA2C	GNB2	0.9
GNG12	ADRA2A	0.9
PDPK1	GNB4	0.9
ADRA2C	GNG8	0.9
GNGT2	PDPK1	0.9
GNB1	ADRA2B	0.9
ADRA2B	GNG2	0.9
GNB1	PTK2B	0.9
GNG5	ADRA2A	0.9
GNGT2	ADRA2A	0.9
PTK2B	GNGT1	0.9
GNG7	PDPK1	0.9
ADRA2B	GNGT2	0.9
GNG5	ADCY6	0.9
ADRA2B	GNG5	0.9
PRKAR2B	GNGT1	0.9
LCK	GNG2	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	3559 (IL2RA)	998 (CDC42)	2782 (GNB1)	5567 (PRKACB)	10298 (PAK4)	3265 (HRAS)	5595 (MAPK3)	3845 (KRAS)	3561 (IL2RG)	54331 (GNG2)	6714 (SRC)	2792 (GNGT1)	2787 (GNG5)	2793 (GNGT2)	3932 (LCK)	2783 (GNB2)	5581 (PRKCE)	2786 (GNG4)	2785 (GNG3)	2781 (GNAZ)	55970 (GNG12)	3558 (IL2)	94235 (GNG8)	10681 (GNB5)	111 (ADCY5)	5578 (PRKCA)	115 (ADCY9)	150 (ADRA2A)	152 (ADRA2C)	108 (ADCY2)	112 (ADCY6)	5579 (PRKCB)	5580 (PRKCD)	5499 (PPP1CA)	2185 (PTK2B)	151 (ADRA2B)	5577 (PRKAR2B)	5576 (PRKAR2A)	5582 (PRKCG)	3551 (IKBKB)	1147 (CHUK)	5170 (PDPK1)	59345 (GNB4)	50855 (PARD6A)	5594 (MAPK1)	7416 (VDAC1)	5335 (PLCG1)	2784 (GNB3)
3559 (IL2RA)	1.00	0.49	0.55	0.41	0.46	0.47	0.49	0.59	0.94	0.56	0.56	1.00	0.54	0.13	0.55	0.55	0.52	0.63	1.00	0.50	0.58	0.69	0.51	0.56	0.41	0.40	0.17	0.60	0.61	0.40	0.53	0.42	0.50	0.43	0.48	0.61	0.47	0.51	0.11	0.53	0.50	0.44	0.59	0.62	0.46	0.59	0.47	0.54
998 (CDC42)	0.49	1.00	0.65	0.71	0.65	0.76	0.71	0.54	0.45	0.66	0.71	1.00	0.66	1.00	0.70	0.65	0.67	0.56	1.00	0.73	0.55	0.51	0.65	0.64	0.44	0.71	0.21	0.59	0.51	0.43	0.62	0.67	0.74	0.49	0.63	0.47	0.50	0.53	0.42	0.76	0.70	0.66	0.59	0.61	0.72	0.63	0.55	0.66
2782 (GNB1)	0.55	0.65	1.00	0.45	0.53	0.71	0.54	0.80	0.47	0.87	0.59	1.00	0.85	1.00	0.57	1.00	0.55	0.70	1.00	0.75	0.64	0.57	0.88	0.78	0.51	0.46	0.19	0.55	0.54	0.47	0.60	0.49	0.52	0.52	0.47	0.51	0.50	0.53	0.13	0.57	0.54	0.48	1.00	0.70	0.51	0.64	0.55	0.94
5567 (PRKACB)	0.41	0.71	0.45	1.00	0.71	0.56	0.78	0.46	0.38	0.45	0.73	1.00	0.44	0.19	0.69	0.45	0.71	0.48	1.00	0.54	0.48	0.45	0.41	0.46	0.39	0.76	0.27	0.47	0.43	0.53	0.47	0.67	0.74	0.40	0.67	0.38	0.45	0.48	0.60	0.74	0.75	0.74	0.59	0.52	0.79	0.49	0.41	0.44
10298 (PAK4)	0.46	0.65	0.53	0.71	1.00	0.45	0.80	0.54	0.41	0.52	0.76	1.00	0.51	0.14	0.71	0.53	0.77	0.58	1.00	0.48	0.54	0.50	0.48	0.51	0.43	0.82	0.21	0.50	0.47	0.41	0.52	0.71	0.79	0.53	0.75	0.43	0.43	0.46	0.67	0.80	0.82	0.76	0.59	0.67	0.81	0.55	0.46	0.53
3265 (HRAS)	0.47	0.76	0.71	0.56	0.45	1.00	0.48	0.55	0.42	0.74	0.57	1.00	0.73	1.00	0.56	0.71	0.47	0.58	1.00	0.90	0.58	0.50	0.73	0.69	0.41	0.40	0.19	0.51	0.48	0.40	0.52	0.41	0.46	0.46	0.45	0.44	0.44	0.47	0.11	0.51	0.48	0.42	0.59	0.59	0.45	0.56	0.48	0.73
5595 (MAPK3)	0.49	0.71	0.54	0.78	0.80	0.48	1.00	0.57	0.45	0.55	0.77	1.00	0.54	0.19	0.76	0.54	0.80	0.59	1.00	0.51	0.56	0.52	0.52	0.54	0.47	0.84	0.27	0.53	0.51	0.45	0.55	0.73	0.81	0.47	0.75	0.46	0.46	0.49	0.65	0.85	0.84	0.83	0.59	0.60	0.99	0.60	0.49	0.54
3845 (KRAS)	0.59	0.54	0.80	0.46	0.54	0.55	0.57	1.00	0.48	0.71	0.59	1.00	0.68	0.13	0.58	0.80	0.56	0.85	1.00	0.60	0.74	0.61	0.68	0.64	0.53	0.45	0.17	0.57	0.56	0.47	0.65	0.51	0.52	0.50	0.48	0.54	0.51	0.55	0.13	0.59	0.57	0.48	1.00	0.75	0.52	0.70	0.56	0.68
3561 (IL2RG)	0.94	0.45	0.47	0.38	0.41	0.42	0.45	0.48	1.00	0.47	0.52	1.00	0.45	0.13	0.51	0.47	0.46	0.50	1.00	0.44	0.48	0.58	0.43	0.48	0.34	0.38	0.17	0.62	0.63	0.34	0.46	0.39	0.45	0.39	0.49	0.64	0.43	0.45	0.10	0.49	0.46	0.40	0.59	0.53	0.42	0.50	0.42	0.45
54331 (GNG2)	0.56	0.66	0.87	0.45	0.52	0.74	0.55	0.71	0.47	1.00	0.59	1.00	0.92	1.00	0.58	0.87	0.54	0.83	1.00	0.78	0.67	0.58	0.96	0.82	0.50	0.44	0.19	0.55	0.54	0.46	0.62	0.45	0.51	0.53	0.47	0.51	0.51	0.54	0.13	0.57	0.55	0.48	0.59	0.70	0.51	0.66	0.56	0.92
6714 (SRC)	0.56	0.71	0.59	0.73	0.76	0.57	0.77	0.59	0.52	0.59	1.00	1.00	0.58	0.19	0.85	0.59	0.74	0.60	1.00	0.58	0.59	0.59	0.57	0.58	0.47	0.81	0.27	0.59	0.56	0.46	0.62	0.71	0.79	0.56	0.77	0.55	0.55	0.57	0.39	0.79	0.78	0.75	0.59	0.62	0.77	0.62	0.58	0.59
2792 (GNGT1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.13	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	0.17	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.14	1.00	1.00	1.00	0.59	1.00	1.00	1.00	1.00	1.00
2787 (GNG5)	0.54	0.66	0.85	0.44	0.51	0.73	0.54	0.68	0.45	0.92	0.58	1.00	1.00	1.00	0.57	0.85	0.52	0.73	1.00	0.77	0.76	0.57	0.94	0.81	0.49	0.43	0.19	0.54	0.53	0.45	0.60	0.44	0.50	0.51	0.45	0.49	0.49	0.54	0.12	0.56	0.53	0.46	0.59	0.69	0.49	0.64	0.54	0.90
2793 (GNGT2)	0.13	1.00	1.00	0.19	0.14	1.00	0.19	0.13	0.13	1.00	0.19	0.13	1.00	1.00	0.19	1.00	0.13	0.13	0.13	1.00	0.13	0.13	1.00	1.00	0.19	0.14	0.19	0.13	0.13	0.19	0.19	0.13	0.14	0.26	0.13	0.13	0.17	0.17	0.14	0.14	0.14	0.19	0.13	0.13	0.19	0.13	0.19	1.00
3932 (LCK)	0.55	0.70	0.57	0.69	0.71	0.56	0.76	0.58	0.51	0.58	0.85	1.00	0.57	0.19	1.00	0.57	0.70	0.59	1.00	0.57	0.58	0.58	0.57	0.57	0.46	0.74	0.27	0.59	0.55	0.45	0.63	0.68	0.75	0.66	0.74	0.53	0.56	0.58	0.36	0.77	0.73	0.71	0.59	0.62	0.76	0.63	0.61	0.57
2783 (GNB2)	0.55	0.65	1.00	0.45	0.53	0.71	0.54	0.80	0.47	0.87	0.59	1.00	0.85	1.00	0.57	1.00	0.55	0.70	1.00	0.75	0.64	0.57	0.88	0.78	0.51	0.46	0.19	0.55	0.54	0.47	0.60	0.49	0.52	0.52	0.47	0.51	0.50	0.53	0.13	0.57	0.54	0.48	1.00	0.70	0.51	0.64	0.55	0.94
5581 (PRKCE)	0.52	0.67	0.55	0.71	0.77	0.47	0.80	0.56	0.46	0.54	0.74	1.00	0.52	0.13	0.70	0.55	1.00	0.59	1.00	0.50	0.55	0.62	0.50	0.62	0.46	0.84	0.19	0.53	0.49	0.44	0.56	0.74	0.92	0.44	0.71	0.45	0.54	0.56	0.63	0.79	0.79	0.85	0.59	0.61	0.81	0.57	0.48	0.54
2786 (GNG4)	0.63	0.56	0.70	0.48	0.58	0.58	0.59	0.85	0.50	0.83	0.60	1.00	0.73	0.13	0.59	0.70	0.59	1.00	1.00	0.63	0.78	0.64	0.74	0.67	0.56	0.47	0.17	0.58	0.59	0.50	0.69	0.48	0.54	0.53	0.51	0.58	0.54	0.57	0.12	0.61	0.59	0.51	0.59	0.78	0.54	0.73	0.59	0.73
2785 (GNG3)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.13	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.69	1.00	0.17	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.14	1.00	1.00	1.00	0.59	1.00	1.00	1.00	1.00	1.00
2781 (GNAZ)	0.50	0.73	0.75	0.54	0.48	0.90	0.51	0.60	0.44	0.78	0.58	1.00	0.77	1.00	0.57	0.75	0.50	0.63	1.00	1.00	0.60	0.54	0.78	0.72	0.43	0.43	0.19	0.57	0.53	0.42	0.55	0.44	0.48	0.49	0.44	0.47	0.47	0.50	0.11	0.54	0.51	0.45	0.62	0.63	0.48	0.59	0.51	0.77
55970 (GNG12)	0.58	0.55	0.64	0.48	0.54	0.58	0.56	0.74	0.48	0.67	0.59	1.00	0.76	0.13	0.58	0.64	0.55	0.78	1.00	0.60	1.00	0.60	0.65	0.63	0.50	0.45	0.17	0.56	0.56	0.48	0.63	0.46	0.52	0.50	0.48	0.53	0.51	0.56	0.12	0.59	0.56	0.49	0.59	0.72	0.52	0.68	0.55	0.65
3558 (IL2)	0.69	0.51	0.57	0.45	0.50	0.50	0.52	0.61	0.58	0.58	0.59	1.00	0.57	0.13	0.58	0.57	0.62	0.64	1.00	0.54	0.60	1.00	0.55	0.64	0.42	0.44	0.17	0.53	0.52	0.41	0.56	0.45	0.58	0.47	0.46	0.49	0.58	0.59	0.11	0.55	0.52	0.53	0.59	0.63	0.49	0.60	0.51	0.57
94235 (GNG8)	0.51	0.65	0.88	0.41	0.48	0.73	0.52	0.68	0.43	0.96	0.57	1.00	0.94	1.00	0.57	0.88	0.50	0.74	1.00	0.78	0.65	0.55	1.00	0.83	0.49	0.40	0.19	0.53	0.51	0.45	0.59	0.42	0.48	0.49	0.42	0.46	0.47	0.51	0.13	0.55	0.52	0.43	0.59	0.68	0.47	0.63	0.52	0.94
10681 (GNB5)	0.56	0.64	0.78	0.46	0.51	0.69	0.54	0.64	0.48	0.82	0.58	1.00	0.81	1.00	0.57	0.78	0.62	0.67	1.00	0.72	0.63	0.64	0.83	1.00	0.46	0.45	0.19	0.54	0.53	0.43	0.59	0.46	0.57	0.52	0.47	0.51	0.54	0.57	0.12	0.56	0.54	0.54	0.59	0.66	0.50	0.62	0.54	0.81
111 (ADCY5)	0.41	0.44	0.51	0.39	0.43	0.41	0.47	0.53	0.34	0.50	0.47	0.69	0.49	0.19	0.46	0.51	0.46	0.56	0.69	0.43	0.50	0.42	0.49	0.46	1.00	0.41	1.00	0.49	0.50	0.81	0.74	0.37	0.47	0.41	0.38	0.38	0.41	0.43	0.17	0.54	0.54	0.42	0.41	0.55	0.44	0.50	0.44	0.53
5578 (PRKCA)	0.40	0.71	0.46	0.76	0.82	0.40	0.84	0.45	0.38	0.44	0.81	1.00	0.43	0.14	0.74	0.46	0.84	0.47	1.00	0.43	0.45	0.44	0.40	0.45	0.41	1.00	0.21	0.48	0.43	0.40	0.48	0.82	0.86	0.38	0.76	0.38	0.40	0.43	0.77	0.83	0.84	0.80	0.59	0.52	0.84	0.49	0.41	0.45
115 (ADCY9)	0.17	0.21	0.19	0.27	0.21	0.19	0.27	0.17	0.17	0.19	0.27	0.17	0.19	0.19	0.27	0.19	0.19	0.17	0.17	0.19	0.17	0.17	0.19	0.19	1.00	0.21	1.00	0.17	0.17	1.00	1.00	0.19	0.21	0.23	0.19	0.17	0.18	0.18	0.21	0.21	0.21	0.27	0.17	0.17	0.27	0.17	0.18	0.19
150 (ADRA2A)	0.60	0.59	0.55	0.47	0.50	0.51	0.53	0.57	0.62	0.55	0.59	1.00	0.54	0.13	0.59	0.55	0.53	0.58	1.00	0.57	0.56	0.53	0.53	0.54	0.49	0.48	0.17	1.00	0.89	0.47	0.61	0.49	0.55	0.49	0.52	0.81	0.52	0.53	0.10	0.65	0.60	0.48	0.62	0.62	0.51	0.62	0.56	0.55
152 (ADRA2C)	0.61	0.51	0.54	0.43	0.47	0.48	0.51	0.56	0.63	0.54	0.56	1.00	0.53	0.13	0.55	0.54	0.49	0.59	1.00	0.53	0.56	0.52	0.51	0.53	0.50	0.43	0.17	0.89	1.00	0.47	0.53	0.44	0.48	0.45	0.49	0.89	0.46	0.49	0.10	0.62	0.61	0.44	0.59	0.59	0.48	0.58	0.48	0.53
108 (ADCY2)	0.40	0.43	0.47	0.53	0.41	0.40	0.45	0.47	0.34	0.46	0.46	0.69	0.45	0.19	0.45	0.47	0.44	0.50	0.69	0.42	0.48	0.41	0.45	0.43	0.81	0.40	1.00	0.47	0.47	1.00	0.65	0.36	0.45	0.39	0.37	0.37	0.40	0.41	0.15	0.51	0.50	0.41	0.41	0.50	0.42	0.47	0.42	0.48
112 (ADCY6)	0.53	0.62	0.60	0.47	0.52	0.52	0.55	0.65	0.46	0.62	0.62	1.00	0.60	0.19	0.63	0.60	0.56	0.69	1.00	0.55	0.63	0.56	0.59	0.59	0.74	0.48	1.00	0.61	0.53	0.65	1.00	0.55	0.61	0.50	0.48	0.49	0.55	0.58	0.16	0.66	0.55	0.49	0.59	0.80	0.52	0.75	0.65	0.60
5579 (PRKCB)	0.42	0.67	0.49	0.67	0.71	0.41	0.73	0.51	0.39	0.45	0.71	1.00	0.44	0.13	0.68	0.49	0.74	0.48	1.00	0.44	0.46	0.45	0.42	0.46	0.37	0.82	0.19	0.49	0.44	0.36	0.55	1.00	0.78	0.40	0.67	0.40	0.42	0.45	0.60	0.77	0.74	0.70	0.82	0.57	0.74	0.52	0.46	0.44
5580 (PRKCD)	0.50	0.74	0.52	0.74	0.79	0.46	0.81	0.52	0.45	0.51	0.79	1.00	0.50	0.14	0.75	0.52	0.92	0.54	1.00	0.48	0.52	0.58	0.48	0.57	0.47	0.86	0.21	0.55	0.48	0.45	0.61	0.78	1.00	0.45	0.74	0.45	0.54	0.55	0.61	0.85	0.81	0.85	0.59	0.60	0.81	0.59	0.53	0.51
5499 (PPP1CA)	0.43	0.49	0.52	0.40	0.53	0.46	0.47	0.50	0.39	0.53	0.56	1.00	0.51	0.26	0.66	0.52	0.44	0.53	1.00	0.49	0.50	0.47	0.49	0.52	0.41	0.38	0.23	0.49	0.45	0.39	0.50	0.40	0.45	1.00	0.39	0.40	0.52	0.54	0.14	0.50	0.46	0.41	0.59	0.56	0.44	0.52	0.60	0.51
2185 (PTK2B)	0.48	0.63	0.47	0.67	0.75	0.45	0.75	0.48	0.49	0.47	0.77	1.00	0.45	0.13	0.74	0.47	0.71	0.51	1.00	0.44	0.48	0.46	0.42	0.47	0.38	0.76	0.19	0.52	0.49	0.37	0.48	0.67	0.74	0.39	1.00	0.46	0.40	0.43	0.62	0.77	0.78	0.71	0.59	0.54	0.75	0.57	0.42	0.45
151 (ADRA2B)	0.61	0.47	0.51	0.38	0.43	0.44	0.46	0.54	0.64	0.51	0.55	1.00	0.49	0.13	0.53	0.51	0.45	0.58	1.00	0.47	0.53	0.49	0.46	0.51	0.38	0.38	0.17	0.81	0.89	0.37	0.49	0.40	0.45	0.40	0.46	1.00	0.42	0.45	0.11	0.51	0.48	0.39	0.59	0.59	0.43	0.55	0.44	0.49
5577 (PRKAR2B)	0.47	0.50	0.50	0.45	0.43	0.44	0.46	0.51	0.43	0.51	0.55	1.00	0.49	0.17	0.56	0.50	0.54	0.54	1.00	0.47	0.51	0.58	0.47	0.54	0.41	0.40	0.18	0.52	0.46	0.40	0.55	0.42	0.54	0.52	0.40	0.42	1.00	0.99	0.11	0.53	0.46	0.44	0.59	0.59	0.43	0.57	0.58	0.49
5576 (PRKAR2A)	0.51	0.53	0.53	0.48	0.46	0.47	0.49	0.55	0.45	0.54	0.57	1.00	0.54	0.17	0.58	0.53	0.56	0.57	1.00	0.50	0.56	0.59	0.51	0.57	0.43	0.43	0.18	0.53	0.49	0.41	0.58	0.45	0.55	0.54	0.43	0.45	0.99	1.00	0.11	0.55	0.49	0.47	0.59	0.61	0.46	0.59	0.60	0.52
5582 (PRKCG)	0.11	0.42	0.13	0.60	0.67	0.11	0.65	0.13	0.10	0.13	0.39	0.14	0.12	0.14	0.36	0.13	0.63	0.12	0.14	0.11	0.12	0.11	0.13	0.12	0.17	0.77	0.21	0.10	0.10	0.15	0.16	0.60	0.61	0.14	0.62	0.11	0.11	0.11	1.00	0.56	0.64	0.66	0.14	0.11	0.67	0.11	0.12	0.12
3551 (IKBKB)	0.53	0.76	0.57	0.74	0.80	0.51	0.85	0.59	0.49	0.57	0.79	1.00	0.56	0.14	0.77	0.57	0.79	0.61	1.00	0.54	0.59	0.55	0.55	0.56	0.54	0.83	0.21	0.65	0.62	0.51	0.66	0.77	0.85	0.50	0.77	0.51	0.53	0.55	0.56	1.00	0.96	0.78	0.59	0.66	0.85	0.68	0.58	0.56
1147 (CHUK)	0.50	0.70	0.54	0.75	0.82	0.48	0.84	0.57	0.46	0.55	0.78	1.00	0.53	0.14	0.73	0.54	0.79	0.59	1.00	0.51	0.56	0.52	0.52	0.54	0.54	0.84	0.21	0.60	0.61	0.50	0.55	0.74	0.81	0.46	0.78	0.48	0.46	0.49	0.64	0.96	1.00	0.79	0.59	0.60	0.85	0.58	0.49	0.53
5170 (PDPK1)	0.44	0.66	0.48	0.74	0.76	0.42	0.83	0.48	0.40	0.48	0.75	1.00	0.46	0.19	0.71	0.48	0.85	0.51	1.00	0.45	0.49	0.53	0.43	0.54	0.42	0.80	0.27	0.48	0.44	0.41	0.49	0.70	0.85	0.41	0.71	0.39	0.44	0.47	0.66	0.78	0.79	1.00	0.59	0.54	0.84	0.51	0.43	0.47
59345 (GNB4)	0.59	0.59	1.00	0.59	0.59	0.59	0.59	1.00	0.59	0.59	0.59	0.59	0.59	0.13	0.59	1.00	0.59	0.59	0.59	0.62	0.59	0.59	0.59	0.59	0.41	0.59	0.17	0.62	0.59	0.41	0.59	0.82	0.59	0.59	0.59	0.59	0.59	0.59	0.14	0.59	0.59	0.59	1.00	0.59	0.59	0.59	0.59	0.59
50855 (PARD6A)	0.62	0.61	0.70	0.52	0.67	0.59	0.60	0.75	0.53	0.70	0.62	1.00	0.69	0.13	0.62	0.70	0.61	0.78	1.00	0.63	0.72	0.63	0.68	0.66	0.55	0.52	0.17	0.62	0.59	0.50	0.80	0.57	0.60	0.56	0.54	0.59	0.59	0.61	0.11	0.66	0.60	0.54	0.59	1.00	0.56	0.76	0.66	0.71
5594 (MAPK1)	0.46	0.72	0.51	0.79	0.81	0.45	0.99	0.52	0.42	0.51	0.77	1.00	0.49	0.19	0.76	0.51	0.81	0.54	1.00	0.48	0.52	0.49	0.47	0.50	0.44	0.84	0.27	0.51	0.48	0.42	0.52	0.74	0.81	0.44	0.75	0.43	0.43	0.46	0.67	0.85	0.85	0.84	0.59	0.56	1.00	0.56	0.46	0.50
7416 (VDAC1)	0.59	0.63	0.64	0.49	0.55	0.56	0.60	0.70	0.50	0.66	0.62	1.00	0.64	0.13	0.63	0.64	0.57	0.73	1.00	0.59	0.68	0.60	0.63	0.62	0.50	0.49	0.17	0.62	0.58	0.47	0.75	0.52	0.59	0.52	0.57	0.55	0.57	0.59	0.11	0.68	0.58	0.51	0.59	0.76	0.56	1.00	0.64	0.64
5335 (PLCG1)	0.47	0.55	0.55	0.41	0.46	0.48	0.49	0.56	0.42	0.56	0.58	1.00	0.54	0.19	0.61	0.55	0.48	0.59	1.00	0.51	0.55	0.51	0.52	0.54	0.44	0.41	0.18	0.56	0.48	0.42	0.65	0.46	0.53	0.60	0.42	0.44	0.58	0.60	0.12	0.58	0.49	0.43	0.59	0.66	0.46	0.64	1.00	0.54
2784 (GNB3)	0.54	0.66	0.94	0.44	0.53	0.73	0.54	0.68	0.45	0.92	0.59	1.00	0.90	1.00	0.57	0.94	0.54	0.73	1.00	0.77	0.65	0.57	0.94	0.81	0.53	0.45	0.19	0.55	0.53	0.48	0.60	0.44	0.51	0.51	0.45	0.49	0.49	0.52	0.12	0.56	0.53	0.47	0.59	0.71	0.50	0.64	0.54	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
PRKCE	Sheep	Heart	60 mm Hg	3820 m	110 day	downregulated	-	Western immunoblotting	CA, United States of America	Time-dated pregnant sheep	-	Soldier exposed to high altitude compared to their low altitude profile	30017521

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
SP1	6667	PRKCE	5581	Unknown	10671503	TRUSST
STAT1	6772	PRKCE	5581	Unknown	9560267	TRUSST
PAX5	5079	PRKCE	5581	Repression	17312387	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT003667	hsa-miR-205-5p	Homo sapiens	PRKCE	5581	Homo sapiens	immunoblot//qRT-PCR	Functional MTI (Weak)	19244118
MIRT007205	hsa-miR-1-3p	Homo sapiens	PRKCE	5581	Homo sapiens	Luciferase reporter assay	Functional MTI	23226300
MIRT007286	hsa-miR-31-5p	Homo sapiens	PRKCE	5581	Homo sapiens	Luciferase reporter assay	Functional MTI	23364795
MIRT027937	hsa-miR-96-5p	Homo sapiens	PRKCE	5581	Homo sapiens	Sequencing	Functional MTI (Weak)	20371350
MIRT030913	hsa-miR-21-5p	Homo sapiens	PRKCE	5581	Homo sapiens	Microarray	Functional MTI (Weak)	18591254
MIRT043664	hsa-miR-342-3p	Homo sapiens	PRKCE	5581	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT052955	hsa-miR-107	Homo sapiens	PRKCE	5581	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22158047
MIRT438113	hsa-miR-146a-5p	Homo sapiens	PRKCE	5581	Homo sapiens	Luciferase reporter assay	Functional MTI	23457043
MIRT438113	hsa-miR-146a-5p	Homo sapiens	PRKCE	5581	Homo sapiens	qRT-PCR//Luciferase reporter assay//Western blot	Functional MTI	25308712

Gene Ontology

ID	GO ID	GO Term	GO Type
5581	GO:0032467	positive regulation of cytokinesis	GOTERM_BP_DIRECT
5581	GO:0006468	protein phosphorylation	GOTERM_BP_DIRECT
5581	GO:0050996	positive regulation of lipid catabolic process	GOTERM_BP_DIRECT
5581	GO:0030546	Hsp70 protein binding	GOTERM_MF_DIRECT
5581	GO:0046872	metal ion binding	GOTERM_MF_DIRECT
5581	GO:0005856	cytoskeleton	GOTERM_CC_DIRECT
5581	GO:0004699	cyclin-dependent protein serine/threonine kinase activity	GOTERM_MF_DIRECT
5581	GO:0071889	14-3-3 protein binding	GOTERM_MF_DIRECT
5581	GO:0005783	endoplasmic reticulum	GOTERM_CC_DIRECT
5581	GO:0005829	cytosol	GOTERM_CC_DIRECT
5581	GO:0051209	release of sequestered calcium ion into cytosol	GOTERM_BP_DIRECT
5581	GO:2001031	positive regulation of cellular glucuronidation	GOTERM_BP_DIRECT
5581	GO:0004674	protein serine/threonine kinase activity	GOTERM_MF_DIRECT
5581	GO:0005515	protein binding	GOTERM_MF_DIRECT
5581	GO:0005524	ATP binding	GOTERM_MF_DIRECT
5581	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
5581	GO:0010811	positive regulation of cell-substrate adhesion	GOTERM_BP_DIRECT
5581	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GOTERM_BP_DIRECT
5581	GO:0071361	cellular response to ethanol	GOTERM_BP_DIRECT
5581	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
5581	GO:0032024	positive regulation of insulin secretion	GOTERM_BP_DIRECT
5581	GO:0043278	response to morphine	GOTERM_BP_DIRECT
5581	GO:0004672	protein kinase activity	GOTERM_MF_DIRECT
5581	GO:0007049	cell cycle	GOTERM_BP_DIRECT
5581	GO:0007165	signal transduction	GOTERM_BP_DIRECT
5581	GO:0043410	positive regulation of MAPK cascade	GOTERM_BP_DIRECT
5581	GO:0070257	positive regulation of mucus secretion	GOTERM_BP_DIRECT
5581	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GOTERM_BP_DIRECT
5581	GO:2000273	positive regulation of receptor activity	GOTERM_BP_DIRECT
5581	GO:0004697	cAMP-dependent protein kinase activity	GOTERM_MF_DIRECT
5581	GO:0005739	mitochondrion	GOTERM_CC_DIRECT
5581	GO:0002281	macrophage activation involved in immune response	GOTERM_BP_DIRECT
5581	GO:0035641	locomotory exploration behavior	GOTERM_BP_DIRECT
5581	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	GOTERM_BP_DIRECT
5581	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	GOTERM_BP_DIRECT
5581	GO:0071380	cellular response to prostaglandin E stimulus	GOTERM_BP_DIRECT
5581	GO:0004871	signal transducer activity	GOTERM_MF_DIRECT
5581	GO:0035276	nuclear hormone receptor binding	GOTERM_MF_DIRECT
5581	GO:0005794	Golgi apparatus	GOTERM_CC_DIRECT
5581	GO:0048471	perinuclear region of cytoplasm	GOTERM_CC_DIRECT
5581	GO:0003785	actin monomer binding	GOTERM_MF_DIRECT
5581	GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	GOTERM_BP_DIRECT
5581	GO:0005634	nucleus	GOTERM_CC_DIRECT
5581	GO:0030838	positive regulation of actin filament polymerization	GOTERM_BP_DIRECT
5581	GO:0010634	positive regulation of epithelial cell migration	GOTERM_BP_DIRECT
5581	GO:0010763	positive regulation of fibroblast migration	GOTERM_BP_DIRECT
5581	GO:0018105	peptidyl-serine phosphorylation	GOTERM_BP_DIRECT
5581	GO:0031663	lipopolysaccharide-mediated signaling pathway	GOTERM_BP_DIRECT
5581	GO:0090303	positive regulation of wound healing	GOTERM_BP_DIRECT
5581	GO:0007155	cell adhesion	GOTERM_BP_DIRECT
5581	GO:0030168	platelet activation	GOTERM_BP_DIRECT
5581	GO:0032230	positive regulation of synaptic transmission	GOTERM_BP_DIRECT
5581	GO:0051301	cell division	GOTERM_BP_DIRECT
5581	GO:0008047	enzyme activator activity	GOTERM_MF_DIRECT
5581	GO:0035556	intracellular signal transduction	GOTERM_BP_DIRECT
5581	GO:0031397	negative regulation of protein ubiquitination	GOTERM_BP_DIRECT
5581	GO:0071456	cellular response to hypoxia	GOTERM_BP_DIRECT
5581	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	GOTERM_BP_DIRECT
5581	GO:0019899	enzyme binding	GOTERM_MF_DIRECT
5581	GO:0071944	cell periphery	GOTERM_CC_DIRECT
5581	GO:0006915	apoptotic process	GOTERM_BP_DIRECT
5581	GO:0007202	activation of phospholipase C activity	GOTERM_BP_DIRECT
5581	GO:0051279	regulation of release of sequestered calcium ion into cytosol	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
5581	hsa04022	cGMP-PKG signaling pathway
5581	hsa04071	Sphingolipid signaling pathway
5581	hsa04270	Vascular smooth muscle contraction
5581	hsa04530	Tight junction
5581	hsa04666	Fc gamma R-mediated phagocytosis
5581	hsa04925	Aldosterone synthesis and secretion
5581	hsa04750	Inflammatory mediator regulation of TRP channels
5581	hsa04930	Type II diabetes mellitus
5581	hsa04931	Insulin resistance
5581	hsa05206	MicroRNAs in cancer

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
PRKCE	5581	Nodular glomerulosclerosis	C0017667	Disease or Syndrome	0.3	0.604	0.552	disease
PRKCE	5581	Drug abuse	C0013146	Mental or Behavioral Dysfunction	0.3	0.604	0.552	disease
PRKCE	5581	Myocardial Infarction	C0027051	Disease or Syndrome	0.31	0.604	0.552	disease
PRKCE	5581	Cardiomyopathies, Primary	C0033141	Disease or Syndrome	0.3	0.604	0.552	group
PRKCE	5581	Substance Use Disorders	C0038586	Mental or Behavioral Dysfunction	0.3	0.604	0.552	group
PRKCE	5581	Mechanical Allodynia	C2936719	Sign or Symptom	0.3	0.604	0.552	phenotype
PRKCE	5581	Prescription Drug Abuse	C4316881	Finding	0.3	0.604	0.552	phenotype
PRKCE	5581	Allodynia	C0458247	Finding	0.3	0.604	0.552	phenotype
PRKCE	5581	Diabetic Nephropathy	C0011881	Disease or Syndrome	0.3	0.604	0.552	disease
PRKCE	5581	Myocardial Diseases, Secondary	C0036529	Disease or Syndrome	0.3	0.604	0.552	group
PRKCE	5581	Substance-Related Disorders	C0236969	Mental or Behavioral Dysfunction	0.3	0.604	0.552	group
PRKCE	5581	Drug habituation	C0013170	Mental or Behavioral Dysfunction	0.3	0.604	0.552	phenotype
PRKCE	5581	Streptozotocin Diabetes	C0038433	Experimental Model of Disease	0.3	0.604	0.552	disease
PRKCE	5581	Myocardial Ischemia	C0151744	Disease or Syndrome	0.3	0.604	0.552	disease
PRKCE	5581	Drug Dependence	C1510472	Mental or Behavioral Dysfunction	0.3	0.604	0.552	phenotype
PRKCE	5581	Organic Mental Disorders, Substance-Induced	C0029231	Mental or Behavioral Dysfunction	0.3	0.604	0.552	disease
PRKCE	5581	Peripheral Neuropathy	C0031117	Disease or Syndrome	0.3	0.604	0.552	group
PRKCE	5581	Diabetes Mellitus, Experimental	C0011853	Experimental Model of Disease	0.3	0.604	0.552	disease
PRKCE	5581	Malignant neoplasm of liver	C0345904	Neoplastic Process	0.3	0.604	0.552	disease
PRKCE	5581	Colorectal Neoplasms	C0009404	Neoplastic Process	0.3	0.604	0.552	group
PRKCE	5581	Coronary Stenosis	C0242231	Disease or Syndrome	0.3	0.604	0.552	disease
PRKCE	5581	Substance abuse problem	C0740858	Mental or Behavioral Dysfunction	0.3	0.604	0.552	disease
PRKCE	5581	Alloxan Diabetes	C0002152	Experimental Model of Disease	0.3	0.604	0.552	disease
PRKCE	5581	Hyperalgesia, Thermal	C0751214	Sign or Symptom	0.3	0.604	0.552	phenotype
PRKCE	5581	Colorectal Carcinoma	C0009402	Neoplastic Process	0.3	0.604	0.552	disease
PRKCE	5581	Drug Use Disorders	C0013222	Mental or Behavioral Dysfunction	0.3	0.604	0.552	group
PRKCE	5581	Liver neoplasms	C0023903	Neoplastic Process	0.3	0.604	0.552	group
PRKCE	5581	Substance Dependence	C0038580	Mental or Behavioral Dysfunction	0.3	0.604	0.552	disease
PRKCE	5581	Hyperalgesia, Primary	C0751211	Sign or Symptom	0.3	0.604	0.552	phenotype
PRKCE	5581	Cardiomyopathies	C0878544	Disease or Syndrome	0.3	0.604	0.552	group
PRKCE	5581	Tactile Allodynia	C0751213	Sign or Symptom	0.3	0.604	0.552	phenotype
PRKCE	5581	Hyperalgesia	C0020429	Sign or Symptom	0.31	0.604	0.552	phenotype
PRKCE	5581	Hyperalgesia, Secondary	C0751212	Sign or Symptom	0.3	0.604	0.552	phenotype
PRKCE	5581	Colorectal Cancer	C1527249	Neoplastic Process	0.5	0.604	0.552	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
PRKCE	5581	(7S)-HYDROXYL-STAUROSPORINE	(7S)-HYDROXYL-STAUROSPORINE	CHEMBL574737	inhibitor
PRKCE	5581	7-HYDROXYSTAUROSPORINE	CHEMBL1236539	CHEMBL1236539	inhibitor
PRKCE	5581	BALANOL	BALANOL	CHEMBL60254	inhibitor
PRKCE	5581	BRYOSTATIN	BRYOSTATIN	CHEMBL449158	None
PRKCE	5581	BRYOSTATIN-1	BRYOSTATIN	CHEMBL449158	None
PRKCE	5581	CEP-2563	CEP-2563	CHEMBL3545332	inhibitor
PRKCE	5581	CHELERYTHRINE	CHELERYTHRINE	CHEMBL13045	inhibitor
PRKCE	5581	ENZASTAURIN	ENZASTAURIN	CHEMBL300138	inhibitor
PRKCE	5581	GSK-690693	GSK-690693	CHEMBL494089	inhibitor
PRKCE	5581	INGENOL MEBUTATE	INGENOL MEBUTATE	CHEMBL1863513	None
PRKCE	5581	INGENOL MEBUTATE	INGENOL MEBUTATE	CHEMBL1863513	activator
PRKCE	5581	KAI-1678	None	None	None
PRKCE	5581	KAI-1455	MEPROBAMATE	CHEMBL979	None
PRKCE	5581	KAI-1455	MEPROBAMATE	CHEMBL979	activator
PRKCE	5581	MIDOSTAURIN	MIDOSTAURIN	CHEMBL608533	inhibitor
PRKCE	5581	SOPHORETIN	QUERCETIN	CHEMBL50	inhibitor
PRKCE	5581	SOTRASTAURIN	SOTRASTAURIN	CHEMBL565612	inhibitor
PRKCE	5581	SOTRASTAURIN	SOTRASTAURIN	CHEMBL565612	inhibitor
PRKCE	5581	Y27632	Y-27632	CHEMBL559147	inhibitor