Actin, aortic smooth muscle

AltitudeomicsDB
Protein Official symbol ACTA2
Aliases ACTA2 ACTSA ACTVS GIG46
Chromosomal Location  10
Length 377
Uniprot ID P62736
EC number None
Protein family Information(Pfam) PF00022;
PDB id None
InterPro ID IPR004000;IPR020902;IPR004001;IPR043129;
dbSNP rs794728021 rs112602953 rs751300489 rs121434526 rs1554841298 rs387906592 rs1057521105 rs1803028 rs397516685 rs121434528 rs121434527 rs1803027 rs777832794 rs1062398

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MAML1 NOTCH1 0.999
MAML3 NOTCH2 0.999
MAML3 NOTCH1 0.999
MAML2 NOTCH2 0.999
RBPJ NOTCH1 0.999
MAML3 RBPJ 0.999
MAML2 NOTCH1 0.999
MAML3 NOTCH4 0.999
PXN VCL 0.999
MAML2 MAML1 0.999
TLN1 VCL 0.999
MAML2 RBPJ 0.999
MAML2 NOTCH4 0.999
MAML3 MAML1 0.999
MYL12B MYL6 0.998
RBPJ NOTCH2 0.998
RBPJ MAML1 0.997
MYLK MYL9 0.997
MYLK MYL12A 0.996
ACTA2 MYH11 0.993
KAT2B EP300 0.993
MYL12B MYLK 0.993
MYL5 MYLK 0.992
MYL6B MYLK 0.992
MAML1 NOTCH2 0.992
MYLK MYL10 0.992
MYL6 MYLK 0.991
ACTA2 TPM1 0.991
MYLK MYLPF 0.991
EP300 KAT2A 0.99
MYLK MYL7 0.99
EP300 CREBBP 0.99
KAT2B CREBBP 0.989
ACTG2 TPM2 0.988
SORBS1 VCL 0.987
ACTA2 TPM2 0.986
ACTG2 MYH11 0.986
TPM3 TPM1 0.986
ACTG2 TPM1 0.986
ACTG2 TPM4 0.986
ACTA2 TPM4 0.985
NOTCH4 RBPJ 0.985
ACTG2 TPM3 0.985
ACTA2 MYLPF 0.985
CREBBP KAT2A 0.985
MYL12B MYH11 0.985
ACTG2 MYLPF 0.984
TLN1 PXN 0.984
CALD1 MYLK 0.984
ACTA2 TPM3 0.983
TPM2 TPM1 0.983
MYH11 MYL9 0.982
TPM2 MYL9 0.981
TPM2 TPM3 0.979
MYH11 MYL12A 0.979
NOTCH4 MAML1 0.978
MYL6 MYH11 0.978
MYH11 MYLK 0.978
MYL6B MYH11 0.977
TPM1 TPM4 0.977
MYH11 MYLPF 0.976
MYL6 TPM2 0.976
MYH11 MYL10 0.976
ACTA2 MYL9 0.975
MYH11 MYL7 0.975
MYL5 MYH11 0.975
SORBS3 VCL 0.974
TPM2 TPM4 0.974
NOTCH1 EP300 0.974
MAML3 MAMLD1 0.973
ACTA2 MYLK 0.973
RBPJ KAT2B 0.971
ACTA2 VCL 0.97
ACTG2 VCL 0.969
CALD1 MYL9 0.969
ACTG2 MYL9 0.969
MAML1 EP300 0.969
MYL6 TPM3 0.969
TPM1 VCL 0.969
MYH11 CALD1 0.968
ITGB5 ITGA1 0.968
RBPJ KAT2A 0.968
TPM1 MYL9 0.967
MYL12B TPM3 0.966
MAMLD1 RBPJ 0.966
MYL12B MYL12A 0.966
ACTA2 LMOD1 0.966
RBPJ SNW1 0.966
ACTG2 LMOD1 0.966
TPM2 MYLPF 0.966
MYL6 TPM4 0.965
MYL12B TPM2 0.964
TPM1 MYLPF 0.963
MYL12B ACTA2 0.963
TPM4 MYL9 0.963
MYL12B TPM4 0.963
TPM4 MYL12A 0.963
ACTG2 MYLK 0.962
SORBS1 PXN 0.962
ACTA2 CALD1 0.961
CALD1 TPM1 0.961
MYL12B TPM1 0.961
MYL6B TPM4 0.961
MYL6B TPM2 0.961
RBPJ EP300 0.961
TPM2 MYL12A 0.96
TPM4 MYLPF 0.96
MYL6B TPM1 0.959
MYL6B TPM3 0.959
MYH11 TPM2 0.959
TPM3 MYL12A 0.959
CALD1 VCL 0.958
MYH11 TPM1 0.958
TPM2 MYL10 0.958
TPM4 MYL10 0.958
TPM3 MYLPF 0.958
MYLK PXN 0.957
TPM3 MYL9 0.957
TPM1 MYL12A 0.957
NOTCH1 KAT2B 0.957
PXN SORBS3 0.957
MYL6 TPM1 0.957
ACTG2 CALD1 0.957
MYLK VCL 0.957
TPM4 MYL7 0.956
MYL5 TPM4 0.956
NOTCH1 SNW1 0.956
TPM2 CALD1 0.955
TLN1 ITGA1 0.955
MYH11 LMOD1 0.955
TLN1 ITGB5 0.955
TPM1 MYL10 0.954
TPM1 MYL7 0.954
TPM2 MYL7 0.954
MYL5 TPM2 0.954
MYL5 TPM1 0.954
ACTG2 MYL12A 0.953
NOTCH1 KAT2A 0.953
TPM3 MYL10 0.953
TPM3 VCL 0.953
MYL5 TPM3 0.953
NOTCH1 CREBBP 0.953
ACTA2 MYL7 0.953
MYL12B ACTG2 0.953
MAML1 CREBBP 0.952
TPM4 VCL 0.952
TPM3 MYL7 0.952
MYH11 VCL 0.952
MYH11 TPM4 0.951
ACTA2 MYL12A 0.949
MYL6 CALD1 0.949
ACTG2 MYL10 0.949
MYH11 TPM3 0.949
MYL12B CALD1 0.948
EP300 SNW1 0.948
ACTG2 MYL5 0.947
MYL12B TLN1 0.947
MYLK TPM1 0.946
CALD1 TPM4 0.946
TPM2 VCL 0.946
MYL9 VCL 0.946
ACTG2 MYL7 0.946
MYL6 TLN1 0.946
MYL9 PXN 0.946
ACTA2 MYL5 0.945
ACTA2 MYL10 0.943
MYL6B ACTG2 0.943
RBPJ CREBBP 0.943
MYL6 ACTG2 0.942
MAML2 EP300 0.942
TPM3 CALD1 0.942
TPM2 MYLK 0.941
CALD1 MYL12A 0.941
MYL12A VCL 0.941
MYL6 ACTA2 0.941
ACTA2 NOTCH1 0.941
MYL12B VCL 0.94
LMOD1 MYLK 0.94
MYL6B CALD1 0.939
MYL5 CALD1 0.939
MYL6B ACTA2 0.939
CALD1 MYL10 0.939
EP300 NOTCH2 0.938
TPM3 TPM4 0.938
CALD1 PXN 0.938
TPM3 MYLK 0.937
CALD1 MYLPF 0.937
MYL6B MYL6 0.937
ACTA2 PXN 0.937
MYL6 MYL12A 0.936
MAML2 MAMLD1 0.936
MYLK TPM4 0.936
CALD1 MYL7 0.936
ITGB5 PXN 0.935
MAML2 MAML3 0.935
PXN MYL12A 0.935
ITGB5 VCL 0.935
MAML2 CREBBP 0.934
TPM2 LMOD1 0.934
ACTG2 PXN 0.934
CREBBP NOTCH2 0.933
ACTA2 ACTG2 0.932
MYL12B PXN 0.931
SORBS1 ITGA1 0.931
LMOD1 MYL9 0.93
CALD1 TLN1 0.929
TPM1 PXN 0.929
MAMLD1 MAML1 0.929
MYL6 VCL 0.929
MYH11 PXN 0.929
MAML1 KAT2B 0.927
CREBBP SNW1 0.927
MYLPF VCL 0.926
KAT2B KAT2A 0.926
MAML1 KAT2A 0.926
TPM4 TLN1 0.925
TLN1 SORBS3 0.925
MYL6 MYL9 0.925
TPM2 PXN 0.925
MYLK TLN1 0.924
TPM4 PXN 0.924
KAT2B SNW1 0.924
SORBS1 MYL9 0.924
MYL9 MYL12A 0.923
NOTCH4 NOTCH1 0.923
TPM1 TLN1 0.923
MYLPF PXN 0.923
NOTCH4 SNW1 0.923
MYL5 VCL 0.922
MYL7 VCL 0.922
ACTA2 EP300 0.922
NOTCH4 NOTCH2 0.922
MYL10 VCL 0.922
ITGA1 PXN 0.922
LMOD1 TPM4 0.922
LMOD1 TPM1 0.922
MYL6 PXN 0.921
MYL6B VCL 0.921
PXN MYL10 0.92
ACTA2 ITGA1 0.92
ACTA2 KAT2B 0.92
ACTA2 ITGB5 0.92
MYL5 PXN 0.92
TPM2 TLN1 0.92
TPM3 TLN1 0.919
MYL12B MYL6B 0.919
SORBS1 SORBS3 0.919
MYL6B PXN 0.919
MAML3 EP300 0.919
TPM3 PXN 0.919
ACTA2 TLN1 0.919
ACTA2 KAT2A 0.919
MYH11 TLN1 0.919
TLN1 MYL9 0.918
MYLK SORBS3 0.918
PXN MYL7 0.918
MYL6B MYL9 0.918
MYL12B SORBS1 0.918
MYL6B MYL12A 0.918
CALD1 ITGB5 0.917
TPM2 ITGB5 0.917
MAMLD1 NOTCH1 0.917
ACTA2 CREBBP 0.917
ITGA1 VCL 0.917
ACTG2 TLN1 0.917
MYH11 ITGB5 0.917
MAML3 KAT2B 0.917
SNW1 NOTCH2 0.917
TPM3 LMOD1 0.916
NOTCH2 KAT2A 0.916
MAML2 KAT2B 0.916
ACTA2 NOTCH2 0.915
SORBS1 MYL12A 0.915
ACTA2 NOTCH4 0.915
MAML3 KAT2A 0.915
TPM1 ITGB5 0.915
TLN1 MYL12A 0.915
KAT2B NOTCH2 0.915
MAML1 SNW1 0.915
MAML2 SNW1 0.915
MYL6 MYL7 0.915
NOTCH1 NOTCH2 0.913
LMOD1 CALD1 0.913
SORBS1 MYLK 0.913
TPM4 ITGB5 0.913
SORBS1 TLN1 0.913
MYH11 SORBS1 0.912
MYL6 MYL10 0.912
MYLPF ITGB5 0.912
CALD1 SORBS3 0.912
NOTCH4 CREBBP 0.912
MYL6 MYLPF 0.912
MYL9 SORBS3 0.911
SNW1 KAT2A 0.911
ITGB5 MYL9 0.911
MYLK ITGB5 0.91
CALD1 ITGA1 0.91
SORBS1 TPM3 0.909
MAMLD1 SNW1 0.909
MYL6 ITGB5 0.909
MAML3 CREBBP 0.909
ACTA2 RBPJ 0.908
SORBS1 LMOD1 0.908
ACTG2 ITGB5 0.908
MYL6 MYL5 0.908
MAML2 KAT2A 0.908
LMOD1 SORBS3 0.907
TPM2 SORBS3 0.907
MYL6B TLN1 0.907
NOTCH4 KAT2B 0.907
MAML3 SNW1 0.906
ACTA2 SORBS1 0.906
ACTA2 SNW1 0.906
NOTCH4 KAT2A 0.905
TPM1 ITGA1 0.905
ITGB5 SORBS3 0.905
ITGA1 MYL9 0.905
MYH11 SORBS3 0.905
ACTG2 ITGA1 0.905
MYL6B MYLPF 0.905
TPM3 ITGB5 0.905
MYLK ITGA1 0.905
ITGB5 MYL10 0.905
LMOD1 ITGA1 0.905
SORBS1 TPM1 0.905
SORBS1 MYLPF 0.905
TPM3 SORBS3 0.905
MAMLD1 KAT2A 0.904
LMOD1 ITGB5 0.904
MAMLD1 CREBBP 0.904
MYL6B SORBS3 0.904
MYH11 ITGA1 0.904
TPM2 SORBS1 0.904
SORBS1 TPM4 0.904
MYL5 MYL9 0.904
SORBS1 CALD1 0.904
MYLPF MYL7 0.904
MAMLD1 KAT2B 0.903
SORBS3 MYL12A 0.903
MYL6B MYL7 0.903
SORBS3 MYL10 0.903
LMOD1 PXN 0.903
LMOD1 MYL12A 0.903
MYL6 SORBS1 0.903
TPM1 SORBS3 0.903
MYL6B MYL5 0.903
ITGA1 MYL10 0.903
MYL5 SORBS1 0.903
MYL6 SORBS3 0.903
MYL5 SORBS3 0.903
SORBS1 MYL10 0.903
MYL6B SORBS1 0.903
MYL12B LMOD1 0.903
MYL12B MYL9 0.903
SORBS3 MYL7 0.902
TPM2 ITGA1 0.902
TPM4 SORBS3 0.902
MYL6B LMOD1 0.902
MYL12B SORBS3 0.902
MYLPF ITGA1 0.902
MYL5 TLN1 0.902
MYLPF TLN1 0.902
LMOD1 VCL 0.902
TLN1 MYL10 0.902
MYLPF MYL10 0.902
SORBS1 MYL7 0.902
ACTA2 SORBS3 0.902
TLN1 MYL7 0.902
ITGA1 MYL7 0.902
MYL6B ITGA1 0.902
MYL5 MYL10 0.902
TPM3 ITGA1 0.902
MYLPF SORBS3 0.902
MYL6 ITGA1 0.902
ACTG2 SORBS1 0.902
TPM4 ITGA1 0.902
MYLPF MYL9 0.902
MYL6 LMOD1 0.902
ITGA1 SORBS3 0.902
MYL5 ITGA1 0.901
MYL12B ITGA1 0.901
MYL10 MYL12A 0.901
MYL9 MYL7 0.901
MAMLD1 NOTCH4 0.901
MYL7 MYL10 0.901
ITGA1 MYL12A 0.901
MYL12B MYL7 0.901
MYL6B MYL10 0.901
MYL7 MYL12A 0.901
MYL6B ITGB5 0.901
ACTG2 SORBS3 0.901
LMOD1 TLN1 0.901
MYLPF MYL12A 0.901
MYL12B MYL10 0.901
MAMLD1 ACTA2 0.9
MYL5 ITGB5 0.9
ITGB5 MYL12A 0.9
MAML2 ACTA2 0.9
ACTA2 MAML1 0.9
MAMLD1 NOTCH2 0.9
LMOD1 MYL10 0.9
SORBS1 ITGB5 0.9
MYL5 LMOD1 0.9
MYL5 MYL7 0.9
ITGB5 MYL7 0.9
MYL5 MYL12A 0.9
MAML3 ACTA2 0.9
MYL5 MYLPF 0.9
MYL12B ITGB5 0.9
LMOD1 MYL7 0.9
MYL12B MYLPF 0.9
MAMLD1 EP300 0.9
MYL12B MYL5 0.9
LMOD1 MYLPF 0.9
MYL9 MYL10 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 9794 (MAML1) 55534 (MAML3) 84441 (MAML2) 3516 (RBPJ) 5829 (PXN) 7094 (TLN1) 103910 (MYL12B) 4638 (MYLK) 59 (ACTA2) 8850 (KAT2B) 4636 (MYL5) 140465 (MYL6B) 4637 (MYL6) 2033 (EP300) 10580 (SORBS1) 7170 (TPM3) 4855 (NOTCH4) 1387 (CREBBP) 800 (CALD1) 7169 (TPM2) 4629 (MYH11) 7168 (TPM1) 10174 (SORBS3) 4851 (NOTCH1) 3693 (ITGB5) 10046 (MAMLD1) 7171 (TPM4) 10398 (MYL9) 10627 (MYL12A) 25802 (LMOD1) 29895 (MYLPF) 58498 (MYL7) 3672 (ITGA1) 22938 (SNW1) 4853 (NOTCH2) 7414 (VCL) 2648 (KAT2A)
9794 (MAML1) 1.00 1.00 1.00 0.46 0.66 0.60 1.00 0.49 1.00 0.61 0.26 0.51 0.46 0.47 0.64 0.61 0.55 0.54 0.65 0.54 0.57 0.60 0.59 0.52 0.61 0.48 0.58 0.26 1.00 0.69 0.26 1.00 0.61 0.71 0.56 0.67 0.53
55534 (MAML3) 1.00 1.00 1.00 0.18 0.18 0.18 0.18 0.18 0.11 1.00 0.18 0.18 0.18 1.00 0.18 0.32 0.18 1.00 0.18 0.18 0.18 0.18 0.18 0.18 0.18 0.32 0.18 0.18 0.18 0.12 0.18 0.18 0.18 1.00 0.18 0.18 1.00
84441 (MAML2) 1.00 1.00 1.00 0.18 0.18 0.18 0.18 0.18 0.11 1.00 0.18 0.18 0.18 1.00 0.18 0.32 0.18 1.00 0.18 0.18 0.18 0.18 0.18 0.18 0.18 0.32 0.18 0.18 0.18 0.12 0.18 0.18 0.18 1.00 0.18 0.18 1.00
3516 (RBPJ) 0.46 0.18 0.18 1.00 0.54 0.51 1.00 0.46 0.60 0.47 0.26 0.45 0.44 0.59 0.52 0.53 0.47 0.72 0.51 0.45 0.46 0.52 0.48 0.71 0.48 0.48 0.50 0.26 1.00 0.69 0.26 1.00 0.50 0.57 0.46 0.56 0.46
5829 (PXN) 0.66 0.18 0.18 0.54 1.00 0.75 1.00 0.63 0.60 0.50 0.26 0.65 0.59 0.47 0.76 0.72 0.67 0.51 0.78 0.62 0.72 0.69 0.80 0.63 0.76 0.48 0.67 0.26 1.00 0.70 0.26 1.00 0.81 0.63 0.71 0.79 0.49
7094 (TLN1) 0.60 0.18 0.18 0.51 0.75 1.00 1.00 0.57 0.60 0.47 0.59 0.65 0.60 0.44 0.73 0.68 0.61 0.49 0.77 0.64 0.72 0.77 0.88 0.56 0.79 0.48 0.68 0.59 1.00 0.70 0.59 1.00 0.67 0.59 0.63 0.75 0.47
103910 (MYL12B) 1.00 0.18 0.18 1.00 1.00 1.00 1.00 1.00 0.60 1.00 0.26 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 1.00 1.00 1.00 0.48 1.00 0.26 1.00 0.69 0.26 1.00 1.00 1.00 1.00 1.00 1.00
4638 (MYLK) 0.49 0.18 0.18 0.46 0.63 0.57 1.00 1.00 0.60 0.45 0.26 0.44 0.40 0.44 0.61 0.57 0.50 0.46 0.61 0.52 0.50 0.58 0.54 0.45 0.55 0.48 0.55 0.26 1.00 0.69 0.26 1.00 0.56 0.53 0.49 0.65 0.40
59 (ACTA2) 1.00 0.11 0.11 0.60 0.60 0.60 0.60 0.60 1.00 1.00 0.16 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.48 0.60 0.60 0.60 0.73 0.60 0.28 0.60 0.16 0.60 0.40 0.16 0.60 0.60 0.73 0.60 0.60 0.60
8850 (KAT2B) 0.61 1.00 1.00 0.47 0.50 0.47 1.00 0.45 1.00 1.00 0.26 0.41 0.40 0.74 0.49 0.50 0.44 0.77 0.47 0.42 0.43 0.49 0.45 0.47 0.44 0.48 0.47 0.26 1.00 0.69 0.26 1.00 0.47 0.62 0.43 0.52 0.82
4636 (MYL5) 0.26 0.18 0.18 0.26 0.26 0.59 0.26 0.26 0.16 0.26 1.00 1.00 1.00 0.26 0.26 0.48 0.26 0.26 0.26 1.00 1.00 1.00 0.59 0.26 0.26 0.48 1.00 1.00 0.26 0.18 1.00 0.26 0.26 0.26 0.26 0.26 0.26
140465 (MYL6B) 0.51 0.18 0.18 0.45 0.65 0.65 1.00 0.44 0.60 0.41 1.00 1.00 0.94 0.40 0.63 0.62 0.52 0.44 0.63 0.70 0.83 0.74 0.67 0.47 0.58 0.48 0.71 1.00 1.00 0.69 1.00 1.00 0.58 0.54 0.52 0.66 0.40
4637 (MYL6) 0.46 0.18 0.18 0.44 0.59 0.60 1.00 0.40 0.60 0.40 1.00 0.94 1.00 0.39 0.57 0.56 0.47 0.42 0.56 0.64 0.71 0.69 0.59 0.43 0.50 0.48 0.66 1.00 1.00 0.69 1.00 1.00 0.52 0.51 0.45 0.61 0.39
2033 (EP300) 0.47 1.00 1.00 0.59 0.47 0.44 1.00 0.44 0.60 0.74 0.26 0.40 0.39 1.00 0.45 0.45 0.41 0.79 0.43 0.38 0.41 0.46 0.42 0.47 0.42 0.48 0.44 0.26 1.00 0.69 0.26 1.00 0.43 0.61 0.41 0.48 0.68
10580 (SORBS1) 0.64 0.18 0.18 0.52 0.76 0.73 1.00 0.61 0.60 0.49 0.26 0.63 0.57 0.45 1.00 0.74 0.65 0.50 0.77 0.71 0.70 0.75 0.72 0.60 0.79 0.48 0.68 0.26 1.00 0.84 0.26 1.00 0.73 0.61 0.69 0.79 0.48
7170 (TPM3) 0.61 0.32 0.32 0.53 0.72 0.68 1.00 0.57 0.60 0.50 0.48 0.62 0.56 0.45 0.74 1.00 0.62 0.51 0.73 0.73 0.69 0.76 0.69 0.58 0.71 1.00 0.74 0.48 1.00 0.69 0.48 1.00 0.69 0.60 0.66 0.75 0.47
4855 (NOTCH4) 0.55 0.18 0.18 0.47 0.67 0.61 1.00 0.50 0.60 0.44 0.26 0.52 0.47 0.41 0.65 0.62 1.00 0.46 0.66 0.62 0.59 0.66 0.60 0.51 0.62 0.48 0.77 0.26 1.00 0.69 0.26 1.00 0.62 0.56 0.84 0.68 0.42
1387 (CREBBP) 0.54 1.00 1.00 0.72 0.51 0.49 1.00 0.46 0.60 0.77 0.26 0.44 0.42 0.79 0.50 0.51 0.46 1.00 0.49 0.43 0.45 0.50 0.47 0.58 0.47 0.48 0.48 0.26 1.00 0.69 0.26 1.00 0.48 0.61 0.45 0.53 0.73
800 (CALD1) 0.65 0.18 0.18 0.51 0.78 0.77 1.00 0.61 0.60 0.47 0.26 0.63 0.56 0.43 0.77 0.73 0.66 0.49 1.00 0.63 0.73 0.69 0.73 0.59 0.78 0.48 0.66 0.26 1.00 1.00 0.26 1.00 0.72 0.61 0.72 0.83 0.46
7169 (TPM2) 0.54 0.18 0.18 0.45 0.62 0.64 0.82 0.52 0.48 0.42 1.00 0.70 0.64 0.38 0.71 0.73 0.62 0.43 0.63 1.00 0.77 0.95 0.67 0.51 0.62 0.48 0.91 1.00 0.82 0.70 1.00 0.82 0.61 0.51 0.57 0.68 0.42
4629 (MYH11) 0.57 0.18 0.18 0.46 0.72 0.72 1.00 0.50 0.60 0.43 1.00 0.83 0.71 0.41 0.70 0.69 0.59 0.45 0.73 0.77 1.00 0.79 0.77 0.52 0.69 0.48 0.78 1.00 1.00 0.69 1.00 1.00 0.66 0.57 0.62 0.72 0.41
7168 (TPM1) 0.60 0.18 0.18 0.52 0.69 0.77 1.00 0.58 0.60 0.49 1.00 0.74 0.69 0.46 0.75 0.76 0.66 0.50 0.69 0.95 0.79 1.00 0.80 0.57 0.66 0.48 0.91 1.00 1.00 0.84 1.00 1.00 0.65 0.59 0.62 0.73 0.49
10174 (SORBS3) 0.59 0.18 0.18 0.48 0.80 0.88 1.00 0.54 0.60 0.45 0.59 0.67 0.59 0.42 0.72 0.69 0.60 0.47 0.73 0.67 0.77 0.80 1.00 0.54 0.69 0.48 0.69 0.59 1.00 0.70 0.59 1.00 0.66 0.58 0.63 0.72 0.43
4851 (NOTCH1) 0.52 0.18 0.18 0.71 0.63 0.56 1.00 0.45 0.73 0.47 0.26 0.47 0.43 0.47 0.60 0.58 0.51 0.58 0.59 0.51 0.52 0.57 0.54 1.00 0.55 0.48 0.55 0.26 1.00 0.69 0.26 1.00 0.58 0.57 0.51 0.64 0.41
3693 (ITGB5) 0.61 0.18 0.18 0.48 0.76 0.79 1.00 0.55 0.60 0.44 0.26 0.58 0.50 0.42 0.79 0.71 0.62 0.47 0.78 0.62 0.69 0.66 0.69 0.55 1.00 0.48 0.65 0.26 1.00 0.69 0.26 1.00 0.72 0.59 0.68 0.75 0.43
10046 (MAMLD1) 0.48 0.32 0.32 0.48 0.48 0.48 0.48 0.48 0.28 0.48 0.48 0.48 0.48 0.48 0.48 1.00 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 1.00 0.48 0.48 0.48 0.32 0.48 0.48 0.48 0.48 0.48 0.48 0.48
7171 (TPM4) 0.58 0.18 0.18 0.50 0.67 0.68 1.00 0.55 0.60 0.47 1.00 0.71 0.66 0.44 0.68 0.74 0.77 0.48 0.66 0.91 0.78 0.91 0.69 0.55 0.65 0.48 1.00 1.00 1.00 0.69 1.00 1.00 0.64 0.58 0.60 0.69 0.46
10398 (MYL9) 0.26 0.18 0.18 0.26 0.26 0.59 0.26 0.26 0.16 0.26 1.00 1.00 1.00 0.26 0.26 0.48 0.26 0.26 0.26 1.00 1.00 1.00 0.59 0.26 0.26 0.48 1.00 1.00 0.26 0.18 1.00 0.26 0.26 0.26 0.26 0.26 0.26
10627 (MYL12A) 1.00 0.18 0.18 1.00 1.00 1.00 1.00 1.00 0.60 1.00 0.26 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 1.00 1.00 1.00 0.48 1.00 0.26 1.00 0.69 0.26 1.00 1.00 1.00 1.00 1.00 1.00
25802 (LMOD1) 0.69 0.12 0.12 0.69 0.70 0.70 0.69 0.69 0.40 0.69 0.18 0.69 0.69 0.69 0.84 0.69 0.69 0.69 1.00 0.70 0.69 0.84 0.70 0.69 0.69 0.32 0.69 0.18 0.69 1.00 0.18 0.69 0.69 0.69 0.69 0.70 0.69
29895 (MYLPF) 0.26 0.18 0.18 0.26 0.26 0.59 0.26 0.26 0.16 0.26 1.00 1.00 1.00 0.26 0.26 0.48 0.26 0.26 0.26 1.00 1.00 1.00 0.59 0.26 0.26 0.48 1.00 1.00 0.26 0.18 1.00 0.26 0.26 0.26 0.26 0.26 0.26
58498 (MYL7) 1.00 0.18 0.18 1.00 1.00 1.00 1.00 1.00 0.60 1.00 0.26 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 1.00 1.00 1.00 0.48 1.00 0.26 1.00 0.69 0.26 1.00 1.00 1.00 1.00 1.00 1.00
3672 (ITGA1) 0.61 0.18 0.18 0.50 0.81 0.67 1.00 0.56 0.60 0.47 0.26 0.58 0.52 0.43 0.73 0.69 0.62 0.48 0.72 0.61 0.66 0.65 0.66 0.58 0.72 0.48 0.64 0.26 1.00 0.69 0.26 1.00 1.00 0.60 0.65 0.72 0.45
22938 (SNW1) 0.71 1.00 1.00 0.57 0.63 0.59 1.00 0.53 0.73 0.62 0.26 0.54 0.51 0.61 0.61 0.60 0.56 0.61 0.61 0.51 0.57 0.59 0.58 0.57 0.59 0.48 0.58 0.26 1.00 0.69 0.26 1.00 0.60 1.00 0.57 0.64 0.59
4853 (NOTCH2) 0.56 0.18 0.18 0.46 0.71 0.63 1.00 0.49 0.60 0.43 0.26 0.52 0.45 0.41 0.69 0.66 0.84 0.45 0.72 0.57 0.62 0.62 0.63 0.51 0.68 0.48 0.60 0.26 1.00 0.69 0.26 1.00 0.65 0.57 1.00 0.72 0.40
7414 (VCL) 0.67 0.18 0.18 0.56 0.79 0.75 1.00 0.65 0.60 0.52 0.26 0.66 0.61 0.48 0.79 0.75 0.68 0.53 0.83 0.68 0.72 0.73 0.72 0.64 0.75 0.48 0.69 0.26 1.00 0.70 0.26 1.00 0.72 0.64 0.72 1.00 0.52
2648 (KAT2A) 0.53 1.00 1.00 0.46 0.49 0.47 1.00 0.40 0.60 0.82 0.26 0.40 0.39 0.68 0.48 0.47 0.42 0.73 0.46 0.42 0.41 0.49 0.43 0.41 0.43 0.48 0.46 0.26 1.00 0.69 0.26 1.00 0.45 0.59 0.40 0.52 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ACTA2 Toad Heart - 3464 m 33 day downregulated -2.177295726 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
HEY2 23493 ACTA2 59 Unknown 1460048 TRUSST
HEY1 23462 ACTA2 59 Unknown 1460048 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT041870 hsa-miR-484 Homo sapiens ACTA2 59 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
59 GO:0072144 glomerular mesangial cell development GOTERM_BP_DIRECT
59 GO:0005615 extracellular space GOTERM_CC_DIRECT
59 GO:0005829 cytosol GOTERM_CC_DIRECT
59 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
59 GO:0008217 regulation of blood pressure GOTERM_BP_DIRECT
59 GO:0005737 cytoplasm GOTERM_CC_DIRECT
59 GO:0019901 protein kinase binding GOTERM_MF_DIRECT
59 GO:0030027 lamellipodium GOTERM_CC_DIRECT
59 GO:0044297 cell body GOTERM_CC_DIRECT
59 GO:0030175 filopodium GOTERM_CC_DIRECT
59 GO:0014829 vascular smooth muscle contraction GOTERM_BP_DIRECT
59 GO:0015629 actin cytoskeleton GOTERM_CC_DIRECT
59 GO:0030485 smooth muscle contractile fiber GOTERM_CC_DIRECT
59 GO:0006936 muscle contraction GOTERM_BP_DIRECT
59 GO:0090131 mesenchyme migration GOTERM_BP_DIRECT
59 GO:0005524 ATP binding GOTERM_MF_DIRECT
59 GO:0009615 response to virus GOTERM_BP_DIRECT
59 GO:0043234 protein complex GOTERM_CC_DIRECT
59 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
59 hsa04270 Vascular smooth muscle contraction
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ACTA2 59 Marfan Syndrome C0024796 Disease or Syndrome 0.32 0.54 0.69 disease
ACTA2 59 Malignant neoplasm of breast C0006142 Neoplastic Process 0.3 0.54 0.69 disease
ACTA2 59 Liver Cirrhosis C0023890 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Fetal Growth Retardation C0015934 Pathologic Function 0.3 0.54 0.69 phenotype
ACTA2 59 Kidney Diseases C0022658 Disease or Syndrome 0.3 0.54 0.69 group
ACTA2 59 Liver diseases C0023895 Disease or Syndrome 0.3 0.54 0.69 group
ACTA2 59 Hyalinosis, Segmental Glomerular C0086432 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Ischemia C0022116 Pathologic Function 0.3 0.54 0.69 phenotype
ACTA2 59 Myocardial Infarction C0027051 Disease or Syndrome 0.31 0.54 0.69 disease
ACTA2 59 Liver Dysfunction C0086565 Finding 0.3 0.54 0.69 phenotype
ACTA2 59 Endometrioma C0269102 Neoplastic Process 0.3 0.54 0.69 disease
ACTA2 59 Cholestasis, Extrahepatic C0005398 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Malignant tumor of colon C0007102 Neoplastic Process 0.3 0.54 0.69 disease
ACTA2 59 Colonic Neoplasms C0009375 Neoplastic Process 0.3 0.54 0.69 group
ACTA2 59 Fibrosis, Liver C0239946 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Chronic active hepatitis C0520463 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.54 0.69 group
ACTA2 59 Nephrogenic Fibrosing Dermopathy C1619692 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Focal glomerulosclerosis C0017668 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Mammary Neoplasms C1458155 Neoplastic Process 0.3 0.54 0.69 group
ACTA2 59 Hepatitis, Chronic C0019189 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.54 0.69 disease
ACTA2 59 Systemic Scleroderma C0036421 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Aortic Aneurysm, Thoracoabdominal C0340630 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Cryptogenic Chronic Hepatitis C0524611 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Copper-Overload Cirrhosis C1876165 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Chronic Persistent Hepatitis C0149519 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Endometriosis C0014175 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Breast Carcinoma C0678222 Neoplastic Process 0.3 0.54 0.69 disease
ACTA2 59 Aortic Aneurysm, Thoracic C0162872 Disease or Syndrome 0.7 0.54 0.69 disease
ACTA2 59 Aortic Aneurysm, Familial Thoracic 6 C2673186 Disease or Syndrome 0.6 0.54 0.69 disease
ACTA2 59 MOYAMOYA DISEASE 5 C3279690 Disease or Syndrome 0.6 0.54 0.69 disease
ACTA2 59 Cakut C1968949 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.4 0.54 0.69 group
ACTA2 59 Ehlers-Danlos Syndrome C0013720 Disease or Syndrome 0.3 0.54 0.69 disease
ACTA2 59 Cerebrovascular Disorders C0007820 Disease or Syndrome 0.31 0.54 0.69 group
ACTA2 59 Congenital aneurysm of ascending aorta C0345050 Congenital Abnormality 0.32 0.54 0.69 disease
ACTA2 59 Moyamoya disease 1 C2931384 Disease or Syndrome 0.34 0.54 0.69 disease
ACTA2 59 Moyamoya Disease C0026654 Disease or Syndrome 0.38 0.54 0.69 disease
ACTA2 59 MULTISYSTEMIC SMOOTH MUSCLE DYSFUNCTION SYNDROME C3151201 Disease or Syndrome 0.64 0.54 0.69 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types