Complement component C8 alpha chain
AltitudeomicsDB
| Protein Official symbol |
C8A |
| Aliases |
C8A |
| Chromosomal Location |
1 |
| Length |
584 |
| Uniprot ID |
P07357 |
| EC number |
None |
| Protein family Information(Pfam) |
PF00057;PF01823;PF00090; |
| PDB id |
2QOS;2QQH;2RD7;3OJY;6H03;6H04; |
| InterPro ID |
IPR037565;IPR009030;IPR036055;IPR023415;IPR002172;IPR001862;IPR020864;IPR020863;IPR000884;IPR036383; |
| dbSNP |
rs652785 rs706479 rs17114555 rs1620075 rs1342440 rs17300936 |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| C8A |
C8G |
0.997 |
| C8B |
C8A |
0.997 |
| C8B |
C8G |
0.995 |
| C4B |
C4A |
0.995 |
| C6 |
C5 |
0.993 |
| VDAC1 |
PPIF |
0.9890000000000001 |
| C8B |
C5 |
0.978 |
| C7 |
C5 |
0.968 |
| C8A |
C5 |
0.963 |
| CLU |
C9 |
0.963 |
| CD59 |
C9 |
0.961 |
| C8A |
C9 |
0.96 |
| C8A |
C6 |
0.9570000000000001 |
| C9 |
VTN |
0.9570000000000001 |
| C8B |
C9 |
0.956 |
| SPG7 |
VDAC1 |
0.955 |
| SPG7 |
PPIF |
0.9540000000000001 |
| C9 |
C5 |
0.9540000000000001 |
| C8B |
CLU |
0.9490000000000001 |
| CD59 |
C8A |
0.9470000000000001 |
| C7 |
CLU |
0.9470000000000001 |
| CD59 |
C8B |
0.941 |
| C9 |
C8G |
0.9390000000000001 |
| CD59 |
C5 |
0.9359999999999999 |
| C8B |
C6 |
0.935 |
| VTN |
C5 |
0.934 |
| C8B |
VTN |
0.9329999999999999 |
| C8A |
VTN |
0.9309999999999999 |
| C8G |
C5 |
0.93 |
| C6 |
C8G |
0.929 |
| CLU |
C5 |
0.9279999999999999 |
| C6 |
C9 |
0.9279999999999999 |
| C4A |
C5 |
0.924 |
| C7 |
C6 |
0.924 |
| C4A |
C8A |
0.922 |
| C4B |
C5 |
0.922 |
| C4B |
C8A |
0.922 |
| C6 |
VTN |
0.9209999999999999 |
| CLU |
C6 |
0.9209999999999999 |
| CD59 |
C8G |
0.92 |
| C7 |
C8G |
0.917 |
| C7 |
VTN |
0.917 |
| CD59 |
C7 |
0.9159999999999999 |
| C7 |
C9 |
0.915 |
| VTN |
C8G |
0.915 |
| C8A |
C7 |
0.9129999999999999 |
| CLU |
C8G |
0.9109999999999999 |
| C8B |
C7 |
0.907 |
| C8A |
CLU |
0.907 |
| CD59 |
C6 |
0.907 |
| C8A |
VDAC1 |
0.902 |
| PPIF |
C5 |
0.9009999999999999 |
| VDAC1 |
C9 |
0.9 |
| VDAC1 |
C5 |
0.9 |
| C8A |
PPIF |
0.9 |
| VDAC1 |
C6 |
0.9 |
| C7 |
SPG7 |
0.9 |
| SPG7 |
C5 |
0.9 |
| C7 |
VDAC1 |
0.9 |
| C9 |
PPIF |
0.9 |
| SPG7 |
C6 |
0.9 |
| SPG7 |
C9 |
0.9 |
| C7 |
PPIF |
0.9 |
| C8B |
VDAC1 |
0.9 |
| C8B |
SPG7 |
0.9 |
| C8B |
PPIF |
0.9 |
| C6 |
PPIF |
0.9 |
| C8A |
SPG7 |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
| # |
721 (C4B) |
729 (C6) |
7416 (VDAC1) |
1191 (CLU) |
966 (CD59) |
6687 (SPG7) |
7448 (VTN) |
720 (C4A) |
10105 (PPIF) |
727 (C5) |
|
721 (C4B)
|
1.00
|
0.82
|
0.53
|
0.56
|
0.71
|
0.66
|
0.50
|
0.77
|
0.52
|
0.56
|
|
729 (C6)
|
0.82
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.61
|
1.00
|
1.00
|
|
7416 (VDAC1)
|
0.53
|
1.00
|
1.00
|
0.68
|
0.73
|
0.61
|
0.63
|
0.39
|
0.63
|
0.70
|
|
1191 (CLU)
|
0.56
|
1.00
|
0.68
|
1.00
|
0.73
|
0.64
|
0.66
|
0.41
|
0.70
|
0.72
|
|
966 (CD59)
|
0.71
|
1.00
|
0.73
|
0.73
|
1.00
|
0.66
|
0.72
|
0.56
|
0.70
|
0.82
|
|
6687 (SPG7)
|
0.66
|
1.00
|
0.61
|
0.64
|
0.66
|
1.00
|
0.56
|
0.57
|
0.65
|
0.63
|
|
7448 (VTN)
|
0.50
|
1.00
|
0.63
|
0.66
|
0.72
|
0.56
|
1.00
|
0.36
|
0.59
|
0.69
|
|
720 (C4A)
|
0.77
|
0.61
|
0.39
|
0.41
|
0.56
|
0.57
|
0.36
|
1.00
|
0.39
|
0.42
|
|
10105 (PPIF)
|
0.52
|
1.00
|
0.63
|
0.70
|
0.70
|
0.65
|
0.59
|
0.39
|
1.00
|
0.66
|
|
727 (C5)
|
0.56
|
1.00
|
0.70
|
0.72
|
0.82
|
0.63
|
0.69
|
0.42
|
0.66
|
1.00
|
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| C8A |
Human |
Peripheral venous blood |
- |
4875 m |
9 hours |
upregulated |
1.8 |
LTQ-XL Mass Spectrometry |
Western US |
Americans |
1 |
Men and women living near Denver, Colorado (1,609 m) |
24265281 |
Association with TF
| TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 731 |
GO:0070062 |
extracellular exosome |
GOTERM_CC_DIRECT |
| 731 |
GO:0005615 |
extracellular space |
GOTERM_CC_DIRECT |
| 731 |
GO:0030449 |
regulation of complement activation |
GOTERM_BP_DIRECT |
| 731 |
GO:0005579 |
membrane attack complex |
GOTERM_CC_DIRECT |
| 731 |
GO:0016020 |
membrane |
GOTERM_CC_DIRECT |
| 731 |
GO:0006957 |
complement activation |
GOTERM_BP_DIRECT |
| 731 |
GO:0072562 |
blood microparticle |
GOTERM_CC_DIRECT |
| 731 |
GO:0006955 |
immune response |
GOTERM_BP_DIRECT |
| 731 |
GO:0006956 |
complement activation |
GOTERM_BP_DIRECT |
| 731 |
GO:0019835 |
cytolysis |
GOTERM_BP_DIRECT |
| 731 |
GO:0001848 |
phosphatidylserine binding |
GOTERM_MF_DIRECT |
| 731 |
GO:0032403 |
protein complex binding |
GOTERM_MF_DIRECT |
| 731 |
GO:0006958 |
complement activation |
GOTERM_BP_DIRECT |
| 731 |
GO:0005576 |
extracellular region |
GOTERM_CC_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
| 731 |
hsa04610 |
Complement and coagulation cascades |
| 731 |
hsa05020 |
Prion diseases |
| 731 |
hsa05146 |
Amoebiasis |
| 731 |
hsa05322 |
Systemic lupus erythematosus |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
| C8A |
731 |
Meningitis |
C0025289 |
Disease or Syndrome |
0.4 |
0.815 |
0.138 |
disease |
| C8A |
731 |
Neisseriaceae Infections |
C0085396 |
Disease or Syndrome |
0.3 |
0.815 |
0.138 |
group |
| C8A |
731 |
Immunologic Deficiency Syndromes |
C0021051 |
Disease or Syndrome |
0.3 |
0.815 |
0.138 |
group |
| C8A |
731 |
COMPLEMENT COMPONENT 8 DEFICIENCY, TYPE I |
C3151081 |
Disease or Syndrome |
0.3 |
0.815 |
0.138 |
disease |
| C8A |
731 |
Antibody Deficiency Syndrome |
C0003257 |
Disease or Syndrome |
0.3 |
0.815 |
0.138 |
disease |
| C8A |
731 |
Pachymeningitis |
C0030167 |
Disease or Syndrome |
0.3 |
0.815 |
0.138 |
disease |
Association with Drug
| Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |