Vasodilator-stimulated phosphoprotein
AltitudeomicsDB
Protein Official symbol |
VASP |
Aliases |
VASP |
Chromosomal Location |
19 |
Length |
380 |
Uniprot ID |
P50552 |
EC number |
None |
Protein family Information(Pfam) |
PF08776;PF00568; |
PDB id |
1EGX;1JNG;1USD;1USE;2PAV;2PBD;3CHW; |
InterPro ID |
IPR042180;IPR011993;IPR034367;IPR017354;IPR038023;IPR014885;IPR000697; |
dbSNP |
rs10415373 rs34345197 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
CTNNB1 |
CDH1 |
0.995 |
FYB |
LCP2 |
0.995 |
CXCR2 |
CXCL8 |
0.993 |
SLIT2 |
ROBO1 |
0.992 |
CTNND1 |
CDH1 |
0.991 |
ZYX |
VASP |
0.989 |
CTNNB1 |
CTNNA1 |
0.983 |
VASP |
PFN1 |
0.982 |
CTNND1 |
CTNNA1 |
0.979 |
CDC42 |
CDH1 |
0.978 |
CTNND1 |
CTNNB1 |
0.977 |
VASP |
PFN2 |
0.977 |
PRKG1 |
VASP |
0.972 |
FBLIM1 |
VASP |
0.968 |
CDC42 |
CTNND1 |
0.964 |
CDC42 |
PFN1 |
0.964 |
JUP |
CDH1 |
0.963 |
CTNNB1 |
VASP |
0.959 |
ROBO1 |
ENAH |
0.957 |
CTNND1 |
ENAH |
0.955 |
CDC42 |
CTNNB1 |
0.955 |
PRKG2 |
VASP |
0.954 |
CTNNA1 |
CDH1 |
0.953 |
CDC42 |
LCP2 |
0.952 |
LPP |
VASP |
0.952 |
CTNND1 |
JUP |
0.951 |
JUP |
CTNNA1 |
0.95 |
CDC42 |
ENAH |
0.948 |
CXCR2 |
VASP |
0.947 |
SLIT2 |
ENAH |
0.946 |
SLIT2 |
CDC42 |
0.946 |
FYB |
VASP |
0.945 |
CDC42 |
PFN2 |
0.943 |
ROBO1 |
CDC42 |
0.937 |
EVL |
PFN1 |
0.935 |
ENAH |
PFN1 |
0.933 |
VASP |
LCP2 |
0.932 |
EVL |
PFN2 |
0.931 |
CTNND1 |
ZYX |
0.931 |
CDH1 |
VASP |
0.93 |
CDC42 |
VASP |
0.929 |
ENAH |
PFN2 |
0.929 |
ZYX |
CTNNA1 |
0.928 |
ZYX |
CDH1 |
0.928 |
CTNND1 |
VASP |
0.927 |
FYB |
EVL |
0.924 |
ROBO1 |
CTNNB1 |
0.924 |
ENAH |
CDH1 |
0.923 |
CDC42 |
CTNNA1 |
0.922 |
ENAH |
CTNNA1 |
0.922 |
ROBO1 |
VASP |
0.921 |
EVL |
LCP2 |
0.92 |
ENAH |
CTNNB1 |
0.918 |
APBB1IP |
VASP |
0.918 |
CXCL8 |
VASP |
0.917 |
CDC42 |
JUP |
0.916 |
JUP |
VASP |
0.916 |
CTNNB1 |
ZYX |
0.915 |
ROBO1 |
EVL |
0.912 |
SLIT2 |
VASP |
0.911 |
FYB |
ENAH |
0.91 |
ROBO1 |
CTNND1 |
0.909 |
ENAH |
VASP |
0.909 |
ROBO1 |
PFN2 |
0.909 |
CTNNA1 |
VASP |
0.909 |
SLIT2 |
EVL |
0.908 |
ROBO1 |
CTNNA1 |
0.908 |
SLIT2 |
PFN2 |
0.907 |
EVL |
VASP |
0.906 |
JUP |
ZYX |
0.906 |
EVL |
ENAH |
0.904 |
SLIT2 |
PFN1 |
0.904 |
PFN2 |
PFN1 |
0.903 |
ROBO1 |
PFN1 |
0.903 |
JUP |
CTNNB1 |
0.902 |
ENAH |
LCP2 |
0.901 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
1499 (CTNNB1) |
2533 (FYB) |
3579 (CXCR2) |
9353 (SLIT2) |
1500 (CTNND1) |
7791 (ZYX) |
7408 (VASP) |
998 (CDC42) |
5592 (PRKG1) |
54751 (FBLIM1) |
3728 (JUP) |
6091 (ROBO1) |
5593 (PRKG2) |
1495 (CTNNA1) |
4026 (LPP) |
51466 (EVL) |
55740 (ENAH) |
999 (CDH1) |
54518 (APBB1IP) |
3576 (CXCL8) |
5217 (PFN2) |
5216 (PFN1) |
3937 (LCP2) |
1499 (CTNNB1)
|
1.00
|
0.71
|
0.59
|
0.64
|
0.74
|
0.67
|
0.72
|
0.63
|
0.59
|
0.69
|
0.80
|
0.67
|
0.10
|
0.71
|
1.00
|
0.69
|
0.69
|
0.72
|
1.00
|
0.66
|
0.64
|
0.67
|
1.00
|
2533 (FYB)
|
0.71
|
1.00
|
0.51
|
0.65
|
0.94
|
0.80
|
0.86
|
0.57
|
0.49
|
0.88
|
0.65
|
0.74
|
0.13
|
0.78
|
1.00
|
0.86
|
0.88
|
0.77
|
1.00
|
0.78
|
0.64
|
0.65
|
1.00
|
3579 (CXCR2)
|
0.59
|
0.51
|
1.00
|
0.50
|
0.52
|
0.46
|
0.52
|
0.46
|
0.37
|
0.50
|
0.52
|
0.71
|
0.09
|
0.56
|
1.00
|
0.52
|
0.50
|
0.61
|
1.00
|
0.47
|
0.46
|
0.49
|
1.00
|
9353 (SLIT2)
|
0.64
|
0.65
|
0.50
|
1.00
|
0.65
|
0.59
|
0.64
|
0.57
|
0.50
|
0.62
|
0.62
|
0.64
|
0.10
|
0.68
|
1.00
|
0.64
|
0.62
|
0.79
|
1.00
|
0.59
|
0.57
|
0.60
|
1.00
|
1500 (CTNND1)
|
0.74
|
0.94
|
0.52
|
0.65
|
1.00
|
0.77
|
0.94
|
0.58
|
0.51
|
0.84
|
0.70
|
0.74
|
0.12
|
0.83
|
1.00
|
0.84
|
0.84
|
0.81
|
1.00
|
0.77
|
0.65
|
0.71
|
1.00
|
7791 (ZYX)
|
0.67
|
0.80
|
0.46
|
0.59
|
0.77
|
1.00
|
0.77
|
0.53
|
0.42
|
0.76
|
0.60
|
0.67
|
0.12
|
0.87
|
1.00
|
0.77
|
0.76
|
0.74
|
1.00
|
0.65
|
0.58
|
0.74
|
1.00
|
7408 (VASP)
|
0.72
|
0.86
|
0.52
|
0.64
|
0.94
|
0.77
|
1.00
|
0.57
|
0.51
|
0.84
|
0.69
|
0.74
|
0.12
|
0.83
|
1.00
|
0.90
|
0.84
|
0.81
|
1.00
|
0.74
|
0.65
|
0.71
|
1.00
|
998 (CDC42)
|
0.63
|
0.57
|
0.46
|
0.57
|
0.58
|
0.53
|
0.57
|
1.00
|
0.66
|
0.55
|
0.56
|
0.57
|
0.30
|
0.62
|
1.00
|
0.58
|
0.56
|
0.65
|
1.00
|
0.53
|
0.60
|
0.55
|
1.00
|
5592 (PRKG1)
|
0.59
|
0.49
|
0.37
|
0.50
|
0.51
|
0.42
|
0.51
|
0.66
|
1.00
|
0.47
|
0.51
|
0.47
|
0.74
|
0.57
|
1.00
|
0.51
|
0.47
|
0.61
|
1.00
|
0.44
|
0.43
|
0.48
|
1.00
|
54751 (FBLIM1)
|
0.69
|
0.88
|
0.50
|
0.62
|
0.84
|
0.76
|
0.84
|
0.55
|
0.47
|
1.00
|
0.63
|
0.72
|
0.12
|
0.77
|
1.00
|
0.84
|
0.85
|
0.78
|
1.00
|
0.72
|
0.63
|
0.64
|
1.00
|
3728 (JUP)
|
0.80
|
0.65
|
0.52
|
0.62
|
0.70
|
0.60
|
0.69
|
0.56
|
0.51
|
0.63
|
1.00
|
0.62
|
0.12
|
0.69
|
1.00
|
0.64
|
0.63
|
0.75
|
1.00
|
0.60
|
0.57
|
0.62
|
1.00
|
6091 (ROBO1)
|
0.67
|
0.74
|
0.71
|
0.64
|
0.74
|
0.67
|
0.74
|
0.57
|
0.47
|
0.72
|
0.62
|
1.00
|
0.11
|
0.75
|
1.00
|
0.74
|
0.73
|
0.76
|
1.00
|
0.65
|
0.59
|
0.61
|
1.00
|
5593 (PRKG2)
|
0.10
|
0.13
|
0.09
|
0.10
|
0.12
|
0.12
|
0.12
|
0.30
|
0.74
|
0.12
|
0.12
|
0.11
|
1.00
|
0.11
|
0.14
|
0.12
|
0.12
|
0.11
|
0.14
|
0.10
|
0.11
|
0.10
|
0.14
|
1495 (CTNNA1)
|
0.71
|
0.78
|
0.56
|
0.68
|
0.83
|
0.87
|
0.83
|
0.62
|
0.57
|
0.77
|
0.69
|
0.75
|
0.11
|
1.00
|
1.00
|
0.77
|
0.77
|
0.86
|
1.00
|
0.71
|
0.66
|
0.79
|
1.00
|
4026 (LPP)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.14
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
51466 (EVL)
|
0.69
|
0.86
|
0.52
|
0.64
|
0.84
|
0.77
|
0.90
|
0.58
|
0.51
|
0.84
|
0.64
|
0.74
|
0.12
|
0.77
|
1.00
|
1.00
|
0.84
|
0.77
|
1.00
|
0.74
|
0.65
|
0.65
|
1.00
|
55740 (ENAH)
|
0.69
|
0.88
|
0.50
|
0.62
|
0.84
|
0.76
|
0.84
|
0.56
|
0.47
|
0.85
|
0.63
|
0.73
|
0.12
|
0.77
|
1.00
|
0.84
|
1.00
|
0.76
|
1.00
|
0.72
|
0.63
|
0.63
|
1.00
|
999 (CDH1)
|
0.72
|
0.77
|
0.61
|
0.79
|
0.81
|
0.74
|
0.81
|
0.65
|
0.61
|
0.78
|
0.75
|
0.76
|
0.11
|
0.86
|
1.00
|
0.77
|
0.76
|
1.00
|
1.00
|
0.72
|
0.70
|
0.73
|
1.00
|
54518 (APBB1IP)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.14
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
3576 (CXCL8)
|
0.66
|
0.78
|
0.47
|
0.59
|
0.77
|
0.65
|
0.74
|
0.53
|
0.44
|
0.72
|
0.60
|
0.65
|
0.10
|
0.71
|
1.00
|
0.74
|
0.72
|
0.72
|
1.00
|
1.00
|
0.57
|
0.60
|
1.00
|
5217 (PFN2)
|
0.64
|
0.64
|
0.46
|
0.57
|
0.65
|
0.58
|
0.65
|
0.60
|
0.43
|
0.63
|
0.57
|
0.59
|
0.11
|
0.66
|
1.00
|
0.65
|
0.63
|
0.70
|
1.00
|
0.57
|
1.00
|
0.79
|
1.00
|
5216 (PFN1)
|
0.67
|
0.65
|
0.49
|
0.60
|
0.71
|
0.74
|
0.71
|
0.55
|
0.48
|
0.64
|
0.62
|
0.61
|
0.10
|
0.79
|
1.00
|
0.65
|
0.63
|
0.73
|
1.00
|
0.60
|
0.79
|
1.00
|
1.00
|
3937 (LCP2)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.14
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
VASP |
Human |
Blood |
- |
3600 m |
Native |
upregulated |
- |
TMT-based proteomic analysis/LC-MS |
Central Asia |
Tibetans |
- |
High altitude native vs. low Lander |
30908922 |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
7408 |
GO:0001843 |
neural tube closure |
GOTERM_BP_DIRECT |
7408 |
GO:0034329 |
cell junction assembly |
GOTERM_BP_DIRECT |
7408 |
GO:0030175 |
filopodium |
GOTERM_CC_DIRECT |
7408 |
GO:0005522 |
insulin-like growth factor binding |
GOTERM_MF_DIRECT |
7408 |
GO:0005886 |
plasma membrane |
GOTERM_CC_DIRECT |
7408 |
GO:0005913 |
cell-cell adherens junction |
GOTERM_CC_DIRECT |
7408 |
GO:0005925 |
focal adhesion |
GOTERM_CC_DIRECT |
7408 |
GO:0031258 |
lamellipodium membrane |
GOTERM_CC_DIRECT |
7408 |
GO:0005737 |
cytoplasm |
GOTERM_CC_DIRECT |
7408 |
GO:0005923 |
bicellular tight junction |
GOTERM_CC_DIRECT |
7408 |
GO:0070062 |
extracellular exosome |
GOTERM_CC_DIRECT |
7408 |
GO:0007411 |
axon guidance |
GOTERM_BP_DIRECT |
7408 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
7408 |
GO:0008154 |
actin polymerization or depolymerization |
GOTERM_BP_DIRECT |
7408 |
GO:0030838 |
positive regulation of actin filament polymerization |
GOTERM_BP_DIRECT |
7408 |
GO:0003779 |
actin binding |
GOTERM_MF_DIRECT |
7408 |
GO:0017124 |
SH3 domain binding |
GOTERM_MF_DIRECT |
7408 |
GO:0030027 |
lamellipodium |
GOTERM_CC_DIRECT |
7408 |
GO:0031527 |
filopodium membrane |
GOTERM_CC_DIRECT |
7408 |
GO:0005856 |
cytoskeleton |
GOTERM_CC_DIRECT |
7408 |
GO:0051289 |
protein homotetramerization |
GOTERM_BP_DIRECT |
7408 |
GO:0098609 |
cell-cell adhesion |
GOTERM_BP_DIRECT |
7408 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
7408 |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
GOTERM_MF_DIRECT |
7408 |
GO:0015629 |
actin cytoskeleton |
GOTERM_CC_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
7408 |
hsa04015 |
Rap1 signaling pathway |
7408 |
hsa04022 |
cGMP-PKG signaling pathway |
7408 |
hsa04611 |
Platelet activation |
7408 |
hsa04510 |
Focal adhesion |
7408 |
hsa04666 |
Fc gamma R-mediated phagocytosis |
7408 |
hsa04670 |
Leukocyte transendothelial migration |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
VASP |
7408 |
Liver Cirrhosis, Experimental |
C0023893 |
Experimental Model of Disease |
0.3 |
0.735 |
0.276 |
disease |
Association with Drug
Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |