β-Tubulin

AltitudeomicsDB
Protein Official symbol TUBA1B
Aliases TUBA1B
Chromosomal Location 12
Length 451
Uniprot ID P68363
EC number None
Protein family Information(Pfam) PF00091;PF03953;
PDB id 2E4H;5IJ0;5IJ9;5N5N;6E7B;6E7C;6I2I;6J4V;6QUS;6QUY;6QVE;6QVJ;6S8L;
InterPro ID IPR002452;IPR008280;IPR000217;IPR018316;IPR037103;IPR036525;IPR023123;IPR017975;IPR003008;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TCP1 CCT3 0.999
CCT3 CCT5 0.999
CCT2 CCT5 0.999
TCP1 CCT5 0.999
CCT2 CCT3 0.999
TCP1 CCT2 0.999
TUBB4B TUBA1B 0.995
TUBB4B TUBB 0.993
TUBB TUBA1B 0.992
TUBA1B TUBA1C 0.978
TUBB4B TUBA1C 0.957
TUBA1A TBCB 0.947
TUBB8 TUBA1C 0.946
TUBB8 TUBA1B 0.943
TUBB4B TBCB 0.942
TUBA1B TBCB 0.942
TUBB8 TUBB4B 0.94
TUBA1C CCT2 0.938
TUBA1B CCT2 0.937
TUBA1B TCP1 0.937
TUBA1B CCT3 0.934
TUBA1C TBCB 0.933
TUBA1C TUBA1A 0.93
TUBB CCT2 0.929
TUBA1B TUBA1A 0.928
TUBB4B TUBA1A 0.927
TUBA1B CCT5 0.926
TUBB4B CCT5 0.925
TUBA1C CCT5 0.925
TUBA1C CCT3 0.925
TCP1 TUBA1C 0.923
TUBB TUBA1A 0.923
TUBB4B CCT3 0.92
TUBB8 TUBA1A 0.918
TUBB4B CCT2 0.917
TUBB4B TCP1 0.915
TUBA1A CCT3 0.908
TCP1 TUBA1A 0.907
TUBA1A CCT2 0.904
TUBA1A CCT5 0.903
TUBB TUBA1C 0.877
TUBB TBCB 0.443
TUBB TCP1 0.409
Gene Ontology Semantic Similarity
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# 7203 (CCT3) 22948 (CCT5) 10576 (CCT2) 10376 (TUBA1B) 203068 (TUBB) 84790 (TUBA1C) 1155 (TBCB) 10383 (TUBB4B) 6950 (TCP1) 7846 (TUBA1A) 347688 (TUBB8)
7203 (CCT3) 1.00 0.79 0.77 0.65 0.55 0.54 1.00 0.64 0.92 0.54 0.35
22948 (CCT5) 0.79 1.00 0.69 0.60 0.54 0.53 1.00 0.56 0.77 0.53 0.31
10576 (CCT2) 0.77 0.69 1.00 0.67 0.70 0.62 1.00 0.59 0.86 0.62 0.35
10376 (TUBA1B) 0.65 0.60 0.67 1.00 0.91 0.89 1.00 0.86 0.73 0.89 0.71
203068 (TUBB) 0.55 0.54 0.70 0.91 1.00 0.92 1.00 0.84 0.65 0.92 0.72
84790 (TUBA1C) 0.54 0.53 0.62 0.89 0.92 1.00 1.00 0.81 0.55 1.00 0.84
1155 (TBCB) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 0.48
10383 (TUBB4B) 0.64 0.56 0.59 0.86 0.84 0.81 0.82 1.00 0.62 0.81 0.68
6950 (TCP1) 0.92 0.77 0.86 0.73 0.65 0.55 1.00 0.62 1.00 0.55 0.34
7846 (TUBA1A) 0.54 0.53 0.62 0.89 0.92 1.00 1.00 0.81 0.55 1.00 0.84
347688 (TUBB8) 0.35 0.31 0.35 0.71 0.72 0.84 0.48 0.68 0.34 0.84 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
TUBA1B Human Blood - 3250 m 4 day downregulated -1.5714 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
TUBA1B Rat Brain cortex 300hPa 9144 m 1 hour upregulated 533.05 ± 0.15 2-DE Southwestern europe Male wistar rats 642.19 ± 0.11 adult male wistar rats weighing 350 g 25064252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
E2F1 1869 TUBA1B 10376 proximal_filtered 22955619 TRANSFAC
RORA 6095 TUBA1B 10376 Activation 10080955 TRUSST
PPARA 5465 TUBA1B 10376 Unknown 10707962 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT016595 hsa-miR-193b-3p Homo sapiens TUBA1B 10376 Homo sapiens Proteomics Functional MTI (Weak) 21512034
MIRT036296 hsa-miR-1229-3p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT036931 hsa-miR-877-3p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT036718 hsa-miR-760 Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT037246 hsa-miR-877-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT037513 hsa-miR-744-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038384 hsa-miR-296-3p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT037972 hsa-miR-505-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038647 hsa-miR-140-3p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039463 hsa-miR-652-3p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039413 hsa-miR-421 Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040370 hsa-miR-615-3p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042042 hsa-miR-484 Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT043044 hsa-miR-324-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044555 hsa-miR-320a Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047209 hsa-miR-182-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047458 hsa-miR-10b-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048190 hsa-miR-196a-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048292 hsa-miR-107 Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049937 hsa-miR-30a-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051439 hsa-let-7e-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052015 hsa-let-7b-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052893 hsa-miR-3934-5p Homo sapiens TUBA1B 10376 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT504413 hsa-miR-4534 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504407 hsa-miR-5095 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504407 hsa-miR-5095 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504408 hsa-miR-466 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504416 hsa-miR-1322 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504409 hsa-miR-6124 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504409 hsa-miR-6124 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504417 hsa-miR-1272 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504418 hsa-miR-552-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504420 hsa-miR-4789-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504414 hsa-miR-6504-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504418 hsa-miR-552-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504406 hsa-miR-7151-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504420 hsa-miR-4789-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504406 hsa-miR-7151-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504410 hsa-miR-3148 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504412 hsa-miR-8082 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504414 hsa-miR-6504-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504408 hsa-miR-466 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504416 hsa-miR-1322 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504415 hsa-miR-3688-3p Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504411 hsa-miR-3134 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504413 hsa-miR-4534 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504419 hsa-miR-4643 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504419 hsa-miR-4643 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504411 hsa-miR-3134 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504412 hsa-miR-8082 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504410 hsa-miR-3148 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504417 hsa-miR-1272 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT563810 hsa-miR-569 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563809 hsa-miR-2053 Homo sapiens TUBA1B 10376 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
Gene Ontology
ID GO ID GO Term GO Type
10376 GO:0030705 cytoskeleton-dependent intracellular transport GOTERM_BP_DIRECT
10376 GO:0007017 microtubule-based process GOTERM_BP_DIRECT
10376 GO:0043209 myelin sheath GOTERM_CC_DIRECT
10376 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
10376 GO:0005200 structural constituent of cytoskeleton GOTERM_MF_DIRECT
10376 GO:0003924 GTPase activity GOTERM_MF_DIRECT
10376 GO:0005525 GTP binding GOTERM_MF_DIRECT
10376 GO:0003725 double-stranded RNA binding GOTERM_MF_DIRECT
10376 GO:0051301 cell division GOTERM_BP_DIRECT
10376 GO:0005881 cytoplasmic microtubule GOTERM_CC_DIRECT
10376 GO:0000226 microtubule cytoskeleton organization GOTERM_BP_DIRECT
10376 GO:0005515 protein binding GOTERM_MF_DIRECT
10376 GO:0005874 microtubule GOTERM_CC_DIRECT
10376 GO:0071353 cellular response to interleukin-4 GOTERM_BP_DIRECT
10376 GO:0031625 ubiquitin protein ligase binding GOTERM_MF_DIRECT
10376 GO:0005198 structural molecule activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
10376 hsa04145 Phagosome
10376 hsa04540 Gap junction
10376 hsa05130 Pathogenic Escherichia coli infection
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
TUBA1B 10376 Osteoporosis, Age-Related C0001787 Disease or Syndrome 0.3 0.642 0.586 disease
TUBA1B 10376 Osteoporosis, Senile C0029459 Disease or Syndrome 0.3 0.642 0.586 disease
TUBA1B 10376 Osteoporosis C0029456 Disease or Syndrome 0.3 0.642 0.586 disease
TUBA1B 10376 Post-Traumatic Osteoporosis C0751406 Disease or Syndrome 0.3 0.642 0.586 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
TUBA1B 10376 BRENTUXIMAB VEDOTIN BRENTUXIMAB VEDOTIN CHEMBL1742994 inhibitor
TUBA1B 10376 CABAZITAXEL CABAZITAXEL CHEMBL1201748 inhibitor
TUBA1B 10376 COLCHICINE COLCHICINE CHEMBL107 inhibitor
TUBA1B 10376 CROLIBULIN CROLIBULIN CHEMBL2103852 inhibitor
TUBA1B 10376 DAVUNETIDE DAVUNETIDE CHEMBL2103826 None
TUBA1B 10376 DOCETAXEL HYDRATE DOCETAXEL HYDRATE CHEMBL3545252 inhibitor
TUBA1B 10376 ERIBULIN MESYLATE ERIBULIN MESYLATE CHEMBL1683544 inhibitor
TUBA1B 10376 FOSBRETABULIN DISODIUM FOSBRETABULIN DISODIUM CHEMBL289351 inhibitor
TUBA1B 10376 FOSBRETABULIN TROMETHAMINE FOSBRETABULIN TROMETHAMINE CHEMBL2105643 None
TUBA1B 10376 INDIBULIN INDIBULIN CHEMBL49642 inhibitor
TUBA1B 10376 IXABEPILONE IXABEPILONE CHEMBL1201752 inhibitor
TUBA1B 10376 LEXIBULIN LEXIBULIN CHEMBL552212 inhibitor
TUBA1B 10376 PACLITAXEL POLIGLUMEX PACLITAXEL POLIGLUMEX CHEMBL2108628 None
TUBA1B 10376 PACLITAXEL PACLITAXEL CHEMBL428647 inhibitor
TUBA1B 10376 PLINABULIN PLINABULIN CHEMBL1096380 inhibitor
TUBA1B 10376 SAGOPILONE SAGOPILONE CHEMBL2304041 None
TUBA1B 10376 TRASTUZUMAB EMTANSINE TRASTUZUMAB EMTANSINE CHEMBL1743082 inhibitor
TUBA1B 10376 VERUBULIN VERUBULIN CHEMBL492399 None
TUBA1B 10376 VINFLUNINE VINFLUNINE CHEMBL2110725 inhibitor
TUBA1B 10376 VINCRISTINE SULFATE VINCRISTINE SULFATE CHEMBL501867 inhibitor
TUBA1B 10376 VINBLASTINE SULFATE VINBLASTINE SULFATE CHEMBL378544 inhibitor
TUBA1B 10376 VINORELBIN DITARTRATE VINORELBIN DITARTRATE CHEMBL538943 inhibitor