Tubulin beta-8 chain

AltitudeomicsDB
Protein Official symbol TUBB8
Aliases TUBB8
Chromosomal Location  10
Length 444
Uniprot ID Q3ZCM7
EC number None
Protein family Information(Pfam) PF00091;PF03953;
PDB id None
InterPro ID IPR013838;IPR002453;IPR008280;IPR000217;IPR018316;IPR037103;IPR036525;IPR023123;IPR017975;IPR003008;
dbSNP rs869025273 rs869025609 rs781853492 rs869025271 rs1057520306 rs782269374 rs869025610 rs782486119 rs869025612 rs4880608 rs1270068662 rs869025611 rs869025272

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TUBB4B TUBA1B 0.995
TUBA1B TUBA1C 0.978
TUBB4B TUBA1C 0.957
TUBB8 TUBA1C 0.946
TUBB8 TUBA1B 0.943
TUBB8 TUBB4B 0.94
TUBB2A TUBB2B 0.932
TUBA1A TTL 0.931
TUBA1C TUBA1A 0.93
TUBA1B TUBA1A 0.928
TUBA1A TUBB2B 0.927
TUBB4B TUBA1A 0.927
TUBB2A TUBA1B 0.924
TUBB2A TUBA1A 0.924
TUBB2A TUBA1C 0.924
TUBA1A TUBB4A 0.923
TUBB6 TUBA1C 0.921
TUBB2A TTL 0.921
TUBB6 TUBB4A 0.92
TUBA1B TUBB2B 0.92
TUBB8 TUBA3E 0.919
TUBB2A TUBA3E 0.918
TUBA1C TUBB4A 0.918
TUBA1C TUBB2B 0.918
TUBA3E TUBB2B 0.918
TUBB8 TUBA1A 0.918
TUBA1B TUBB4A 0.918
TUBA3E TUBB4A 0.917
TUBB4B TUBA3E 0.917
TUBB4A TUBB2B 0.917
TUBA1B TUBB8P12 0.916
TUBB8P12 TUBA1C 0.916
TUBB6 TUBA1A 0.916
TUBA3E TUBB8P12 0.916
TUBB8P12 TUBA1A 0.916
TUBA1A TUBB1 0.913
TUBB2A TUBB4A 0.913
TUBA3E TUBB1 0.912
TUBA1B TUBB6 0.912
TUBA1C TUBB1 0.912
TUBB4A TTL 0.911
TUBA1C TTL 0.911
TUBA1B TUBB1 0.911
TUBB6 TUBA3E 0.91
TUBB2A TUBB4B 0.91
TUBB2B TTL 0.906
TUBA3E TTL 0.906
TUBB2A TUBB6 0.906
TUBA1B TTL 0.906
TUBB8P12 TTL 0.905
TUBB4B TUBB6 0.905
TUBB4B TTL 0.905
TUBB8 TTL 0.905
TUBB8 TUBB2A 0.905
TUBB2A TUBB8P12 0.904
TUBB6 TTL 0.904
TTL TUBB1 0.904
TUBB6 TUBB2B 0.904
TUBB4B TUBB2B 0.903
TUBB4B TUBB4A 0.902
TUBB8P12 TUBB2B 0.902
TUBB8 TUBB2B 0.902
TUBB8P12 TUBB4A 0.902
TUBB8 TUBB4A 0.902
TUBB4B TUBB1 0.901
TUBB2A TUBB1 0.901
TUBB8 TUBB1 0.901
TUBB6 TUBB1 0.901
TUBA3E TUBA1A 0.901
TUBB6 TUBB8P12 0.9
TUBA1B TUBA3E 0.9
TUBB4B TUBB8P12 0.9
TUBB8 TUBB8P12 0.9
TUBB4A TUBB1 0.9
TUBB2B TUBB1 0.9
TUBB8P12 TUBB1 0.9
TUBA3E TUBA1C 0.9
TUBB8 TUBB6 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 10383 (TUBB4B) 10376 (TUBA1B) 347688 (TUBB8) 7280 (TUBB2A) 7846 (TUBA1A) 84790 (TUBA1C) 84617 (TUBB6) 112714 (TUBA3E) 10382 (TUBB4A) 347733 (TUBB2B) 150465 (TTL)
10383 (TUBB4B) 1.00 0.86 0.68 0.82 0.81 0.81 0.68 0.78 0.76 0.79 0.16
10376 (TUBA1B) 0.86 1.00 0.71 0.86 0.89 0.89 0.71 0.83 0.81 0.84 0.21
347688 (TUBB8) 0.68 0.71 1.00 0.83 0.84 0.84 1.00 0.93 0.75 0.75 0.28
7280 (TUBB2A) 0.82 0.86 0.83 1.00 0.97 0.97 0.83 0.93 0.91 0.96 0.16
7846 (TUBA1A) 0.81 0.89 0.84 0.97 1.00 1.00 0.84 0.93 0.89 0.93 0.21
84790 (TUBA1C) 0.81 0.89 0.84 0.97 1.00 1.00 0.84 0.93 0.89 0.93 0.21
84617 (TUBB6) 0.68 0.71 1.00 0.83 0.84 0.84 1.00 0.93 0.75 0.75 0.28
112714 (TUBA3E) 0.78 0.83 0.93 0.93 0.93 0.93 0.93 1.00 0.85 0.90 0.28
10382 (TUBB4A) 0.76 0.81 0.75 0.91 0.89 0.89 0.75 0.85 1.00 0.88 0.16
347733 (TUBB2B) 0.79 0.84 0.75 0.96 0.93 0.93 0.75 0.90 0.88 1.00 0.16
150465 (TTL) 0.16 0.21 0.28 0.16 0.21 0.21 0.28 0.28 0.16 0.16 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
TUBB8 Toad Heart - 3464 m 33 day downregulated -2.105572212 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT517362 hsa-miR-6862-5p Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT517360 hsa-miR-7156-3p Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT517360 hsa-miR-7156-3p Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT517362 hsa-miR-6862-5p Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT517361 hsa-miR-486-3p Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT517363 hsa-miR-4253 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT517364 hsa-miR-3185 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT517366 hsa-miR-5680 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT517364 hsa-miR-3185 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT517363 hsa-miR-4253 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT517366 hsa-miR-5680 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT517365 hsa-miR-8060 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT517365 hsa-miR-8060 Homo sapiens TUBB8 347688 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
Gene Ontology
ID GO ID GO Term GO Type
347688 GO:0005874 microtubule GOTERM_CC_DIRECT
347688 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
347688 GO:0005737 cytoplasm GOTERM_CC_DIRECT
347688 GO:0007056 spindle assembly involved in female meiosis GOTERM_BP_DIRECT
347688 GO:0005525 GTP binding GOTERM_MF_DIRECT
347688 GO:0072687 meiotic spindle GOTERM_CC_DIRECT
347688 GO:0007017 microtubule-based process GOTERM_BP_DIRECT
347688 GO:0005200 structural constituent of cytoskeleton GOTERM_MF_DIRECT
347688 GO:0003924 GTPase activity GOTERM_MF_DIRECT
347688 GO:0001556 oocyte maturation GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
347688 hsa04145 Phagosome
347688 hsa04540 Gap junction
347688 hsa05130 Pathogenic Escherichia coli infection
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
TUBB8 347688 OOCYTE MATURATION DEFECT 2 C4225210 Disease or Syndrome 0.6 1 None disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
TUBB8 347688 BRENTUXIMAB VEDOTIN BRENTUXIMAB VEDOTIN CHEMBL1742994 inhibitor
TUBB8 347688 CABAZITAXEL CABAZITAXEL CHEMBL1201748 inhibitor
TUBB8 347688 COLCHICINE COLCHICINE CHEMBL107 inhibitor
TUBB8 347688 CROLIBULIN CROLIBULIN CHEMBL2103852 inhibitor
TUBB8 347688 DAVUNETIDE DAVUNETIDE CHEMBL2103826 None
TUBB8 347688 DOCETAXEL HYDRATE DOCETAXEL HYDRATE CHEMBL3545252 inhibitor
TUBB8 347688 ERIBULIN MESYLATE ERIBULIN MESYLATE CHEMBL1683544 inhibitor
TUBB8 347688 FOSBRETABULIN TROMETHAMINE FOSBRETABULIN TROMETHAMINE CHEMBL2105643 None
TUBB8 347688 FOSBRETABULIN DISODIUM FOSBRETABULIN DISODIUM CHEMBL289351 inhibitor
TUBB8 347688 INDIBULIN INDIBULIN CHEMBL49642 inhibitor
TUBB8 347688 IXABEPILONE IXABEPILONE CHEMBL1201752 inhibitor
TUBB8 347688 LEXIBULIN LEXIBULIN CHEMBL552212 inhibitor
TUBB8 347688 PACLITAXEL POLIGLUMEX PACLITAXEL POLIGLUMEX CHEMBL2108628 None
TUBB8 347688 PACLITAXEL PACLITAXEL CHEMBL428647 inhibitor
TUBB8 347688 PLINABULIN PLINABULIN CHEMBL1096380 inhibitor
TUBB8 347688 SAGOPILONE SAGOPILONE CHEMBL2304041 None
TUBB8 347688 TRASTUZUMAB EMTANSINE TRASTUZUMAB EMTANSINE CHEMBL1743082 inhibitor
TUBB8 347688 VINORELBIN DITARTRATE VINORELBIN DITARTRATE CHEMBL538943 inhibitor
TUBB8 347688 VERUBULIN VERUBULIN CHEMBL492399 None
TUBB8 347688 VINCRISTINE SULFATE VINCRISTINE SULFATE CHEMBL501867 inhibitor
TUBB8 347688 VINFLUNINE VINFLUNINE CHEMBL2110725 inhibitor
TUBB8 347688 VINBLASTINE SULFATE VINBLASTINE SULFATE CHEMBL378544 inhibitor