Periostin

AltitudeomicsDB
Protein Official symbol POSTN
Aliases POSTN OSF2
Chromosomal Location  13
Length 836
Uniprot ID Q15063
EC number None
Protein family Information(Pfam) PF02469;
PDB id 5WT7;5YJG;5YJH;
InterPro ID IPR011489;IPR036378;IPR000782;IPR016666;
dbSNP rs9594223 rs9547952

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
COL1A2 COL1A1 0.999
COL5A2 COL1A2 0.996
COL3A1 COL1A2 0.994
COL5A2 COL1A1 0.994
COL3A1 COL1A1 0.994
COL5A2 COL3A1 0.993
COL1A2 LUM 0.993
MMP2 DCN 0.989
COL1A2 COL6A3 0.988
COL1A2 SPARC 0.987
COL3A1 COL6A3 0.985
COL6A3 COL1A1 0.982
COL3A1 LUM 0.977
SPARC COL1A1 0.976
FN1 SPARC 0.974
COL5A2 COL6A3 0.971
COL5A2 COL12A1 0.968
LUM COL1A1 0.966
COL12A1 COL3A1 0.963
COL12A1 COL1A1 0.96
BMP1 LOX 0.959
COL1A2 DCN 0.958
BMP1 COL1A2 0.958
COL12A1 COL1A2 0.955
COL1A1 MMP2 0.954
BMP1 COL1A1 0.953
FN1 IL13 0.95
COL1A2 MMP2 0.949
COL1A1 DCN 0.946
SPARC MMP2 0.945
COL12A1 COL6A3 0.942
BMP1 COL3A1 0.941
LUM DCN 0.941
COL5A2 BMP1 0.935
BGN DCN 0.933
COL5A2 LUM 0.929
COL3A1 DCN 0.922
IL13 COL1A2 0.916
POSTN COL3A1 0.907
SPARC DCN 0.904
POSTN DCN 0.897
POSTN COL1A2 0.872
POSTN COL5A2 0.872
FN1 DCN 0.865
POSTN COL1A1 0.864
POSTN FN1 0.863
FN1 LOX 0.859
FN1 COL3A1 0.848
LUM MMP2 0.841
COL6A3 DCN 0.838
COL3A1 CDH11 0.837
POSTN IL13 0.834
FN1 COL1A2 0.834
ASPN COL3A1 0.832
POSTN MMP2 0.829
BGN COL1A2 0.825
SERPINB2 IL13 0.816
FN1 BGN 0.807
FN1 COL1A1 0.798
BGN COL1A1 0.795
IL13 CLCA1 0.794
POSTN LUM 0.792
BGN COL3A1 0.789
POSTN CDH11 0.783
COL6A3 LUM 0.783
COL3A1 SPARC 0.776
POSTN COL6A3 0.773
POSTN SPARC 0.773
COL1A2 CDH11 0.77
COL5A2 SPARC 0.761
COL3A1 MMP2 0.758
BGN SPARC 0.756
LOX COL1A1 0.752
SERPINB2 CLCA1 0.748
POSTN CLCA1 0.741
COL5A2 CDH11 0.738
FN1 BMP1 0.734
POSTN LOX 0.733
FN1 LUM 0.732
POSTN BGN 0.731
POSTN COL12A1 0.716
SERPINB2 POSTN 0.714
CDH11 COL1A1 0.712
POSTN BMP1 0.707
POSTN ASPN 0.701
Gene Ontology Semantic Similarity
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# 1277 (COL1A1) 1278 (COL1A2) 1281 (COL3A1) 4060 (LUM) 1634 (DCN) 1293 (COL6A3) 6678 (SPARC) 1303 (COL12A1) 4015 (LOX) 4313 (MMP2) 3596 (IL13) 649 (BMP1) 1290 (COL5A2) 2335 (FN1) 1009 (CDH11) 633 (BGN) 1179 (CLCA1) 10631 (POSTN) 54829 (ASPN) 5055 (SERPINB2)
1277 (COL1A1) 1.00 0.98 0.94 0.85 0.76 1.00 0.62 1.00 0.60 0.51 1.00 0.54 0.61 0.79 0.57 0.56 0.10 0.78 0.47 0.12
1278 (COL1A2) 0.98 1.00 0.93 0.83 0.76 1.00 0.63 1.00 0.62 0.53 1.00 0.55 0.56 0.79 0.57 0.52 0.10 0.77 0.45 0.12
1281 (COL3A1) 0.94 0.93 1.00 0.83 0.73 1.00 0.61 1.00 0.56 0.48 1.00 0.48 0.59 0.81 0.53 0.55 0.10 0.76 0.46 0.12
4060 (LUM) 0.85 0.83 0.83 1.00 0.83 0.82 0.68 0.82 0.54 0.44 1.00 0.45 0.68 0.78 0.52 0.74 0.10 0.78 0.62 0.12
1634 (DCN) 0.76 0.76 0.73 0.83 1.00 0.66 0.59 0.66 0.55 0.43 1.00 0.45 0.54 0.68 0.54 0.65 0.10 0.69 0.59 0.12
1293 (COL6A3) 1.00 1.00 1.00 0.82 0.66 1.00 0.21 1.00 0.21 0.21 0.21 0.21 1.00 0.82 0.17 0.82 0.10 0.82 0.66 0.10
6678 (SPARC) 0.62 0.63 0.61 0.68 0.59 0.21 1.00 0.21 0.62 0.50 1.00 0.50 0.22 0.68 0.74 0.22 0.10 0.70 0.52 0.12
1303 (COL12A1) 1.00 1.00 1.00 0.82 0.66 1.00 0.21 1.00 0.21 0.21 0.21 0.21 1.00 0.82 0.17 0.82 0.10 0.82 0.66 0.10
4015 (LOX) 0.60 0.62 0.56 0.54 0.55 0.21 0.62 0.21 1.00 0.45 1.00 0.49 0.22 0.62 0.57 0.22 0.12 0.57 0.26 0.12
4313 (MMP2) 0.51 0.53 0.48 0.44 0.43 0.21 0.50 0.21 0.45 1.00 1.00 0.95 0.19 0.55 0.45 0.19 0.52 0.47 0.21 0.12
3596 (IL13) 1.00 1.00 1.00 1.00 1.00 0.21 1.00 0.21 1.00 1.00 1.00 1.00 0.26 1.00 0.82 0.26 0.13 1.00 0.36 0.12
649 (BMP1) 0.54 0.55 0.48 0.45 0.45 0.21 0.50 0.21 0.49 0.95 1.00 1.00 0.20 0.57 0.47 0.20 0.48 0.48 0.21 0.12
1290 (COL5A2) 0.61 0.56 0.59 0.68 0.54 1.00 0.22 1.00 0.22 0.19 0.26 0.20 1.00 0.34 0.18 0.91 0.10 0.52 0.61 0.12
2335 (FN1) 0.79 0.79 0.81 0.78 0.68 0.82 0.68 0.82 0.62 0.55 1.00 0.57 0.34 1.00 0.56 0.34 0.09 0.78 0.34 0.12
1009 (CDH11) 0.57 0.57 0.53 0.52 0.54 0.17 0.74 0.17 0.57 0.45 0.82 0.47 0.18 0.56 1.00 0.18 0.08 0.69 0.48 0.10
633 (BGN) 0.56 0.52 0.55 0.74 0.65 0.82 0.22 0.82 0.22 0.19 0.26 0.20 0.91 0.34 0.18 1.00 0.10 0.52 0.74 0.12
1179 (CLCA1) 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.12 0.52 0.13 0.48 0.10 0.09 0.08 0.10 1.00 0.10 0.08 0.05
10631 (POSTN) 0.78 0.77 0.76 0.78 0.69 0.82 0.70 0.82 0.57 0.47 1.00 0.48 0.52 0.78 0.69 0.52 0.10 1.00 0.62 0.12
54829 (ASPN) 0.47 0.45 0.46 0.62 0.59 0.66 0.52 0.66 0.26 0.21 0.36 0.21 0.61 0.34 0.48 0.74 0.08 0.62 1.00 0.10
5055 (SERPINB2) 0.12 0.12 0.12 0.12 0.12 0.10 0.12 0.10 0.12 0.12 0.12 0.12 0.12 0.12 0.10 0.12 0.05 0.12 0.10 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
POSTN Human Cardiac tissue 3-10% Oxygen 5800 m 2 hours downregulated - - - - - Soldier exposed to high altitude compared to their low altitude profile http://dx.doi.org/10.4172/jpb.S3-004
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
CEBPB 1051 POSTN 10631 distal 22955619 TRANSFAC
TCF12 6938 POSTN 10631 distal 22955619 TRANSFAC
USF1 7391 POSTN 10631 distal 22955619 TRANSFAC
YY1 7528 POSTN 10631 distal 22955619 TRANSFAC
SP1 6667 POSTN 10631 distal 22955619 TRANSFAC
NANOG 79923 POSTN 10631 distal 22955619 TRANSFAC
POU5F1 5460 POSTN 10631 distal 22955619 TRANSFAC
TAL1 6886 POSTN 10631 distal 22955619 TRANSFAC
JUND 3727 POSTN 10631 distal 22955619 TRANSFAC
JUN 3725 POSTN 10631 distal 22955619 TRANSFAC
MAX 4149 POSTN 10631 distal 22955619 TRANSFAC
EP300 2033 POSTN 10631 distal 22955619 TRANSFAC
GATA2 2624 POSTN 10631 distal 22955619 TRANSFAC
HDAC2 3066 POSTN 10631 distal 22955619 TRANSFAC
TWIST2 117581 POSTN 10631 Unknown 15664452 TRUSST
CDX1 1044 POSTN 10631 Unknown 15225769 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT734758 hsa-let-7f-5p Homo sapiens POSTN 10631 Homo sapiens Flow//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 25735962
Gene Ontology
ID GO ID GO Term GO Type
10631 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
10631 GO:0009612 response to mechanical stimulus GOTERM_BP_DIRECT
10631 GO:0071307 cellular response to vitamin K GOTERM_BP_DIRECT
10631 GO:0005515 protein binding GOTERM_MF_DIRECT
10631 GO:0008201 heparin binding GOTERM_MF_DIRECT
10631 GO:0003073 regulation of systemic arterial blood pressure GOTERM_BP_DIRECT
10631 GO:0014911 positive regulation of smooth muscle cell migration GOTERM_BP_DIRECT
10631 GO:1990523 bone regeneration GOTERM_BP_DIRECT
10631 GO:0046872 metal ion binding GOTERM_MF_DIRECT
10631 GO:0031012 extracellular matrix GOTERM_CC_DIRECT
10631 GO:0044344 cellular response to fibroblast growth factor stimulus GOTERM_BP_DIRECT
10631 GO:0001501 skeletal system development GOTERM_BP_DIRECT
10631 GO:0001953 negative regulation of cell-matrix adhesion GOTERM_BP_DIRECT
10631 GO:0071560 cellular response to transforming growth factor beta stimulus GOTERM_BP_DIRECT
10631 GO:1990138 neuron projection extension GOTERM_BP_DIRECT
10631 GO:0014850 response to muscle activity GOTERM_BP_DIRECT
10631 GO:0005615 extracellular space GOTERM_CC_DIRECT
10631 GO:0031594 neuromuscular junction GOTERM_CC_DIRECT
10631 GO:0030198 extracellular matrix organization GOTERM_BP_DIRECT
10631 GO:0032355 response to estradiol GOTERM_BP_DIRECT
10631 GO:1900025 negative regulation of substrate adhesion-dependent cell spreading GOTERM_BP_DIRECT
10631 GO:0071356 cellular response to tumor necrosis factor GOTERM_BP_DIRECT
10631 GO:1904209 positive regulation of chemokine GOTERM_BP_DIRECT
10631 GO:0008593 regulation of Notch signaling pathway GOTERM_BP_DIRECT
10631 GO:0007155 cell adhesion GOTERM_BP_DIRECT
10631 GO:0050839 cell adhesion molecule binding GOTERM_MF_DIRECT
10631 GO:0005802 trans-Golgi network GOTERM_CC_DIRECT
10631 GO:0005737 cytoplasm GOTERM_CC_DIRECT
10631 GO:0005578 proteinaceous extracellular matrix GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
POSTN 10631 Muscular Dystrophy, Duchenne C0013264 Disease or Syndrome 0.3 0.598 0.724 disease
POSTN 10631 Bronchopulmonary Dysplasia C0006287 Disease or Syndrome 0.3 0.598 0.724 disease
POSTN 10631 Drug Allergy C0013182 Pathologic Function 0.3 0.598 0.724 phenotype
POSTN 10631 Colorectal Cancer C1527249 Neoplastic Process 0.3 0.598 0.724 disease
POSTN 10631 Asthma, Aspirin-Induced C1319853 Disease or Syndrome 0.3 0.598 0.724 disease
POSTN 10631 Colorectal Carcinoma C0009402 Neoplastic Process 0.3 0.598 0.724 disease
POSTN 10631 Becker Muscular Dystrophy C0917713 Disease or Syndrome 0.3 0.598 0.724 disease
POSTN 10631 Colorectal Neoplasms C0009404 Neoplastic Process 0.3 0.598 0.724 group
POSTN 10631 Duchenne and Becker Muscular Dystrophy C3542021 Disease or Syndrome 0.3 0.598 0.724 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
POSTN 10631 ANTISERUM None None None