Histone H1.2

AltitudeomicsDB
Protein Official symbol HIST1H1C
Aliases H1-2 H1F2 HIST1H1C
Chromosomal Location  6
Length 213
Uniprot ID P16403
EC number None
Protein family Information(Pfam) PF00538;
PDB id None
InterPro ID IPR005818;IPR005819;IPR036388;IPR036390;
dbSNP rs2230653 rs34810376 rs12111009

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TP53 RB1 0.978
CABIN1 UBN1 0.975
HIRA ASF1A 0.972
HMGA2 TP53 0.972
UBN1 ASF1A 0.97
UBN1 HIRA 0.968
CABIN1 ASF1A 0.966
HIST1H1E HIST1H1D 0.964
CABIN1 HIRA 0.958
CABIN1 TP53 0.952
HIST1H1C TP53 0.952
HMGA2 RB1 0.951
H1F0 TP53 0.95
H1F0 ASF1A 0.944
HMGA1 TP53 0.942
H1F0 LMNB1 0.94
HMGA1 HIST1H1B 0.939
HIST1H1B HIST1H1D 0.933
HIST1H1C HIST1H1E 0.933
HIST1H1B HIST1H1E 0.933
HMGA1 H1F0 0.932
H1F0 DFFB 0.932
H1F0 HIST1H1D 0.93
EP400 TP53 0.928
H1F0 HIST1H1E 0.928
HMGB1 H1F0 0.928
HMGB1 HMGB2 0.928
H1F0 HIST1H1B 0.928
H1F0 HIST1H1C 0.928
HIST1H1B HIST1H1A 0.927
H1F0 RB1 0.926
HIST1H1C HIST1H1D 0.923
HIST1H1A HIST1H1D 0.923
HIST1H1E HIST1H1A 0.922
RB1 ASF1A 0.92
HMGA2 H1F0 0.92
HIST1H1C ASF1A 0.919
HMGA1 LMNB1 0.919
H1F0 HIST1H1A 0.919
EP400 H1F0 0.919
TP53 ASF1A 0.918
LMNB1 ASF1A 0.918
HIST1H1E TP53 0.918
HIST1H1D ASF1A 0.917
HIST1H1B TP53 0.917
HMGA2 HMGA1 0.917
HIST1H1C HIST1H1A 0.916
TP53 HIST1H1A 0.916
HIST1H1E ASF1A 0.915
EP400 ASF1A 0.915
LMNB1 HIST1H1D 0.915
HIST1H1C LMNB1 0.914
HIST1H1B ASF1A 0.914
HMGA2 LMNB1 0.914
HIST1H1A ASF1A 0.914
H1F0 HMGB2 0.913
HIST1H1E LMNB1 0.913
TP53 HIST1H1D 0.913
HIST1H1C DFFB 0.913
UBN1 EP400 0.913
DFFB HIST1H1D 0.913
UBN1 TP53 0.912
HIST1H1C HIST1H1B 0.912
EP400 HIRA 0.911
HMGA2 ASF1A 0.91
HIST1H1B LMNB1 0.91
LMNB1 HIST1H1A 0.91
HMGB1 HIST1H1C 0.91
HMGB1 DFFB 0.91
HIST1H1C HMGB2 0.91
CABIN1 EP400 0.909
HMGB2 HIST1H1A 0.909
HIST1H1B HIRA 0.908
CABIN1 HIST1H1A 0.908
HIRA LMNB1 0.908
HMGB2 HIST1H1D 0.907
HMGB1 HIST1H1D 0.907
H1F0 HIRA 0.907
UBN1 LMNB1 0.907
HMGB1 HIST1H1A 0.907
DFFB HIST1H1B 0.906
HIST1H1B HMGB2 0.906
DFFB HMGB2 0.905
DFFB HIST1H1A 0.905
DFFB HIST1H1E 0.905
HIST1H1E HMGB2 0.905
HMGA2 HIST1H1A 0.904
HMGB1 HIST1H1B 0.904
HMGB1 HIST1H1E 0.904
CABIN1 LMNB1 0.904
UBN1 RB1 0.904
UBN1 H1F0 0.903
HMGA1 RB1 0.903
HMGA1 CABIN1 0.903
EP400 HIST1H1C 0.903
RB1 HIST1H1D 0.903
RB1 HIRA 0.902
HIRA HIST1H1D 0.902
HMGA1 HIST1H1A 0.902
EP400 HIST1H1A 0.902
HMGA2 HIST1H1B 0.902
HIST1H1E HIRA 0.902
HMGA1 HIRA 0.902
HIST1H1C HIRA 0.902
CABIN1 RB1 0.902
HIRA HIST1H1A 0.902
HMGA1 HIST1H1D 0.901
HMGA1 HIST1H1E 0.901
HMGA2 HIST1H1D 0.901
EP400 HIST1H1D 0.9
CABIN1 HIST1H1D 0.9
TP53 HIRA 0.9
UBN1 HIST1H1B 0.9
HMGA2 EP400 0.9
EP400 HIST1H1E 0.9
CABIN1 HIST1H1C 0.9
HMGA1 ASF1A 0.9
HIST1H1B RB1 0.9
EP400 HIST1H1B 0.9
HMGA2 UBN1 0.9
HMGA2 CABIN1 0.9
HIST1H1C RB1 0.9
CABIN1 H1F0 0.9
UBN1 HIST1H1E 0.9
HMGA1 EP400 0.9
UBN1 HIST1H1C 0.9
CABIN1 HIST1H1B 0.9
HMGA1 UBN1 0.9
RB1 HIST1H1A 0.9
UBN1 HIST1H1A 0.9
HMGA1 HIST1H1C 0.9
UBN1 HIST1H1D 0.9
HIST1H1E RB1 0.9
HMGA2 HIST1H1C 0.9
CABIN1 HIST1H1E 0.9
HMGA2 HIST1H1E 0.9
HMGA2 HIRA 0.9
Gene Ontology Semantic Similarity
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# 7157 (TP53) 23523 (CABIN1) 7290 (HIRA) 8091 (HMGA2) 29855 (UBN1) 3008 (HIST1H1E) 3006 (HIST1H1C) 3005 (H1F0) 3159 (HMGA1) 3009 (HIST1H1B) 57634 (EP400) 3146 (HMGB1) 3024 (HIST1H1A) 5925 (RB1) 4001 (LMNB1) 3007 (HIST1H1D) 1677 (DFFB) 3148 (HMGB2) 25842 (ASF1A)
7157 (TP53) 1.00 0.30 0.65 0.69 0.59 0.65 0.59 0.59 0.74 0.61 1.00 0.69 0.58 0.76 1.00 0.59 0.60 0.73 0.56
23523 (CABIN1) 0.30 1.00 0.45 0.26 0.35 0.29 0.41 0.41 0.30 0.41 0.55 0.28 0.44 0.28 0.55 0.41 0.34 0.25 0.50
7290 (HIRA) 0.65 0.45 1.00 0.69 0.73 0.56 0.70 0.70 0.70 0.70 1.00 0.70 0.69 0.73 1.00 0.70 0.54 0.77 0.62
8091 (HMGA2) 0.69 0.26 0.69 1.00 0.50 0.55 0.61 0.61 0.77 0.61 1.00 0.72 0.61 0.74 1.00 0.61 0.50 0.74 0.44
29855 (UBN1) 0.59 0.35 0.73 0.50 1.00 0.38 0.51 0.51 0.57 0.54 1.00 0.53 0.54 0.62 1.00 0.51 0.61 0.52 0.71
3008 (HIST1H1E) 0.65 0.29 0.56 0.55 0.38 1.00 0.76 0.76 0.54 0.75 1.00 0.62 0.71 0.55 1.00 0.76 0.43 0.65 0.47
3006 (HIST1H1C) 0.59 0.41 0.70 0.61 0.51 0.76 1.00 1.00 0.61 0.97 1.00 0.67 0.96 0.62 1.00 1.00 0.54 0.74 0.64
3005 (H1F0) 0.59 0.41 0.70 0.61 0.51 0.76 1.00 1.00 0.61 0.97 1.00 0.67 0.96 0.62 1.00 1.00 0.54 0.74 0.64
3159 (HMGA1) 0.74 0.30 0.70 0.77 0.57 0.54 0.61 0.61 1.00 0.62 1.00 0.70 0.60 0.73 1.00 0.61 0.56 0.75 0.56
3009 (HIST1H1B) 0.61 0.41 0.70 0.61 0.54 0.75 0.97 0.97 0.62 1.00 1.00 0.68 0.94 0.62 1.00 0.97 0.57 0.73 0.65
57634 (EP400) 1.00 0.55 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
3146 (HMGB1) 0.69 0.28 0.70 0.72 0.53 0.62 0.67 0.67 0.70 0.68 1.00 1.00 0.65 0.70 1.00 0.67 0.50 0.88 0.49
3024 (HIST1H1A) 0.58 0.44 0.69 0.61 0.54 0.71 0.96 0.96 0.60 0.94 1.00 0.65 1.00 0.61 1.00 0.96 0.56 0.71 0.68
5925 (RB1) 0.76 0.28 0.73 0.74 0.62 0.55 0.62 0.62 0.73 0.62 1.00 0.70 0.61 1.00 1.00 0.62 0.65 0.76 0.54
4001 (LMNB1) 1.00 0.55 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
3007 (HIST1H1D) 0.59 0.41 0.70 0.61 0.51 0.76 1.00 1.00 0.61 0.97 1.00 0.67 0.96 0.62 1.00 1.00 0.54 0.74 0.64
1677 (DFFB) 0.60 0.34 0.54 0.50 0.61 0.43 0.54 0.54 0.56 0.57 1.00 0.50 0.56 0.65 1.00 0.54 1.00 0.47 0.66
3148 (HMGB2) 0.73 0.25 0.77 0.74 0.52 0.65 0.74 0.74 0.75 0.73 1.00 0.88 0.71 0.76 1.00 0.74 0.47 1.00 0.47
25842 (ASF1A) 0.56 0.50 0.62 0.44 0.71 0.47 0.64 0.64 0.56 0.65 1.00 0.49 0.68 0.54 1.00 0.64 0.66 0.47 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HIST1H1C Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
GTF2B 2959 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
TAF7 6879 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
TBP 6908 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
SMARCB1 6598 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
GTF2F1 2962 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
KAT2A 2648 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
SIN3A 25942 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
JUND 3727 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
BCL3 602 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
TCF12 6938 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
ETS1 2113 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
POU2F2 5452 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
BCLAF1 9774 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
SMARCA4 6597 HIST1H1C 3006 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT025536 hsa-miR-34a-5p Homo sapiens HIST1H1C 3006 Homo sapiens Proteomics Functional MTI (Weak) 21566225
MIRT027797 hsa-miR-98-5p Homo sapiens HIST1H1C 3006 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT038090 hsa-miR-423-5p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039500 hsa-miR-652-3p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040862 hsa-miR-18a-3p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042928 hsa-miR-324-3p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044173 hsa-miR-99b-5p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT045075 hsa-miR-186-5p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046184 hsa-miR-27b-3p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051144 hsa-miR-16-5p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051896 hsa-let-7b-5p Homo sapiens HIST1H1C 3006 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT100036 hsa-miR-760 Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT100042 hsa-miR-6822-3p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504382 hsa-miR-4507 Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504381 hsa-miR-6839-3p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504381 hsa-miR-6839-3p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504382 hsa-miR-4507 Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504384 hsa-miR-629-5p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504383 hsa-miR-3940-5p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT504383 hsa-miR-3940-5p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT504384 hsa-miR-629-5p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT511804 hsa-miR-1276 Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT511802 hsa-miR-4766-5p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT511803 hsa-miR-146a-3p Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT511801 hsa-miR-8057 Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT511800 hsa-miR-5693 Homo sapiens HIST1H1C 3006 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
Gene Ontology
ID GO ID GO Term GO Type
3006 GO:0006334 nucleosome assembly GOTERM_BP_DIRECT
3006 GO:0098532 histone H3-K27 trimethylation GOTERM_BP_DIRECT
3006 GO:0000122 negative regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
3006 GO:0005719 nuclear euchromatin GOTERM_CC_DIRECT
3006 GO:0080182 histone H3-K4 trimethylation GOTERM_BP_DIRECT
3006 GO:0035327 transcriptionally active chromatin GOTERM_CC_DIRECT
3006 GO:0016584 nucleosome positioning GOTERM_BP_DIRECT
3006 GO:0031490 chromatin DNA binding GOTERM_MF_DIRECT
3006 GO:0005515 protein binding GOTERM_MF_DIRECT
3006 GO:0044822 poly GOTERM_MF_DIRECT
3006 GO:0000786 nucleosome GOTERM_CC_DIRECT
3006 GO:0005634 nucleus GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HIST1H1C 3006 Acute Myeloid Leukemia, M1 C0026998 Neoplastic Process 0.3 0.815 0.172 disease
HIST1H1C 3006 Leukemia, Myelocytic, Acute C0023467 Neoplastic Process 0.3 0.815 0.172 disease
HIST1H1C 3006 Acute Myeloid Leukemia (AML-M2) C1879321 Neoplastic Process 0.3 0.815 0.172 disease
HIST1H1C 3006 Breast Carcinoma C0678222 Neoplastic Process 0.3 0.815 0.172 disease
HIST1H1C 3006 Malignant neoplasm of breast C0006142 Neoplastic Process 0.3 0.815 0.172 disease
HIST1H1C 3006 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.815 0.172 group
HIST1H1C 3006 Mammary Neoplasms C1458155 Neoplastic Process 0.3 0.815 0.172 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types