DNA fragmentation factor subunit beta

AltitudeomicsDB
Protein Official symbol DFFB
Aliases DFFB CAD DFF2 DFF40
Chromosomal Location  1
Length 338
Uniprot ID O76075
EC number 3.-.-.-
Protein family Information(Pfam) PF02017;PF09230;
PDB id 1IBX;
InterPro ID IPR003508;IPR039729;IPR015311;
dbSNP rs12738235 rs12564400

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
DFFA DFFB 0.999
HMGB1 HMGB2 0.998
KPNA1 KPNB1 0.996
H1F0 H1FX 0.993
DFFA CASP3 0.985
DFFB CASP3 0.979
H1FX H1FOO 0.974
HIST1H1E HIST1H1D 0.964
H1F0 H1FOO 0.956
H1F0 DFFB 0.951
DFFB CIDEB 0.944
HMGB1 H1F0 0.939
DFFB HIST1H1D 0.937
HIST1H1B HIST1H1E 0.933
HIST1H1B HIST1H1D 0.933
HIST1H1C HIST1H1E 0.933
DFFB HIST1H1B 0.932
DFFB HIST1H1A 0.931
H1F0 HIST1H1D 0.93
H1F0 HIST1H1E 0.928
H1F0 HIST1H1C 0.928
H1F0 HIST1H1B 0.928
HIST1H1B HIST1H1A 0.927
H1F0 HMGB2 0.926
HIST1H1C HMGB2 0.924
HMGB1 HIST1H1C 0.924
HMGB2 HIST1H1A 0.923
HIST1H1C HIST1H1D 0.923
HIST1H1A HIST1H1D 0.923
HIST1H1E HIST1H1A 0.922
HMGB1 HIST1H1D 0.921
HMGB2 HIST1H1D 0.921
HMGB1 HIST1H1A 0.921
CASP3 KPNB1 0.92
HIST1H1B HMGB2 0.92
HIST1H1E HMGB2 0.919
H1F0 HIST1H1A 0.919
HMGB1 HIST1H1B 0.918
HMGB1 HIST1H1E 0.918
HIST1H1C HIST1H1A 0.916
HMGB1 H1FX 0.915
H1FOO HMGB2 0.915
H1FX HMGB2 0.915
HMGB1 H1FOO 0.915
DFFA CIDEB 0.914
HIST1H1C DFFB 0.913
HIST1H1C HIST1H1B 0.912
HMGB1 DFFB 0.91
KPNA1 CASP3 0.906
DFFB HMGB2 0.905
DFFB HIST1H1E 0.905
DFFA KPNB1 0.904
DFFA KPNA1 0.9
KPNA1 DFFB 0.9
DFFB H1FOO 0.9
DFFB KPNB1 0.9
DFFB H1FX 0.9
Gene Ontology Semantic Similarity
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# 1676 (DFFA) 3146 (HMGB1) 3836 (KPNA1) 3005 (H1F0) 1677 (DFFB) 8971 (H1FX) 3008 (HIST1H1E) 3009 (HIST1H1B) 3006 (HIST1H1C) 3148 (HMGB2) 3024 (HIST1H1A) 836 (CASP3) 132243 (H1FOO) 3837 (KPNB1) 3007 (HIST1H1D) 27141 (CIDEB)
1676 (DFFA) 1.00 0.49 0.63 0.57 0.68 0.62 0.44 0.58 0.57 0.47 0.60 0.43 0.64 0.69 0.57 0.77
3146 (HMGB1) 0.49 1.00 0.47 0.67 0.50 0.68 0.62 0.68 0.67 0.88 0.65 0.44 0.65 0.63 0.67 0.49
3836 (KPNA1) 0.63 0.47 1.00 0.49 0.58 0.54 0.38 0.51 0.49 0.44 0.50 0.32 0.54 0.73 0.49 0.68
3005 (H1F0) 0.57 0.67 0.49 1.00 0.54 0.95 0.76 0.97 1.00 0.74 0.96 0.33 0.93 0.72 1.00 0.59
1677 (DFFB) 0.68 0.50 0.58 0.54 1.00 0.58 0.43 0.57 0.54 0.47 0.56 0.48 0.59 0.67 0.54 0.72
8971 (H1FX) 0.62 0.68 0.54 0.95 0.58 1.00 0.72 0.92 0.95 0.74 0.90 0.36 0.92 0.73 0.95 0.65
3008 (HIST1H1E) 0.44 0.62 0.38 0.76 0.43 0.72 1.00 0.75 0.76 0.65 0.71 0.29 0.67 0.61 0.76 0.43
3009 (HIST1H1B) 0.58 0.68 0.51 0.97 0.57 0.92 0.75 1.00 0.97 0.73 0.94 0.36 0.90 0.73 0.97 0.60
3006 (HIST1H1C) 0.57 0.67 0.49 1.00 0.54 0.95 0.76 0.97 1.00 0.74 0.96 0.33 0.93 0.72 1.00 0.59
3148 (HMGB2) 0.47 0.88 0.44 0.74 0.47 0.74 0.65 0.73 0.74 1.00 0.71 0.37 0.71 0.65 0.74 0.47
3024 (HIST1H1A) 0.60 0.65 0.50 0.96 0.56 0.90 0.71 0.94 0.96 0.71 1.00 0.33 0.97 0.65 0.96 0.63
836 (CASP3) 0.43 0.44 0.32 0.33 0.48 0.36 0.29 0.36 0.33 0.37 0.33 1.00 0.33 0.40 0.33 0.38
132243 (H1FOO) 0.64 0.65 0.54 0.93 0.59 0.92 0.67 0.90 0.93 0.71 0.97 0.33 1.00 0.67 0.93 0.70
3837 (KPNB1) 0.69 0.63 0.73 0.72 0.67 0.73 0.61 0.73 0.72 0.65 0.65 0.40 0.67 1.00 0.72 0.69
3007 (HIST1H1D) 0.57 0.67 0.49 1.00 0.54 0.95 0.76 0.97 1.00 0.74 0.96 0.33 0.93 0.72 1.00 0.59
27141 (CIDEB) 0.77 0.49 0.68 0.59 0.72 0.65 0.43 0.60 0.59 0.47 0.63 0.38 0.70 0.69 0.59 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
DFFB Toad Heart - 3464 m 33 day downregulated -2.136648265 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
ZEB1 6935 DFFB 1677 proximal_filtered 22955619 TRANSFAC
NRF1 4899 DFFB 1677 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT002560 hsa-miR-124-3p Homo sapiens DFFB 1677 Homo sapiens Microarray Functional MTI (Weak) 15685193
MIRT002560 hsa-miR-124-3p Homo sapiens DFFB 1677 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT039441 hsa-miR-421 Homo sapiens DFFB 1677 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT709655 hsa-miR-589-5p Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709652 hsa-miR-6884-5p Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709661 hsa-miR-1255b-2-3p Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709654 hsa-miR-3928-3p Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709651 hsa-miR-7160-5p Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709656 hsa-miR-4478 Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709648 hsa-miR-665 Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709657 hsa-miR-4419b Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709662 hsa-miR-4428 Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709660 hsa-miR-4476 Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709650 hsa-miR-4533 Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709653 hsa-miR-485-5p Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709649 hsa-miR-3915 Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709659 hsa-miR-6876-5p Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT709658 hsa-miR-3929 Homo sapiens DFFB 1677 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT762197 hsa-miR-1285-3p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT762299 hsa-miR-1292-3p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT763492 hsa-miR-196a-3p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT765300 hsa-miR-3187-5p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT773135 hsa-miR-508-5p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT773550 hsa-miR-5189-5p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT775841 hsa-miR-612 Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT776888 hsa-miR-6512-3p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT777415 hsa-miR-661 Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT777734 hsa-miR-6720-5p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT780271 hsa-miR-6849-3p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT780549 hsa-miR-6860 Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT781843 hsa-miR-766-3p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
MIRT782796 hsa-miR-939-3p Homo sapiens DFFB 1677 Homo sapiens PAR-CLIP Functional MTI (Weak) 27292025
Gene Ontology
ID GO ID GO Term GO Type
1677 GO:0005622 intracellular GOTERM_CC_DIRECT
1677 GO:0004518 monooxygenase activity GOTERM_MF_DIRECT
1677 GO:0004536 RNA-DNA hybrid ribonuclease activity GOTERM_MF_DIRECT
1677 GO:0006309 apoptotic DNA fragmentation GOTERM_BP_DIRECT
1677 GO:0003677 DNA binding GOTERM_MF_DIRECT
1677 GO:0000790 nuclear chromatin GOTERM_CC_DIRECT
1677 GO:0005634 nucleus GOTERM_CC_DIRECT
1677 GO:0030263 apoptotic chromosome condensation GOTERM_BP_DIRECT
1677 GO:0005737 cytoplasm GOTERM_CC_DIRECT
1677 GO:0016787 transferase activity GOTERM_MF_DIRECT
1677 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
1677 GO:0005829 cytosol GOTERM_CC_DIRECT
1677 GO:0019899 kinesin binding GOTERM_MF_DIRECT
1677 GO:0005730 nucleolus GOTERM_CC_DIRECT
1677 GO:0006915 apoptotic process GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1677 hsa04210 Apoptosis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
DFFB 1677 CISPLATIN None None None
DFFB 1677 CURCUMIN CURCUMIN CHEMBL116438 None