Histone H1.5

AltitudeomicsDB
Protein Official symbol HIST1H1B
Aliases H1-5 H1F5 HIST1H1B
Chromosomal Location 6
Length 226
Uniprot ID P16401
EC number None
Protein family Information(Pfam) PF00538;
PDB id 2FE2;2RHI;
InterPro ID IPR005818;IPR005819;IPR036388;IPR036390;
dbSNP rs11970638 rs34144478

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TP53 RB1 0.978
CABIN1 UBN1 0.975
HMGA2 TP53 0.972
HIRA ASF1A 0.972
UBN1 ASF1A 0.97
UBN1 HIRA 0.968
CABIN1 ASF1A 0.966
HIST1H1E HIST1H1D 0.964
CABIN1 HIRA 0.958
CABIN1 TP53 0.952
HIST1H1C TP53 0.952
HMGA2 RB1 0.951
H1F0 TP53 0.95
H1F0 ASF1A 0.944
HMGA1 TP53 0.942
H1F0 LMNB1 0.94
HMGA1 HIST1H1B 0.939
HIST1H1C HIST1H1E 0.933
HIST1H1B HIST1H1D 0.933
HIST1H1B HIST1H1E 0.933
H1F0 DFFB 0.932
HMGA1 H1F0 0.932
H1F0 HIST1H1D 0.93
H1F0 HIST1H1B 0.928
EP400 TP53 0.928
HMGB1 H1F0 0.928
H1F0 HIST1H1E 0.928
HMGB1 HMGB2 0.928
H1F0 HIST1H1C 0.928
HIST1H1B HIST1H1A 0.927
H1F0 RB1 0.926
HIST1H1A HIST1H1D 0.923
HIST1H1C HIST1H1D 0.923
HIST1H1E HIST1H1A 0.922
RB1 ASF1A 0.92
HMGA2 H1F0 0.92
HIST1H1C ASF1A 0.919
H1F0 HIST1H1A 0.919
EP400 H1F0 0.919
HMGA1 LMNB1 0.919
LMNB1 ASF1A 0.918
HIST1H1E TP53 0.918
TP53 ASF1A 0.918
HIST1H1D ASF1A 0.917
HMGA2 HMGA1 0.917
HIST1H1B TP53 0.917
HIST1H1C HIST1H1A 0.916
TP53 HIST1H1A 0.916
EP400 ASF1A 0.915
LMNB1 HIST1H1D 0.915
HIST1H1E ASF1A 0.915
HIST1H1C LMNB1 0.914
HIST1H1A ASF1A 0.914
HMGA2 LMNB1 0.914
HIST1H1B ASF1A 0.914
HIST1H1C DFFB 0.913
DFFB HIST1H1D 0.913
HIST1H1E LMNB1 0.913
TP53 HIST1H1D 0.913
UBN1 EP400 0.913
H1F0 HMGB2 0.913
HIST1H1C HIST1H1B 0.912
UBN1 TP53 0.912
EP400 HIRA 0.911
HIST1H1B LMNB1 0.91
HIST1H1C HMGB2 0.91
HMGB1 HIST1H1C 0.91
HMGA2 ASF1A 0.91
HMGB1 DFFB 0.91
LMNB1 HIST1H1A 0.91
CABIN1 EP400 0.909
HMGB2 HIST1H1A 0.909
CABIN1 HIST1H1A 0.908
HIRA LMNB1 0.908
HIST1H1B HIRA 0.908
UBN1 LMNB1 0.907
HMGB1 HIST1H1A 0.907
HMGB1 HIST1H1D 0.907
HMGB2 HIST1H1D 0.907
H1F0 HIRA 0.907
HIST1H1B HMGB2 0.906
DFFB HIST1H1B 0.906
HIST1H1E HMGB2 0.905
DFFB HIST1H1E 0.905
DFFB HMGB2 0.905
DFFB HIST1H1A 0.905
HMGB1 HIST1H1E 0.904
HMGA2 HIST1H1A 0.904
CABIN1 LMNB1 0.904
UBN1 RB1 0.904
HMGB1 HIST1H1B 0.904
EP400 HIST1H1C 0.903
UBN1 H1F0 0.903
RB1 HIST1H1D 0.903
HMGA1 RB1 0.903
HMGA1 CABIN1 0.903
RB1 HIRA 0.902
CABIN1 RB1 0.902
EP400 HIST1H1A 0.902
HMGA2 HIST1H1B 0.902
HIRA HIST1H1D 0.902
HMGA1 HIRA 0.902
HIRA HIST1H1A 0.902
HIST1H1C HIRA 0.902
HMGA1 HIST1H1A 0.902
HIST1H1E HIRA 0.902
HMGA1 HIST1H1D 0.901
HMGA1 HIST1H1E 0.901
HMGA2 HIST1H1D 0.901
HMGA2 HIST1H1C 0.9
HIST1H1C RB1 0.9
TP53 HIRA 0.9
CABIN1 HIST1H1D 0.9
CABIN1 H1F0 0.9
HMGA1 EP400 0.9
HIST1H1B RB1 0.9
RB1 HIST1H1A 0.9
HMGA2 HIRA 0.9
UBN1 HIST1H1C 0.9
HMGA1 HIST1H1C 0.9
CABIN1 HIST1H1E 0.9
CABIN1 HIST1H1B 0.9
EP400 HIST1H1E 0.9
HMGA2 CABIN1 0.9
UBN1 HIST1H1B 0.9
HMGA1 ASF1A 0.9
HMGA2 EP400 0.9
UBN1 HIST1H1E 0.9
UBN1 HIST1H1A 0.9
UBN1 HIST1H1D 0.9
HIST1H1E RB1 0.9
EP400 HIST1H1D 0.9
CABIN1 HIST1H1C 0.9
HMGA2 HIST1H1E 0.9
HMGA1 UBN1 0.9
HMGA2 UBN1 0.9
EP400 HIST1H1B 0.9
Gene Ontology Semantic Similarity
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# 7157 (TP53) 23523 (CABIN1) 8091 (HMGA2) 7290 (HIRA) 29855 (UBN1) 3008 (HIST1H1E) 3006 (HIST1H1C) 3005 (H1F0) 3159 (HMGA1) 3009 (HIST1H1B) 57634 (EP400) 3146 (HMGB1) 3024 (HIST1H1A) 5925 (RB1) 4001 (LMNB1) 3007 (HIST1H1D) 1677 (DFFB) 3148 (HMGB2) 25842 (ASF1A)
7157 (TP53) 1.00 0.30 0.69 0.65 0.59 0.65 0.59 0.59 0.74 0.61 1.00 0.69 0.58 0.76 1.00 0.59 0.60 0.73 0.56
23523 (CABIN1) 0.30 1.00 0.26 0.45 0.35 0.29 0.41 0.41 0.30 0.41 0.55 0.28 0.44 0.28 0.55 0.41 0.34 0.25 0.50
8091 (HMGA2) 0.69 0.26 1.00 0.69 0.50 0.55 0.61 0.61 0.77 0.61 1.00 0.72 0.61 0.74 1.00 0.61 0.50 0.74 0.44
7290 (HIRA) 0.65 0.45 0.69 1.00 0.73 0.56 0.70 0.70 0.70 0.70 1.00 0.70 0.69 0.73 1.00 0.70 0.54 0.77 0.62
29855 (UBN1) 0.59 0.35 0.50 0.73 1.00 0.38 0.51 0.51 0.57 0.54 1.00 0.53 0.54 0.62 1.00 0.51 0.61 0.52 0.71
3008 (HIST1H1E) 0.65 0.29 0.55 0.56 0.38 1.00 0.76 0.76 0.54 0.75 1.00 0.62 0.71 0.55 1.00 0.76 0.43 0.65 0.47
3006 (HIST1H1C) 0.59 0.41 0.61 0.70 0.51 0.76 1.00 1.00 0.61 0.97 1.00 0.67 0.96 0.62 1.00 1.00 0.54 0.74 0.64
3005 (H1F0) 0.59 0.41 0.61 0.70 0.51 0.76 1.00 1.00 0.61 0.97 1.00 0.67 0.96 0.62 1.00 1.00 0.54 0.74 0.64
3159 (HMGA1) 0.74 0.30 0.77 0.70 0.57 0.54 0.61 0.61 1.00 0.62 1.00 0.70 0.60 0.73 1.00 0.61 0.56 0.75 0.56
3009 (HIST1H1B) 0.61 0.41 0.61 0.70 0.54 0.75 0.97 0.97 0.62 1.00 1.00 0.68 0.94 0.62 1.00 0.97 0.57 0.73 0.65
57634 (EP400) 1.00 0.55 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
3146 (HMGB1) 0.69 0.28 0.72 0.70 0.53 0.62 0.67 0.67 0.70 0.68 1.00 1.00 0.65 0.70 1.00 0.67 0.50 0.88 0.49
3024 (HIST1H1A) 0.58 0.44 0.61 0.69 0.54 0.71 0.96 0.96 0.60 0.94 1.00 0.65 1.00 0.61 1.00 0.96 0.56 0.71 0.68
5925 (RB1) 0.76 0.28 0.74 0.73 0.62 0.55 0.62 0.62 0.73 0.62 1.00 0.70 0.61 1.00 1.00 0.62 0.65 0.76 0.54
4001 (LMNB1) 1.00 0.55 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
3007 (HIST1H1D) 0.59 0.41 0.61 0.70 0.51 0.76 1.00 1.00 0.61 0.97 1.00 0.67 0.96 0.62 1.00 1.00 0.54 0.74 0.64
1677 (DFFB) 0.60 0.34 0.50 0.54 0.61 0.43 0.54 0.54 0.56 0.57 1.00 0.50 0.56 0.65 1.00 0.54 1.00 0.47 0.66
3148 (HMGB2) 0.73 0.25 0.74 0.77 0.52 0.65 0.74 0.74 0.75 0.73 1.00 0.88 0.71 0.76 1.00 0.74 0.47 1.00 0.47
25842 (ASF1A) 0.56 0.50 0.44 0.62 0.71 0.47 0.64 0.64 0.56 0.65 1.00 0.49 0.68 0.54 1.00 0.64 0.66 0.47 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HIST1H1B Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
BCL3 602 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
JUN 3725 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
BCLAF1 9774 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
TBP 6908 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
ETS1 2113 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
KAT2A 2648 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
JUND 3727 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
GATA1 2623 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
TAF7 6879 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
POU2F2 5452 HIST1H1B 3009 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT023593 hsa-miR-1-3p Homo sapiens HIST1H1B 3009 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT025285 hsa-miR-34a-5p Homo sapiens HIST1H1B 3009 Homo sapiens Proteomics Functional MTI (Weak) 21566225
MIRT041257 hsa-miR-193b-3p Homo sapiens HIST1H1B 3009 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052852 hsa-miR-3615 Homo sapiens HIST1H1B 3009 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT523305 hsa-miR-6822-3p Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523308 hsa-miR-1276 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523296 hsa-miR-5693 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523302 hsa-miR-185-3p Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523303 hsa-miR-4283 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523304 hsa-miR-4489 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523298 hsa-miR-5572 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523301 hsa-miR-1227-5p Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523307 hsa-miR-146a-3p Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523297 hsa-miR-4260 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523306 hsa-miR-4766-5p Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523309 hsa-miR-760 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523299 hsa-miR-450a-2-3p Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT523300 hsa-miR-8057 Homo sapiens HIST1H1B 3009 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
Gene Ontology
ID GO ID GO Term GO Type
3009 GO:0000122 negative regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
3009 GO:0006334 nucleosome assembly GOTERM_BP_DIRECT
3009 GO:0044822 poly GOTERM_MF_DIRECT
3009 GO:0000786 nucleosome GOTERM_CC_DIRECT
3009 GO:0000790 nuclear chromatin GOTERM_CC_DIRECT
3009 GO:0050821 protein stabilization GOTERM_BP_DIRECT
3009 GO:0071169 establishment of protein localization to chromatin GOTERM_BP_DIRECT
3009 GO:0006325 chromatin organization GOTERM_BP_DIRECT
3009 GO:0030307 positive regulation of cell growth GOTERM_BP_DIRECT
3009 GO:0051574 positive regulation of histone H3-K9 methylation GOTERM_BP_DIRECT
3009 GO:0005720 nuclear heterochromatin GOTERM_CC_DIRECT
3009 GO:0031490 myosin V binding GOTERM_MF_DIRECT
3009 GO:0042826 histone deacetylase binding GOTERM_MF_DIRECT
3009 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HIST1H1B 3009 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.31 0.886 0.138 disease
HIST1H1B 3009 Colorectal Cancer C1527249 Neoplastic Process 0.3 0.886 0.138 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types