ALTITUDEOMICSDB

Matrilysin

AltitudeomicsDB

Protein Official symbol	MMP7
Aliases	MMP7 MPSL1 PUMP1
Chromosomal Location	11
Length	267
Uniprot ID	P09237
EC number	3.4.24.23
Protein family Information(Pfam)	PF00413;PF01471;
PDB id	1MMP;1MMQ;1MMR;2DDY;2MZE;2MZH;2MZI;2Y6C;2Y6D;5UE2;5UE5;
InterPro ID	IPR033739;IPR028707;IPR024079;IPR001818;IPR021190;IPR021158;IPR006026;IPR002477;IPR036365;
dbSNP	rs10502001 rs17884789 rs17886506

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
CTNNB1	CTNNA1	0.999
CTNNB1	CDH1	0.999
CTNND1	CDH1	0.999
JUP	CDH1	0.995
MMP2	DCN	0.993
JUP	CTNNA1	0.993
CD44	SPP1	0.992
MMP9	PLG	0.991
CTNND1	CTNNB1	0.988
CD44	MMP9	0.987
ACAN	MMP3	0.987
CTNND1	CTNNA1	0.987
MMP3	MMP10	0.987
ACAN	MMP13	0.986
COL18A1	MMP2	0.985
MMP9	CDH1	0.981
ACAN	MMP1	0.98
NGF	PLG	0.98
PLG	MMP3	0.979
SPP1	MMP7	0.979
LAMB3	LAMC2	0.978
LAMB3	LAMA3	0.976
PLG	MMP7	0.976
CTNNA1	CDH1	0.974
MMP9	MMP10	0.973
MMP3	DCN	0.973
CD44	MMP7	0.972
ACAN	MMP2	0.972
SPP1	MMP3	0.972
CTNND1	JUP	0.972
A2M	PLG	0.972
CDH1	MMP7	0.971
A2M	MMP2	0.968
JUP	CTNNB1	0.968
CTNNB1	MMP7	0.966
MMP9	COL18A1	0.964
ACAN	MMP9	0.963
CD44	MMP2	0.963
MMP9	MMP1	0.961
MMP1	PLG	0.96
MMP3	CDH1	0.96
MMP9	MMP3	0.959
ACAN	MMP7	0.959
SDC1	DCN	0.958
MMP7	DCN	0.958
CTSK	MMP13	0.958
BCAN	DCN	0.956
BDNF	PLG	0.955
MMP1	MMP3	0.953
PLG	MMP10	0.952
MMP9	MMP7	0.95
SDC1	MMP7	0.95
PLG	MMP13	0.949
BCAN	MMP3	0.948
PLG	CDH1	0.948
LAMA3	LAMC2	0.948
SDC1	MMP9	0.947
NGF	MMP7	0.947
BCAN	MMP2	0.946
LAMA3	NID1	0.944
ELANE	MMP1	0.943
CTNNB1	MMP3	0.942
MMP3	NID1	0.942
MMP9	NID1	0.942
BCAN	MMP7	0.941
MMP1	MMP7	0.941
COL18A1	MMP3	0.941
NID1	MMP7	0.941
LAMA3	PLG	0.94
COL18A1	MMP7	0.94
BCAN	MMP13	0.939
ELANE	MMP7	0.939
CTSK	MMP7	0.938
MMP1	MMP10	0.936
BCAN	MMP1	0.936
CTNND1	MMP7	0.935
MMP1	NID1	0.935
BCAN	MMP10	0.933
LAMC2	CDH1	0.933
MMP9	A2M	0.932
A2M	MMP1	0.932
BDNF	CTNNB1	0.932
SDC1	MMP1	0.929
SDC1	BCAN	0.928
COL15A1	MMP3	0.928
BDNF	MMP3	0.927
A2M	MMP3	0.926
LAMC2	MMP7	0.925
LAMC2	MMP2	0.925
COL18A1	MMP13	0.924
LAMB3	MMP3	0.924
MMP2	MMP11	0.923
MMP3	MMP2	0.923
LAMB3	MMP2	0.923
MMP1	MMP2	0.922
BDNF	MMP7	0.922
LAMB3	MMP13	0.921
BDNF	NGF	0.92
LAMA3	MMP7	0.919
MMP9	MMP13	0.919
CTSV	COL18A1	0.918
LAMB3	MMP7	0.918
LAMA3	MMP3	0.918
LAMA3	MMP2	0.917
MMP3	LAMC2	0.917
COL15A1	COL18A1	0.917
LAMA3	MMP13	0.916
ELANE	NID1	0.916
MMP9	PRSS1	0.916
MMP7	MMP11	0.915
LAMC2	MMP13	0.915
A2M	MMP13	0.914
COL15A1	MMP9	0.914
CTNND1	MMP3	0.913
MMP1	MMP11	0.913
MMP10	MMP7	0.913
COL15A1	MMP13	0.912
MMP10	MMP2	0.911
COL15A1	MMP7	0.911
MMP13	MMP2	0.911
A2M	MMP7	0.911
BDNF	CTNNA1	0.91
MMP3	MMP13	0.91
MMP7	MMP2	0.91
COL18A1	CTSK	0.91
MMP3	MMP7	0.91
MMP1	MMP13	0.909
CTNNA1	MMP7	0.909
OPTC	MMP13	0.909
MMP10	MMP13	0.909
MMP1	PRSS1	0.909
PRSS1	MMP7	0.908
MMP9	MMP2	0.908
JUP	MMP7	0.908
PLG	LAMC2	0.908
MMP13	MMP7	0.907
BDNF	CTNND1	0.907
JUP	MMP3	0.907
LAMB3	PLG	0.905
CTNNA1	MMP3	0.905
OPTC	MMP7	0.904
CTSV	COL15A1	0.904
PRSS1	MMP13	0.904
CTSV	MMP7	0.903
A2M	MMP11	0.903
OPTC	MMP2	0.903
PRSS1	MMP3	0.902
CTSV	MMP13	0.9
ELANE	JUP	0.9
A2M	MMP10	0.9
PRSS1	MMP10	0.9

Gene Ontology Semantic Similarity

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#	1499 (CTNNB1)	1500 (CTNND1)	3728 (JUP)	4313 (MMP2)	960 (CD44)	4318 (MMP9)	176 (ACAN)	4314 (MMP3)	80781 (COL18A1)	4803 (NGF)	5340 (PLG)	6696 (SPP1)	3914 (LAMB3)	1495 (CTNNA1)	2 (A2M)	999 (CDH1)	4312 (MMP1)	6382 (SDC1)	4316 (MMP7)	1513 (CTSK)	627 (BDNF)	3909 (LAMA3)	1991 (ELANE)	4811 (NID1)	3918 (LAMC2)	1306 (COL15A1)	1515 (CTSV)	4319 (MMP10)	4322 (MMP13)	26254 (OPTC)	5644 (PRSS1)	1634 (DCN)	4320 (MMP11)
1499 (CTNNB1)	1.00	0.74	0.80	0.61	0.63	0.59	0.64	0.59	0.19	0.65	0.70	0.68	0.67	0.71	0.70	0.72	0.11	0.72	0.61	0.62	0.69	0.25	0.65	0.50	0.26	0.19	0.61	0.09	0.40	0.26	0.11	0.65	0.11
1500 (CTNND1)	0.74	1.00	0.70	0.56	0.60	0.53	0.66	0.51	0.23	0.72	0.69	0.82	0.77	0.83	0.71	0.81	0.13	0.86	0.56	0.60	0.84	0.29	0.55	0.57	0.26	0.23	0.56	0.11	0.39	0.26	0.13	0.68	0.13
3728 (JUP)	0.80	0.70	1.00	0.53	0.55	0.53	0.69	0.51	0.34	0.58	0.62	0.62	0.74	0.69	0.63	0.75	0.13	0.66	0.53	0.56	0.69	0.44	0.59	0.55	0.76	0.34	0.53	0.11	0.35	0.76	0.12	0.64	0.13
4313 (MMP2)	0.61	0.56	0.53	1.00	0.42	0.88	0.41	0.98	0.19	0.45	0.83	0.50	0.48	0.60	0.56	0.64	0.82	0.58	1.00	0.80	0.69	0.24	0.75	0.42	0.26	0.19	0.84	0.82	0.75	0.26	0.71	0.43	0.88
960 (CD44)	0.63	0.60	0.55	0.42	1.00	0.49	0.48	0.39	0.20	0.51	0.59	0.56	0.54	0.63	0.59	0.66	0.12	0.62	0.42	0.55	0.69	0.25	0.48	0.56	0.26	0.20	0.42	0.10	0.40	0.26	0.11	0.49	0.12
4318 (MMP9)	0.59	0.53	0.53	0.88	0.49	1.00	0.44	0.90	0.18	0.46	0.82	0.49	0.48	0.59	0.55	0.67	0.66	0.57	0.88	0.82	0.69	0.23	0.75	0.47	0.26	0.18	0.78	0.59	0.87	0.26	0.53	0.45	0.66
176 (ACAN)	0.64	0.66	0.69	0.41	0.48	0.44	1.00	0.38	0.78	0.53	0.60	0.61	0.83	0.67	0.61	0.69	0.14	0.68	0.41	0.49	0.69	0.78	0.45	0.78	1.00	0.78	0.41	0.12	0.31	1.00	0.14	0.86	0.14
4314 (MMP3)	0.59	0.51	0.51	0.98	0.39	0.90	0.38	1.00	0.19	0.42	0.85	0.45	0.44	0.56	0.54	0.61	0.87	0.52	0.98	0.81	0.69	0.24	0.79	0.39	0.26	0.19	0.85	0.81	0.75	0.26	0.71	0.39	0.87
80781 (COL18A1)	0.19	0.23	0.34	0.19	0.20	0.18	0.78	0.19	1.00	0.19	0.20	0.25	0.60	0.21	0.19	0.21	0.14	0.23	0.19	0.19	0.18	0.90	0.19	0.55	1.00	1.00	0.19	0.12	0.14	1.00	0.13	0.54	0.14
4803 (NGF)	0.65	0.72	0.58	0.45	0.51	0.46	0.53	0.42	0.19	1.00	0.63	0.64	0.60	0.68	0.72	0.70	0.11	0.70	0.45	0.52	1.00	0.24	0.48	0.48	0.26	0.19	0.45	0.09	0.33	0.26	0.11	0.55	0.11
5340 (PLG)	0.70	0.69	0.62	0.83	0.59	0.82	0.60	0.85	0.20	0.63	1.00	0.65	0.64	0.67	0.68	0.69	0.45	0.68	0.83	0.82	0.84	0.25	0.79	0.51	0.26	0.20	0.83	0.38	0.62	0.26	0.41	0.61	0.42
6696 (SPP1)	0.68	0.82	0.62	0.50	0.56	0.49	0.61	0.45	0.25	0.64	0.65	1.00	0.73	0.75	0.67	0.76	0.14	0.84	0.50	0.56	0.69	0.32	0.51	0.61	0.26	0.25	0.50	0.12	0.36	0.26	0.14	0.63	0.14
3914 (LAMB3)	0.67	0.77	0.74	0.48	0.54	0.48	0.83	0.44	0.60	0.60	0.64	0.73	1.00	0.73	0.65	0.74	0.18	0.79	0.48	0.55	0.69	0.78	0.50	0.70	0.76	0.60	0.48	0.15	0.35	0.76	0.17	0.72	0.18
1495 (CTNNA1)	0.71	0.83	0.69	0.60	0.63	0.59	0.67	0.56	0.21	0.68	0.67	0.75	0.73	1.00	0.68	0.86	0.13	0.82	0.60	0.62	0.69	0.27	0.58	0.54	0.26	0.21	0.60	0.10	0.40	0.26	0.12	0.80	0.13
2 (A2M)	0.70	0.71	0.63	0.56	0.59	0.55	0.61	0.54	0.19	0.72	0.68	0.67	0.65	0.68	1.00	0.70	0.11	0.69	0.56	0.58	0.84	0.25	0.61	0.49	0.26	0.19	0.56	0.09	0.37	0.26	0.11	0.62	0.11
999 (CDH1)	0.72	0.81	0.75	0.64	0.66	0.67	0.69	0.61	0.21	0.70	0.69	0.76	0.74	0.86	0.70	1.00	0.12	0.81	0.64	0.65	0.69	0.27	0.62	0.54	0.26	0.21	0.64	0.10	0.52	0.26	0.12	0.70	0.12
4312 (MMP1)	0.11	0.13	0.13	0.82	0.12	0.66	0.14	0.87	0.14	0.11	0.45	0.14	0.18	0.13	0.11	0.12	1.00	0.14	0.82	0.54	0.11	0.18	0.55	0.12	0.16	0.14	0.73	0.96	0.63	0.16	0.83	0.13	0.93
6382 (SDC1)	0.72	0.86	0.66	0.58	0.62	0.57	0.68	0.52	0.23	0.70	0.68	0.84	0.79	0.82	0.69	0.81	0.14	1.00	0.58	0.61	0.69	0.30	0.56	0.58	0.26	0.23	0.58	0.11	0.40	0.26	0.13	0.70	0.14
4316 (MMP7)	0.61	0.56	0.53	1.00	0.42	0.88	0.41	0.98	0.19	0.45	0.83	0.50	0.48	0.60	0.56	0.64	0.82	0.58	1.00	0.80	0.69	0.24	0.75	0.42	0.26	0.19	0.84	0.82	0.75	0.26	0.71	0.43	0.88
1513 (CTSK)	0.62	0.60	0.56	0.80	0.55	0.82	0.49	0.81	0.19	0.52	0.82	0.56	0.55	0.62	0.58	0.65	0.54	0.61	0.80	1.00	0.69	0.24	0.74	0.61	0.26	0.19	0.91	0.47	0.67	0.26	0.50	0.50	0.52
627 (BDNF)	0.69	0.84	0.69	0.69	0.69	0.69	0.69	0.69	0.18	1.00	0.84	0.69	0.69	0.69	0.84	0.69	0.11	0.69	0.69	0.69	1.00	0.23	0.69	0.49	0.18	0.18	0.69	0.08	0.42	0.18	0.10	0.69	0.11
3909 (LAMA3)	0.25	0.29	0.44	0.24	0.25	0.23	0.78	0.24	0.90	0.24	0.25	0.32	0.78	0.27	0.25	0.27	0.18	0.30	0.24	0.24	0.23	1.00	0.25	0.57	1.00	0.90	0.24	0.15	0.18	1.00	0.17	0.56	0.18
1991 (ELANE)	0.65	0.55	0.59	0.75	0.48	0.75	0.45	0.79	0.19	0.48	0.79	0.51	0.50	0.58	0.61	0.62	0.55	0.56	0.75	0.74	0.69	0.25	1.00	0.42	0.26	0.19	0.75	0.46	0.57	0.26	0.48	0.46	0.51
4811 (NID1)	0.50	0.57	0.55	0.42	0.56	0.47	0.78	0.39	0.55	0.48	0.51	0.61	0.70	0.54	0.49	0.54	0.12	0.58	0.42	0.61	0.49	0.57	0.42	1.00	1.00	0.55	0.42	0.10	0.42	1.00	0.12	0.65	0.12
3918 (LAMC2)	0.26	0.26	0.76	0.26	0.26	0.26	1.00	0.26	1.00	0.26	0.26	0.26	0.76	0.26	0.26	0.26	0.16	0.26	0.26	0.26	0.18	1.00	0.26	1.00	1.00	1.00	0.26	0.13	0.16	1.00	0.15	0.82	0.16
1306 (COL15A1)	0.19	0.23	0.34	0.19	0.20	0.18	0.78	0.19	1.00	0.19	0.20	0.25	0.60	0.21	0.19	0.21	0.14	0.23	0.19	0.19	0.18	0.90	0.19	0.55	1.00	1.00	0.19	0.12	0.14	1.00	0.13	0.54	0.14
1515 (CTSV)	0.61	0.56	0.53	0.84	0.42	0.78	0.41	0.85	0.19	0.45	0.83	0.50	0.48	0.60	0.56	0.64	0.73	0.58	0.84	0.91	0.69	0.24	0.75	0.42	0.26	0.19	1.00	0.66	0.64	0.26	0.71	0.43	0.69
4319 (MMP10)	0.09	0.11	0.11	0.82	0.10	0.59	0.12	0.81	0.12	0.09	0.38	0.12	0.15	0.10	0.09	0.10	0.96	0.11	0.82	0.47	0.08	0.15	0.46	0.10	0.13	0.12	0.66	1.00	0.60	0.13	0.86	0.11	0.96
4322 (MMP13)	0.40	0.39	0.35	0.75	0.40	0.87	0.31	0.75	0.14	0.33	0.62	0.36	0.35	0.40	0.37	0.52	0.63	0.40	0.75	0.67	0.42	0.18	0.57	0.42	0.16	0.14	0.64	0.60	1.00	0.16	0.53	0.32	0.63
26254 (OPTC)	0.26	0.26	0.76	0.26	0.26	0.26	1.00	0.26	1.00	0.26	0.26	0.26	0.76	0.26	0.26	0.26	0.16	0.26	0.26	0.26	0.18	1.00	0.26	1.00	1.00	1.00	0.26	0.13	0.16	1.00	0.15	0.82	0.16
5644 (PRSS1)	0.11	0.13	0.12	0.71	0.11	0.53	0.14	0.71	0.13	0.11	0.41	0.14	0.17	0.12	0.11	0.12	0.83	0.13	0.71	0.50	0.10	0.17	0.48	0.12	0.15	0.13	0.71	0.86	0.53	0.15	1.00	0.12	0.82
1634 (DCN)	0.65	0.68	0.64	0.43	0.49	0.45	0.86	0.39	0.54	0.55	0.61	0.63	0.72	0.80	0.62	0.70	0.13	0.70	0.43	0.50	0.69	0.56	0.46	0.65	0.82	0.54	0.43	0.11	0.32	0.82	0.12	1.00	0.13
4320 (MMP11)	0.11	0.13	0.13	0.88	0.12	0.66	0.14	0.87	0.14	0.11	0.42	0.14	0.18	0.13	0.11	0.12	0.93	0.14	0.88	0.52	0.11	0.18	0.51	0.12	0.16	0.14	0.69	0.96	0.63	0.16	0.82	0.13	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
MMP7	Toad	Liver	-	3464 m	33 day	upregulated	2.731946874	RNA-seq	Tibetan Plateau	Asiatic toad	1	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	28673260

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
CTNNB1	1499	MMP7	4316	Activation	20300972	TRUSST
NCOA3	8202	MMP7	4316	Repression	17244530	TRUSST
LEF1	51176	MMP7	4316	Unknown	19219074	TRUSST
ETV4	2118	MMP7	4316	Unknown	19671687	TRUSST
FOS	2353	MMP7	4316	Activation	11477071	TRUSST
JUN	3725	MMP7	4316	Unknown	19219074	TRUSST
FOXA2	3170	MMP7	4316	Unknown	10037443	TRUSST
STAT3	6774	MMP7	4316	Activation	10523670	TRUSST
HNF4A	3172	MMP7	4316	Unknown	10037443	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT007268	hsa-miR-126-5p	Homo sapiens	MMP7	4316	Homo sapiens	Luciferase reporter assay	Functional MTI	23437250
MIRT007269	hsa-miR-126-3p	Homo sapiens	MMP7	4316	Homo sapiens	Luciferase reporter assay	Functional MTI	23437250
MIRT052917	hsa-miR-148a-3p	Homo sapiens	MMP7	4316	Homo sapiens	In situ hybridization//Microarray//qRT-PCR//Western blot//Luciferase reporter assay	Functional MTI	24283384
MIRT437979	hsa-miR-34a-5p	Homo sapiens	MMP7	4316	Homo sapiens	ELISA//qRT-PCR	Functional MTI (Weak)	24981249
MIRT734405	hsa-miR-203a-5p	Homo sapiens	MMP7	4316	Homo sapiens	Western blot	Functional MTI	26278219
MIRT734829	hsa-miR-543	Homo sapiens	MMP7	4316	Homo sapiens	ELISA//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26402225
MIRT735077	hsa-miR-489-3p	Homo sapiens	MMP7	4316	Homo sapiens	Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	28189067

Gene Ontology

ID	GO ID	GO Term	GO Type
4316	GO:0004252	serine-type endopeptidase activity	GOTERM_MF_DIRECT
4316	GO:0071260	cellular response to mechanical stimulus	GOTERM_BP_DIRECT
4316	GO:0008201	heparin binding	GOTERM_MF_DIRECT
4316	GO:0008270	zinc ion binding	GOTERM_MF_DIRECT
4316	GO:0007568	aging	GOTERM_BP_DIRECT
4316	GO:0022617	extracellular matrix disassembly	GOTERM_BP_DIRECT
4316	GO:0044849	estrous cycle	GOTERM_BP_DIRECT
4316	GO:0005615	extracellular space	GOTERM_CC_DIRECT
4316	GO:0006508	proteolysis	GOTERM_BP_DIRECT
4316	GO:0005576	extracellular region	GOTERM_CC_DIRECT
4316	GO:0031012	extracellular matrix	GOTERM_CC_DIRECT
4316	GO:0005578	proteinaceous extracellular matrix	GOTERM_CC_DIRECT
4316	GO:0009986	cell surface	GOTERM_CC_DIRECT
4316	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
4316	GO:0060135	maternal process involved in female pregnancy	GOTERM_BP_DIRECT
4316	GO:0030574	collagen catabolic process	GOTERM_BP_DIRECT
4316	GO:0004222	cysteine-type endopeptidase activity	GOTERM_MF_DIRECT
4316	GO:0031667	response to nutrient levels	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
4316	hsa04310	Wnt signaling pathway

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
MMP7	4316	Malignant tumor of colon	C0007102	Neoplastic Process	0.4	0.47	0.724	disease
MMP7	4316	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.4	0.47	0.724	disease
MMP7	4316	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.47	0.724	disease
MMP7	4316	Colonic Neoplasms	C0009375	Neoplastic Process	0.34	0.47	0.724	group
MMP7	4316	Abortion, Tubal	C0000822	Pathologic Function	0.3	0.47	0.724	disease
MMP7	4316	Stomach Neoplasms	C0038356	Neoplastic Process	0.33	0.47	0.724	group
MMP7	4316	Spontaneous abortion	C0000786	Pathologic Function	0.3	0.47	0.724	phenotype

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
MMP7	4316	BB-3644	SOLIMASTAT	CHEMBL2107228	inhibitor
MMP7	4316	BATIMASTAT	BATIMASTAT	CHEMBL279786	inhibitor
MMP7	4316	BMS 275291	REBIMASTAT	CHEMBL76222	inhibitor
MMP7	4316	DOXYCYCLINE	DOXYCYCLINE	CHEMBL1433	inhibitor
MMP7	4316	DOXYCYCLINE CALCIUM	DOXYCYCLINE CALCIUM	CHEMBL2364574	inhibitor
MMP7	4316	DOXYCYCLINE HYCLATE	DOXYCYCLINE HYCLATE	CHEMBL1200567	inhibitor
MMP7	4316	DOXYCYCLINE HYDRATE	DOXYCYCLINE HYDRATE	CHEMBL1200699	inhibitor
MMP7	4316	MARIMASTAT	MARIMASTAT	CHEMBL279785	inhibitor
MMP7	4316	PRINOMASTAT	PRINOMASTAT	CHEMBL75094	inhibitor
MMP7	4316	RS 39066	MEGLUMINE	CHEMBL1200570	inhibitor
MMP7	4316	SL422	URIDINE DIPHOSPHATE GLUCOSE	CHEMBL375951	inhibitor