ALTITUDEOMICSDB

Mimecan

AltitudeomicsDB

Protein Official symbol	OGN
Aliases	OGN OIF SLRR3A
Chromosomal Location	:13
Length	298
Uniprot ID	P20774
EC number	None
Protein family Information(Pfam)	PF13855;
PDB id	None
InterPro ID	IPR001611;IPR003591;IPR032675;IPR027211;
dbSNP	None

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
ACAN	FMOD	0.981
CHST1	LUM	0.974
CHST6	LUM	0.974
B4GALT3	PRELP	0.973
CHST1	KERA	0.973
CHST5	LUM	0.973
PRELP	B4GALT2	0.973
CHST6	KERA	0.968
ACAN	LUM	0.966
B4GALT2	ST3GAL3	0.966
ACAN	OMD	0.965
B4GALT1	ST3GAL3	0.965
OMD	OGN	0.964
ST3GAL6	B4GALT1	0.963
B4GALT4	B3GNT2	0.962
B3GNT7	KERA	0.958
B3GNT4	B4GALT2	0.955
ACAN	PRELP	0.954
B4GALT1	B3GNT4	0.952
B4GALT2	B3GNT2	0.95
B4GALT1	B3GNT2	0.948
B4GALT4	B3GNT3	0.943
ACAN	KERA	0.943
ACAN	OGN	0.943
ST3GAL6	B4GALT4	0.943
LUM	OGN	0.942
B4GALT1	B3GNT3	0.94
ST3GAL6	B3GNT3	0.938
FMOD	LUM	0.938
CHST2	LUM	0.937
B4GALT3	B3GNT4	0.937
B4GALT3	B3GNT2	0.936
PRELP	OGN	0.935
FMOD	OGN	0.935
KERA	OGN	0.933
B4GALT3	ST3GAL3	0.933
CHST5	KERA	0.932
B3GNT3	B4GALT2	0.931
B4GALT3	B3GNT3	0.931
ST3GAL6	B3GNT2	0.929
ST3GAL6	B4GALT3	0.929
ST3GAL6	B4GALT2	0.926
B3GNT7	LUM	0.926
FMOD	PRELP	0.926
B4GALT1	B3GNT1	0.921
B3GNT2	LUM	0.919
KERA	LUM	0.917
CHST5	OGN	0.917
OMD	FMOD	0.917
FMOD	KERA	0.916
PRELP	LUM	0.916
B3GNT7	OGN	0.914
OMD	PRELP	0.914
B4GALT2	OGN	0.911
OMD	LUM	0.911
CHST6	OGN	0.91
B4GALT3	LUM	0.91
ACAN	CHST2	0.908
B4GALT3	OGN	0.908
B4GALT2	LUM	0.908
PRELP	KERA	0.908
FMOD	B4GALT2	0.907
OMD	KERA	0.907
ST3GAL6	B3GNT4	0.907
B4GALT4	KERA	0.906
B4GALT1	LUM	0.905
B4GALT4	OGN	0.905
B3GNT2	OGN	0.905
ACAN	CHST1	0.905
B4GALT3	FMOD	0.905
B4GALT4	FMOD	0.904
B4GALT4	LUM	0.904
B4GALT2	B3GNT1	0.902
CHST1	OGN	0.902
B4GALT4	B3GNT4	0.902
PRELP	ST3GAL3	0.902
ST3GAL1	OGN	0.902
ST3GAL2	FMOD	0.902
ST3GAL2	OGN	0.902
ACAN	B4GALT5	0.902
FMOD	CHST1	0.902
FMOD	B3GNT4	0.901
OMD	B3GNT3	0.901
FMOD	B3GNT2	0.901
B4GALT3	B3GNT1	0.901
B3GNT3	OGN	0.901
B4GALT1	OGN	0.901
B3GNT3	LUM	0.901
ACAN	CHST6	0.901
B3GNT4	LUM	0.901
ST3GAL1	LUM	0.901
FMOD	B3GNT3	0.901
CHST2	KERA	0.901
FMOD	B3GNT7	0.901
ACAN	B4GALT6	0.901
PRELP	B3GNT2	0.901
OMD	B3GNT2	0.901
ST3GAL6	LUM	0.901
B3GNT4	OGN	0.901
B3GNT3	KERA	0.901
PRELP	B3GNT4	0.901
OMD	B3GNT7	0.901
B3GNT4	KERA	0.901
OMD	B3GNT4	0.901
PRELP	B3GNT3	0.901
PRELP	B3GNT7	0.901
B3GNT2	KERA	0.901
B4GALT3	ACAN	0.9
FMOD	CHST5	0.9
B4GALT6	LUM	0.9
ST3GAL1	KERA	0.9
ACAN	B4GALT1	0.9
ACAN	B4GALT2	0.9
ST3GAL4	ACAN	0.9
B3GNT1	KERA	0.9
ST3GAL6	PRELP	0.9
B4GALT5	OGN	0.9
ST3GAL4	OGN	0.9
PRELP	B4GALT6	0.9
PRELP	CHST1	0.9
B4GALT6	KERA	0.9
ST3GAL4	KERA	0.9
ACAN	B3GNT7	0.9
ACAN	B3GNT4	0.9
FMOD	CHST2	0.9
ACAN	CHST5	0.9
FMOD	B4GALT6	0.9
B4GALT5	FMOD	0.9
ST3GAL6	OMD	0.9
ACAN	ST3GAL3	0.9
ACAN	ST3GAL2	0.9
B4GALT5	LUM	0.9
ST3GAL4	FMOD	0.9
B3GNT1	LUM	0.9
FMOD	B3GNT1	0.9
B4GALT1	FMOD	0.9
OMD	B3GNT1	0.9
ST3GAL1	PRELP	0.9
B4GALT1	PRELP	0.9
ST3GAL1	FMOD	0.9
B4GALT3	OMD	0.9
B4GALT1	OMD	0.9
OMD	CHST6	0.9
B4GALT4	OMD	0.9
ST3GAL4	LUM	0.9
B4GALT6	OGN	0.9
PRELP	CHST5	0.9
CHST2	OGN	0.9
OMD	B4GALT2	0.9
B4GALT1	KERA	0.9
ST3GAL6	KERA	0.9
ST3GAL3	OGN	0.9
PRELP	B3GNT1	0.9
ST3GAL2	KERA	0.9
FMOD	CHST6	0.9
ST3GAL1	ACAN	0.9
ST3GAL1	OMD	0.9
OMD	B4GALT6	0.9
B4GALT4	ACAN	0.9
ST3GAL4	PRELP	0.9
ACAN	B3GNT1	0.9
B3GNT1	OGN	0.9
PRELP	CHST6	0.9
KERA	ST3GAL3	0.9
ACAN	B3GNT3	0.9
LUM	ST3GAL3	0.9
OMD	ST3GAL3	0.9
PRELP	CHST2	0.9
B4GALT5	PRELP	0.9
ACAN	B3GNT2	0.9
ST3GAL2	OMD	0.9
B4GALT5	KERA	0.9
B4GALT2	KERA	0.9
FMOD	ST3GAL3	0.9
OMD	CHST2	0.9
B4GALT4	PRELP	0.9
OMD	CHST5	0.9
B4GALT3	KERA	0.9
OMD	CHST1	0.9
ST3GAL4	OMD	0.9
ST3GAL2	LUM	0.9
ST3GAL6	FMOD	0.9
ST3GAL2	PRELP	0.9
ST3GAL6	ACAN	0.9
ST3GAL6	OGN	0.9
OMD	B4GALT5	0.9

Gene Ontology Semantic Similarity

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#	2331 (FMOD)	4060 (LUM)	5549 (PRELP)	11081 (KERA)	8704 (B4GALT2)	6487 (ST3GAL3)	4969 (OGN)	2683 (B4GALT1)	10678 (B3GNT2)	79369 (B3GNT4)	10331 (B3GNT3)	8702 (B4GALT4)	8703 (B4GALT3)	11041 (B3GNT1)	9435 (CHST2)	8534 (CHST1)	9334 (B4GALT5)	4166 (CHST6)	93010 (B3GNT7)	9331 (B4GALT6)	176 (ACAN)	23563 (CHST5)	6483 (ST3GAL2)	10402 (ST3GAL6)	6482 (ST3GAL1)	6484 (ST3GAL4)
2331 (FMOD)	1.00	1.00	1.00	0.38	0.13	0.15	1.00	0.13	0.11	0.11	0.11	0.13	0.13	0.21	0.15	0.15	0.13	0.13	0.11	0.13	1.00	0.15	0.13	0.15	0.13	0.15
4060 (LUM)	1.00	1.00	0.69	0.48	0.14	0.16	0.91	0.18	0.12	0.12	0.12	0.14	0.14	0.48	0.16	0.16	0.14	0.16	0.12	0.14	0.95	0.16	0.14	0.16	0.16	0.16
5549 (PRELP)	1.00	0.69	1.00	0.48	0.13	0.15	0.69	0.17	0.12	0.12	0.12	0.13	0.13	0.23	0.15	0.15	0.13	0.16	0.12	0.13	0.77	0.15	0.14	0.15	0.16	0.15
11081 (KERA)	0.38	0.48	0.48	1.00	0.28	0.32	0.48	0.28	0.24	0.24	0.24	0.28	0.28	0.48	0.32	0.32	0.28	0.28	0.24	0.28	0.48	0.32	0.28	0.32	0.28	0.32
8704 (B4GALT2)	0.13	0.14	0.13	0.28	1.00	0.54	0.14	0.82	0.68	0.68	0.68	1.00	1.00	0.54	0.36	0.36	1.00	0.34	0.68	1.00	0.14	0.36	0.48	0.54	0.51	0.54
6487 (ST3GAL3)	0.15	0.16	0.15	0.32	0.54	1.00	0.17	0.46	0.49	0.49	0.49	0.54	0.54	0.44	0.43	0.43	0.54	0.40	0.49	0.54	0.17	0.43	0.93	0.97	1.00	0.97
4969 (OGN)	1.00	0.91	0.69	0.48	0.14	0.17	1.00	0.18	0.13	0.13	0.13	0.14	0.14	0.50	0.17	0.17	0.14	0.16	0.13	0.14	0.96	0.17	0.15	0.17	0.16	0.17
2683 (B4GALT1)	0.13	0.18	0.17	0.28	0.82	0.46	0.18	1.00	0.67	0.67	0.67	0.82	0.82	0.59	0.31	0.31	0.82	0.34	0.67	0.82	0.17	0.31	0.40	0.47	0.51	0.47
10678 (B3GNT2)	0.11	0.12	0.12	0.24	0.68	0.49	0.13	0.67	1.00	1.00	1.00	0.68	0.68	0.71	0.32	0.32	0.68	0.31	1.00	0.68	0.13	0.32	0.43	0.49	0.46	0.49
79369 (B3GNT4)	0.11	0.12	0.12	0.24	0.68	0.49	0.13	0.67	1.00	1.00	1.00	0.68	0.68	0.71	0.32	0.32	0.68	0.31	1.00	0.68	0.13	0.32	0.43	0.49	0.46	0.49
10331 (B3GNT3)	0.11	0.12	0.12	0.24	0.68	0.49	0.13	0.67	1.00	1.00	1.00	0.68	0.68	0.71	0.32	0.32	0.68	0.31	1.00	0.68	0.13	0.32	0.43	0.49	0.46	0.49
8702 (B4GALT4)	0.13	0.14	0.13	0.28	1.00	0.54	0.14	0.82	0.68	0.68	0.68	1.00	1.00	0.54	0.36	0.36	1.00	0.34	0.68	1.00	0.14	0.36	0.48	0.54	0.51	0.54
8703 (B4GALT3)	0.13	0.14	0.13	0.28	1.00	0.54	0.14	0.82	0.68	0.68	0.68	1.00	1.00	0.54	0.36	0.36	1.00	0.34	0.68	1.00	0.14	0.36	0.48	0.54	0.51	0.54
11041 (B3GNT1)	0.21	0.48	0.23	0.48	0.54	0.44	0.50	0.59	0.71	0.71	0.71	0.54	0.54	1.00	0.31	0.31	0.54	0.31	0.71	0.54	0.46	0.31	0.39	0.45	0.46	0.45
9435 (CHST2)	0.15	0.16	0.15	0.32	0.36	0.43	0.17	0.31	0.32	0.32	0.32	0.36	0.36	0.31	1.00	0.97	0.36	1.00	0.32	0.36	0.17	1.00	0.38	0.43	0.40	0.43
8534 (CHST1)	0.15	0.16	0.15	0.32	0.36	0.43	0.17	0.31	0.32	0.32	0.32	0.36	0.36	0.31	0.97	1.00	0.36	1.00	0.32	0.36	0.17	0.97	0.38	0.42	0.40	0.42
9334 (B4GALT5)	0.13	0.14	0.13	0.28	1.00	0.54	0.14	0.82	0.68	0.68	0.68	1.00	1.00	0.54	0.36	0.36	1.00	0.34	0.68	1.00	0.14	0.36	0.48	0.54	0.51	0.54
4166 (CHST6)	0.13	0.16	0.16	0.28	0.34	0.40	0.16	0.34	0.31	0.31	0.31	0.34	0.34	0.31	1.00	1.00	0.34	1.00	0.31	0.34	0.16	1.00	0.34	0.40	0.34	0.40
93010 (B3GNT7)	0.11	0.12	0.12	0.24	0.68	0.49	0.13	0.67	1.00	1.00	1.00	0.68	0.68	0.71	0.32	0.32	0.68	0.31	1.00	0.68	0.13	0.32	0.43	0.49	0.46	0.49
9331 (B4GALT6)	0.13	0.14	0.13	0.28	1.00	0.54	0.14	0.82	0.68	0.68	0.68	1.00	1.00	0.54	0.36	0.36	1.00	0.34	0.68	1.00	0.14	0.36	0.48	0.54	0.51	0.54
176 (ACAN)	1.00	0.95	0.77	0.48	0.14	0.17	0.96	0.17	0.13	0.13	0.13	0.14	0.14	0.46	0.17	0.17	0.14	0.16	0.13	0.14	1.00	0.17	0.15	0.17	0.16	0.17
23563 (CHST5)	0.15	0.16	0.15	0.32	0.36	0.43	0.17	0.31	0.32	0.32	0.32	0.36	0.36	0.31	1.00	0.97	0.36	1.00	0.32	0.36	0.17	1.00	0.38	0.43	0.40	0.43
6483 (ST3GAL2)	0.13	0.14	0.14	0.28	0.48	0.93	0.15	0.40	0.43	0.43	0.43	0.48	0.48	0.39	0.38	0.38	0.48	0.34	0.43	0.48	0.15	0.38	1.00	0.89	1.00	0.97
10402 (ST3GAL6)	0.15	0.16	0.15	0.32	0.54	0.97	0.17	0.47	0.49	0.49	0.49	0.54	0.54	0.45	0.43	0.42	0.54	0.40	0.49	0.54	0.17	0.43	0.89	1.00	1.00	0.95
6482 (ST3GAL1)	0.13	0.16	0.16	0.28	0.51	1.00	0.16	0.51	0.46	0.46	0.46	0.51	0.51	0.46	0.40	0.40	0.51	0.34	0.46	0.51	0.16	0.40	1.00	1.00	1.00	1.00
6484 (ST3GAL4)	0.15	0.16	0.15	0.32	0.54	0.97	0.17	0.47	0.49	0.49	0.49	0.54	0.54	0.45	0.43	0.42	0.54	0.40	0.49	0.54	0.17	0.43	0.97	0.95	1.00	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
OGN	Toad	Heart	-	3464 m	33 day	downregulated	-1.961774773	RNA-seq	Tibetan Plateau	Asiatic toad	1	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	28673260

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
IRF1	3659	OGN	4969	Unknown	19723873	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT447694	hsa-miR-526b-5p	Homo sapiens	OGN	4969	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	22100165

Gene Ontology

ID	GO ID	GO Term	GO Type
4969	GO:0042340	keratan sulfate catabolic process	GOTERM_BP_DIRECT
4969	GO:0008201	heparin binding	GOTERM_MF_DIRECT
4969	GO:0018146	keratan sulfate biosynthetic process	GOTERM_BP_DIRECT
4969	GO:0005576	extracellular region	GOTERM_CC_DIRECT
4969	GO:0031012	extracellular matrix	GOTERM_CC_DIRECT
4969	GO:1903561	extracellular vesicle	GOTERM_CC_DIRECT
4969	GO:0048662	negative regulation of smooth muscle cell proliferation	GOTERM_BP_DIRECT
4969	GO:0050770	regulation of axonogenesis	GOTERM_BP_DIRECT
4969	GO:0005578	proteinaceous extracellular matrix	GOTERM_CC_DIRECT
4969	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
4969	GO:0005615	extracellular space	GOTERM_CC_DIRECT
4969	GO:0048846	axon extension involved in axon guidance	GOTERM_BP_DIRECT
4969	GO:0008083	growth factor activity	GOTERM_MF_DIRECT
4969	GO:0043202	lysosomal lumen	GOTERM_CC_DIRECT
4969	GO:0005796	Golgi lumen	GOTERM_CC_DIRECT
4969	GO:0035385	Roundabout signaling pathway	GOTERM_BP_DIRECT
4969	GO:0048495	Rac GTPase binding	GOTERM_MF_DIRECT
4969	GO:0007409	axonogenesis	GOTERM_BP_DIRECT
4969	GO:0005515	protein binding	GOTERM_MF_DIRECT
4969	GO:0005783	endoplasmic reticulum	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
OGN	4969	Neoplasm Metastasis	C0027627	Neoplastic Process	0.3	0.785	0.172	phenotype

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types