WD repeat protein 1

AltitudeomicsDB
Protein Official symbol WDR1
Aliases WDR1
Chromosomal Location 4
Length 606
Uniprot ID O75083
EC number None
Protein family Information(Pfam) PF00400;
PDB id None
InterPro ID IPR020472;IPR011045;IPR015943;IPR001680;IPR019775;IPR017986;IPR036322;
dbSNP rs13441

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ACTR2 ACTR3 0.9990000000000001
CFL1 ACTB 0.9990000000000001
CAPZB CAPZA2 0.9990000000000001
CAPZB CAPZA1 0.9990000000000001
ACTB CFL2 0.99
CAPZA2 CAPZA1 0.973
ACTR2 CAPZA2 0.9670000000000001
ACTR2 ACTB 0.9570000000000001
CFL1 CAP1 0.9570000000000001
ACTR2 CAP1 0.953
ACTB ACTR3 0.953
LCP1 GSN 0.95
CFL1 WDR1 0.9490000000000001
WDR1 UBE2K 0.9390000000000001
ACTB DSTN 0.912
ACTR2 GSN 0.91
CFL1 ACTR2 0.909
WDR1 ACTR2 0.895
DBNL ACTR2 0.89
DBNL LCP1 0.879
ACTR2 CAPZA1 0.878
WDR1 DSTN 0.872
ACTR3 CAPZA1 0.8690000000000001
WDR1 GGCT 0.866
CAPZB ACTB 0.865
TXN UBE2K 0.852
CFL1 CFL2 0.852
CAP1 ACTB 0.845
WDR1 CFL2 0.843
GSN ACTB 0.84
CAPZB ACTR2 0.833
CFL1 LCP1 0.831
WDR1 TYMS 0.8240000000000001
TYMS UBE2K 0.8220000000000001
WDR1 PPIH 0.818
WDR1 TXNDC17 0.816
UBE2K TXNDC17 0.8140000000000001
DBNL CAPZB 0.8079999999999999
WDR1 CAPZB 0.804
TYMS TXNDC17 0.8
WDR1 CAPZA1 0.797
WDR1 CAPZA2 0.7959999999999999
CAPZB ACTR3 0.784
WDR1 LCP1 0.782
DBNL GSN 0.7809999999999999
WDR1 TXN 0.778
GSN ACTR3 0.76
LCP1 ACTR2 0.752
WDR1 DBNL 0.7509999999999999
CFL1 GSN 0.7509999999999999
WDR1 ACTR3 0.742
CFL1 CAPZB 0.737
ACTR2 DSTN 0.736
WDR1 GSN 0.736
DBNL ACTR3 0.7340000000000001
CFL1 DBNL 0.7340000000000001
WDR1 CORO2A 0.7240000000000001
ACTR2 CFL2 0.722
WDR1 CAP1 0.72
WDR1 ACTB 0.7070000000000001
Gene Ontology Semantic Similarity
Download Tab separated file
# 10097 (ACTR2) 1072 (CFL1) 832 (CAPZB) 60 (ACTB) 830 (CAPZA2) 3936 (LCP1) 9948 (WDR1) 28988 (DBNL) 10096 (ACTR3) 7295 (TXN) 10487 (CAP1) 2934 (GSN) 7298 (TYMS) 3093 (UBE2K) 829 (CAPZA1) 1073 (CFL2) 11034 (DSTN) 79017 (GGCT) 10465 (PPIH) 84817 (TXNDC17) 7464 (CORO2A)
10097 (ACTR2) 1.00 0.69 0.64 0.43 1.00 0.57 1.00 0.58 0.90 0.37 0.50 0.47 0.15 0.29 0.64 0.69 0.69 0.24 0.36 0.32 0.51
1072 (CFL1) 0.69 1.00 0.90 0.54 1.00 0.72 1.00 0.80 0.85 0.72 0.71 0.73 0.23 0.51 0.90 1.00 1.00 0.42 0.62 0.57 1.00
832 (CAPZB) 0.64 0.90 1.00 0.56 1.00 0.76 1.00 0.91 0.81 0.71 0.76 0.80 0.22 0.55 1.00 0.90 0.90 0.42 0.64 0.60 1.00
60 (ACTB) 0.43 0.54 0.56 1.00 0.52 0.46 0.52 0.54 0.62 0.55 0.44 0.54 0.22 0.47 0.56 0.54 0.54 0.34 0.52 0.48 1.00
830 (CAPZA2) 1.00 1.00 1.00 0.52 1.00 1.00 1.00 1.00 1.00 0.51 0.72 0.72 0.16 0.51 1.00 1.00 1.00 0.33 0.51 0.51 0.51
3936 (LCP1) 0.57 0.72 0.76 0.46 1.00 1.00 1.00 0.70 0.65 0.53 0.67 0.80 0.18 0.43 0.76 0.72 0.72 0.32 0.48 0.46 0.69
9948 (WDR1) 1.00 1.00 1.00 0.52 1.00 1.00 1.00 1.00 1.00 0.51 0.72 0.72 0.16 0.51 1.00 1.00 1.00 0.33 0.51 0.51 0.51
28988 (DBNL) 0.58 0.80 0.91 0.54 1.00 0.70 1.00 1.00 0.74 0.64 0.67 0.73 0.21 0.52 0.91 0.80 0.80 0.38 0.60 0.55 1.00
10096 (ACTR3) 0.90 0.85 0.81 0.62 1.00 0.65 1.00 0.74 1.00 0.63 0.60 0.67 0.22 0.48 0.81 0.85 0.85 0.37 0.58 0.52 1.00
7295 (TXN) 0.37 0.72 0.71 0.55 0.51 0.53 0.51 0.64 0.63 1.00 0.58 0.67 0.46 0.49 0.71 0.72 0.72 0.40 0.60 0.54 1.00
10487 (CAP1) 0.50 0.71 0.76 0.44 0.72 0.67 0.72 0.67 0.60 0.58 1.00 0.70 0.17 0.43 0.76 0.71 0.71 0.34 0.48 0.46 0.69
2934 (GSN) 0.47 0.73 0.80 0.54 0.72 0.80 0.72 0.73 0.67 0.67 0.70 1.00 0.22 0.52 0.80 0.73 0.73 0.39 0.61 0.57 1.00
7298 (TYMS) 0.15 0.23 0.22 0.22 0.16 0.18 0.16 0.21 0.22 0.46 0.17 0.22 1.00 0.27 0.22 0.23 0.23 0.21 0.25 0.23 0.29
3093 (UBE2K) 0.29 0.51 0.55 0.47 0.51 0.43 0.51 0.52 0.48 0.49 0.43 0.52 0.27 1.00 0.55 0.51 0.51 0.42 0.52 0.47 1.00
829 (CAPZA1) 0.64 0.90 1.00 0.56 1.00 0.76 1.00 0.91 0.81 0.71 0.76 0.80 0.22 0.55 1.00 0.90 0.90 0.42 0.64 0.60 1.00
1073 (CFL2) 0.69 1.00 0.90 0.54 1.00 0.72 1.00 0.80 0.85 0.72 0.71 0.73 0.23 0.51 0.90 1.00 1.00 0.42 0.62 0.57 1.00
11034 (DSTN) 0.69 1.00 0.90 0.54 1.00 0.72 1.00 0.80 0.85 0.72 0.71 0.73 0.23 0.51 0.90 1.00 1.00 0.42 0.62 0.57 1.00
79017 (GGCT) 0.24 0.42 0.42 0.34 0.33 0.32 0.33 0.38 0.37 0.40 0.34 0.39 0.21 0.42 0.42 0.42 0.42 1.00 0.39 0.37 0.61
10465 (PPIH) 0.36 0.62 0.64 0.52 0.51 0.48 0.51 0.60 0.58 0.60 0.48 0.61 0.25 0.52 0.64 0.62 0.62 0.39 1.00 0.55 1.00
84817 (TXNDC17) 0.32 0.57 0.60 0.48 0.51 0.46 0.51 0.55 0.52 0.54 0.46 0.57 0.23 0.47 0.60 0.57 0.57 0.37 0.55 1.00 1.00
7464 (CORO2A) 0.51 1.00 1.00 1.00 0.51 0.69 0.51 1.00 1.00 1.00 0.69 1.00 0.29 1.00 1.00 1.00 1.00 0.61 1.00 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
WDR1 Human Skeletal muscle - 4559 m 9 day downregulated -1.34 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
ELF1 1997 WDR1 9948 proximal_filtered 22955619 TRANSFAC
SRF 6722 WDR1 9948 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT019985 hsa-miR-375 Homo sapiens WDR1 9948 Homo sapiens Microarray Functional MTI (Weak) 20215506
MIRT028095 hsa-miR-93-5p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT028095 hsa-miR-93-5p Homo sapiens WDR1 9948 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT036411 hsa-miR-1226-3p Homo sapiens WDR1 9948 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT036948 hsa-miR-877-3p Homo sapiens WDR1 9948 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039865 hsa-miR-615-3p Homo sapiens WDR1 9948 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT049572 hsa-miR-92a-3p Homo sapiens WDR1 9948 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT163905 hsa-miR-5680 Homo sapiens WDR1 9948 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT163869 hsa-miR-539-5p Homo sapiens WDR1 9948 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT439290 hsa-miR-218-5p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 23212916
MIRT439291 hsa-miR-20a-5p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT439293 hsa-miR-106b-5p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT452506 hsa-miR-3178 Homo sapiens WDR1 9948 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT452507 hsa-miR-3123 Homo sapiens WDR1 9948 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT452509 hsa-miR-3925-5p Homo sapiens WDR1 9948 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT452508 hsa-miR-3976 Homo sapiens WDR1 9948 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT452510 hsa-miR-3121-3p Homo sapiens WDR1 9948 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT726106 hsa-miR-519d-3p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726105 hsa-miR-19b-3p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726108 hsa-miR-20b-5p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726109 hsa-miR-17-5p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726107 hsa-miR-19a-3p Homo sapiens WDR1 9948 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
Gene Ontology
ID GO ID GO Term GO Type
9948 GO:0030043 actin filament fragmentation GOTERM_BP_DIRECT
9948 GO:0005911 cell-cell junction GOTERM_CC_DIRECT
9948 actinportion None GOTERM_CC_DIRECT
9948 GO:0043297 apical junction assembly GOTERM_BP_DIRECT
9948 GO:0005576 extracellular region GOTERM_CC_DIRECT
9948 GO:0030220 platelet formation GOTERM_BP_DIRECT
9948 GO:1990266 neutrophil migration GOTERM_BP_DIRECT
9948 GO:0002446 neutrophil mediated immunity GOTERM_BP_DIRECT
9948 GO:0030834 regulation of actin filament depolymerization GOTERM_BP_DIRECT
9948 GO:0030836 positive regulation of actin filament depolymerization GOTERM_BP_DIRECT
9948 GO:0051015 cobalt ion binding GOTERM_MF_DIRECT
9948 GO:0030864 cortical actin cytoskeleton GOTERM_CC_DIRECT
9948 GO:0043209 myelin sheath GOTERM_CC_DIRECT
9948 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
9948 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization GOTERM_BP_DIRECT
9948 GO:0002102 podosome GOTERM_CC_DIRECT
9948 GO:0007605 sensory perception of sound GOTERM_BP_DIRECT
9948 GO:0005737 cytoplasm GOTERM_CC_DIRECT
9948 GO:0030865 cortical cytoskeleton organization GOTERM_BP_DIRECT
9948 GO:0040011 locomotion GOTERM_BP_DIRECT
9948 GO:0045199 maintenance of epithelial cell apical/basal polarity GOTERM_BP_DIRECT
9948 GO:0045214 sarcomere organization GOTERM_BP_DIRECT
9948 GO:0005884 actin filament GOTERM_CC_DIRECT
9948 GO:0042643 actomyosin GOTERM_CC_DIRECT
9948 GO:0002576 platelet degranulation GOTERM_BP_DIRECT
9948 GO:0042247 establishment of planar polarity of follicular epithelium GOTERM_BP_DIRECT
9948 GO:0005829 cytosol GOTERM_CC_DIRECT
9948 GO:0042995 cell projection GOTERM_CC_DIRECT
9948 GO:0048713 regulation of oligodendrocyte differentiation GOTERM_BP_DIRECT
9948 GO:0008360 regulation of cell shape GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
WDR1 9948 Thrombocytopenia C0040034 Disease or Syndrome 0.3 0.713 0.483 phenotype
WDR1 9948 Osteoporosis, Senile C0029459 Disease or Syndrome 0.3 0.713 0.483 disease
WDR1 9948 Post-Traumatic Osteoporosis C0751406 Disease or Syndrome 0.3 0.713 0.483 disease
WDR1 9948 Inflammation C0021368 Pathologic Function 0.3 0.713 0.483 phenotype
WDR1 9948 Osteoporosis, Age-Related C0001787 Disease or Syndrome 0.3 0.713 0.483 disease
WDR1 9948 Osteoporosis C0029456 Disease or Syndrome 0.3 0.713 0.483 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types