ALTITUDEOMICSDB

Annexin A5

AltitudeomicsDB

Protein Official symbol	ANXA5
Aliases	ANXA5 ANX5 ENX2 PP4
Chromosomal Location	4
Length	320
Uniprot ID	P08758
EC number	None
Protein family Information(Pfam)	PF00191;
PDB id	1ANW;1ANX;1AVH;1AVR;1HAK;1HVD;1HVE;1HVF;1HVG;1SAV;2XO2;2XO3;6K22;6K25;
InterPro ID	IPR001464;IPR018502;IPR018252;IPR037104;IPR002392;
dbSNP	None

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
XIAP	CASP8	0.9990000000000001
CASP8	BCL2L1	0.9990000000000001
XIAP	CASP3	0.9990000000000001
BCL2L1	TP53	0.9990000000000001
BECN1	BCL2L1	0.9990000000000001
VEGFA	KDR	0.9990000000000001
CASP8	CASP3	0.9990000000000001
CASP7	CASP8	0.9990000000000001
XIAP	CASP9	0.9990000000000001
BCL2L11	BCL2L1	0.9990000000000001
CASP9	CYCS	0.998
EGFR	STAT3	0.998
BCL2L11	MCL1	0.998
CYCS	BCL2L1	0.996
XIAP	CASP7	0.996
CASP3	CYCS	0.995
MAPK8	TP53	0.995
EGFR	CDH1	0.995
AKT1	STAT3	0.9940000000000001
VEGFA	STAT3	0.9940000000000001
AKT1	CASP9	0.9940000000000001
CASP8	CASP9	0.9940000000000001
AKT1	TP53	0.9940000000000001
STAT3	CCND1	0.993
AKT1	BCL2L1	0.993
BCL2L1	STAT3	0.993
MYC	AKT1	0.992
MAPK8	BCL2L11	0.991
PARP1	CASP3	0.99
MYC	STAT3	0.99
BCL2L11	CASP3	0.988
CASP8	TP53	0.987
TP53	STAT3	0.986
TNF	CASP8	0.986
STAT3	MAPK3	0.986
MAPK8	BCL2L1	0.986
VEGFA	ALB	0.986
MCL1	STAT3	0.985
BCL2L11	MAPK3	0.985
MCL1	TP53	0.9840000000000001
CASP3	CDH1	0.983
CASP7	PARP1	0.981
CASP7	CYCS	0.981
CASP8	MAPK3	0.98
MYC	MAPK3	0.98
PTGS2	STAT3	0.98
VEGFA	EGFR	0.9790000000000001
MYC	TNF	0.976
TNF	STAT3	0.976
CASP9	CASP3	0.972
CASP9	BCL2L1	0.971
BCL2L1	MAPK3	0.9690000000000001
MYC	TP53	0.9690000000000001
AKT1	CASP3	0.9690000000000001
GPNMB	EGFR	0.966
MAPK3	CDH1	0.966
VEGFA	AKT1	0.966
TP53	MAPK3	0.966
EGFR	TP53	0.9640000000000001
MYC	CCND1	0.9640000000000001
TP53	CCND1	0.963
TNF	XIAP	0.96
MCL1	BCL2L1	0.9520000000000001
PARP1	CASP9	0.9520000000000001
AKT1	GAPDH	0.95
MAPK8	MAPK3	0.948
CASP7	CASP9	0.948
EGFR	MAPK3	0.946
CASP3	TP53	0.9440000000000001
AKT1	CCND1	0.943
PTPRC	CD44	0.943
CASP3	BCL2L1	0.937
CASP7	CASP3	0.935
AKT1	BECN1	0.934
MCL1	BECN1	0.929
TP53	GAPDH	0.927
TNF	PTGS2	0.9259999999999999
AKT1	BCL2L11	0.9259999999999999
BECN1	CASP3	0.925
CASP3	ANXA5	0.9229999999999999
PARP1	WDTC1	0.922
CD44	EGFR	0.9209999999999999
VEGFA	TNF	0.919
VEGFA	TP53	0.9179999999999999
VEGFA	PTGS2	0.9179999999999999
EGFR	CCND1	0.917
PTGS2	TP53	0.915
CASP8	CYCS	0.914
CD44	TP53	0.914
AKT1	XIAP	0.9129999999999999
MCL1	CASP3	0.912
ACTG1	CASP3	0.912
TNF	MAPK8	0.91
CD44	STAT3	0.907
AKT1	MAPK3	0.907
MAPK8	STAT3	0.9059999999999999
AKT1	CDH1	0.904
DNTT	CASP3	0.902
MAPK8	CASP3	0.9009999999999999
XIAP	BCL2L1	0.9
HEPN1	ANXA5	0.9
ACTG1	GAPDH	0.898
WDTC1	CASP3	0.892
TP53	CDH1	0.8909999999999999
PARP1	TP53	0.8859999999999999
EGFR	GAPDH	0.885
MYC	MAPK8	0.882
MCL1	IL7	0.88
AKT1	ANXA5	0.879
BECN1	TP53	0.8759999999999999
AKT1	TNF	0.8759999999999999
TNF	CASP3	0.873
MYC	EGFR	0.872
PTGS2	EGFR	0.872
CASP9	ANXA5	0.871
AKT1	CYCS	0.87
MAPK8	MCL1	0.866
MAPK8	CASP8	0.865
CASP3	MAPK3	0.862
BCL2L11	BECN1	0.861
WDTC1	CYCS	0.861
CASP3	GAPDH	0.86
CASP3	STAT3	0.858
MYC	MCL1	0.858
MAPK8	BECN1	0.855
AKT1	PTGS2	0.8540000000000001
MYC	VEGFA	0.8540000000000001
CASP3	CCND1	0.8540000000000001
TP53	KDR	0.853
PTPRC	TNF	0.853
TNF	ALB	0.851
ACTG1	CASP7	0.85
AKT1	MCL1	0.85
CASP9	TP53	0.8490000000000001
MAPK3	GAPDH	0.8490000000000001
ALB	GAPDH	0.847
MCL1	CASP9	0.847
MYC	CDH1	0.846
CYCS	GAPDH	0.845
CASP8	ANXA5	0.8420000000000001
XIAP	MCL1	0.84
MAPK8	PTGS2	0.84
CYCS	TP53	0.8390000000000001
CD44	CDH1	0.838
BCL2L1	ANXA5	0.8370000000000001
CASP3	ALB	0.835
TNF	BCL2L1	0.833
STAT3	CDH1	0.831
BCL2L1	CCND1	0.83
BECN1	EGFR	0.826
VEGFA	CDH1	0.826
TNF	CD44	0.825
TNF	TP53	0.825
CDH1	CCND1	0.825
PTGS2	MAPK3	0.821
PARP1	CASP8	0.82
MAPK8	CCND1	0.818
CASP9	MAPK3	0.818
VEGFA	MAPK8	0.8170000000000001
DNTT	ANXA5	0.816
CYCS	ANXA5	0.815
MYC	GAPDH	0.815
PTGS2	GAPDH	0.812
ANXA5	GAPDH	0.8109999999999999
MYC	BCL2L11	0.8109999999999999
BCL2L11	CYCS	0.809
MCL1	CYCS	0.8079999999999999
VEGFA	CD44	0.805
ANXA5	TP53	0.805
MCL1	CASP8	0.805
ANXA5	ALB	0.805
PTGS2	ANXA5	0.804
DNTT	ALB	0.8009999999999999
MYC	BCL2L1	0.8
PTPRC	ALB	0.799
MYC	ALB	0.7979999999999999
CD44	ALB	0.7979999999999999
PTGS2	ALB	0.797
CASP7	BCL2L1	0.7959999999999999
VEGFA	ANXA5	0.7929999999999999
CASP9	WDTC1	0.792
BECN1	STAT3	0.7909999999999999
CDH1	GAPDH	0.7909999999999999
AKT1	PARP1	0.7909999999999999
VEGFA	MAPK3	0.79
STAT3	KDR	0.789
XIAP	CYCS	0.787
BCL2L11	CASP9	0.7859999999999999
BCL2L11	EGFR	0.785
VEGFA	CCND1	0.784
ANXA5	CCND1	0.782
CD44	CCND1	0.78
MCL1	MAPK3	0.7759999999999999
ACTG1	ANXA5	0.7759999999999999
MYC	CASP3	0.775
ALB	KDR	0.774
BECN1	GAPDH	0.774
VEGFA	MCL1	0.773
CYCS	ALB	0.773
AKT1	ALB	0.772
MAPK8	CYCS	0.772
GAPDH	CCND1	0.769
MCL1	GAPDH	0.767
ALB	EGFR	0.767
BCL2L11	CASP8	0.767
MCL1	ANXA5	0.763
PTPRC	STAT3	0.762
ALB	CDH1	0.759
MAPK8	GAPDH	0.758
ALB	MAPK3	0.757
MYC	PARP1	0.755
BNIPL	ANXA5	0.753
TNF	IL7	0.752
DNTT	CASP9	0.752
MCL1	CCND1	0.752
PTPRC	KDR	0.7509999999999999
CASP3	EGFR	0.7509999999999999
MAPK3	CCND1	0.75
TNF	GAPDH	0.75
AKT1	CASP8	0.746
VEGFA	GAPDH	0.745
GPNMB	ANXA5	0.745
PTGS2	CDH1	0.7440000000000001
PARP1	ANXA5	0.743
BCL2L11	ANXA5	0.743
TNF	MAPK3	0.742
MAPK8	CASP9	0.741
ANXA5	EGFR	0.738
VEGFA	CASP3	0.737
CASP9	CCND1	0.737
AKT1	CD44	0.737
CASP8	EGFR	0.736
WDTC1	ANXA5	0.735
MAPK8	PARP1	0.735
CASP8	WDTC1	0.7340000000000001
TNF	ANXA5	0.7340000000000001
STAT3	GAPDH	0.7340000000000001
ANXA5	CDH1	0.7340000000000001
WDTC1	TP53	0.733
BECN1	ANXA5	0.732
CASP7	ANXA5	0.732
MYC	ANXA5	0.731
BCL2L11	TP53	0.728
AKT1	WDTC1	0.727
RNASE1	ANXA5	0.727
TNF	KDR	0.727
CYCS	MAPK3	0.726
TNF	CCND1	0.725
XIAP	TP53	0.7240000000000001
ANXA5	STAT3	0.723
BECN1	CASP9	0.7170000000000001
TNF	EGFR	0.716
CASP9	GAPDH	0.716
DNTT	CYCS	0.715
ANXA5	MAPK3	0.713
ALB	STAT3	0.711
MAPK8	ANXA5	0.71
PTPRC	ANXA5	0.71
WDTC1	BCL2L1	0.7090000000000001
ANXA5	IL7	0.7090000000000001
DNTT	TP53	0.708
BECN1	CYCS	0.706
BCL2L11	XIAP	0.705
TNF	CASP9	0.703
CD44	ANXA5	0.703
ANXA5	KDR	0.701
XIAP	CCND1	0.701
XIAP	ANXA5	0.7
WDTC1	ALB	0.7

Gene Ontology Semantic Similarity

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#	331 (XIAP)	841 (CASP8)	598 (BCL2L1)	8678 (BECN1)	7422 (VEGFA)	840 (CASP7)	10018 (BCL2L11)	842 (CASP9)	1956 (EGFR)	54205 (CYCS)	836 (CASP3)	5599 (MAPK8)	207 (AKT1)	6774 (STAT3)	4609 (MYC)	142 (PARP1)	7157 (TP53)	7124 (TNF)	4170 (MCL1)	5743 (PTGS2)	10457 (GPNMB)	5595 (MAPK3)	5788 (PTPRC)	960 (CD44)	71 (ACTG1)	1791 (DNTT)	23038 (WDTC1)	213 (ALB)	999 (CDH1)	308 (ANXA5)	2597 (GAPDH)	149428 (BNIPL)	6035 (RNASE1)	3791 (KDR)	595 (CCND1)	3574 (IL7)
331 (XIAP)	1.00	0.50	0.62	0.58	0.60	0.44	0.54	0.51	0.51	0.45	0.44	0.58	0.55	0.49	0.49	0.62	0.51	0.60	0.51	0.49	0.53	0.55	0.46	0.49	0.59	0.58	1.00	0.55	0.66	0.51	0.56	0.63	0.48	0.50	0.60	0.56
841 (CASP8)	0.50	1.00	0.54	0.57	0.57	0.91	0.49	0.83	0.49	0.49	0.85	0.49	0.48	0.50	0.47	0.55	0.52	0.54	0.48	0.50	0.50	0.48	0.50	0.47	0.58	0.48	1.00	0.52	0.59	0.45	0.50	0.54	0.55	0.46	0.55	0.50
598 (BCL2L1)	0.62	0.54	1.00	0.77	0.66	0.51	0.74	0.61	0.51	0.59	0.43	0.57	0.52	0.58	0.57	0.70	0.57	0.73	0.78	0.58	0.64	0.56	0.70	0.64	0.75	0.68	1.00	0.62	0.78	0.60	0.60	0.86	0.61	0.53	0.79	0.77
8678 (BECN1)	0.58	0.57	0.77	1.00	0.64	0.50	0.79	0.54	0.52	0.60	0.42	0.57	0.50	0.52	0.58	0.63	0.56	0.71	0.68	0.58	0.65	0.57	0.61	0.66	0.84	0.72	1.00	0.60	0.80	0.61	0.56	0.85	0.62	0.53	0.75	0.82
7422 (VEGFA)	0.60	0.57	0.66	0.64	1.00	0.55	0.63	0.56	0.56	0.58	0.51	0.57	0.56	0.59	0.57	0.62	0.57	0.69	0.64	0.57	0.78	0.57	0.58	0.62	0.65	0.61	1.00	0.62	0.68	0.61	0.59	0.68	0.59	0.56	0.64	0.68
840 (CASP7)	0.44	0.91	0.51	0.50	0.55	1.00	0.45	0.86	0.42	0.45	0.87	0.45	0.43	0.44	0.45	0.52	0.48	0.51	0.44	0.46	0.48	0.44	0.47	0.42	0.48	0.44	1.00	0.49	0.61	0.39	0.44	0.49	0.53	0.41	0.54	0.47
10018 (BCL2L11)	0.54	0.49	0.74	0.79	0.63	0.45	1.00	0.50	0.47	0.54	0.37	0.52	0.46	0.50	0.57	0.60	0.52	0.69	0.64	0.53	0.63	0.52	0.56	0.64	0.70	0.67	1.00	0.58	0.79	0.56	0.64	0.83	0.57	0.50	0.71	0.80
842 (CASP9)	0.51	0.83	0.61	0.54	0.56	0.86	0.50	1.00	0.49	0.48	0.85	0.55	0.51	0.50	0.47	0.59	0.52	0.54	0.48	0.49	0.51	0.47	0.57	0.47	0.51	0.49	1.00	0.51	0.62	0.49	0.47	0.53	0.54	0.45	0.62	0.52
1956 (EGFR)	0.51	0.49	0.51	0.52	0.56	0.42	0.47	0.49	1.00	0.44	0.42	0.68	0.69	0.59	0.53	0.57	0.63	0.54	0.48	0.48	0.49	0.65	0.51	0.56	0.52	0.51	1.00	0.54	0.56	0.46	0.50	0.49	0.43	0.71	0.54	0.47
54205 (CYCS)	0.45	0.49	0.59	0.60	0.58	0.45	0.54	0.48	0.44	1.00	0.39	0.45	0.43	0.50	0.53	0.56	0.53	0.59	0.51	0.58	0.53	0.44	0.65	0.49	0.56	0.49	1.00	0.56	0.68	0.45	0.45	0.60	0.55	0.43	0.61	0.58
836 (CASP3)	0.44	0.85	0.43	0.42	0.51	0.87	0.37	0.85	0.42	0.39	1.00	0.43	0.42	0.42	0.41	0.48	0.47	0.45	0.38	0.41	0.42	0.38	0.41	0.36	0.41	0.37	1.00	0.45	0.54	0.36	0.39	0.40	0.46	0.37	0.48	0.39
5599 (MAPK8)	0.58	0.49	0.57	0.57	0.57	0.45	0.52	0.55	0.68	0.45	0.43	1.00	0.78	0.49	0.48	0.62	0.54	0.56	0.50	0.52	0.52	0.86	0.47	0.49	0.54	0.62	1.00	0.52	0.63	0.51	0.52	0.55	0.47	0.68	0.66	0.54
207 (AKT1)	0.55	0.48	0.52	0.50	0.56	0.43	0.46	0.51	0.69	0.43	0.42	0.78	1.00	0.48	0.46	0.58	0.56	0.53	0.45	0.48	0.50	0.74	0.44	0.45	0.51	0.56	1.00	0.53	0.57	0.56	0.51	0.51	0.44	0.66	0.55	0.47
6774 (STAT3)	0.49	0.50	0.58	0.52	0.59	0.44	0.50	0.50	0.59	0.50	0.42	0.49	0.48	1.00	0.84	0.64	0.79	0.65	0.50	0.51	0.52	0.49	0.51	0.50	0.53	0.48	1.00	0.63	0.57	0.47	0.49	0.54	0.47	0.48	0.60	0.51
4609 (MYC)	0.49	0.47	0.57	0.58	0.57	0.45	0.57	0.47	0.53	0.53	0.41	0.48	0.46	0.84	1.00	0.63	0.73	0.70	0.53	0.52	0.56	0.48	0.49	0.55	0.56	0.52	1.00	0.64	0.64	0.50	0.50	0.58	0.49	0.49	0.63	0.57
142 (PARP1)	0.62	0.55	0.70	0.63	0.62	0.52	0.60	0.59	0.57	0.56	0.48	0.62	0.58	0.64	0.63	1.00	0.66	0.67	0.57	0.60	0.58	0.60	0.60	0.56	0.63	0.62	1.00	0.63	0.67	0.54	0.60	0.66	0.56	0.54	0.72	0.62
7157 (TP53)	0.51	0.52	0.57	0.56	0.57	0.48	0.52	0.52	0.63	0.53	0.47	0.54	0.56	0.79	0.73	0.66	1.00	0.64	0.53	0.56	0.53	0.52	0.53	0.51	0.56	0.51	1.00	0.66	0.57	0.51	0.56	0.54	0.50	0.49	0.63	0.53
7124 (TNF)	0.60	0.54	0.73	0.71	0.69	0.51	0.69	0.54	0.54	0.59	0.45	0.56	0.53	0.65	0.70	0.67	0.64	1.00	0.63	0.59	0.63	0.56	0.58	0.62	0.71	0.65	1.00	0.66	0.74	0.59	0.59	0.77	0.59	0.53	0.70	0.72
4170 (MCL1)	0.51	0.48	0.78	0.68	0.64	0.44	0.64	0.48	0.48	0.51	0.38	0.50	0.45	0.50	0.53	0.57	0.53	0.63	1.00	0.50	0.58	0.49	0.52	0.56	0.63	0.58	1.00	0.56	0.72	0.53	0.50	0.69	0.52	0.48	0.66	0.67
5743 (PTGS2)	0.49	0.50	0.58	0.58	0.57	0.46	0.53	0.49	0.48	0.58	0.41	0.52	0.48	0.51	0.52	0.60	0.56	0.59	0.50	1.00	0.52	0.50	0.48	0.49	0.55	0.51	1.00	0.58	0.65	0.46	0.51	0.56	0.48	0.45	0.64	0.55
10457 (GPNMB)	0.53	0.50	0.64	0.65	0.78	0.48	0.63	0.51	0.49	0.53	0.42	0.52	0.50	0.52	0.56	0.58	0.53	0.63	0.58	0.52	1.00	0.52	0.54	0.62	0.62	0.58	1.00	0.59	0.71	0.58	0.52	0.66	0.54	0.58	0.65	0.65
5595 (MAPK3)	0.55	0.48	0.56	0.57	0.57	0.44	0.52	0.47	0.65	0.44	0.38	0.86	0.74	0.49	0.48	0.60	0.52	0.56	0.49	0.50	0.52	1.00	0.45	0.49	0.53	0.66	1.00	0.52	0.65	0.44	0.52	0.56	0.46	0.71	0.60	0.54
5788 (PTPRC)	0.46	0.50	0.70	0.61	0.58	0.47	0.56	0.57	0.51	0.65	0.41	0.47	0.44	0.51	0.49	0.60	0.53	0.58	0.52	0.48	0.54	0.45	1.00	0.61	0.56	0.50	1.00	0.53	0.68	0.46	0.46	0.61	0.58	0.52	0.69	0.59
960 (CD44)	0.49	0.47	0.64	0.66	0.62	0.42	0.64	0.47	0.56	0.49	0.36	0.49	0.45	0.50	0.55	0.56	0.51	0.62	0.56	0.49	0.62	0.49	0.61	1.00	0.61	0.56	1.00	0.55	0.72	0.51	0.50	0.66	0.50	0.59	0.64	0.64
71 (ACTG1)	0.59	0.58	0.75	0.84	0.65	0.48	0.70	0.51	0.52	0.56	0.41	0.54	0.51	0.53	0.56	0.63	0.56	0.71	0.63	0.55	0.62	0.53	0.56	0.61	1.00	0.64	1.00	0.61	0.75	0.57	0.57	0.81	0.57	0.51	0.70	0.73
1791 (DNTT)	0.58	0.48	0.68	0.72	0.61	0.44	0.67	0.49	0.51	0.49	0.37	0.62	0.56	0.48	0.52	0.62	0.51	0.65	0.58	0.51	0.58	0.66	0.50	0.56	0.64	1.00	1.00	0.56	0.75	0.51	0.54	0.74	0.52	0.57	0.68	0.71
23038 (WDTC1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
213 (ALB)	0.55	0.52	0.62	0.60	0.62	0.49	0.58	0.51	0.54	0.56	0.45	0.52	0.53	0.63	0.64	0.63	0.66	0.66	0.56	0.58	0.59	0.52	0.53	0.55	0.61	0.56	1.00	1.00	0.65	0.59	0.54	0.63	0.53	0.50	0.61	0.59
999 (CDH1)	0.66	0.59	0.78	0.80	0.68	0.61	0.79	0.62	0.56	0.68	0.54	0.63	0.57	0.57	0.64	0.67	0.57	0.74	0.72	0.65	0.71	0.65	0.68	0.72	0.75	0.75	1.00	0.65	1.00	0.69	0.64	0.82	0.70	0.62	0.75	0.80
308 (ANXA5)	0.51	0.45	0.60	0.61	0.61	0.39	0.56	0.49	0.46	0.45	0.36	0.51	0.56	0.47	0.50	0.54	0.51	0.59	0.53	0.46	0.58	0.44	0.46	0.51	0.57	0.51	1.00	0.59	0.69	1.00	0.45	0.62	0.46	0.44	0.62	0.59
2597 (GAPDH)	0.56	0.50	0.60	0.56	0.59	0.44	0.64	0.47	0.50	0.45	0.39	0.52	0.51	0.49	0.50	0.60	0.56	0.59	0.50	0.51	0.52	0.52	0.46	0.50	0.57	0.54	1.00	0.54	0.64	0.45	1.00	0.60	0.47	0.49	0.58	0.54
149428 (BNIPL)	0.63	0.54	0.86	0.85	0.68	0.49	0.83	0.53	0.49	0.60	0.40	0.55	0.51	0.54	0.58	0.66	0.54	0.77	0.69	0.56	0.66	0.56	0.61	0.66	0.81	0.74	1.00	0.63	0.82	0.62	0.60	1.00	0.63	0.53	0.75	0.88
6035 (RNASE1)	0.48	0.55	0.61	0.62	0.59	0.53	0.57	0.54	0.43	0.55	0.46	0.47	0.44	0.47	0.49	0.56	0.50	0.59	0.52	0.48	0.54	0.46	0.58	0.50	0.57	0.52	1.00	0.53	0.70	0.46	0.47	0.63	1.00	0.44	0.62	0.60
3791 (KDR)	0.50	0.46	0.53	0.53	0.56	0.41	0.50	0.45	0.71	0.43	0.37	0.68	0.66	0.48	0.49	0.54	0.49	0.53	0.48	0.45	0.58	0.71	0.52	0.59	0.51	0.57	1.00	0.50	0.62	0.44	0.49	0.53	0.44	1.00	0.56	0.52
595 (CCND1)	0.60	0.55	0.79	0.75	0.64	0.54	0.71	0.62	0.54	0.61	0.48	0.66	0.55	0.60	0.63	0.72	0.63	0.70	0.66	0.64	0.65	0.60	0.69	0.64	0.70	0.68	1.00	0.61	0.75	0.62	0.58	0.75	0.62	0.56	1.00	0.73
3574 (IL7)	0.56	0.50	0.77	0.82	0.68	0.47	0.80	0.52	0.47	0.58	0.39	0.54	0.47	0.51	0.57	0.62	0.53	0.72	0.67	0.55	0.65	0.54	0.59	0.64	0.73	0.71	1.00	0.59	0.80	0.59	0.54	0.88	0.60	0.52	0.73	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
ANXA5	Rat	Lungs	-	7600 m	24 hours	upregulated	-0.4	2-DE	Northern indo-australian plate	Sprague-Dawley	1	Male SD rats weighing 220g	26022216
ANXA5	Rat	Lungs	-	7600 m	12 hours	downregulated	1.2	2-DE	Northern indo-australian plate	Sprague-Dawley	1	Male SD rats weighing 220g	26022216

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT022801	hsa-miR-124-3p	Homo sapiens	ANXA5	308	Homo sapiens	Proteomics;Microarray	Functional MTI (Weak)	18668037
MIRT029721	hsa-miR-26b-5p	Homo sapiens	ANXA5	308	Homo sapiens	Microarray	Functional MTI (Weak)	19088304
MIRT038248	hsa-miR-330-5p	Homo sapiens	ANXA5	308	Homo sapiens	CLASH	Functional MTI (Weak)	23622248
MIRT329265	hsa-miR-190a-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT329269	hsa-miR-5011-5p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545123	hsa-miR-6781-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545131	hsa-miR-6819-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545128	hsa-miR-3688-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545132	hsa-miR-1277-5p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545133	hsa-miR-522-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545129	hsa-miR-410-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545130	hsa-miR-6877-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545127	hsa-miR-302a-5p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545122	hsa-miR-6124	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545124	hsa-miR-3148	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545125	hsa-miR-2682-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545135	hsa-miR-224-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545134	hsa-miR-4694-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545121	hsa-miR-4435	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT545126	hsa-miR-4755-3p	Homo sapiens	ANXA5	308	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407

Gene Ontology

ID	GO ID	GO Term	GO Type
308	GO:0005509	calcium ion binding	GOTERM_MF_DIRECT
308	GO:0005515	protein binding	GOTERM_MF_DIRECT
308	GO:0005544	phospholipid binding	GOTERM_MF_DIRECT
308	GO:0007165	signal transduction	GOTERM_BP_DIRECT
308	GO:0007596	blood coagulation	GOTERM_BP_DIRECT
308	GO:0043086	negative regulation of catalytic activity	GOTERM_BP_DIRECT
308	GO:0009897	external side of plasma membrane	GOTERM_CC_DIRECT
308	GO:0050819	negative regulation of coagulation	GOTERM_BP_DIRECT
308	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
308	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
308	GO:0072563	endothelial microparticle	GOTERM_CC_DIRECT
308	GO:0005925	focal adhesion	GOTERM_CC_DIRECT
308	GO:0016020	membrane	GOTERM_CC_DIRECT
308	GO:0005622	intracellular	GOTERM_CC_DIRECT
308	GO:0043066	negative regulation of apoptotic process	GOTERM_BP_DIRECT
308	GO:0005543	hyaluronic acid binding	GOTERM_MF_DIRECT
308	GO:0010033	response to organic substance	GOTERM_BP_DIRECT
308	GO:0004859	enzyme inhibitor activity	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
ANXA5	308	Mouth Neoplasms	C0026640	Neoplastic Process	0.3	0.49	0.69	group
ANXA5	308	Acute Myeloid Leukemia, M1	C0026998	Neoplastic Process	0.3	0.49	0.69	disease
ANXA5	308	Pre-Eclampsia	C0032914	Pathologic Function	0.3	0.49	0.69	phenotype
ANXA5	308	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.49	0.69	disease
ANXA5	308	Leukemia, Myelocytic, Acute	C0023467	Neoplastic Process	0.32	0.49	0.69	disease
ANXA5	308	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.31	0.49	0.69	disease
ANXA5	308	Squamous cell carcinoma	C0007137	Neoplastic Process	0.31	0.49	0.69	disease
ANXA5	308	Hepatolenticular Degeneration	C0019202	Disease or Syndrome	0.5	0.49	0.69	disease
ANXA5	308	Weight Gain	C0043094	Finding	0.3	0.49	0.69	phenotype
ANXA5	308	Adenocarcinoma of lung (disorder)	C0152013	Neoplastic Process	0.3	0.49	0.69	disease
ANXA5	308	PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 3	C3280674	Finding	0.3	0.49	0.69	phenotype
ANXA5	308	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.49	0.69	disease
ANXA5	308	Stomach Neoplasms	C0038356	Neoplastic Process	0.3	0.49	0.69	group
ANXA5	308	Malignant neoplasm of mouth	C0153381	Neoplastic Process	0.3	0.49	0.69	disease
ANXA5	308	Hepatic Form of Wilson Disease	C1527352	Disease or Syndrome	0.3	0.49	0.69	disease
ANXA5	308	Acute Myeloid Leukemia (AML-M2)	C1879321	Neoplastic Process	0.3	0.49	0.69	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
ANXA5	308	[ALA31,AIB32]NPY (PIG)	None	None	agonist
ANXA5	308	[LEU31,PRO34]PYY (HUMAN)	None	None	agonist
ANXA5	308	[LEU31,PRO34]NPY (PIG)	None	None	agonist
ANXA5	308	[PP1-17,ALA31,AIB32]NPY (HUMAN)	None	None	agonist
ANXA5	308	[D-TRP32]NPY	None	None	agonist
ANXA5	308	BETA-LAPACHONE	BETA-LAPACHONE	CHEMBL15192	None
ANXA5	308	DNR	DAUNORUBICIN	CHEMBL178	None
ANXA5	308	FMS586	None	None	antagonist
ANXA5	308	L-152,804	CHEMBL1421016	CHEMBL1421016	antagonist
ANXA5	308	NEUROPEPTIDE Y	NAPHTHALENE	CHEMBL16293	agonist
ANXA5	308	NPY-(13-36) (PIG)	None	None	agonist
ANXA5	308	NPY-(3-36) (PIG)	None	None	agonist
ANXA5	308	NPY-(2-36)	None	None	agonist
ANXA5	308	NPY-(18-36) (HUMAN, PIG)	None	None	agonist
ANXA5	308	PANCREATIC POLYPEPTIDE	PHENYLPYRUVATE	CHEMBL1162488	agonist
ANXA5	308	PANCREATIC POLYPEPTIDE	PHENYLPYRUVATE	CHEMBL1162488	agonist
ANXA5	308	PEPTIDE YY	CHEMBL435278	CHEMBL435278	agonist
ANXA5	308	PYY-(3-36)	CHEMBL435278	CHEMBL435278	agonist
ANXA5	308	PYY-(13-36) (MOUSE, RAT, PIG)	None	None	agonist