p21 (RAC1) activated kinase 3
AltitudeomicsDB
Protein Official symbol |
PAK3 |
Aliases |
PAK3 OPHN3 |
Chromosomal Location |
X |
Length |
559 |
Uniprot ID |
O75914 |
EC number |
2.7.11.1 |
Protein family Information(Pfam) |
PF00786;PF00069; |
PDB id |
6FD3; |
InterPro ID |
IPR000095;IPR036936;IPR011009;IPR033923;IPR000719;IPR017441;IPR008271;IPR035063; |
dbSNP |
rs121434612 rs121434613 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
MYL12B |
MYH9 |
0.998 |
EPHB2 |
EFNB2 |
0.994 |
SRC |
PXN |
0.994 |
EPHB1 |
EFNB2 |
0.993 |
SLIT2 |
ROBO1 |
0.992 |
CTTN |
SRC |
0.991 |
EPHB1 |
EFNB3 |
0.99 |
EPHB2 |
EFNB3 |
0.99 |
HRAS |
RAF1 |
0.989 |
VAV1 |
LCK |
0.987 |
CDC42 |
SRC |
0.986 |
CDC42 |
ARHGEF7 |
0.984 |
CTNND1 |
SRC |
0.983 |
PAK4 |
CDC42 |
0.983 |
GIT1 |
PXN |
0.983 |
HRAS |
SRC |
0.983 |
CDC42 |
PXN |
0.981 |
GIT1 |
ARHGEF7 |
0.981 |
GIT2 |
PXN |
0.98 |
NCK1 |
CDC42 |
0.979 |
NRAS |
RAF1 |
0.978 |
VAV1 |
CDC42 |
0.978 |
GIT2 |
ARHGEF6 |
0.978 |
MYH10 |
MYL9 |
0.976 |
CDC42 |
CTTN |
0.976 |
CTTN |
PXN |
0.976 |
HRAS |
SOS1 |
0.976 |
ARHGEF7 |
GIT2 |
0.976 |
MYL12B |
MYH10 |
0.976 |
CDC42 |
VAV2 |
0.975 |
PPP1R12A |
MYL9 |
0.975 |
MYH11 |
MYL9 |
0.975 |
KRAS |
RAF1 |
0.975 |
PAK3 |
ARHGEF6 |
0.974 |
MYH14 |
MYL12B |
0.974 |
MYL9 |
MYH9 |
0.974 |
SOS1 |
KRAS |
0.973 |
MYH14 |
MYL9 |
0.973 |
CDC42 |
LIMK1 |
0.973 |
CTNND1 |
CTTN |
0.972 |
CTNND1 |
VAV2 |
0.972 |
MYL12B |
MYH11 |
0.971 |
SRC |
KRAS |
0.971 |
MYH11 |
MYL12A |
0.971 |
CDC42 |
PAK3 |
0.97 |
SOS1 |
SRC |
0.97 |
VAV1 |
RAC1 |
0.969 |
CDC42 |
ARHGEF6 |
0.968 |
RAC1 |
PXN |
0.968 |
VAV2 |
RAC1 |
0.967 |
HRAS |
FYN |
0.967 |
FYN |
PXN |
0.967 |
CDC42 |
VAV3 |
0.966 |
NCK1 |
GIT1 |
0.966 |
MYL12B |
MYL12A |
0.966 |
SRC |
EFNB2 |
0.966 |
CDC42 |
PAK7 |
0.966 |
CDC42 |
GIT1 |
0.965 |
CDC42 |
CTNND1 |
0.964 |
SOS1 |
NRAS |
0.964 |
CDC42 |
FYN |
0.964 |
CDC42 |
NCK2 |
0.964 |
MYL12B |
PPP1R12A |
0.963 |
NCK1 |
EPHB1 |
0.962 |
CDC42 |
GIT2 |
0.962 |
FYN |
KRAS |
0.961 |
CTTN |
FYN |
0.96 |
ITGB1 |
PXN |
0.96 |
CDC42 |
MYL9 |
0.96 |
MYL12B |
CDC42 |
0.959 |
SRC |
RAC1 |
0.959 |
GIT1 |
PAK3 |
0.959 |
HRAS |
SOS2 |
0.957 |
ITGB1 |
LAMA5 |
0.956 |
VAV3 |
RAC1 |
0.956 |
CTTN |
RAC1 |
0.955 |
NCK1 |
PXN |
0.955 |
RAC1 |
LIMK1 |
0.954 |
SOS1 |
CDC42 |
0.954 |
PPP1R12B |
PPP1CB |
0.953 |
PPP1R12A |
PPP1CB |
0.953 |
CDC42 |
MAPK14 |
0.952 |
NCK1 |
RAC1 |
0.951 |
ARHGEF7 |
PXN |
0.951 |
ARHGEF7 |
PAK3 |
0.951 |
CTNND1 |
FYN |
0.951 |
CDC42 |
ITGB1 |
0.95 |
CDC42 |
ACTA1 |
0.95 |
CDC42 |
LCK |
0.95 |
HRAS |
LCK |
0.949 |
VAV1 |
SOS1 |
0.949 |
SOS1 |
RAC1 |
0.949 |
SOS1 |
VAV2 |
0.949 |
CDC42 |
EPHB2 |
0.948 |
ITGB1 |
SRC |
0.947 |
GIT1 |
NCK2 |
0.947 |
PPP1R12B |
MYL9 |
0.947 |
EPHB2 |
NCK2 |
0.947 |
CDC42 |
NF2 |
0.947 |
SRC |
NRAS |
0.947 |
MYL9 |
PXN |
0.946 |
SLIT2 |
CDC42 |
0.946 |
CTNND1 |
RAC1 |
0.946 |
EPHB1 |
NCK2 |
0.945 |
CTTN |
PAK3 |
0.945 |
ARHGEF7 |
SRC |
0.944 |
NCK2 |
EFNB3 |
0.944 |
RAC1 |
FYN |
0.943 |
GIT1 |
RAC1 |
0.943 |
EFNB2 |
NCK2 |
0.943 |
VAV1 |
HRAS |
0.942 |
PXN |
NCK2 |
0.942 |
ACTA1 |
DMD |
0.942 |
CDC42 |
EFNB2 |
0.942 |
RAC1 |
GIT2 |
0.941 |
NCK1 |
GIT2 |
0.941 |
PXN |
ARHGEF6 |
0.941 |
LCK |
PXN |
0.94 |
GIT1 |
ARHGEF6 |
0.94 |
NCK1 |
PAK3 |
0.94 |
PPP1R12A |
CDC42 |
0.94 |
PPP1CB |
MYL9 |
0.94 |
SRC |
GIT2 |
0.939 |
LCK |
KRAS |
0.939 |
PPP1R12B |
MYH11 |
0.939 |
PAK4 |
RAC1 |
0.939 |
SRC |
EFNB3 |
0.938 |
RAC1 |
SOS2 |
0.938 |
NCK1 |
SOS1 |
0.938 |
CDC42 |
MYH9 |
0.938 |
PPP1R12B |
MYL12B |
0.938 |
PAK4 |
PXN |
0.937 |
ACTA1 |
PXN |
0.937 |
VAV1 |
FYN |
0.937 |
ROBO1 |
CDC42 |
0.937 |
CDC42 |
EFNB3 |
0.936 |
ARHGEF7 |
RAC1 |
0.936 |
PAK4 |
CTTN |
0.935 |
DMD |
PXN |
0.935 |
VAV1 |
NCK1 |
0.935 |
CDC42 |
SOS2 |
0.935 |
CDC42 |
MYH10 |
0.935 |
PXN |
MYL12A |
0.935 |
ACTA1 |
RAC1 |
0.934 |
SOS1 |
FYN |
0.934 |
SOS1 |
LCK |
0.934 |
CDC42 |
MAPK11 |
0.934 |
SRC |
MAPK14 |
0.934 |
CTTN |
ACTA1 |
0.934 |
NCK1 |
FYN |
0.933 |
NCK1 |
EPHB2 |
0.933 |
NCK1 |
HRAS |
0.932 |
RAC1 |
ARHGEF6 |
0.932 |
RAC1 |
NCK2 |
0.932 |
PAK3 |
NCK2 |
0.932 |
RAC1 |
LCK |
0.931 |
NCK1 |
LCK |
0.931 |
NRAS |
LCK |
0.931 |
EPHB2 |
RAC1 |
0.931 |
MYL12B |
PXN |
0.931 |
SRC |
VAV2 |
0.93 |
PAK3 |
PXN |
0.93 |
RAC1 |
MAPK14 |
0.93 |
FYN |
EFNB2 |
0.929 |
SRC |
MAPK11 |
0.929 |
PPP1R12A |
MYH9 |
0.929 |
NCK1 |
SRC |
0.929 |
HRAS |
EPHB2 |
0.929 |
PAK4 |
NCK1 |
0.929 |
PAK7 |
ARHGEF6 |
0.928 |
CTTN |
GIT2 |
0.928 |
PAK4 |
ARHGEF6 |
0.928 |
PAK4 |
ARHGEF7 |
0.928 |
PAK3 |
GIT2 |
0.927 |
CDC42 |
MYH11 |
0.927 |
PPP1R12A |
MYL12A |
0.927 |
EPHB2 |
KRAS |
0.927 |
FYN |
EFNB3 |
0.927 |
SRC |
RAF1 |
0.927 |
RAC1 |
NF2 |
0.926 |
PXN |
EFNB3 |
0.926 |
SRC |
ACTA1 |
0.926 |
SRC |
DMD |
0.926 |
NRAS |
FYN |
0.926 |
PAK3 |
RAC1 |
0.926 |
MYL12B |
RAC1 |
0.925 |
DMD |
PAK3 |
0.925 |
VAV3 |
LCK |
0.924 |
PAK3 |
MYH10 |
0.924 |
PAK4 |
SRC |
0.924 |
FYN |
MAPK14 |
0.924 |
CDC42 |
LAMA5 |
0.924 |
EPHB1 |
RAC1 |
0.924 |
RAC1 |
MYH9 |
0.924 |
SRC |
NCK2 |
0.924 |
SRC |
ARHGEF6 |
0.924 |
ITGB1 |
FYN |
0.924 |
PPP1R12A |
MYH10 |
0.923 |
SOS1 |
NCK2 |
0.923 |
RAC1 |
EFNB2 |
0.923 |
PXN |
EFNB2 |
0.923 |
MYH14 |
CDC42 |
0.923 |
ITGB1 |
DMD |
0.923 |
ARHGEF7 |
FYN |
0.923 |
PAK4 |
GIT2 |
0.922 |
RAC1 |
MYL12A |
0.922 |
MYH11 |
PXN |
0.922 |
CDC42 |
DMD |
0.922 |
PPP1R12A |
MYH11 |
0.922 |
CDC42 |
PPP1CB |
0.921 |
NCK1 |
PAK7 |
0.921 |
ITGB1 |
ACTA1 |
0.921 |
RAC1 |
MYL9 |
0.921 |
ITGB1 |
CTTN |
0.921 |
PAK4 |
RAF1 |
0.921 |
PAK3 |
FYN |
0.921 |
PAK3 |
SOS2 |
0.92 |
GIT1 |
EPHB2 |
0.92 |
NCK1 |
MAPK14 |
0.92 |
MYH10 |
RAC1 |
0.92 |
ROBO1 |
NCK1 |
0.92 |
SOS1 |
PAK3 |
0.92 |
PPP1R12B |
MYH9 |
0.92 |
PAK3 |
KRAS |
0.919 |
FYN |
NCK2 |
0.919 |
PAK3 |
MAPK11 |
0.919 |
EPHB1 |
SRC |
0.919 |
CTTN |
ARHGEF7 |
0.919 |
GIT1 |
FYN |
0.919 |
RAC1 |
EFNB3 |
0.919 |
NCK1 |
SOS2 |
0.918 |
LCK |
MAPK14 |
0.918 |
DMD |
LAMA5 |
0.918 |
SRC |
LAMA5 |
0.918 |
NCK1 |
MAPK11 |
0.918 |
HRAS |
PAK3 |
0.918 |
PAK3 |
NF2 |
0.918 |
EPHB1 |
PXN |
0.918 |
NCK1 |
ARHGEF7 |
0.918 |
NRAS |
PAK3 |
0.918 |
VAV2 |
FYN |
0.918 |
SRC |
PAK3 |
0.917 |
CTTN |
ARHGEF6 |
0.917 |
SLIT2 |
NCK1 |
0.917 |
EPHB1 |
GIT1 |
0.917 |
EPHB2 |
SRC |
0.917 |
FYN |
MAPK11 |
0.917 |
HRAS |
RAC1 |
0.917 |
ITGB1 |
RAC1 |
0.916 |
ACTA1 |
LIMK1 |
0.916 |
MYH11 |
RAC1 |
0.916 |
RAC1 |
KRAS |
0.916 |
PAK7 |
PXN |
0.916 |
RAC1 |
MAPK11 |
0.915 |
NRAS |
RAC1 |
0.915 |
PAK4 |
SOS1 |
0.915 |
PAK3 |
MAPK14 |
0.915 |
HRAS |
EFNB2 |
0.915 |
PPP1CB |
RAC1 |
0.915 |
VAV2 |
LCK |
0.914 |
VAV3 |
FYN |
0.914 |
ROBO1 |
NCK2 |
0.914 |
PAK7 |
RAC1 |
0.914 |
HRAS |
EPHB1 |
0.914 |
PAK3 |
MYH9 |
0.914 |
ACTA1 |
PAK3 |
0.914 |
MYH11 |
PAK3 |
0.914 |
PPP1R12A |
RAC1 |
0.914 |
PPP1R12B |
MYH10 |
0.914 |
GIT1 |
EFNB3 |
0.913 |
ITGB1 |
ARHGEF6 |
0.913 |
SLIT2 |
RAC1 |
0.913 |
ROBO1 |
RAC1 |
0.913 |
PAK4 |
PAK3 |
0.913 |
LCK |
NCK2 |
0.913 |
ITGB1 |
ARHGEF7 |
0.913 |
EPHB2 |
FYN |
0.913 |
PAK7 |
ARHGEF7 |
0.912 |
SOS1 |
VAV3 |
0.912 |
EPHB1 |
FYN |
0.912 |
FYN |
LIMK1 |
0.912 |
PAK7 |
PAK3 |
0.912 |
PAK3 |
EFNB2 |
0.912 |
FYN |
RAF1 |
0.912 |
PAK7 |
GIT2 |
0.911 |
PAK3 |
MYL9 |
0.911 |
PAK3 |
LIMK1 |
0.911 |
ROBO1 |
PAK7 |
0.911 |
PAK7 |
CTTN |
0.911 |
EFNB2 |
EFNB3 |
0.911 |
GIT1 |
EFNB2 |
0.911 |
CTTN |
DMD |
0.911 |
ROBO1 |
SOS2 |
0.911 |
PPP1CB |
MYH10 |
0.911 |
CTNND1 |
PAK3 |
0.911 |
DMD |
ARHGEF6 |
0.911 |
ITGB1 |
PAK3 |
0.911 |
MYH14 |
MYH10 |
0.91 |
MAPK4 |
CDC42 |
0.91 |
MYH10 |
MYH9 |
0.91 |
PAK3 |
MYL12A |
0.91 |
LCK |
MAPK11 |
0.91 |
PAK3 |
RAF1 |
0.91 |
HRAS |
EFNB3 |
0.91 |
ARHGEF7 |
LCK |
0.909 |
ARHGEF7 |
MYL12A |
0.909 |
MYH14 |
PAK3 |
0.909 |
PAK4 |
NCK2 |
0.909 |
SOS1 |
PAK7 |
0.909 |
ROBO1 |
CTNND1 |
0.909 |
MYL12B |
PAK3 |
0.909 |
VAV1 |
CTNND1 |
0.909 |
MYH11 |
MYH10 |
0.909 |
SLIT2 |
PAK3 |
0.909 |
MYL12B |
PPP1CB |
0.908 |
ARHGEF7 |
EFNB2 |
0.908 |
PAK4 |
SLIT2 |
0.908 |
PAK3 |
LCK |
0.908 |
DMD |
RAC1 |
0.908 |
EPHB2 |
NRAS |
0.908 |
PPP1R12A |
PAK3 |
0.908 |
ROBO1 |
PAK3 |
0.908 |
PPP1R12B |
PAK3 |
0.908 |
PAK7 |
SRC |
0.908 |
ARHGEF7 |
NCK2 |
0.908 |
PPP1CB |
PAK3 |
0.908 |
PPP1R12B |
MYH14 |
0.907 |
KRAS |
EFNB2 |
0.907 |
SLIT2 |
PAK7 |
0.907 |
FYN |
LCK |
0.907 |
PAK4 |
SOS2 |
0.907 |
PAK7 |
NCK2 |
0.907 |
VAV2 |
PAK3 |
0.907 |
PAK3 |
EFNB3 |
0.907 |
VAV1 |
PAK3 |
0.907 |
VAV3 |
PAK3 |
0.907 |
MYH10 |
MYL12A |
0.907 |
MAPK4 |
PAK3 |
0.907 |
SLIT2 |
NCK2 |
0.907 |
PAK3 |
LAMA5 |
0.907 |
EPHB1 |
PAK3 |
0.907 |
MYH14 |
PPP1R12A |
0.907 |
PAK7 |
SOS2 |
0.907 |
SOS1 |
SOS2 |
0.906 |
EPHB2 |
PAK3 |
0.906 |
GIT2 |
NCK2 |
0.906 |
SRC |
LCK |
0.906 |
CDC42 |
RAC1 |
0.906 |
MYH14 |
RAC1 |
0.906 |
SLIT2 |
SOS2 |
0.905 |
FYN |
MYL12A |
0.905 |
VAV1 |
VAV3 |
0.905 |
PPP1R12B |
PPP1R12A |
0.905 |
DMD |
GIT2 |
0.905 |
SLIT2 |
SOS1 |
0.905 |
MYL9 |
MYL12A |
0.905 |
PAK7 |
ACTA1 |
0.905 |
KRAS |
EFNB3 |
0.905 |
EPHB1 |
LCK |
0.905 |
GIT1 |
MYL12A |
0.905 |
VAV1 |
VAV2 |
0.905 |
NCK2 |
SOS2 |
0.905 |
PAK4 |
ROBO1 |
0.905 |
ROBO1 |
SOS1 |
0.905 |
PAK4 |
ACTA1 |
0.905 |
RAC1 |
LAMA5 |
0.905 |
GIT2 |
LCK |
0.905 |
EPHB2 |
LCK |
0.905 |
PPP1R12B |
CDC42 |
0.904 |
NRAS |
KRAS |
0.904 |
CTTN |
LAMA5 |
0.904 |
SOS1 |
ITGB1 |
0.904 |
MAPK4 |
RAC1 |
0.904 |
GIT2 |
FYN |
0.904 |
ITGB1 |
GIT2 |
0.904 |
NCK2 |
MAPK14 |
0.904 |
ARHGEF7 |
EFNB3 |
0.904 |
PPP1CB |
MYH9 |
0.904 |
EPHB1 |
EPHB2 |
0.903 |
PAK4 |
PAK7 |
0.903 |
MYL12B |
MYL9 |
0.903 |
ARHGEF7 |
ARHGEF6 |
0.903 |
SRC |
FYN |
0.903 |
EPHB1 |
ARHGEF7 |
0.903 |
MAPK11 |
NCK2 |
0.903 |
ITGB1 |
PAK7 |
0.903 |
PAK4 |
LAMA5 |
0.903 |
MYH14 |
MYH11 |
0.903 |
VAV2 |
VAV3 |
0.903 |
ARHGEF7 |
EPHB2 |
0.903 |
GIT2 |
LAMA5 |
0.903 |
ARHGEF7 |
DMD |
0.902 |
ACTA1 |
LAMA5 |
0.902 |
MYL12A |
MYH9 |
0.902 |
MYH14 |
MYH9 |
0.902 |
PAK4 |
ITGB1 |
0.902 |
HRAS |
NRAS |
0.902 |
NCK1 |
NCK2 |
0.902 |
NRAS |
EFNB2 |
0.902 |
MYH11 |
PPP1CB |
0.902 |
MYH14 |
PPP1CB |
0.902 |
MAPK11 |
MAPK14 |
0.902 |
HRAS |
KRAS |
0.902 |
PPP1R12B |
RAC1 |
0.901 |
EPHB2 |
MYL12A |
0.901 |
PXN |
LAMA5 |
0.901 |
NRAS |
EFNB3 |
0.901 |
ACTA1 |
GIT2 |
0.901 |
EPHB1 |
MYL12A |
0.901 |
CTNND1 |
VAV3 |
0.901 |
PAK4 |
DMD |
0.9 |
EFNB3 |
MYL12A |
0.9 |
LAMA5 |
ARHGEF6 |
0.9 |
EFNB2 |
MYL12A |
0.9 |
ARHGEF7 |
LAMA5 |
0.9 |
ACTA1 |
ARHGEF6 |
0.9 |
NRAS |
SOS2 |
0.9 |
ARHGEF7 |
ACTA1 |
0.9 |
NCK2 |
MYL12A |
0.9 |
PAK7 |
DMD |
0.9 |
MYH11 |
MYH9 |
0.9 |
PAK7 |
LAMA5 |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
4627 (MYH9) |
1948 (EFNB2) |
5829 (PXN) |
6091 (ROBO1) |
6714 (SRC) |
1949 (EFNB3) |
5894 (RAF1) |
3932 (LCK) |
8874 (ARHGEF7) |
998 (CDC42) |
9459 (ARHGEF6) |
10398 (MYL9) |
2017 (CTTN) |
6654 (SOS1) |
9815 (GIT2) |
4628 (MYH10) |
7410 (VAV2) |
103910 (MYL12B) |
3845 (KRAS) |
3984 (LIMK1) |
4629 (MYH11) |
10627 (MYL12A) |
5063 (PAK3) |
5879 (RAC1) |
2534 (FYN) |
10451 (VAV3) |
28964 (GIT1) |
57144 (PAK7) |
1500 (CTNND1) |
4893 (NRAS) |
8440 (NCK2) |
4659 (PPP1R12A) |
2047 (EPHB1) |
6655 (SOS2) |
3911 (LAMA5) |
5500 (PPP1CB) |
1432 (MAPK14) |
3688 (ITGB1) |
58 (ACTA1) |
2048 (EPHB2) |
4771 (NF2) |
3265 (HRAS) |
1756 (DMD) |
4690 (NCK1) |
5600 (MAPK11) |
9353 (SLIT2) |
79784 (MYH14) |
7409 (VAV1) |
10298 (PAK4) |
4660 (PPP1R12B) |
5596 (MAPK4) |
4627 (MYH9)
|
1.00
|
0.48
|
0.53
|
0.51
|
0.60
|
0.33
|
0.49
|
0.54
|
0.47
|
0.68
|
0.44
|
0.26
|
0.55
|
0.43
|
1.00
|
0.91
|
0.47
|
1.00
|
0.49
|
0.47
|
0.47
|
1.00
|
0.45
|
0.69
|
0.49
|
0.45
|
1.00
|
0.47
|
0.56
|
0.49
|
0.51
|
0.48
|
0.41
|
0.46
|
0.37
|
0.48
|
0.47
|
0.63
|
0.62
|
0.42
|
1.00
|
0.73
|
0.55
|
0.55
|
0.45
|
0.55
|
0.62
|
0.44
|
0.46
|
0.44
|
0.50
|
1948 (EFNB2)
|
0.48
|
1.00
|
0.71
|
0.64
|
0.79
|
0.88
|
0.84
|
0.74
|
0.55
|
0.63
|
0.49
|
0.26
|
0.72
|
0.45
|
1.00
|
0.41
|
0.55
|
1.00
|
0.68
|
0.87
|
0.62
|
1.00
|
0.76
|
0.67
|
0.74
|
0.50
|
1.00
|
0.79
|
0.75
|
0.68
|
0.64
|
0.58
|
0.76
|
0.54
|
0.39
|
0.48
|
0.73
|
0.64
|
0.51
|
0.71
|
1.00
|
0.51
|
0.61
|
0.63
|
0.80
|
0.58
|
0.29
|
0.57
|
0.77
|
0.49
|
0.75
|
5829 (PXN)
|
0.53
|
0.71
|
1.00
|
0.72
|
0.62
|
0.47
|
0.64
|
0.65
|
0.65
|
0.58
|
0.60
|
0.26
|
0.79
|
0.56
|
1.00
|
0.49
|
0.65
|
1.00
|
0.77
|
0.65
|
0.72
|
1.00
|
0.61
|
0.63
|
0.60
|
0.59
|
1.00
|
0.67
|
0.81
|
0.77
|
0.72
|
0.66
|
0.53
|
0.66
|
0.41
|
0.58
|
0.66
|
0.68
|
0.61
|
0.52
|
1.00
|
0.61
|
0.72
|
0.68
|
0.63
|
0.64
|
0.36
|
0.57
|
0.60
|
0.60
|
0.63
|
6091 (ROBO1)
|
0.51
|
0.64
|
0.72
|
1.00
|
0.59
|
0.50
|
0.61
|
0.60
|
0.59
|
0.57
|
0.53
|
0.26
|
0.74
|
0.49
|
1.00
|
0.44
|
0.59
|
1.00
|
0.71
|
0.59
|
0.65
|
1.00
|
0.56
|
0.57
|
0.57
|
0.53
|
1.00
|
0.60
|
0.74
|
0.71
|
0.67
|
0.61
|
0.72
|
0.58
|
0.36
|
0.52
|
0.56
|
0.71
|
0.55
|
0.68
|
1.00
|
0.55
|
0.63
|
0.63
|
0.57
|
0.64
|
0.30
|
0.51
|
0.54
|
0.54
|
0.59
|
6714 (SRC)
|
0.60
|
0.79
|
0.62
|
0.59
|
1.00
|
0.66
|
0.81
|
0.85
|
0.58
|
0.71
|
0.54
|
0.26
|
0.64
|
0.53
|
1.00
|
0.52
|
0.57
|
1.00
|
0.59
|
0.77
|
0.58
|
1.00
|
0.73
|
0.73
|
0.81
|
0.58
|
1.00
|
0.73
|
0.67
|
0.59
|
0.64
|
0.59
|
0.73
|
0.56
|
0.40
|
0.57
|
0.75
|
0.66
|
0.56
|
0.71
|
1.00
|
0.57
|
0.59
|
0.67
|
0.74
|
0.58
|
0.32
|
0.67
|
0.76
|
0.55
|
0.74
|
1949 (EFNB3)
|
0.33
|
0.88
|
0.47
|
0.50
|
0.66
|
1.00
|
0.70
|
0.62
|
0.33
|
0.49
|
0.29
|
0.18
|
0.44
|
0.27
|
0.69
|
0.26
|
0.33
|
0.69
|
0.40
|
0.72
|
0.36
|
0.69
|
0.62
|
0.50
|
0.64
|
0.30
|
0.69
|
0.62
|
0.51
|
0.40
|
0.40
|
0.36
|
0.85
|
0.32
|
0.29
|
0.31
|
0.58
|
0.46
|
0.31
|
0.75
|
0.69
|
0.31
|
0.39
|
0.45
|
0.66
|
0.39
|
0.19
|
0.41
|
0.64
|
0.29
|
0.60
|
5894 (RAF1)
|
0.49
|
0.84
|
0.64
|
0.61
|
0.81
|
0.70
|
1.00
|
0.79
|
0.53
|
0.75
|
0.47
|
0.26
|
0.62
|
0.44
|
1.00
|
0.42
|
0.51
|
1.00
|
0.58
|
0.92
|
0.54
|
1.00
|
0.85
|
0.79
|
0.74
|
0.48
|
1.00
|
0.86
|
0.62
|
0.58
|
0.58
|
0.55
|
0.74
|
0.50
|
0.32
|
0.50
|
0.85
|
0.62
|
0.49
|
0.71
|
1.00
|
0.49
|
0.58
|
0.59
|
0.88
|
0.58
|
0.29
|
0.62
|
0.86
|
0.47
|
0.86
|
3932 (LCK)
|
0.54
|
0.74
|
0.65
|
0.60
|
0.85
|
0.62
|
0.79
|
1.00
|
0.59
|
0.70
|
0.53
|
0.26
|
0.60
|
0.52
|
1.00
|
0.50
|
0.59
|
1.00
|
0.58
|
0.73
|
0.57
|
1.00
|
0.69
|
0.71
|
0.78
|
0.53
|
1.00
|
0.69
|
0.64
|
0.58
|
0.62
|
0.60
|
0.70
|
0.55
|
0.37
|
0.68
|
0.74
|
0.61
|
0.54
|
0.68
|
1.00
|
0.56
|
0.58
|
0.62
|
0.70
|
0.59
|
0.32
|
0.68
|
0.71
|
0.53
|
0.73
|
8874 (ARHGEF7)
|
0.47
|
0.55
|
0.65
|
0.59
|
0.58
|
0.33
|
0.53
|
0.59
|
1.00
|
0.56
|
0.87
|
0.26
|
0.65
|
0.86
|
1.00
|
0.40
|
0.90
|
1.00
|
0.61
|
0.52
|
0.55
|
1.00
|
0.47
|
0.59
|
0.62
|
0.83
|
1.00
|
0.52
|
0.65
|
0.61
|
0.60
|
0.73
|
0.39
|
0.94
|
0.33
|
0.54
|
0.54
|
0.62
|
0.48
|
0.41
|
1.00
|
0.48
|
0.58
|
0.63
|
0.47
|
0.58
|
0.26
|
0.76
|
0.47
|
0.61
|
0.59
|
998 (CDC42)
|
0.68
|
0.63
|
0.58
|
0.57
|
0.71
|
0.49
|
0.75
|
0.70
|
0.56
|
1.00
|
0.47
|
0.26
|
0.57
|
0.45
|
1.00
|
0.63
|
0.50
|
1.00
|
0.54
|
0.69
|
0.52
|
1.00
|
0.64
|
0.88
|
0.64
|
0.47
|
1.00
|
0.65
|
0.58
|
0.54
|
0.55
|
0.57
|
0.58
|
0.49
|
0.30
|
0.55
|
0.69
|
0.58
|
0.61
|
0.57
|
1.00
|
0.76
|
0.55
|
0.58
|
0.67
|
0.57
|
0.40
|
0.52
|
0.65
|
0.47
|
0.72
|
9459 (ARHGEF6)
|
0.44
|
0.49
|
0.60
|
0.53
|
0.54
|
0.29
|
0.47
|
0.53
|
0.87
|
0.47
|
1.00
|
0.26
|
0.59
|
0.98
|
1.00
|
0.36
|
0.87
|
1.00
|
0.53
|
0.46
|
0.48
|
1.00
|
0.41
|
0.48
|
0.60
|
0.95
|
1.00
|
0.45
|
0.59
|
0.53
|
0.55
|
0.63
|
0.34
|
0.90
|
0.31
|
0.40
|
0.46
|
0.59
|
0.43
|
0.37
|
1.00
|
0.43
|
0.54
|
0.59
|
0.41
|
0.60
|
0.22
|
0.73
|
0.42
|
0.64
|
0.45
|
10398 (MYL9)
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.18
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
1.00
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
1.00
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.26
|
0.40
|
0.26
|
0.26
|
0.26
|
0.59
|
0.26
|
0.26
|
0.26
|
0.59
|
0.26
|
0.26
|
0.26
|
1.00
|
0.40
|
0.26
|
0.26
|
0.13
|
0.26
|
0.26
|
0.26
|
0.26
|
2017 (CTTN)
|
0.55
|
0.72
|
0.79
|
0.74
|
0.64
|
0.44
|
0.62
|
0.60
|
0.65
|
0.57
|
0.59
|
0.26
|
1.00
|
0.54
|
1.00
|
0.46
|
0.65
|
1.00
|
0.82
|
0.66
|
0.75
|
1.00
|
0.60
|
0.61
|
0.57
|
0.58
|
1.00
|
0.68
|
0.94
|
0.82
|
0.73
|
0.67
|
0.50
|
0.66
|
0.45
|
0.57
|
0.59
|
0.73
|
0.60
|
0.50
|
1.00
|
0.60
|
0.67
|
0.71
|
0.63
|
0.64
|
0.34
|
0.55
|
0.62
|
0.59
|
0.62
|
6654 (SOS1)
|
0.43
|
0.45
|
0.56
|
0.49
|
0.53
|
0.27
|
0.44
|
0.52
|
0.86
|
0.45
|
0.98
|
0.26
|
0.54
|
1.00
|
1.00
|
0.35
|
0.86
|
1.00
|
0.49
|
0.43
|
0.44
|
1.00
|
0.39
|
0.46
|
0.63
|
0.94
|
1.00
|
0.42
|
0.54
|
0.49
|
0.51
|
0.60
|
0.33
|
0.90
|
0.29
|
0.38
|
0.45
|
0.57
|
0.41
|
0.36
|
1.00
|
0.41
|
0.52
|
0.56
|
0.38
|
0.58
|
0.21
|
0.74
|
0.40
|
0.62
|
0.43
|
9815 (GIT2)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.69
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.26
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.50
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.51
|
1.00
|
1.00
|
1.00
|
1.00
|
4628 (MYH10)
|
0.91
|
0.41
|
0.49
|
0.44
|
0.52
|
0.26
|
0.42
|
0.50
|
0.40
|
0.63
|
0.36
|
0.26
|
0.46
|
0.35
|
1.00
|
1.00
|
0.40
|
1.00
|
0.42
|
0.40
|
0.40
|
1.00
|
0.37
|
0.66
|
0.45
|
0.38
|
1.00
|
0.39
|
0.46
|
0.42
|
0.46
|
0.42
|
0.33
|
0.38
|
0.26
|
0.41
|
0.41
|
0.56
|
0.61
|
0.35
|
1.00
|
0.71
|
0.52
|
0.49
|
0.36
|
0.48
|
0.65
|
0.37
|
0.38
|
0.37
|
0.40
|
7410 (VAV2)
|
0.47
|
0.55
|
0.65
|
0.59
|
0.57
|
0.33
|
0.51
|
0.59
|
0.90
|
0.50
|
0.87
|
0.26
|
0.65
|
0.86
|
1.00
|
0.40
|
1.00
|
1.00
|
0.61
|
0.52
|
0.55
|
1.00
|
0.47
|
0.52
|
0.62
|
0.83
|
1.00
|
0.52
|
0.65
|
0.61
|
0.69
|
0.64
|
0.39
|
0.94
|
0.33
|
0.45
|
0.50
|
0.62
|
0.48
|
0.41
|
1.00
|
0.48
|
0.58
|
0.61
|
0.47
|
0.58
|
0.26
|
0.84
|
0.47
|
0.61
|
0.50
|
103910 (MYL12B)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.69
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.26
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.50
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.51
|
1.00
|
1.00
|
1.00
|
1.00
|
3845 (KRAS)
|
0.49
|
0.68
|
0.77
|
0.71
|
0.59
|
0.40
|
0.58
|
0.58
|
0.61
|
0.54
|
0.53
|
0.26
|
0.82
|
0.49
|
1.00
|
0.42
|
0.61
|
1.00
|
1.00
|
0.61
|
0.71
|
1.00
|
0.55
|
0.58
|
0.55
|
0.53
|
1.00
|
0.64
|
0.82
|
1.00
|
0.70
|
0.63
|
0.44
|
0.61
|
0.44
|
0.52
|
0.56
|
0.72
|
0.55
|
0.54
|
1.00
|
0.55
|
0.65
|
0.65
|
0.57
|
0.61
|
0.35
|
0.50
|
0.54
|
0.54
|
0.58
|
3984 (LIMK1)
|
0.47
|
0.87
|
0.65
|
0.59
|
0.77
|
0.72
|
0.92
|
0.73
|
0.52
|
0.69
|
0.46
|
0.26
|
0.66
|
0.43
|
1.00
|
0.40
|
0.52
|
1.00
|
0.61
|
1.00
|
0.56
|
1.00
|
0.86
|
0.73
|
0.70
|
0.47
|
1.00
|
0.88
|
0.66
|
0.61
|
0.60
|
0.55
|
0.74
|
0.50
|
0.32
|
0.47
|
0.81
|
0.62
|
0.48
|
0.70
|
1.00
|
0.48
|
0.58
|
0.60
|
0.92
|
0.56
|
0.28
|
0.60
|
0.86
|
0.47
|
0.85
|
4629 (MYH11)
|
0.47
|
0.62
|
0.72
|
0.65
|
0.58
|
0.36
|
0.54
|
0.57
|
0.55
|
0.52
|
0.48
|
1.00
|
0.75
|
0.44
|
1.00
|
0.40
|
0.55
|
1.00
|
0.71
|
0.56
|
1.00
|
1.00
|
0.50
|
0.55
|
0.53
|
0.49
|
1.00
|
0.57
|
0.75
|
0.71
|
0.68
|
0.59
|
0.39
|
0.54
|
0.54
|
0.47
|
0.52
|
0.65
|
0.60
|
0.41
|
1.00
|
0.50
|
0.80
|
0.63
|
0.50
|
0.58
|
0.28
|
0.46
|
0.50
|
0.48
|
0.53
|
10627 (MYL12A)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.69
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.26
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.50
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.51
|
1.00
|
1.00
|
1.00
|
1.00
|
5063 (PAK3)
|
0.45
|
0.76
|
0.61
|
0.56
|
0.73
|
0.62
|
0.85
|
0.69
|
0.47
|
0.64
|
0.41
|
0.26
|
0.60
|
0.39
|
1.00
|
0.37
|
0.47
|
1.00
|
0.55
|
0.86
|
0.50
|
1.00
|
1.00
|
0.69
|
0.66
|
0.43
|
1.00
|
0.95
|
0.60
|
0.55
|
0.56
|
0.51
|
0.65
|
0.45
|
0.29
|
0.42
|
0.82
|
0.60
|
0.44
|
0.62
|
1.00
|
0.44
|
0.55
|
0.57
|
0.84
|
0.53
|
0.25
|
0.53
|
0.90
|
0.42
|
0.78
|
5879 (RAC1)
|
0.69
|
0.67
|
0.63
|
0.57
|
0.73
|
0.50
|
0.79
|
0.71
|
0.59
|
0.88
|
0.48
|
0.26
|
0.61
|
0.46
|
1.00
|
0.66
|
0.52
|
1.00
|
0.58
|
0.73
|
0.55
|
1.00
|
0.69
|
1.00
|
0.65
|
0.49
|
1.00
|
0.69
|
0.61
|
0.58
|
0.58
|
0.60
|
0.60
|
0.51
|
0.30
|
0.57
|
0.76
|
0.61
|
0.64
|
0.58
|
1.00
|
0.82
|
0.58
|
0.60
|
0.71
|
0.56
|
0.44
|
0.54
|
0.69
|
0.49
|
0.75
|
2534 (FYN)
|
0.49
|
0.74
|
0.60
|
0.57
|
0.81
|
0.64
|
0.74
|
0.78
|
0.62
|
0.64
|
0.60
|
0.26
|
0.57
|
0.63
|
1.00
|
0.45
|
0.62
|
1.00
|
0.55
|
0.70
|
0.53
|
1.00
|
0.66
|
0.65
|
1.00
|
0.59
|
1.00
|
0.66
|
0.62
|
0.55
|
0.56
|
0.56
|
0.67
|
0.62
|
0.34
|
0.50
|
0.68
|
0.59
|
0.50
|
0.65
|
1.00
|
0.50
|
0.56
|
0.60
|
0.66
|
0.58
|
0.29
|
0.70
|
0.68
|
0.53
|
0.67
|
10451 (VAV3)
|
0.45
|
0.50
|
0.59
|
0.53
|
0.58
|
0.30
|
0.48
|
0.53
|
0.83
|
0.47
|
0.95
|
0.26
|
0.58
|
0.94
|
1.00
|
0.38
|
0.83
|
1.00
|
0.53
|
0.47
|
0.49
|
1.00
|
0.43
|
0.49
|
0.59
|
1.00
|
1.00
|
0.47
|
0.58
|
0.53
|
0.64
|
0.62
|
0.36
|
0.86
|
0.31
|
0.42
|
0.47
|
0.59
|
0.44
|
0.38
|
1.00
|
0.44
|
0.54
|
0.65
|
0.42
|
0.60
|
0.23
|
0.71
|
0.44
|
0.63
|
0.46
|
28964 (GIT1)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.69
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.26
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.50
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.51
|
1.00
|
1.00
|
1.00
|
1.00
|
57144 (PAK7)
|
0.47
|
0.79
|
0.67
|
0.60
|
0.73
|
0.62
|
0.86
|
0.69
|
0.52
|
0.65
|
0.45
|
0.26
|
0.68
|
0.42
|
1.00
|
0.39
|
0.52
|
1.00
|
0.64
|
0.88
|
0.57
|
1.00
|
0.95
|
0.69
|
0.66
|
0.47
|
1.00
|
1.00
|
0.68
|
0.64
|
0.62
|
0.55
|
0.64
|
0.50
|
0.32
|
0.46
|
0.77
|
0.63
|
0.48
|
0.62
|
1.00
|
0.48
|
0.59
|
0.60
|
0.86
|
0.56
|
0.27
|
0.54
|
0.92
|
0.46
|
0.80
|
1500 (CTNND1)
|
0.56
|
0.75
|
0.81
|
0.74
|
0.67
|
0.51
|
0.62
|
0.64
|
0.65
|
0.58
|
0.59
|
0.26
|
0.94
|
0.54
|
1.00
|
0.46
|
0.65
|
1.00
|
0.82
|
0.66
|
0.75
|
1.00
|
0.60
|
0.61
|
0.62
|
0.58
|
1.00
|
0.68
|
1.00
|
0.82
|
0.73
|
0.67
|
0.50
|
0.66
|
0.51
|
0.57
|
0.59
|
0.73
|
0.60
|
0.50
|
1.00
|
0.60
|
0.67
|
0.75
|
0.63
|
0.65
|
0.34
|
0.55
|
0.62
|
0.59
|
0.62
|
4893 (NRAS)
|
0.49
|
0.68
|
0.77
|
0.71
|
0.59
|
0.40
|
0.58
|
0.58
|
0.61
|
0.54
|
0.53
|
0.26
|
0.82
|
0.49
|
1.00
|
0.42
|
0.61
|
1.00
|
1.00
|
0.61
|
0.71
|
1.00
|
0.55
|
0.58
|
0.55
|
0.53
|
1.00
|
0.64
|
0.82
|
1.00
|
0.70
|
0.63
|
0.44
|
0.61
|
0.44
|
0.52
|
0.56
|
0.72
|
0.55
|
0.54
|
1.00
|
0.55
|
0.65
|
0.65
|
0.57
|
0.61
|
0.35
|
0.50
|
0.54
|
0.54
|
0.58
|
8440 (NCK2)
|
0.51
|
0.64
|
0.72
|
0.67
|
0.64
|
0.40
|
0.58
|
0.62
|
0.60
|
0.55
|
0.55
|
0.40
|
0.73
|
0.51
|
1.00
|
0.46
|
0.69
|
1.00
|
0.70
|
0.60
|
0.68
|
1.00
|
0.56
|
0.58
|
0.56
|
0.64
|
1.00
|
0.62
|
0.73
|
0.70
|
1.00
|
0.62
|
0.48
|
0.60
|
0.38
|
0.54
|
0.56
|
0.66
|
0.58
|
0.48
|
1.00
|
0.56
|
0.66
|
0.80
|
0.57
|
0.61
|
0.33
|
0.60
|
0.55
|
0.55
|
0.58
|
4659 (PPP1R12A)
|
0.48
|
0.58
|
0.66
|
0.61
|
0.59
|
0.36
|
0.55
|
0.60
|
0.73
|
0.57
|
0.63
|
0.26
|
0.67
|
0.60
|
1.00
|
0.42
|
0.64
|
1.00
|
0.63
|
0.55
|
0.59
|
1.00
|
0.51
|
0.60
|
0.56
|
0.62
|
1.00
|
0.55
|
0.67
|
0.63
|
0.62
|
1.00
|
0.43
|
0.65
|
0.34
|
0.57
|
0.56
|
0.63
|
0.51
|
0.44
|
1.00
|
0.51
|
0.60
|
0.69
|
0.51
|
0.66
|
0.28
|
0.56
|
0.51
|
0.90
|
0.61
|
2047 (EPHB1)
|
0.41
|
0.76
|
0.53
|
0.72
|
0.73
|
0.85
|
0.74
|
0.70
|
0.39
|
0.58
|
0.34
|
0.26
|
0.50
|
0.33
|
1.00
|
0.33
|
0.39
|
1.00
|
0.44
|
0.74
|
0.39
|
1.00
|
0.65
|
0.60
|
0.67
|
0.36
|
1.00
|
0.64
|
0.50
|
0.44
|
0.48
|
0.43
|
1.00
|
0.36
|
0.25
|
0.36
|
0.66
|
0.64
|
0.37
|
0.92
|
1.00
|
0.37
|
0.49
|
0.52
|
0.66
|
0.47
|
0.20
|
0.48
|
0.68
|
0.35
|
0.65
|
6655 (SOS2)
|
0.46
|
0.54
|
0.66
|
0.58
|
0.56
|
0.32
|
0.50
|
0.55
|
0.94
|
0.49
|
0.90
|
0.26
|
0.66
|
0.90
|
1.00
|
0.38
|
0.94
|
1.00
|
0.61
|
0.50
|
0.54
|
1.00
|
0.45
|
0.51
|
0.62
|
0.86
|
1.00
|
0.50
|
0.66
|
0.61
|
0.60
|
0.65
|
0.36
|
1.00
|
0.34
|
0.43
|
0.49
|
0.62
|
0.46
|
0.39
|
1.00
|
0.46
|
0.58
|
0.61
|
0.45
|
0.58
|
0.25
|
0.78
|
0.46
|
0.61
|
0.49
|
3911 (LAMA5)
|
0.37
|
0.39
|
0.41
|
0.36
|
0.40
|
0.29
|
0.32
|
0.37
|
0.33
|
0.30
|
0.31
|
0.59
|
0.45
|
0.29
|
0.50
|
0.26
|
0.33
|
0.50
|
0.44
|
0.32
|
0.54
|
0.50
|
0.29
|
0.30
|
0.34
|
0.31
|
0.50
|
0.32
|
0.51
|
0.44
|
0.38
|
0.34
|
0.25
|
0.34
|
1.00
|
0.28
|
0.29
|
0.48
|
0.39
|
0.27
|
0.50
|
0.29
|
0.45
|
0.40
|
0.30
|
0.34
|
0.29
|
0.30
|
0.31
|
0.32
|
0.30
|
5500 (PPP1CB)
|
0.48
|
0.48
|
0.58
|
0.52
|
0.57
|
0.31
|
0.50
|
0.68
|
0.54
|
0.55
|
0.40
|
0.26
|
0.57
|
0.38
|
1.00
|
0.41
|
0.45
|
1.00
|
0.52
|
0.47
|
0.47
|
1.00
|
0.42
|
0.57
|
0.50
|
0.42
|
1.00
|
0.46
|
0.57
|
0.52
|
0.54
|
0.57
|
0.36
|
0.43
|
0.28
|
1.00
|
0.50
|
0.58
|
0.43
|
0.38
|
1.00
|
0.47
|
0.53
|
0.58
|
0.42
|
0.51
|
0.31
|
0.41
|
0.44
|
0.41
|
0.53
|
1432 (MAPK14)
|
0.47
|
0.73
|
0.66
|
0.56
|
0.75
|
0.58
|
0.85
|
0.74
|
0.54
|
0.69
|
0.46
|
0.26
|
0.59
|
0.45
|
1.00
|
0.41
|
0.50
|
1.00
|
0.56
|
0.81
|
0.52
|
1.00
|
0.82
|
0.76
|
0.68
|
0.47
|
1.00
|
0.77
|
0.59
|
0.56
|
0.56
|
0.56
|
0.66
|
0.49
|
0.29
|
0.50
|
1.00
|
0.61
|
0.48
|
0.64
|
1.00
|
0.48
|
0.57
|
0.58
|
0.84
|
0.54
|
0.27
|
0.56
|
0.77
|
0.47
|
0.84
|
3688 (ITGB1)
|
0.63
|
0.64
|
0.68
|
0.71
|
0.66
|
0.46
|
0.62
|
0.61
|
0.62
|
0.58
|
0.59
|
0.26
|
0.73
|
0.57
|
1.00
|
0.56
|
0.62
|
1.00
|
0.72
|
0.62
|
0.65
|
1.00
|
0.60
|
0.61
|
0.59
|
0.59
|
1.00
|
0.63
|
0.73
|
0.72
|
0.66
|
0.63
|
0.64
|
0.62
|
0.48
|
0.58
|
0.61
|
1.00
|
0.60
|
0.67
|
1.00
|
0.59
|
0.67
|
0.67
|
0.61
|
0.64
|
0.40
|
0.57
|
0.60
|
0.59
|
0.61
|
58 (ACTA1)
|
0.62
|
0.51
|
0.61
|
0.55
|
0.56
|
0.31
|
0.49
|
0.54
|
0.48
|
0.61
|
0.43
|
0.59
|
0.60
|
0.41
|
1.00
|
0.61
|
0.48
|
1.00
|
0.55
|
0.48
|
0.60
|
1.00
|
0.44
|
0.64
|
0.50
|
0.44
|
1.00
|
0.48
|
0.60
|
0.55
|
0.58
|
0.51
|
0.37
|
0.46
|
0.39
|
0.43
|
0.48
|
0.60
|
1.00
|
0.39
|
1.00
|
0.71
|
0.74
|
0.58
|
0.44
|
0.56
|
0.27
|
0.43
|
0.45
|
0.44
|
0.47
|
2048 (EPHB2)
|
0.42
|
0.71
|
0.52
|
0.68
|
0.71
|
0.75
|
0.71
|
0.68
|
0.41
|
0.57
|
0.37
|
0.26
|
0.50
|
0.36
|
1.00
|
0.35
|
0.41
|
1.00
|
0.54
|
0.70
|
0.41
|
1.00
|
0.62
|
0.58
|
0.65
|
0.38
|
1.00
|
0.62
|
0.50
|
0.54
|
0.48
|
0.44
|
0.92
|
0.39
|
0.27
|
0.38
|
0.64
|
0.67
|
0.39
|
1.00
|
1.00
|
0.39
|
0.49
|
0.52
|
0.63
|
0.48
|
0.23
|
0.48
|
0.65
|
0.37
|
0.63
|
4771 (NF2)
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.69
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.26
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.50
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.51
|
1.00
|
1.00
|
1.00
|
1.00
|
3265 (HRAS)
|
0.73
|
0.51
|
0.61
|
0.55
|
0.57
|
0.31
|
0.49
|
0.56
|
0.48
|
0.76
|
0.43
|
0.26
|
0.60
|
0.41
|
1.00
|
0.71
|
0.48
|
1.00
|
0.55
|
0.48
|
0.50
|
1.00
|
0.44
|
0.82
|
0.50
|
0.44
|
1.00
|
0.48
|
0.60
|
0.55
|
0.56
|
0.51
|
0.37
|
0.46
|
0.29
|
0.47
|
0.48
|
0.59
|
0.71
|
0.39
|
1.00
|
1.00
|
0.55
|
0.57
|
0.44
|
0.56
|
0.47
|
0.43
|
0.45
|
0.43
|
0.47
|
1756 (DMD)
|
0.55
|
0.61
|
0.72
|
0.63
|
0.59
|
0.39
|
0.58
|
0.58
|
0.58
|
0.55
|
0.54
|
1.00
|
0.67
|
0.52
|
1.00
|
0.52
|
0.58
|
1.00
|
0.65
|
0.58
|
0.80
|
1.00
|
0.55
|
0.58
|
0.56
|
0.54
|
1.00
|
0.59
|
0.67
|
0.65
|
0.66
|
0.60
|
0.49
|
0.58
|
0.45
|
0.53
|
0.57
|
0.67
|
0.74
|
0.49
|
1.00
|
0.55
|
1.00
|
0.63
|
0.56
|
0.61
|
0.38
|
0.52
|
0.55
|
0.55
|
0.57
|
4690 (NCK1)
|
0.55
|
0.63
|
0.68
|
0.63
|
0.67
|
0.45
|
0.59
|
0.62
|
0.63
|
0.58
|
0.59
|
0.40
|
0.71
|
0.56
|
1.00
|
0.49
|
0.61
|
1.00
|
0.65
|
0.60
|
0.63
|
1.00
|
0.57
|
0.60
|
0.60
|
0.65
|
1.00
|
0.60
|
0.75
|
0.65
|
0.80
|
0.69
|
0.52
|
0.61
|
0.40
|
0.58
|
0.58
|
0.67
|
0.58
|
0.52
|
1.00
|
0.57
|
0.63
|
1.00
|
0.58
|
0.64
|
0.32
|
0.56
|
0.58
|
0.65
|
0.60
|
5600 (MAPK11)
|
0.45
|
0.80
|
0.63
|
0.57
|
0.74
|
0.66
|
0.88
|
0.70
|
0.47
|
0.67
|
0.41
|
0.26
|
0.63
|
0.38
|
1.00
|
0.36
|
0.47
|
1.00
|
0.57
|
0.92
|
0.50
|
1.00
|
0.84
|
0.71
|
0.66
|
0.42
|
1.00
|
0.86
|
0.63
|
0.57
|
0.57
|
0.51
|
0.66
|
0.45
|
0.30
|
0.42
|
0.84
|
0.61
|
0.44
|
0.63
|
1.00
|
0.44
|
0.56
|
0.58
|
1.00
|
0.54
|
0.25
|
0.54
|
0.82
|
0.41
|
0.90
|
9353 (SLIT2)
|
0.55
|
0.58
|
0.64
|
0.64
|
0.58
|
0.39
|
0.58
|
0.59
|
0.58
|
0.57
|
0.60
|
0.26
|
0.64
|
0.58
|
1.00
|
0.48
|
0.58
|
1.00
|
0.61
|
0.56
|
0.58
|
1.00
|
0.53
|
0.56
|
0.58
|
0.60
|
1.00
|
0.56
|
0.65
|
0.61
|
0.61
|
0.66
|
0.47
|
0.58
|
0.34
|
0.51
|
0.54
|
0.64
|
0.56
|
0.48
|
1.00
|
0.56
|
0.61
|
0.64
|
0.54
|
1.00
|
0.29
|
0.53
|
0.53
|
0.64
|
0.60
|
79784 (MYH14)
|
0.62
|
0.29
|
0.36
|
0.30
|
0.32
|
0.19
|
0.29
|
0.32
|
0.26
|
0.40
|
0.22
|
0.13
|
0.34
|
0.21
|
0.51
|
0.65
|
0.26
|
0.51
|
0.35
|
0.28
|
0.28
|
0.51
|
0.25
|
0.44
|
0.29
|
0.23
|
0.51
|
0.27
|
0.34
|
0.35
|
0.33
|
0.28
|
0.20
|
0.25
|
0.29
|
0.31
|
0.27
|
0.40
|
0.27
|
0.23
|
0.51
|
0.47
|
0.38
|
0.32
|
0.25
|
0.29
|
1.00
|
0.23
|
0.25
|
0.23
|
0.27
|
7409 (VAV1)
|
0.44
|
0.57
|
0.57
|
0.51
|
0.67
|
0.41
|
0.62
|
0.68
|
0.76
|
0.52
|
0.73
|
0.26
|
0.55
|
0.74
|
1.00
|
0.37
|
0.84
|
1.00
|
0.50
|
0.60
|
0.46
|
1.00
|
0.53
|
0.54
|
0.70
|
0.71
|
1.00
|
0.54
|
0.55
|
0.50
|
0.60
|
0.56
|
0.48
|
0.78
|
0.30
|
0.41
|
0.56
|
0.57
|
0.43
|
0.48
|
1.00
|
0.43
|
0.52
|
0.56
|
0.54
|
0.53
|
0.23
|
1.00
|
0.55
|
0.52
|
0.55
|
10298 (PAK4)
|
0.46
|
0.77
|
0.60
|
0.54
|
0.76
|
0.64
|
0.86
|
0.71
|
0.47
|
0.65
|
0.42
|
0.26
|
0.62
|
0.40
|
1.00
|
0.38
|
0.47
|
1.00
|
0.54
|
0.86
|
0.50
|
1.00
|
0.90
|
0.69
|
0.68
|
0.44
|
1.00
|
0.92
|
0.62
|
0.54
|
0.55
|
0.51
|
0.68
|
0.46
|
0.31
|
0.44
|
0.77
|
0.60
|
0.45
|
0.65
|
1.00
|
0.45
|
0.55
|
0.58
|
0.82
|
0.53
|
0.25
|
0.55
|
1.00
|
0.43
|
0.78
|
4660 (PPP1R12B)
|
0.44
|
0.49
|
0.60
|
0.54
|
0.55
|
0.29
|
0.47
|
0.53
|
0.61
|
0.47
|
0.64
|
0.26
|
0.59
|
0.62
|
1.00
|
0.37
|
0.61
|
1.00
|
0.54
|
0.47
|
0.48
|
1.00
|
0.42
|
0.49
|
0.53
|
0.63
|
1.00
|
0.46
|
0.59
|
0.54
|
0.55
|
0.90
|
0.35
|
0.61
|
0.32
|
0.41
|
0.47
|
0.59
|
0.44
|
0.37
|
1.00
|
0.43
|
0.55
|
0.65
|
0.41
|
0.64
|
0.23
|
0.52
|
0.43
|
1.00
|
0.46
|
5596 (MAPK4)
|
0.50
|
0.75
|
0.63
|
0.59
|
0.74
|
0.60
|
0.86
|
0.73
|
0.59
|
0.72
|
0.45
|
0.26
|
0.62
|
0.43
|
1.00
|
0.40
|
0.50
|
1.00
|
0.58
|
0.85
|
0.53
|
1.00
|
0.78
|
0.75
|
0.67
|
0.46
|
1.00
|
0.80
|
0.62
|
0.58
|
0.58
|
0.61
|
0.65
|
0.49
|
0.30
|
0.53
|
0.84
|
0.61
|
0.47
|
0.63
|
1.00
|
0.47
|
0.57
|
0.60
|
0.90
|
0.60
|
0.27
|
0.55
|
0.78
|
0.46
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
PAK3 |
Human |
Blood |
- |
3250 m |
4 day |
upregulated |
1.64 |
Microarray |
Himalayas |
Indians |
1 |
Sea level healthy individuals |
24465776 |
PAK3 |
Human |
Blood |
- |
3250 m |
4 day |
upregulated |
1.64 |
Microarray |
Himalayas |
Indians |
1 |
Sea level healthy individuals |
24465776 |
Association with TF
TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
5063 |
GO:0010763 |
positive regulation of fibroblast migration |
GOTERM_BP_DIRECT |
5063 |
GO:2000573 |
positive regulation of DNA biosynthetic process |
GOTERM_BP_DIRECT |
5063 |
GO:0004708 |
MAP kinase kinase activity |
GOTERM_MF_DIRECT |
5063 |
GO:0000165 |
MAPK cascade |
GOTERM_BP_DIRECT |
5063 |
GO:0000187 |
activation of MAPK activity |
GOTERM_BP_DIRECT |
5063 |
GO:0050852 |
T cell receptor signaling pathway |
GOTERM_BP_DIRECT |
5063 |
GO:0030833 |
regulation of actin filament polymerization |
GOTERM_BP_DIRECT |
5063 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
5063 |
GO:0000278 |
mitotic cell cycle |
GOTERM_BP_DIRECT |
5063 |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
GOTERM_BP_DIRECT |
5063 |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
GOTERM_BP_DIRECT |
5063 |
GO:0031295 |
T cell costimulation |
GOTERM_BP_DIRECT |
5063 |
GO:0071407 |
cellular response to organic cyclic compound |
GOTERM_BP_DIRECT |
5063 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
5063 |
GO:0005768 |
endosome |
GOTERM_CC_DIRECT |
5063 |
GO:0007409 |
axonogenesis |
GOTERM_BP_DIRECT |
5063 |
GO:0043525 |
positive regulation of neuron apoptotic process |
GOTERM_BP_DIRECT |
5063 |
GO:0017124 |
SH3 domain binding |
GOTERM_MF_DIRECT |
5063 |
GO:0017048 |
TBP-class protein binding |
GOTERM_MF_DIRECT |
5063 |
GO:0048013 |
ephrin receptor signaling pathway |
GOTERM_BP_DIRECT |
5063 |
GO:0060997 |
dendritic spine morphogenesis |
GOTERM_BP_DIRECT |
5063 |
GO:0004674 |
protein serine/threonine kinase activity |
GOTERM_MF_DIRECT |
5063 |
GO:0005886 |
plasma membrane |
GOTERM_CC_DIRECT |
5063 |
GO:0004702 |
receptor signaling protein serine/threonine kinase activity |
GOTERM_MF_DIRECT |
5063 |
GO:0016358 |
dendrite development |
GOTERM_BP_DIRECT |
5063 |
GO:0050808 |
synapse organization |
GOTERM_BP_DIRECT |
5063 |
GO:0005524 |
ATP binding |
GOTERM_MF_DIRECT |
5063 |
GO:0046872 |
metal ion binding |
GOTERM_MF_DIRECT |
5063 |
GO:0005737 |
cytoplasm |
GOTERM_CC_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
5063 |
hsa04014 |
Ras signaling pathway |
5063 |
hsa04012 |
ErbB signaling pathway |
5063 |
hsa04660 |
T cell receptor signaling pathway |
5063 |
hsa04510 |
Focal adhesion |
5063 |
hsa04360 |
Axon guidance |
5063 |
hsa04810 |
Regulation of actin cytoskeleton |
5063 |
hsa05211 |
Renal cell carcinoma |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
PAK3 |
5063 |
Mental Retardation, X-Linked 30 |
C0796237 |
Disease or Syndrome |
0.6 |
0.633 |
0.552 |
disease |
PAK3 |
5063 |
Intellectual Disability |
C3714756 |
Mental or Behavioral Dysfunction |
0.5 |
0.633 |
0.552 |
group |
PAK3 |
5063 |
Mental Retardation, X-Linked 1 |
C2931498 |
Disease or Syndrome |
0.32 |
0.633 |
0.552 |
disease |
PAK3 |
5063 |
Adenocarcinoma of large intestine |
C1319315 |
Neoplastic Process |
0.3 |
0.633 |
0.552 |
disease |
PAK3 |
5063 |
Mental Retardation, X-Linked 47 |
C0796249 |
Disease or Syndrome |
0.3 |
0.633 |
0.552 |
disease |
Association with Drug
Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |
PAK3 |
5063 |
COMPOUND 4 [PMID: 24432870] |
None |
None |
inhibitor |
PAK3 |
5063 |
FRAX597 |
None |
None |
inhibitor |
PAK3 |
5063 |
FRAX486 |
None |
None |
inhibitor |
PAK3 |
5063 |
PF-3758309 |
None |
None |
inhibitor |