Solute carrier family 25 (mitochondrial carrier, Aralar), member 12

AltitudeomicsDB
Protein Official symbol SLC25A12
Aliases SLC25A12 ARALAR1
Chromosomal Location  2
Length 678
Uniprot ID O75746
EC number None
Protein family Information(Pfam) PF00153;
PDB id 4P5X;4P60;
InterPro ID IPR011992;IPR018247;IPR002048;IPR002067;IPR018108;IPR023395;
dbSNP rs886037851 rs35565687 rs121434396

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
HSPD1 HSPA9 0.999
ATP5A1 ATP5B 0.999
TIMM8A TIMM13 0.999
TIMM8B TIMM13 0.999
IDH3G ACO2 0.998
CYC1 ATP5B 0.997
ATP5G1 ATP5B 0.997
TIMM23 TIMM8A 0.996
ATP5A1 ATP5G1 0.996
TIMM23 TIMM13 0.996
CS ACO2 0.995
TIMM23 TIMM22 0.994
TOMM40 TIMM13 0.993
CS ATP5B 0.991
ATP5G1 CYC1 0.991
ATP5B ACO2 0.99
SLC25A12 TIMM13 0.989
TOMM40 CYC1 0.988
HSPA9 VDAC1 0.988
TOMM40 VDAC1 0.987
ATP5A1 VDAC1 0.985
TIMM23 TOMM40 0.984
HSPD1 ATP5B 0.984
TIMM22 TIMM13 0.983
VDAC1 ATP5B 0.983
TIMM8A TIMM22 0.983
TOMM40 TIMM8A 0.98
SLC25A4 ATP5B 0.98
TIMM23 HSPA9 0.98
SLC25A12 TIMM8A 0.98
TOMM40 TIMM22 0.978
TOMM40 HSPA9 0.978
CYC1 VDAC1 0.978
HSPA9 ATP5B 0.976
TIMM23 SLC25A12 0.975
SLC25A4 VDAC1 0.973
CS VDAC1 0.973
ATP5A1 SLC25A4 0.973
TIMM23 TIMM8B 0.972
HSPD1 CS 0.972
TOMM40 HSPD1 0.972
SLC25A12 ACO2 0.972
ATP5A1 HSPA9 0.97
ATP5B IDH3G 0.968
ATP5A1 HSPD1 0.967
TIMM8B TIMM22 0.966
TIMM23 HSPD1 0.963
TIMM23 CYC1 0.963
HSPA9 ACO2 0.961
HSPD1 VDAC1 0.96
HSPD1 ACO2 0.958
TIMM8B TOMM40 0.956
TIMM22 CYC1 0.955
CS HSPA9 0.955
CYC1 SLC25A4 0.954
ATP5A1 CYC1 0.953
VDAC1 ACO2 0.953
TIMM8A HSPA9 0.95
HSPA9 TIMM13 0.949
HSPD1 TIMM22 0.949
VDAC1 TIMM13 0.948
TIMM23 VDAC1 0.947
HSPD1 CYC1 0.947
CS SLC25A4 0.946
TIMM22 HSPA9 0.945
TIMM8A VDAC1 0.944
HSPD1 TIMM8A 0.944
TOMM40 ACO2 0.943
CYC1 HSPA9 0.943
BCS1L HSPD1 0.942
TIMM23 SLC25A4 0.942
TIMM22 VDAC1 0.939
BCS1L TIMM8A 0.938
TIMM8B ATP5G1 0.937
SLC25A4 ACO2 0.936
TOMM40 ATP5B 0.936
ATP5G1 ACO2 0.935
BCS1L TOMM40 0.933
TIMM23 ATP5B 0.931
SLC25A12 CYC1 0.93
TIMM8B HSPD1 0.929
HSPD1 TIMM13 0.929
BCS1L TIMM13 0.929
TIMM8B VDAC1 0.928
TIMM23 CS 0.928
BCS1L ATP5G1 0.928
SLC25A12 VDAC1 0.928
ATP5G1 SLC25A4 0.928
SLC25A12 ATP5A1 0.927
TIMM22 SLC25A4 0.927
TIMM23 BCS1L 0.926
SLC25A12 CS 0.925
CYC1 TIMM13 0.925
TOMM40 ATP5G1 0.925
TIMM8B HSPA9 0.925
TOMM40 SLC25A4 0.925
BCS1L TIMM22 0.925
ATP5A1 CS 0.925
BCS1L SLC25A4 0.924
TOMM40 CS 0.924
ATP5G1 VDAC1 0.923
SLC25A4 TIMM13 0.923
ATP5G1 IDH3G 0.922
SLC25A12 ATP5B 0.921
SLC25A4 IDH3G 0.921
TIMM23 ATP5G1 0.921
TIMM23 ATP5A1 0.92
HSPA9 SLC25A4 0.92
ATP5G1 CS 0.92
BCS1L ATP5B 0.919
ATP5G1 HSPA9 0.919
TIMM8A IDH3G 0.918
ATP5G1 TIMM13 0.918
HSPD1 IDH3G 0.917
TIMM8A SLC25A4 0.917
TOMM40 SLC25A12 0.916
BCS1L VDAC1 0.916
TIMM8B BCS1L 0.916
TIMM8B SLC25A12 0.915
BCS1L HSPA9 0.915
HSPD1 SLC25A4 0.915
CS TIMM13 0.914
TIMM22 ATP5B 0.913
VDAC1 IDH3G 0.913
ATP5G1 TIMM8A 0.912
CS TIMM22 0.911
TIMM8B ATP5B 0.911
SLC25A12 SLC25A4 0.91
TIMM8A CS 0.91
TOMM40 IDH3G 0.909
HSPA9 IDH3G 0.909
ATP5G1 HSPD1 0.909
ATP5G1 TIMM22 0.908
TIMM23 IDH3G 0.908
ACO2 TIMM13 0.907
TIMM23 ACO2 0.907
TIMM8A CYC1 0.907
SLC25A12 HSPA9 0.907
TOMM40 ATP5A1 0.906
TIMM8A ATP5B 0.906
ATP5A1 TIMM22 0.906
TIMM22 IDH3G 0.906
SLC25A12 TIMM22 0.906
TIMM8B CS 0.905
TIMM22 ACO2 0.904
ATP5A1 TIMM8A 0.903
ATP5B TIMM13 0.903
TIMM8B IDH3G 0.903
TIMM8A ACO2 0.903
TIMM8B SLC25A4 0.902
TIMM8B ACO2 0.902
TIMM8B CYC1 0.902
SLC25A12 HSPD1 0.902
ATP5A1 TIMM13 0.902
IDH3G TIMM13 0.902
SLC25A12 ATP5G1 0.9
SLC25A12 IDH3G 0.9
TIMM8B ATP5A1 0.9
BCS1L SLC25A12 0.9
Gene Ontology Semantic Similarity
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# 3329 (HSPD1) 498 (ATP5A1) 1678 (TIMM8A) 26521 (TIMM8B) 3421 (IDH3G) 1537 (CYC1) 516 (ATP5G1) 100287932 (TIMM23) 1431 (CS) 10452 (TOMM40) 506 (ATP5B) 8604 (SLC25A12) 3313 (HSPA9) 29928 (TIMM22) 7416 (VDAC1) 291 (SLC25A4) 617 (BCS1L) 50 (ACO2) 26517 (TIMM13)
3329 (HSPD1) 1.00 0.70 1.00 0.32 0.24 0.19 0.58 0.57 0.42 0.57 0.62 0.42 0.81 0.56 0.60 0.54 1.00 0.28 0.21
498 (ATP5A1) 0.70 1.00 1.00 0.32 0.20 0.17 0.67 0.50 0.35 0.50 0.84 0.39 0.83 0.49 0.52 0.47 1.00 0.24 0.26
1678 (TIMM8A) 1.00 1.00 1.00 0.32 0.36 0.26 1.00 1.00 0.37 1.00 1.00 0.82 1.00 1.00 1.00 1.00 1.00 0.41 0.32
26521 (TIMM8B) 0.32 0.32 0.32 1.00 0.63 0.14 0.32 0.32 0.19 0.32 0.32 0.63 0.32 0.32 0.32 0.32 0.32 0.75 1.00
3421 (IDH3G) 0.24 0.20 0.36 0.63 1.00 0.15 0.23 0.23 0.18 0.23 0.20 0.29 0.23 0.23 0.24 0.19 0.36 0.37 0.38
1537 (CYC1) 0.19 0.17 0.26 0.14 0.15 1.00 0.27 0.23 0.16 0.23 0.22 0.15 0.19 0.22 0.21 0.20 0.26 0.17 0.20
516 (ATP5G1) 0.58 0.67 1.00 0.32 0.23 0.27 1.00 0.60 0.24 0.60 0.86 0.41 0.61 0.56 0.62 0.53 1.00 0.27 0.41
100287932 (TIMM23) 0.57 0.50 1.00 0.32 0.23 0.23 0.60 1.00 0.24 1.00 0.54 0.48 0.56 0.87 0.69 0.64 1.00 0.28 0.48
1431 (CS) 0.42 0.35 0.37 0.19 0.18 0.16 0.24 0.24 1.00 0.24 0.21 0.16 0.37 0.24 0.25 0.20 0.37 0.21 0.16
10452 (TOMM40) 0.57 0.50 1.00 0.32 0.23 0.23 0.60 1.00 0.24 1.00 0.54 0.48 0.56 0.87 0.69 0.64 1.00 0.28 0.48
506 (ATP5B) 0.62 0.84 1.00 0.32 0.20 0.22 0.86 0.54 0.21 0.54 1.00 0.41 0.67 0.52 0.55 0.51 1.00 0.24 0.33
8604 (SLC25A12) 0.42 0.39 0.82 0.63 0.29 0.15 0.41 0.48 0.16 0.48 0.41 1.00 0.40 0.46 0.56 0.45 0.82 0.28 0.38
3313 (HSPA9) 0.81 0.83 1.00 0.32 0.23 0.19 0.61 0.56 0.37 0.56 0.67 0.40 1.00 0.55 0.60 0.52 1.00 0.27 0.21
29928 (TIMM22) 0.56 0.49 1.00 0.32 0.23 0.22 0.56 0.87 0.24 0.87 0.52 0.46 0.55 1.00 0.65 0.59 1.00 0.27 0.42
7416 (VDAC1) 0.60 0.52 1.00 0.32 0.24 0.21 0.62 0.69 0.25 0.69 0.55 0.56 0.60 0.65 1.00 0.63 1.00 0.28 0.26
291 (SLC25A4) 0.54 0.47 1.00 0.32 0.19 0.20 0.53 0.64 0.20 0.64 0.51 0.45 0.52 0.59 0.63 1.00 1.00 0.24 0.33
617 (BCS1L) 1.00 1.00 1.00 0.32 0.36 0.26 1.00 1.00 0.37 1.00 1.00 0.82 1.00 1.00 1.00 1.00 1.00 0.41 0.32
50 (ACO2) 0.28 0.24 0.41 0.75 0.37 0.17 0.27 0.28 0.21 0.28 0.24 0.28 0.27 0.27 0.28 0.24 0.41 1.00 0.40
26517 (TIMM13) 0.21 0.26 0.32 1.00 0.38 0.20 0.41 0.48 0.16 0.48 0.33 0.38 0.21 0.42 0.26 0.33 0.32 0.40 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
SLC25A12 Human Blood - 3650 m 48 hours downregulated 0.665 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT032465 hsa-let-7b-5p Homo sapiens SLC25A12 8604 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT039054 hsa-miR-766-3p Homo sapiens SLC25A12 8604 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047856 hsa-miR-30c-5p Homo sapiens SLC25A12 8604 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051393 hsa-let-7f-5p Homo sapiens SLC25A12 8604 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT156259 hsa-miR-5580-3p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT156225 hsa-miR-493-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT156224 hsa-miR-511-3p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT156229 hsa-miR-510-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498076 hsa-miR-499a-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498074 hsa-miR-4432 Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498072 hsa-miR-100-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498075 hsa-miR-505-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498070 hsa-miR-494-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498073 hsa-miR-8087 Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498071 hsa-miR-4789-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498077 hsa-miR-320b Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498069 hsa-miR-9-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498078 hsa-miR-320a Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498079 hsa-miR-320d Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498080 hsa-miR-4429 Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT498081 hsa-miR-320c Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT563073 hsa-miR-4524b-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563080 hsa-miR-6779-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563090 hsa-miR-15a-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563089 hsa-miR-15b-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563084 hsa-miR-6838-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563081 hsa-miR-4687-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563085 hsa-miR-497-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563087 hsa-miR-195-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563088 hsa-miR-16-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563083 hsa-miR-503-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563088 hsa-miR-16-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT563089 hsa-miR-15b-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT563086 hsa-miR-424-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563087 hsa-miR-195-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT563074 hsa-miR-4524a-5p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563079 hsa-miR-129-1-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563090 hsa-miR-15a-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT563078 hsa-miR-129-2-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563076 hsa-miR-545-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563091 hsa-miR-548p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563075 hsa-miR-4777-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563077 hsa-miR-3613-3p Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT563082 hsa-miR-646 Homo sapiens SLC25A12 8604 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT707899 hsa-miR-1267 Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707895 hsa-miR-6867-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707892 hsa-miR-297 Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707893 hsa-miR-3924 Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707894 hsa-miR-190a-3p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707896 hsa-miR-3177-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707898 hsa-miR-367-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707897 hsa-miR-567 Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707900 hsa-miR-5011-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT707901 hsa-miR-1277-5p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 21572407
MIRT726553 hsa-miR-19a-3p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726552 hsa-miR-19b-3p Homo sapiens SLC25A12 8604 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
Gene Ontology
ID GO ID GO Term GO Type
8604 GO:0005743 mitochondrial inner membrane GOTERM_CC_DIRECT
8604 GO:0043209 myelin sheath GOTERM_CC_DIRECT
8604 GO:0006412 translation GOTERM_BP_DIRECT
8604 GO:0015172 chloride transmembrane transporter activity GOTERM_MF_DIRECT
8604 GO:0015183 L-amino acid transmembrane transporter activity GOTERM_MF_DIRECT
8604 GO:0006094 gluconeogenesis GOTERM_BP_DIRECT
8604 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
8604 GO:0089711 L-glutamate transmembrane transport GOTERM_BP_DIRECT
8604 GO:0003735 structural constituent of ribosome GOTERM_MF_DIRECT
8604 GO:0015813 L-glutamate transport GOTERM_BP_DIRECT
8604 GO:0005509 calcium ion binding GOTERM_MF_DIRECT
8604 GO:0005739 mitochondrion GOTERM_CC_DIRECT
8604 GO:0015810 aspartate transport GOTERM_BP_DIRECT
8604 GO:0043490 malate-aspartate shuttle GOTERM_BP_DIRECT
8604 GO:0051592 response to calcium ion GOTERM_BP_DIRECT
8604 GO:0089712 L-aspartate transmembrane transport GOTERM_BP_DIRECT
8604 GO:0005313 chloride channel activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
SLC25A12 8604 Rheumatoid Arthritis C0003873 Disease or Syndrome 0.3 0.762 0.31 disease
SLC25A12 8604 Autistic Disorder C0004352 Mental or Behavioral Dysfunction 0.4 0.762 0.31 group
SLC25A12 8604 Hypomyelination, Global Cerebral C2751855 Disease or Syndrome 0.7 0.762 0.31 disease
SLC25A12 8604 Mitochondrial Diseases C0751651 Disease or Syndrome 0.3 0.762 0.31 group
SLC25A12 8604 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.31 0.762 0.31 group
SLC25A12 8604 Leukodystrophy C0023520 Disease or Syndrome 0.3 0.762 0.31 disease
SLC25A12 8604 Epileptic encephalopathy C0543888 Disease or Syndrome 0.4 0.762 0.31 disease
SLC25A12 8604 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.01 0.762 0.31 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types