ALTITUDEOMICSDB

ACO2 aconitate hydratase

AltitudeomicsDB

Protein Official symbol	ACO2
Aliases	ACO2
Chromosomal Location	22
Length	780
Uniprot ID	Q99798
EC number	4.2.1.3
Protein family Information(Pfam)	PF00330;PF00694;
PDB id	None
InterPro ID	IPR015931;IPR001030;IPR015928;IPR018136;IPR036008;IPR015932;IPR006248;IPR000573;
dbSNP	rs141772938 rs786200924 rs786204828 rs752034900 rs786204829 rs1804785

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
TIMM44	GRPEL1	0.9990000000000001
TIMM9	TIMM13	0.9990000000000001
TOMM70A	TOMM22	0.9990000000000001
HSPA9	GRPEL1	0.9990000000000001
HSPD1	HSPA9	0.9990000000000001
TOMM7	TOMM22	0.9990000000000001
IDH3A	IDH3G	0.9990000000000001
HSPA9	TIMM44	0.9990000000000001
IDH3B	IDH3A	0.9990000000000001
TIMM8A	TIMM10	0.9990000000000001
TIMM8A	TIMM13	0.9990000000000001
TIMM10	TIMM13	0.9990000000000001
TIMM23	TIMM17A	0.9990000000000001
TIMM9	TIMM10	0.9990000000000001
TOMM40	TOMM70A	0.998
TOMM7	TOMM70A	0.998
TOMM40	TOMM7	0.998
TOMM20	TOMM22	0.998
IDH3G	ACO2	0.998
IDH2	IDH3G	0.998
IDH3A	ACO2	0.998
ATP5G1	ATP5B	0.997
TIMM17A	TIMM44	0.997
TOMM40	TOMM22	0.997
CS	MDH2	0.997
IDH3B	IDH2	0.997
FH	MDH2	0.997
IDH2	IDH3A	0.997
TOMM20	TOMM70A	0.996
TIMM23	TIMM13	0.996
HSPD1	GRPEL1	0.996
TIMM9	TIMM8A	0.996
TIMM23	TIMM8A	0.996
CS	ACO2	0.995
CS	ACLY	0.995
IDH1	IDH3B	0.995
TIMM23	TIMM44	0.995
IDH1	IDH3G	0.995
FH	CS	0.9940000000000001
TOMM20	VDAC1	0.9940000000000001
TIMM23	TIMM22	0.9940000000000001
DNAJC19	TIMM44	0.9940000000000001
IDH3B	ACO2	0.9940000000000001
FXN	HSCB	0.993
TIMM22	TIMM10	0.993
TIMM9	TIMM22	0.993
IDH3B	IDH3G	0.993
TOMM40	TOMM20	0.993
TOMM40	TIMM13	0.993
TOMM40	TIMM44	0.992
DNAJC19	HSPA9	0.992
DNAJC19	TIMM17A	0.991
FXN	ACO2	0.991
CS	ATP5B	0.991
ATP5B	ACO2	0.99
TOMM20	TOMM7	0.99
TIMM17A	GRPEL1	0.99
SLC25A13	TIMM13	0.9890000000000001
IDH1	IDH3A	0.9890000000000001
SLC25A12	TIMM13	0.9890000000000001
TOMM40	TIMM10	0.9890000000000001
TOMM40	TIMM17A	0.988
HSPA9	HSCB	0.988
HSPA9	VDAC1	0.988
TIMM17A	HSPA9	0.987
FH	SDHA	0.987
FXN	HSPA9	0.987
TIMM17A	TIMM10	0.987
TOMM40	VDAC1	0.987
TIMM23	TIMM9	0.987
SLC25A6	TIMM10	0.986
TIMM23	TIMM10	0.986
ATP5G1	NDUFB8	0.985
TIMM23	TOMM40	0.9840000000000001
TIMM9	TIMM17A	0.9840000000000001
HSPD1	ATP5B	0.9840000000000001
VDAC1	ATP5B	0.983
TIMM22	TIMM13	0.983
TOMM40	TIMM9	0.983
TIMM8A	TIMM22	0.983
TIMM44	IDH3G	0.982
GRPEL2	TIMM44	0.982
GRPEL2	HSPA9	0.982
TIMM22	TIMM44	0.982
GRPEL1	HSCB	0.982
IDH2	ACO2	0.981
SLC25A6	ATP5B	0.981
SLC25A12	TIMM8A	0.98
SLC25A13	TIMM8A	0.98
TIMM23	HSPA9	0.98
TOMM40	TIMM8A	0.98
TIMM17A	TIMM22	0.98
SLC25A4	ATP5B	0.98
TIMM23	SLC25A13	0.9790000000000001
IDH1	ACO2	0.9790000000000001
TOMM70A	VDAC1	0.978
TOMM40	TIMM22	0.978
TOMM40	HSPA9	0.978
TIMM22	TOMM70A	0.978
TIMM23	DNAJC19	0.977
TOMM40	DNAJC19	0.976
IDH1	IDH2	0.976
HSPA9	ATP5B	0.976
DNAJC19	GRPEL1	0.975
TIMM23	SLC25A12	0.975
SLC25A4	VDAC1	0.973
CS	VDAC1	0.973
CS	SDHA	0.973
HSPD1	TIMM44	0.972
SLC25A6	VDAC1	0.972
HSPD1	CS	0.972
SLC25A12	ACO2	0.972
TOMM40	HSPD1	0.972
TOMM20	HSPA9	0.971
DNAJC19	HSCB	0.971
TIMM22	TOMM22	0.971
SDHA	ATP5B	0.97
ATP5B	TOMM22	0.97
HSPA9	TOMM22	0.97
ATP5B	IDH3G	0.968
ACLY	ACO2	0.968
COX19	COX17	0.9670000000000001
HSPA9	TOMM70A	0.966
CS	NDUFB8	0.965
NDUFB8	ATP5B	0.9640000000000001
TIMM9	HSPA9	0.963
TIMM23	HSPD1	0.963
HSPA9	TIMM10	0.9620000000000001
HSPA9	ACO2	0.961
TIMM9	SLC25A6	0.961
FXN	CS	0.961
HSPD1	VDAC1	0.96
MDH2	ACLY	0.9590000000000001
HSPD1	TOMM20	0.9590000000000001
TIMM23	GRPEL1	0.9590000000000001
SLC25A13	ACO2	0.9590000000000001
MDH2	ATP5B	0.958
HSPD1	ACO2	0.958
TOMM40	CHCHD3	0.958
TIMM22	GRPEL1	0.9570000000000001
CS	IDH3A	0.9570000000000001
FXN	GRPEL1	0.956
COQ2	ATP5B	0.955
TOMM40	GRPEL1	0.955
CS	HSPA9	0.955
TIMM23	SLC25A6	0.9540000000000001
TIMM17A	GRPEL2	0.953
VDAC1	ACO2	0.953
GRPEL1	TIMM10	0.953
HSPD1	TIMM17A	0.9520000000000001
TIMM44	HSCB	0.9520000000000001
TOMM7	HSPA9	0.9520000000000001
GRPEL2	HSCB	0.9520000000000001
COA6	ATP5B	0.951
TIMM8A	HSPA9	0.95
TOMM20	ATP5B	0.95
TIMM22	CHCHD3	0.9490000000000001
HSPA9	TIMM13	0.9490000000000001
HSPD1	TIMM22	0.9490000000000001
PDHB	ACO2	0.948
VDAC1	TIMM13	0.948
TOMM40	COX19	0.948
TIMM23	VDAC1	0.9470000000000001
TOMM40	GRPEL2	0.9470000000000001
HSPD1	TOMM22	0.946
ATP5G1	TIMM10	0.946
DNAJC19	GRPEL2	0.946
TOMM20	TIMM22	0.946
CS	SLC25A4	0.946
TOMM40	NDUFB8	0.945
TOMM7	TIMM22	0.945
HSPD1	GRPEL2	0.945
TIMM22	HSPA9	0.945
ACO2	HSCB	0.9440000000000001
DNAJC19	TIMM22	0.9440000000000001
TIMM8A	VDAC1	0.9440000000000001
HSPD1	TIMM8A	0.9440000000000001
NDUFB8	SLC25A4	0.943
TOMM40	ACO2	0.943
TOMM40	COX17	0.943
TIMM23	SLC25A4	0.9420000000000001
TOMM20	CS	0.9420000000000001
HSPD1	DNAJC19	0.941
HSPA9	OTC	0.941
TIMM23	GRPEL2	0.941
ATP5G1	GRPEL1	0.941
CS	GRPEL1	0.941
SLC25A6	ACO2	0.94
TOMM22	TIMM13	0.94
TIMM17A	OTC	0.94
CS	TOMM22	0.9390000000000001
TIMM22	VDAC1	0.9390000000000001
HSPD1	OTC	0.938
SLC25A6	CS	0.938
PDHB	LDHD	0.938
TIMM9	ATP5B	0.937
CS	OTC	0.9359999999999999
SLC25A4	ACO2	0.9359999999999999
DNAJC19	FXN	0.9359999999999999
TOMM40	ATP5B	0.9359999999999999
NDUFB8	ACO2	0.9359999999999999
SLC25A6	TIMM22	0.935
TIMM9	SLC25A4	0.935
CHCHD7	ACO2	0.935
ATP5G1	ACO2	0.935
SLC25A4	TIMM10	0.935
TIMM9	HSPD1	0.935
FXN	GRPEL2	0.935
ATP5G1	COA6	0.935
HSPD1	FXN	0.934
CS	COQ2	0.934
HSPD1	TOMM70A	0.9329999999999999
TOMM70A	ATP5B	0.9329999999999999
TIMM44	ATP5B	0.9329999999999999
ATP5G1	CMC2	0.932
HSPA9	CHCHD3	0.932
TIMM23	ATP5B	0.9309999999999999
ATP5G1	TOMM22	0.9309999999999999
ATP5B	COX17	0.93
TIMM17A	HSCB	0.93
GRPEL2	TIMM22	0.93
TOMM40	COA6	0.93
HSPD1	TIMM13	0.929
MDH2	ACO2	0.929
SDHA	ACO2	0.929
ATP5G1	TIMM44	0.929
TOMM70A	ACO2	0.929
COQ2	LDHD	0.9279999999999999
TIMM23	CS	0.9279999999999999
GRPEL2	GRPEL1	0.9279999999999999
SLC25A12	VDAC1	0.9279999999999999
TOMM40	SLC25A6	0.9279999999999999
ATP5G1	SLC25A6	0.9279999999999999
FXN	IDH3G	0.9279999999999999
SLC25A13	TIMM22	0.9279999999999999
TOMM7	ATP5B	0.9279999999999999
ATP5G1	SLC25A4	0.9279999999999999
CS	TOMM70A	0.9279999999999999
FH	IDH3A	0.9279999999999999
FXN	ATP5B	0.927
TOMM70A	SLC25A4	0.927
SLC25A13	ATP5B	0.927
TIMM22	SLC25A4	0.927
CHCHD3	ACO2	0.927
FXN	NDUFB8	0.9259999999999999
COX19	TIMM22	0.9259999999999999
CHCHD10	IDH3G	0.9259999999999999
COQ2	ACO2	0.9259999999999999
HSPD1	TIMM10	0.925
SLC25A6	HSPA9	0.925
HSPD1	HSCB	0.925
SLC25A12	CS	0.925
TOMM40	ATP5G1	0.925
TOMM40	SLC25A4	0.925
ATP5G1	COX17	0.925
MDH2	SDHA	0.925
TOMM40	CS	0.924
NDUFB8	IDH3G	0.924
TOMM20	ACO2	0.9229999999999999
NDUFB8	HSPA9	0.9229999999999999
SLC25A4	TIMM13	0.9229999999999999
TIMM17A	SLC25A4	0.9229999999999999
ATP5G1	VDAC1	0.9229999999999999
TIMM9	CS	0.922
MDH2	IDH3A	0.922
ATP5G1	IDH3G	0.922
SLC25A6	TIMM17A	0.922
CHCHD7	HSPA9	0.922
FXN	TIMM44	0.922
SLC25A4	TOMM22	0.922
CHCHD3	ATP5B	0.9209999999999999
TIMM23	TOMM22	0.9209999999999999
HSPA9	COX17	0.9209999999999999
TIMM23	ATP5G1	0.9209999999999999
HSPD1	SLC25A6	0.9209999999999999
SLC25A12	ATP5B	0.9209999999999999
SLC25A4	IDH3G	0.9209999999999999
FH	ACO2	0.9209999999999999
HSPD1	LDHD	0.9209999999999999
TOMM20	SLC25A4	0.92
ATP5G1	CS	0.92
HSPA9	SLC25A4	0.92
TOMM7	SLC25A4	0.92
CS	GRPEL2	0.92
ATP5G1	OTC	0.919
TOMM40	FXN	0.919
ATP5G1	HSPA9	0.919
LDHD	IDH3G	0.919
IDH2	MDH2	0.919
HSPD1	CHCHD7	0.919
TIMM22	COX17	0.919
HSPD1	NDUFB8	0.919
SLC25A4	TIMM44	0.9179999999999999
TIMM8A	IDH3G	0.9179999999999999
SLC25A13	VDAC1	0.9179999999999999
ATP5G1	TIMM13	0.9179999999999999
LDHD	ACO2	0.9179999999999999
HSPD1	COA6	0.9179999999999999
ATP5G1	CHCHD3	0.9179999999999999
TIMM17A	IDH3G	0.9179999999999999
ACO2	OTC	0.9179999999999999
HSPD1	IDH3G	0.917
CS	CHCHD3	0.917
CHCHD10	HSPD1	0.917
TIMM17A	ATP5B	0.917
TIMM23	LDHD	0.917
CHCHD3	IDH3G	0.917
CS	TIMM44	0.917
SLC25A13	CS	0.917
TIMM8A	SLC25A4	0.917
IDH3G	OTC	0.917
ATP5G1	GRPEL2	0.9159999999999999
FXN	TIMM17A	0.9159999999999999
TOMM40	OTC	0.9159999999999999
TOMM40	SLC25A12	0.9159999999999999
COA6	SLC25A4	0.9159999999999999
TOMM40	HSCB	0.9159999999999999
GRPEL1	ATP5B	0.9159999999999999
ATP5B	TIMM10	0.9159999999999999
ATP5G1	COX19	0.9159999999999999
GRPEL1	ACO2	0.9159999999999999
CS	LDHD	0.915
HSPD1	SLC25A4	0.915
COA6	CS	0.915
CHCHD10	CS	0.915
TIMM17A	CS	0.915
FXN	COQ2	0.915
SLC25A6	IDH3G	0.914
TOMM40	SLC25A13	0.914
GRPEL2	OTC	0.914
SLC25A4	GRPEL1	0.914
GRPEL1	OTC	0.914
TIMM10	TOMM22	0.914
HSPD1	COQ2	0.914
CS	TIMM13	0.914
VDAC1	IDH3G	0.9129999999999999
HSPD1	CHCHD3	0.9129999999999999
CHCHD10	ATP5B	0.9129999999999999
CS	COX17	0.9129999999999999
TIMM22	ATP5B	0.9129999999999999
FXN	SLC25A4	0.9129999999999999
GRPEL2	ATP5B	0.9129999999999999
ATP5G1	TIMM8A	0.912
COA6	TIMM22	0.912
TIMM9	ATP5G1	0.912
CS	HSCB	0.912
FXN	TIMM22	0.912
SLC25A4	CHCHD3	0.912
GRPEL2	ACO2	0.912
CHCHD10	TOMM40	0.912
TIMM22	NDUFB8	0.912
ATP5G1	TOMM70A	0.9109999999999999
SLC25A13	SLC25A4	0.9109999999999999
COX17	ACO2	0.9109999999999999
ATP5G1	TOMM20	0.9109999999999999
COX17	IDH3G	0.9109999999999999
CS	TIMM22	0.9109999999999999
TOMM70A	IDH3G	0.91
TIMM8A	CS	0.91
ACO2	TOMM22	0.91
TOMM40	CMC2	0.91
TIMM10	ACO2	0.91
COA6	IDH3G	0.91
TOMM7	CS	0.91
SLC25A12	SLC25A4	0.91
IDH1	MDH2	0.91
ATP5G1	TOMM7	0.91
DNAJC19	SLC25A4	0.91
HSPD1	TOMM7	0.91
COQ2	HSPA9	0.909
NDUFB8	GRPEL1	0.909
CHCHD10	SLC25A4	0.909
TOMM40	IDH3G	0.909
CMC2	ACO2	0.909
ATP5G1	HSPD1	0.909
HSPA9	IDH3G	0.909
SLC25A13	HSPA9	0.909
GRPEL2	NDUFB8	0.909
CS	COX19	0.909
COQ2	SLC25A4	0.9079999999999999
LDHD	GRPEL1	0.9079999999999999
ATP5G1	TIMM22	0.9079999999999999
GRPEL1	IDH3G	0.9079999999999999
TIMM23	TOMM20	0.9079999999999999
TIMM23	NDUFB8	0.9079999999999999
SLC25A13	IDH3G	0.9079999999999999
CHCHD10	ATP5G1	0.9079999999999999
TIMM22	CMC2	0.9079999999999999
CS	TIMM10	0.9079999999999999
TIMM23	IDH3G	0.9079999999999999
NDUFB8	HSCB	0.9079999999999999
LDHD	OTC	0.9079999999999999
COX19	HSPA9	0.9079999999999999
GRPEL2	SLC25A4	0.907
DNAJC19	OTC	0.907
TIMM17A	ACO2	0.907
COX19	ACO2	0.907
TIMM23	OTC	0.907
TIMM23	ACO2	0.907
CHCHD5	HSPA9	0.907
SLC25A12	HSPA9	0.907
TOMM40	CHCHD5	0.907
ACO2	TIMM13	0.907
HSPD1	COX17	0.907
SLC25A12	TIMM22	0.9059999999999999
COA6	ACO2	0.9059999999999999
ATP5G1	TIMM17A	0.9059999999999999
TOMM20	IDH3G	0.9059999999999999
CHCHD10	ACO2	0.9059999999999999
TIMM8A	ATP5B	0.9059999999999999
DNAJC19	CS	0.9059999999999999
TIMM22	IDH3G	0.9059999999999999
IDH3G	TOMM22	0.9059999999999999
TIMM23	COQ2	0.905
TIMM10	IDH3G	0.905
TIMM17A	NDUFB8	0.905
ATP5G1	CHCHD7	0.905
LDHD	SLC25A4	0.905
TIMM9	ACO2	0.905
TIMM22	CHCHD7	0.905
TOMM7	ACO2	0.905
SLC25A13	HSPD1	0.905
ATP5G1	DNAJC19	0.905
LDHD	ATP5B	0.905
CMC2	IDH3G	0.905
COA6	HSPA9	0.905
TIMM22	ACO2	0.904
TOMM7	IDH3G	0.904
CHCHD5	TIMM22	0.904
ATP5G1	CHCHD5	0.904
DNAJC19	ACO2	0.904
NDUFB8	TIMM44	0.904
GRPEL2	LDHD	0.904
GRPEL2	IDH3G	0.904
COX19	SLC25A4	0.904
CHCHD5	ACO2	0.904
TOMM40	COQ2	0.904
TOMM40	LDHD	0.904
DNAJC19	COQ2	0.904
HSPD1	CMC2	0.903
TIMM23	HSCB	0.903
DNAJC19	NDUFB8	0.903
SLC25A6	SLC25A4	0.903
ATP5G1	FXN	0.903
HSPA9	CMC2	0.903
LDHD	HSPA9	0.903
TIMM22	HSCB	0.903
TIMM8A	ACO2	0.903
ATP5B	CMC2	0.903
ATP5B	OTC	0.903
TIMM23	FXN	0.903
TIMM44	ACO2	0.903
LDHD	TIMM44	0.903
ATP5B	TIMM13	0.903
IDH3G	HSCB	0.902
DNAJC19	IDH3G	0.902
IDH3G	TIMM13	0.902
SLC25A12	HSPD1	0.902
COX19	ATP5B	0.902
TIMM17A	COQ2	0.902
ATP5G1	COQ2	0.902
TIMM22	OTC	0.902
HSPD1	COX19	0.902
DNAJC19	ATP5B	0.902
TOMM40	CHCHD7	0.902
CHCHD10	TIMM22	0.902
CHCHD10	HSPA9	0.902
COX19	IDH3G	0.902
COQ2	IDH3G	0.9009999999999999
ATP5G1	HSCB	0.9009999999999999
ATP5G1	LDHD	0.9009999999999999
TIMM9	IDH3G	0.9009999999999999
COQ2	GRPEL1	0.9009999999999999
TIMM22	COQ2	0.9009999999999999
GRPEL2	COQ2	0.9009999999999999
SLC25A12	ATP5G1	0.9
HSCB	OTC	0.9
LDHD	NDUFB8	0.9
CHCHD7	IDH3G	0.9
NDUFB8	OTC	0.9
CS	CHCHD7	0.9
CS	CMC2	0.9
SLC25A13	ATP5G1	0.9
CS	CHCHD5	0.9
CHCHD7	ATP5B	0.9
SLC25A4	COX17	0.9
COQ2	OTC	0.9
FXN	OTC	0.9
CHCHD5	SLC25A4	0.9
SLC25A4	CMC2	0.9
FXN	LDHD	0.9
SLC25A4	OTC	0.9
CHCHD7	SLC25A4	0.9
COQ2	NDUFB8	0.9
ATP5B	HSCB	0.9
CHCHD5	IDH3G	0.9
HSPD1	CHCHD5	0.9
DNAJC19	LDHD	0.9
SLC25A4	HSCB	0.9
COQ2	HSCB	0.9
TIMM8A	TOMM22	0.9
LDHD	HSCB	0.9
TIMM17A	LDHD	0.9
SLC25A12	IDH3G	0.9
TIMM22	LDHD	0.9
TIMM44	OTC	0.9
CHCHD5	ATP5B	0.9
COQ2	TIMM44	0.9

Gene Ontology Semantic Similarity

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#	10469 (TIMM44)	26520 (TIMM9)	9868 (TOMM70A)	3313 (HSPA9)	3329 (HSPD1)	54543 (TOMM7)	3420 (IDH3B)	1678 (TIMM8A)	26519 (TIMM10)	100287932 (TIMM23)	10452 (TOMM40)	9804 (TOMM20)	3421 (IDH3G)	3418 (IDH2)	516 (ATP5G1)	10440 (TIMM17A)	1431 (CS)	2271 (FH)	3417 (IDH1)	131118 (DNAJC19)	2395 (FXN)	29928 (TIMM22)	506 (ATP5B)	10165 (SLC25A13)	8604 (SLC25A12)	293 (SLC25A6)	7416 (VDAC1)	134266 (GRPEL2)	80273 (GRPEL1)	291 (SLC25A4)	6389 (SDHA)	47 (ACLY)	4714 (NDUFB8)	4191 (MDH2)	27235 (COQ2)	388753 (COA6)	5162 (PDHB)	50 (ACO2)	56993 (TOMM22)	54927 (CHCHD3)	400916 (CHCHD10)	197257 (LDHD)	10063 (COX17)	150274 (HSCB)	26517 (TIMM13)	5009 (OTC)
10469 (TIMM44)	1.00	0.75	0.74	0.77	0.64	0.61	0.34	1.00	0.75	0.73	0.61	0.60	0.14	0.28	0.64	0.11	0.29	0.74	0.53	1.00	0.53	0.66	0.51	0.23	0.21	0.60	0.72	0.63	0.63	0.60	0.58	0.62	0.13	0.29	0.14	0.70	0.63	0.26	0.61	0.73	0.48	1.00	0.62	0.82	0.28	0.16
26520 (TIMM9)	0.75	1.00	0.64	0.65	0.61	0.60	0.44	1.00	1.00	0.63	0.60	0.58	0.19	0.36	0.74	0.30	0.26	0.61	0.63	1.00	0.62	0.59	0.65	0.49	0.35	0.59	0.64	0.50	0.50	0.59	0.56	0.55	0.17	0.26	0.19	0.70	0.56	0.38	0.60	0.64	0.64	1.00	0.73	0.72	0.57	0.21
9868 (TOMM70A)	0.74	0.64	1.00	0.65	0.58	0.96	0.34	1.00	0.64	0.90	0.96	0.79	0.14	0.23	0.60	0.80	0.24	0.57	0.46	1.00	0.45	0.79	0.54	0.36	0.35	0.64	0.67	0.49	0.49	0.64	0.47	0.49	0.13	0.24	0.14	0.56	0.49	0.22	0.96	0.62	0.48	1.00	0.51	0.68	0.48	0.16
3313 (HSPA9)	0.77	0.65	0.65	1.00	0.79	0.58	0.34	1.00	0.65	0.65	0.58	0.61	0.14	0.26	0.60	0.11	0.50	0.66	0.50	1.00	0.52	0.61	0.50	0.22	0.21	0.57	0.66	0.65	0.65	0.57	0.56	0.60	0.13	0.50	0.14	0.82	0.59	0.24	0.58	0.67	0.48	1.00	0.59	0.71	0.24	0.16
3329 (HSPD1)	0.64	0.61	0.58	0.79	1.00	0.56	0.34	1.00	0.61	0.58	0.56	0.58	0.14	0.24	0.60	0.11	0.41	0.59	0.48	1.00	0.54	0.57	0.62	0.23	0.22	0.56	0.60	0.51	0.51	0.56	0.55	0.57	0.13	0.41	0.14	0.71	0.57	0.22	0.56	0.61	0.48	1.00	0.56	0.61	0.22	0.16
54543 (TOMM7)	0.61	0.60	0.96	0.58	0.56	1.00	0.34	1.00	0.60	0.96	1.00	0.84	0.14	0.20	0.55	1.00	0.21	0.48	0.42	1.00	0.42	0.86	0.53	0.35	0.34	0.60	0.65	0.41	0.41	0.60	0.42	0.42	0.13	0.21	0.14	0.49	0.43	0.19	1.00	0.55	0.48	1.00	0.45	0.57	0.48	0.16
3420 (IDH3B)	0.34	0.44	0.34	0.34	0.34	0.34	1.00	0.34	0.44	0.34	0.34	0.34	0.19	0.21	0.44	0.13	0.21	0.34	0.28	0.34	0.34	0.34	0.44	0.44	0.21	0.34	0.34	0.28	0.28	0.34	1.00	0.34	0.17	0.21	0.19	0.34	0.34	0.21	0.34	0.34	0.64	0.34	0.34	0.64	0.28	0.21
1678 (TIMM8A)	1.00	1.00	1.00	1.00	1.00	1.00	0.34	1.00	1.00	1.00	1.00	1.00	0.14	0.36	1.00	0.11	0.37	1.00	0.82	1.00	1.00	1.00	1.00	0.36	0.36	1.00	1.00	0.82	0.82	1.00	1.00	1.00	0.13	0.37	0.14	1.00	1.00	0.32	1.00	1.00	0.48	1.00	1.00	1.00	0.32	0.16
26519 (TIMM10)	0.75	1.00	0.64	0.65	0.61	0.60	0.44	1.00	1.00	0.63	0.60	0.58	0.19	0.36	0.74	0.30	0.26	0.61	0.63	1.00	0.62	0.59	0.65	0.49	0.35	0.59	0.64	0.50	0.50	0.59	0.56	0.55	0.17	0.26	0.19	0.70	0.56	0.38	0.60	0.64	0.64	1.00	0.73	0.72	0.57	0.21
100287932 (TIMM23)	0.73	0.63	0.90	0.65	0.58	0.96	0.34	1.00	0.63	1.00	0.96	0.83	0.14	0.23	0.57	1.00	0.24	0.57	0.46	1.00	0.45	0.87	0.51	0.31	0.30	0.59	0.70	0.48	0.48	0.59	0.47	0.48	0.13	0.24	0.14	0.56	0.48	0.21	0.96	0.62	0.48	1.00	0.50	0.66	0.41	0.16
10452 (TOMM40)	0.61	0.60	0.96	0.58	0.56	1.00	0.34	1.00	0.60	0.96	1.00	0.84	0.14	0.20	0.55	1.00	0.21	0.48	0.42	1.00	0.42	0.86	0.53	0.35	0.34	0.60	0.65	0.41	0.41	0.60	0.42	0.42	0.13	0.21	0.14	0.49	0.43	0.19	1.00	0.55	0.48	1.00	0.45	0.57	0.48	0.16
9804 (TOMM20)	0.60	0.58	0.79	0.61	0.58	0.84	0.34	1.00	0.58	0.83	0.84	1.00	0.14	0.21	0.56	1.00	0.22	0.51	0.43	1.00	0.44	0.93	0.53	0.29	0.29	0.56	0.62	0.50	0.50	0.56	0.45	0.46	0.13	0.22	0.14	0.51	0.46	0.19	0.84	0.55	0.48	1.00	0.48	0.57	0.36	0.16
3421 (IDH3G)	0.14	0.19	0.14	0.14	0.14	0.14	0.19	0.14	0.19	0.14	0.14	0.14	1.00	0.75	0.19	0.06	0.15	0.17	0.75	0.14	0.29	0.14	0.19	0.19	0.08	0.14	0.14	0.11	0.11	0.14	0.35	0.17	0.23	0.57	0.15	0.14	0.35	0.17	0.14	0.14	0.26	0.14	0.14	0.26	0.11	0.17
3418 (IDH2)	0.28	0.36	0.23	0.26	0.24	0.20	0.21	0.36	0.36	0.23	0.20	0.21	0.75	1.00	0.23	0.06	0.18	0.26	0.66	0.36	0.41	0.22	0.20	0.29	0.28	0.19	0.23	0.20	0.20	0.19	0.31	0.24	0.23	0.40	0.15	0.40	0.33	0.40	0.20	0.24	0.28	0.36	0.48	0.31	0.38	0.17
516 (ATP5G1)	0.64	0.74	0.60	0.60	0.60	0.55	0.44	1.00	0.74	0.57	0.55	0.56	0.19	0.23	1.00	0.30	0.24	0.52	0.45	1.00	0.44	0.53	0.86	0.46	0.28	0.53	0.60	0.43	0.43	0.53	0.48	0.46	0.17	0.24	0.19	0.51	0.47	0.22	0.55	0.58	0.64	1.00	0.47	0.68	0.41	0.21
10440 (TIMM17A)	0.11	0.30	0.80	0.11	0.11	1.00	0.13	0.11	0.30	1.00	1.00	1.00	0.06	0.06	0.30	1.00	0.07	0.11	0.09	0.11	0.11	1.00	0.40	0.30	0.30	0.38	0.40	0.09	0.09	0.38	0.13	0.11	0.05	0.07	0.06	0.11	0.11	0.06	1.00	0.11	0.17	0.11	0.11	0.17	0.50	0.06
1431 (CS)	0.29	0.26	0.24	0.50	0.41	0.21	0.21	0.37	0.26	0.24	0.21	0.22	0.15	0.18	0.24	0.07	1.00	0.27	0.23	0.37	0.24	0.23	0.21	0.14	0.11	0.20	0.24	0.26	0.26	0.20	0.25	0.45	0.14	0.58	0.25	0.54	0.26	0.18	0.21	0.25	0.28	0.37	0.24	0.32	0.16	0.29
2271 (FH)	0.74	0.61	0.57	0.66	0.59	0.48	0.34	1.00	0.61	0.57	0.48	0.51	0.17	0.26	0.52	0.11	0.27	1.00	0.49	1.00	0.46	0.52	0.45	0.22	0.18	0.47	0.61	0.49	0.49	0.47	0.50	0.51	0.16	0.27	0.17	0.57	0.53	0.52	0.48	0.62	0.48	1.00	0.51	0.69	0.24	0.20
3417 (IDH1)	0.53	0.63	0.46	0.50	0.48	0.42	0.28	0.82	0.63	0.46	0.42	0.43	0.75	0.66	0.45	0.09	0.23	0.49	1.00	0.82	0.54	0.44	0.42	0.28	0.26	0.42	0.48	0.39	0.39	0.42	0.52	0.45	0.32	0.37	0.21	0.54	0.54	0.32	0.42	0.49	0.38	0.82	0.56	0.53	0.29	0.24
131118 (DNAJC19)	1.00	1.00	1.00	1.00	1.00	1.00	0.34	1.00	1.00	1.00	1.00	1.00	0.14	0.36	1.00	0.11	0.37	1.00	0.82	1.00	1.00	1.00	1.00	0.36	0.36	1.00	1.00	0.82	0.82	1.00	1.00	1.00	0.13	0.37	0.14	1.00	1.00	0.32	1.00	1.00	0.48	1.00	1.00	1.00	0.32	0.16
2395 (FXN)	0.53	0.62	0.45	0.52	0.54	0.42	0.34	1.00	0.62	0.45	0.42	0.44	0.29	0.41	0.44	0.11	0.24	0.46	0.54	1.00	1.00	0.44	0.42	0.33	0.31	0.41	0.49	0.38	0.38	0.41	0.47	0.43	0.27	0.27	0.17	0.60	0.48	0.51	0.42	0.50	0.48	1.00	0.63	0.50	0.41	0.20
29928 (TIMM22)	0.66	0.59	0.79	0.61	0.57	0.86	0.34	1.00	0.59	0.87	0.86	0.93	0.14	0.22	0.53	1.00	0.23	0.52	0.44	1.00	0.44	1.00	0.49	0.30	0.29	0.55	0.65	0.44	0.44	0.55	0.45	0.46	0.13	0.23	0.14	0.52	0.46	0.21	0.86	0.58	0.48	1.00	0.48	0.60	0.36	0.16
506 (ATP5B)	0.51	0.65	0.54	0.50	0.62	0.53	0.44	1.00	0.65	0.51	0.53	0.53	0.19	0.20	0.86	0.40	0.21	0.45	0.42	1.00	0.42	0.49	1.00	0.43	0.28	0.51	0.53	0.37	0.37	0.51	0.45	0.43	0.17	0.21	0.19	0.45	0.43	0.19	0.53	0.49	0.64	1.00	0.43	0.56	0.33	0.21
10165 (SLC25A13)	0.23	0.49	0.36	0.22	0.23	0.35	0.44	0.36	0.49	0.31	0.35	0.29	0.19	0.29	0.46	0.30	0.14	0.22	0.28	0.36	0.33	0.30	0.43	1.00	0.92	0.34	0.31	0.17	0.17	0.34	0.26	0.21	0.17	0.14	0.19	0.31	0.21	0.26	0.35	0.23	0.64	0.36	0.37	0.35	0.47	0.21
8604 (SLC25A12)	0.21	0.35	0.35	0.21	0.22	0.34	0.21	0.36	0.35	0.30	0.34	0.29	0.08	0.28	0.28	0.30	0.11	0.18	0.26	0.36	0.31	0.29	0.28	0.92	1.00	0.33	0.31	0.15	0.15	0.33	0.18	0.17	0.07	0.11	0.08	0.30	0.16	0.25	0.34	0.20	0.28	0.36	0.37	0.24	0.40	0.09
293 (SLC25A6)	0.60	0.59	0.64	0.57	0.56	0.60	0.34	1.00	0.59	0.59	0.60	0.56	0.14	0.19	0.53	0.38	0.20	0.47	0.42	1.00	0.41	0.55	0.51	0.34	0.33	1.00	0.60	0.40	0.40	1.00	0.42	0.42	0.13	0.20	0.14	0.48	0.42	0.18	0.60	0.54	0.48	1.00	0.44	0.56	0.33	0.16
7416 (VDAC1)	0.72	0.64	0.67	0.66	0.60	0.65	0.34	1.00	0.64	0.70	0.65	0.62	0.14	0.23	0.60	0.40	0.24	0.61	0.48	1.00	0.49	0.65	0.53	0.31	0.31	0.60	1.00	0.51	0.51	0.60	0.52	0.54	0.13	0.24	0.14	0.60	0.54	0.21	0.65	0.64	0.48	1.00	0.55	0.67	0.26	0.16
134266 (GRPEL2)	0.63	0.50	0.49	0.65	0.51	0.41	0.28	0.82	0.50	0.48	0.41	0.50	0.11	0.20	0.43	0.09	0.26	0.49	0.39	0.82	0.38	0.44	0.37	0.17	0.15	0.40	0.51	1.00	1.00	0.40	0.40	0.52	0.10	0.26	0.11	0.50	0.42	0.19	0.41	0.52	0.38	0.82	0.43	0.56	0.20	0.13
80273 (GRPEL1)	0.63	0.50	0.49	0.65	0.51	0.41	0.28	0.82	0.50	0.48	0.41	0.50	0.11	0.20	0.43	0.09	0.26	0.49	0.39	0.82	0.38	0.44	0.37	0.17	0.15	0.40	0.51	1.00	1.00	0.40	0.40	0.52	0.10	0.26	0.11	0.50	0.42	0.19	0.41	0.52	0.38	0.82	0.43	0.56	0.20	0.13
291 (SLC25A4)	0.60	0.59	0.64	0.57	0.56	0.60	0.34	1.00	0.59	0.59	0.60	0.56	0.14	0.19	0.53	0.38	0.20	0.47	0.42	1.00	0.41	0.55	0.51	0.34	0.33	1.00	0.60	0.40	0.40	1.00	0.42	0.42	0.13	0.20	0.14	0.48	0.42	0.18	0.60	0.54	0.48	1.00	0.44	0.56	0.33	0.16
6389 (SDHA)	0.58	0.56	0.47	0.56	0.55	0.42	1.00	1.00	0.56	0.47	0.42	0.45	0.35	0.31	0.48	0.13	0.25	0.50	0.52	1.00	0.47	0.45	0.45	0.26	0.18	0.42	0.52	0.40	0.40	0.42	1.00	0.45	0.32	0.32	0.21	0.48	0.56	0.25	0.42	0.54	0.64	1.00	0.45	0.64	0.24	0.24
47 (ACLY)	0.62	0.55	0.49	0.60	0.57	0.42	0.34	1.00	0.55	0.48	0.42	0.46	0.17	0.24	0.46	0.11	0.45	0.51	0.45	1.00	0.43	0.46	0.43	0.21	0.17	0.42	0.54	0.52	0.52	0.42	0.45	1.00	0.16	0.27	0.29	0.51	0.46	0.24	0.42	0.56	0.48	1.00	0.46	0.58	0.22	0.34
4714 (NDUFB8)	0.13	0.17	0.13	0.13	0.13	0.13	0.17	0.13	0.17	0.13	0.13	0.13	0.23	0.23	0.17	0.05	0.14	0.16	0.32	0.13	0.27	0.13	0.17	0.17	0.07	0.13	0.13	0.10	0.10	0.13	0.32	0.16	1.00	0.25	0.14	0.13	0.32	0.16	0.13	0.13	0.23	0.13	0.13	0.23	0.10	0.16
4191 (MDH2)	0.29	0.26	0.24	0.50	0.41	0.21	0.21	0.37	0.26	0.24	0.21	0.22	0.57	0.40	0.24	0.07	0.58	0.27	0.37	0.37	0.27	0.23	0.21	0.14	0.11	0.20	0.24	0.26	0.26	0.20	0.32	0.27	0.25	1.00	0.16	0.54	0.34	0.19	0.21	0.25	0.28	0.37	0.24	0.31	0.16	0.18
27235 (COQ2)	0.14	0.19	0.14	0.14	0.14	0.14	0.19	0.14	0.19	0.14	0.14	0.14	0.15	0.15	0.19	0.06	0.25	0.17	0.21	0.14	0.17	0.14	0.19	0.19	0.08	0.14	0.14	0.11	0.11	0.14	0.21	0.29	0.14	0.16	1.00	0.14	0.21	0.17	0.14	0.14	0.26	0.14	0.14	0.26	0.11	0.29
388753 (COA6)	0.70	0.70	0.56	0.82	0.71	0.49	0.34	1.00	0.70	0.56	0.49	0.51	0.14	0.40	0.51	0.11	0.54	0.57	0.54	1.00	0.60	0.52	0.45	0.31	0.30	0.48	0.60	0.50	0.50	0.48	0.48	0.51	0.13	0.54	0.14	1.00	0.50	0.43	0.49	0.61	0.48	1.00	0.86	0.63	0.44	0.16
5162 (PDHB)	0.63	0.56	0.49	0.59	0.57	0.43	0.34	1.00	0.56	0.48	0.43	0.46	0.35	0.33	0.47	0.11	0.26	0.53	0.54	1.00	0.48	0.46	0.43	0.21	0.16	0.42	0.54	0.42	0.42	0.42	0.56	0.46	0.32	0.34	0.21	0.50	1.00	0.25	0.43	0.56	0.48	1.00	0.46	0.61	0.22	0.24
50 (ACO2)	0.26	0.38	0.22	0.24	0.22	0.19	0.21	0.32	0.38	0.21	0.19	0.19	0.17	0.40	0.22	0.06	0.18	0.52	0.32	0.32	0.51	0.21	0.19	0.26	0.25	0.18	0.21	0.19	0.19	0.18	0.25	0.24	0.16	0.19	0.17	0.43	0.25	1.00	0.19	0.22	0.28	0.32	0.54	0.30	0.44	0.20
56993 (TOMM22)	0.61	0.60	0.96	0.58	0.56	1.00	0.34	1.00	0.60	0.96	1.00	0.84	0.14	0.20	0.55	1.00	0.21	0.48	0.42	1.00	0.42	0.86	0.53	0.35	0.34	0.60	0.65	0.41	0.41	0.60	0.42	0.42	0.13	0.21	0.14	0.49	0.43	0.19	1.00	0.55	0.48	1.00	0.45	0.57	0.48	0.16
54927 (CHCHD3)	0.73	0.64	0.62	0.67	0.61	0.55	0.34	1.00	0.64	0.62	0.55	0.55	0.14	0.24	0.58	0.11	0.25	0.62	0.49	1.00	0.50	0.58	0.49	0.23	0.20	0.54	0.64	0.52	0.52	0.54	0.54	0.56	0.13	0.25	0.14	0.61	0.56	0.22	0.55	1.00	0.48	1.00	0.56	0.70	0.24	0.16
400916 (CHCHD10)	0.48	0.64	0.48	0.48	0.48	0.48	0.64	0.48	0.64	0.48	0.48	0.48	0.26	0.28	0.64	0.17	0.28	0.48	0.38	0.48	0.48	0.48	0.64	0.64	0.28	0.48	0.48	0.38	0.38	0.48	0.64	0.48	0.23	0.28	0.26	0.48	0.48	0.28	0.48	0.48	1.00	0.48	0.48	1.00	0.38	0.28
197257 (LDHD)	1.00	1.00	1.00	1.00	1.00	1.00	0.34	1.00	1.00	1.00	1.00	1.00	0.14	0.36	1.00	0.11	0.37	1.00	0.82	1.00	1.00	1.00	1.00	0.36	0.36	1.00	1.00	0.82	0.82	1.00	1.00	1.00	0.13	0.37	0.14	1.00	1.00	0.32	1.00	1.00	0.48	1.00	1.00	1.00	0.32	0.16
10063 (COX17)	0.62	0.73	0.51	0.59	0.56	0.45	0.34	1.00	0.73	0.50	0.45	0.48	0.14	0.48	0.47	0.11	0.24	0.51	0.56	1.00	0.63	0.48	0.43	0.37	0.37	0.44	0.55	0.43	0.43	0.44	0.45	0.46	0.13	0.24	0.14	0.86	0.46	0.54	0.45	0.56	0.48	1.00	1.00	0.56	0.55	0.16
150274 (HSCB)	0.82	0.72	0.68	0.71	0.61	0.57	0.64	1.00	0.72	0.66	0.57	0.57	0.26	0.31	0.68	0.17	0.32	0.69	0.53	1.00	0.50	0.60	0.56	0.35	0.24	0.56	0.67	0.56	0.56	0.56	0.64	0.58	0.23	0.31	0.26	0.63	0.61	0.30	0.57	0.70	1.00	1.00	0.56	1.00	0.35	0.28
26517 (TIMM13)	0.28	0.57	0.48	0.24	0.22	0.48	0.28	0.32	0.57	0.41	0.48	0.36	0.11	0.38	0.41	0.50	0.16	0.24	0.29	0.32	0.41	0.36	0.33	0.47	0.40	0.33	0.26	0.20	0.20	0.33	0.24	0.22	0.10	0.16	0.11	0.44	0.22	0.44	0.48	0.24	0.38	0.32	0.55	0.35	1.00	0.13
5009 (OTC)	0.16	0.21	0.16	0.16	0.16	0.16	0.21	0.16	0.21	0.16	0.16	0.16	0.17	0.17	0.21	0.06	0.29	0.20	0.24	0.16	0.20	0.16	0.21	0.21	0.09	0.16	0.16	0.13	0.13	0.16	0.24	0.34	0.16	0.18	0.29	0.16	0.24	0.20	0.16	0.16	0.28	0.16	0.16	0.28	0.13	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
ACO2	Human	Skeletal muscle	-	4559 m	9 day	downregulated	-1.37	2-DIGE	Southern Europe	Italians	1	Fasting control subjects at laboratory in Copenhagen with no caffeine intake	18937252
ACO2	Rat	Brain cortex	316 hPa	8810 m	1 hour	downregulated	1.84-2.43	2-DE	Southwestern europe	Male albino wistar Rat	5.37-8.08	Adult male albino Wistar rats weighing 350 g kept at standard conditions	22961459

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)

Gene Ontology

ID	GO ID	GO Term	GO Type
50	GO:0005739	mitochondrion	GOTERM_CC_DIRECT
50	GO:0051538	2 iron	GOTERM_MF_DIRECT
50	GO:0005634	nucleus	GOTERM_CC_DIRECT
50	GO:0043209	myelin sheath	GOTERM_CC_DIRECT
50	GO:0003994	acetyl-CoA C-acyltransferase activity	GOTERM_MF_DIRECT
50	GO:0006101	citrate metabolic process	GOTERM_BP_DIRECT
50	GO:0051539	3 iron	GOTERM_MF_DIRECT
50	GO:0006091	generation of precursor metabolites and energy	GOTERM_BP_DIRECT
50	GO:0005506	iron ion binding	GOTERM_MF_DIRECT
50	GO:0006102	isocitrate metabolic process	GOTERM_BP_DIRECT
50	GO:0046872	metal ion binding	GOTERM_MF_DIRECT
50	GO:0006099	tricarboxylic acid cycle	GOTERM_BP_DIRECT
50	GO:0008152	metabolic process	GOTERM_BP_DIRECT
50	GO:0005759	mitochondrial matrix	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
50	hsa00020	Citrate cycle
50	hsa00630	Glyoxylate and dicarboxylate metabolism
50	hsa01100	Metabolic pathways
50	hsa01210	2-Oxocarboxylic acid metabolism
50	hsa01200	Carbon metabolism
50	hsa01130	Biosynthesis of antibiotics
50	hsa01230	Biosynthesis of amino acids

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
ACO2	50	Respiratory Distress Syndrome, Adult	C0035222	Disease or Syndrome	0.3	0.636	0.483	disease
ACO2	50	Liver carcinoma	C2239176	Neoplastic Process	0.31	0.636	0.483	disease
ACO2	50	INFANTILE CEREBELLAR-RETINAL DEGENERATION	C3281192	Disease or Syndrome	0.72	0.636	0.483	disease
ACO2	50	OPTIC ATROPHY 9	C4225384	Disease or Syndrome	0.6	0.636	0.483	disease
ACO2	50	Intellectual Disability	C3714756	Mental or Behavioral Dysfunction	0.3	0.636	0.483	group
ACO2	50	Mitochondrial Diseases	C0751651	Disease or Syndrome	0.3	0.636	0.483	group
ACO2	50	Malignant neoplasm of breast	C0006142	Neoplastic Process	0.3	0.636	0.483	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types