ALTITUDEOMICSDB

Integrin alpha-IIb

AltitudeomicsDB

Protein Official symbol	ITGA2B
Aliases	ITGA2B GP2B ITGAB
Chromosomal Location	17
Length	1039
Uniprot ID	P08514
EC number	None
Protein family Information(Pfam)	PF01839;PF00357;PF08441;
PDB id	1DPK;1DPQ;1JX5;1KUP;1KUZ;1M8O;1RN0;1S4W;1TYE;1UV9;2K1A;2K9J;2KNC;2MTP;2N9Y;2VC2;2VDK;2VDL;2VDM;2VDN;2VDO;2VDP;2VDQ;2VDR;3FCS;3FCU;3NID;3NIF;3NIG;3T3M;3T3P;3ZDX;3ZDY;3ZDZ;3ZE0;3ZE1;3ZE2;4CAK;4Z7N;4Z7O;4Z7Q;5HDB;6V4P;
InterPro ID	IPR013517;IPR013519;IPR000413;IPR013649;IPR018184;IPR028994;IPR032695;
dbSNP	rs5915 rs1052533574 rs137852911 rs137852907 rs1126554 rs137852910 rs137852908 rs766006685 rs75622274 rs780786843 rs76811038 rs7207402 rs77961246 rs761174160 rs763762304 rs74475415 rs1344532070 rs5911 rs77458039 rs80002943 rs5914 rs78657866 rs78165611 rs879255514 rs766503255

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
FGG	FGB	0.999
FGG	FGA	0.999
FGA	FGB	0.999
AKT1	PIK3CA	0.997
PTK2	PXN	0.997
PXN	VCL	0.997
HRAS	PIK3CA	0.995
SRC	PXN	0.994
ITGB3	ITGA2B	0.993
JAK3	STAT5A	0.993
JAK3	STAT5B	0.993
GATA1	ZFPM1	0.991
JAK1	STAT5B	0.991
JAK1	STAT5A	0.99
PIK3CA	KRAS	0.99
CD47	THBS1	0.988
SRC	VCL	0.987
SRC	PTPN1	0.986
HRAS	MAP2K1	0.986
TLN1	VCL	0.986
ITGA2B	VWF	0.984
PTK2	VCL	0.984
FN1	PXN	0.983
HRAS	SRC	0.983
FN1	VCL	0.983
JAK3	IL2RG	0.983
HRAS	MAPK3	0.981
SRC	STAT5A	0.981
HDAC1	EP300	0.98
FN1	VWF	0.98
NRAS	MAP2K1	0.979
MAPK3	KRAS	0.979
AKT1	PTPN1	0.979
MAP2K1	KRAS	0.979
HRAS	MAPK1	0.979
VWF	THBS1	0.978
BCL2L11	MAPK3	0.977
TLN1	PXN	0.976
FN1	PTK2	0.975
KMT2A	EP300	0.975
SRC	FN1	0.975
AKT1	SHC1	0.974
STAT5A	MAPK1	0.974
SHC1	SYK	0.974
PXN	MAPK1	0.974
HRAS	ARAF	0.974
KRAS	MAPK1	0.973
APBB1IP	RAP1B	0.973
NRAS	MAPK3	0.973
STAT5B	MAPK1	0.973
BCL2L11	MAPK1	0.972
LCK	STAT5B	0.972
FN1	THBS1	0.972
SRC	KRAS	0.971
H2AFX	HIST2H2BE	0.971
SHC1	MAPK3	0.971
FN1	MAPK3	0.97
NRAS	MAPK1	0.97
FYN	STAT5A	0.969
SHC1	LCK	0.968
STAT5B	MAPK3	0.968
ITGB3	TLN1	0.968
SHC1	MAPK1	0.968
GATA1	ITGA2B	0.968
FYN	STAT5B	0.968
NRAS	PIK3CA	0.968
NRAS	ARAF	0.968
STAT5A	MAPK3	0.968
PXN	MAPK3	0.967
ITGB3	VWF	0.967
IL2RG	STAT5A	0.967
MAP2K1	PIK3CA	0.967
FYN	PXN	0.967
HRAS	FYN	0.967
HRAS	SHC1	0.965
APBB1IP	TLN1	0.965
FN1	MAPK1	0.965
APBB1IP	RAP1A	0.964
PXN	CSK	0.964
SHC1	FYN	0.964
IL2RG	STAT5B	0.963
PTPN1	JAK1	0.963
ARAF	KRAS	0.963
PTK2	TLN1	0.962
ITGB3	FN1	0.962
FYN	KRAS	0.961
AKT1	EP300	0.96
SHC1	JAK3	0.96
FN1	ITGA2B	0.96
CBFB	RUNX1	0.96
GATA1	RUNX1	0.959
HDAC1	HIST2H2BE	0.959
ITGB3	VTN	0.958
SHC1	PTK2	0.958
MAPK3	VCL	0.958
HRAS	FN1	0.958
STAT5A	LCK	0.957
SHC1	MAP2K1	0.957
SRC	VTN	0.957
PRMT1	HDAC1	0.956
ITGA2B	VTN	0.956
SRC	PIK3CA	0.956
PRMT1	EP300	0.956
FN1	VTN	0.956
SHC1	KRAS	0.956
ITGB3	VCL	0.955
APBB1IP	VCL	0.955
IL2RG	JAK1	0.955
FYN	VCL	0.954
BCL2L11	MAP2K1	0.954
HRAS	BCL2L11	0.954
AKT1	SRC	0.954
FN1	KRAS	0.953
HIST2H2BE	EP300	0.953
PTPN1	STAT5A	0.953
PTPN1	STAT5B	0.953
RAP1A	TLN1	0.952
HRAS	JAK3	0.952
LMNA	VCL	0.952
HRAS	PTK2	0.952
SYK	STAT5A	0.951
FN1	TLN1	0.95
SYK	STAT5B	0.95
FN1	MAP2K1	0.95
BCL2L11	KRAS	0.95
GATA1	EP300	0.949
BCL2L11	SRC	0.949
HRAS	LCK	0.949
MAPK1	VCL	0.949
MAP2K1	MAPK3	0.948
PTK2	KRAS	0.948
SRC	NRAS	0.947
MAP2K1	MAPK1	0.947
H2AFX	HDAC1	0.947
LCK	ITGA2B	0.947
HRAS	JAK1	0.947
LMNA	MAPK3	0.947
SRC	TLN1	0.947
JAK3	PIK3CA	0.946
ITGB3	SRC	0.946
ITGB3	FGB	0.946
IL2RG	LCK	0.945
TLN1	RAP1B	0.945
ITGB3	PTK2	0.944
STAT5B	EP300	0.944
ITGB3	PXN	0.944
AKT1	FYN	0.943
LMNA	FN1	0.943
HDAC1	RUNX1	0.943
CSK	VCL	0.943
STAT5A	EP300	0.943
ITGB3	AKT1	0.942
JAK3	NRAS	0.942
FGA	VWF	0.942
ITGB3	CD47	0.942
ITGB3	THBS1	0.942
EP300	KRAS	0.942
LMNA	MAPK1	0.942
SHC1	JAK1	0.941
SHC1	SRC	0.941
MAPK3	VWF	0.941
GATA1	HDAC1	0.941
SYK	FN1	0.941
SRC	MAPK3	0.941
LCK	PXN	0.94
SRC	MAPK1	0.94
HRAS	VCL	0.94
BCL2L11	NRAS	0.94
RAP1A	VCL	0.939
LCK	KRAS	0.939
MAP2K1	ARAF	0.939
CBFB	GATA1	0.939
ITGA2B	RAP1B	0.939
NRAS	JAK1	0.939
HRAS	LMNA	0.939
SRC	VWF	0.939
FN1	CSK	0.939
AKT1	LCK	0.939
ZFPM1	ITGA2B	0.939
JAK1	KRAS	0.938
SHC1	PTPN1	0.938
APBB1IP	SRC	0.938
SYK	VWF	0.937
PRMT1	HIST2H2BE	0.936
SRC	MAP2K1	0.936
FN1	FGA	0.935
SRC	RAP1A	0.935
RAP1A	MAPK3	0.935
KRAS	VCL	0.935
SRC	LMNA	0.934
H2AFX	EP300	0.934
JAK3	KRAS	0.934
MAP2K1	VCL	0.934
FGG	VWF	0.934
ITGB3	FGA	0.934
VWF	VCL	0.933
SYK	ITGA2B	0.933
BCL2L11	FN1	0.933
KMT2A	HDAC1	0.933
FYN	MAPK1	0.933
PTK2	MAPK3	0.932
SRC	ITGA2B	0.932
RUNX1	ITGA2B	0.932
AKT1	ITGA2B	0.932
FGB	VWF	0.932
APBB1IP	FN1	0.932
MAPK3	CSK	0.932
HRAS	CSK	0.931
TLN1	ITGA2B	0.931
SHC1	PIK3CA	0.931
SRC	RAP1B	0.931
VWF	MAPK1	0.931
JAK1	MAPK1	0.931
NRAS	LCK	0.931
RAP1A	MAPK1	0.931
MAPK3	RAP1B	0.931
ARAF	MAPK3	0.93
JAK1	PIK3CA	0.93
FN1	FGG	0.93
LCK	MAPK3	0.93
ARAF	MAPK1	0.93
FN1	FGB	0.93
PTK2	MAPK1	0.929
JAK1	MAPK3	0.929
HDAC1	STAT5A	0.929
H2AFX	PRMT1	0.929
PTK2	PIK3CA	0.929
ITGA2B	THBS1	0.929
AKT1	JAK1	0.929
NRAS	FN1	0.928
FN1	RAP1B	0.928
CSK	MAPK1	0.928
ITGB3	MAPK3	0.928
LCK	MAPK1	0.928
SHC1	NRAS	0.928
LMNA	MAP2K1	0.928
APBB1IP	SYK	0.928
CD47	ITGA2B	0.928
PTPN1	FN1	0.928
STAT5A	ITGA2B	0.928
SYK	IL2RG	0.927
PTK2	ITGA2B	0.927
RAP1A	MAP2K1	0.927
STAT5B	ITGA2B	0.927
ITGB3	SYK	0.927
HDAC1	STAT5B	0.927
RAP1A	FN1	0.927
ITGB3	RAP1B	0.927
HDAC1	ZFPM1	0.927
RAP1B	VCL	0.927
TLN1	VWF	0.926
RAP1A	ARAF	0.926
AKT1	IL2RG	0.926
RAP1B	MAPK1	0.926
TLN1	FGB	0.926
NRAS	FYN	0.926
SRC	PTK2	0.926
KMT2A	HIST2H2BE	0.926
CBFB	ITGA2B	0.926
ITGB3	FGG	0.926
ITGB3	RAP1A	0.925
SYK	FGA	0.925
KRAS	CSK	0.925
SYK	TLN1	0.925
MAPK3	ITGA2B	0.925
NRAS	PTK2	0.925
FGB	ITGA2B	0.925
SYK	SRC	0.925
ZFPM1	RUNX1	0.924
AKT1	JAK3	0.924
SHC1	CSK	0.924
ITGA2B	VCL	0.924
ITGB3	MAPK1	0.924
LMNA	KRAS	0.923
LCK	MAP2K1	0.923
FYN	PIK3CA	0.923
JAK3	LCK	0.923
RUNX1	EP300	0.923
PTK2	VWF	0.923
BCL2L11	ARAF	0.923
APBB1IP	PTK2	0.923
SYK	FYN	0.923
PXN	RAP1B	0.923
SYK	LCK	0.922
LCK	VCL	0.922
JAK3	SYK	0.922
ITGB3	HRAS	0.922
JAK3	MAPK3	0.921
FGA	THBS1	0.921
TLN1	FGA	0.921
LCK	PIK3CA	0.921
SHC1	IL2RG	0.921
MAP2K1	CSK	0.921
VWF	RAP1B	0.921
HRAS	VWF	0.921
IL2RG	NRAS	0.921
KMT2A	RUNX1	0.921
APBB1IP	VWF	0.921
ARAF	RAP1B	0.921
HRAS	IL2RG	0.921
KMT2A	PRMT1	0.921
FYN	PTK2	0.92
SRC	FGA	0.92
SRC	CSK	0.92
MAP2K1	RAP1B	0.92
SYK	RAP1B	0.92
JAK3	MAPK1	0.92
FYN	TLN1	0.92
EP300	ITGA2B	0.919
JAK1	MAP2K1	0.919
FGA	ITGA2B	0.919
HRAS	FGG	0.919
MARK3	HRAS	0.919
SYK	PIK3CA	0.919
FGG	TLN1	0.918
FGG	MAPK1	0.918
NRAS	VCL	0.918
FGA	RAP1B	0.918
FGG	MAPK3	0.918
FGB	MAPK1	0.918
BCL2L11	LMNA	0.918
FGB	THBS1	0.918
CBFB	EP300	0.918
EP300	THBS1	0.918
HRAS	ITGA2B	0.918
FGA	MAPK1	0.918
FGB	MAPK3	0.918
PRMT1	THBS1	0.918
FGA	MAPK3	0.918
ITGB3	PIK3CA	0.917
CD47	PTK2	0.917
ITGB3	KRAS	0.917
LCK	CSK	0.917
BCL2L11	VCL	0.917
GATA1	HIST2H2BE	0.917
PIK3CA	RAP1B	0.917
FYN	CSK	0.917
APBB1IP	CSK	0.917
H2AFX	THBS1	0.917
NRAS	CSK	0.917
ITGB3	APBB1IP	0.917
APBB1IP	ITGA2B	0.917
RAP1A	FGA	0.917
PTK2	CSK	0.916
PXN	ITGA2B	0.916
TLN1	MAPK3	0.916
RAP1A	RAP1B	0.916
SYK	PTK2	0.916
FGG	ITGA2B	0.916
PTK2	RAP1B	0.916
H2AFX	GATA1	0.916
PIK3CA	ITGA2B	0.916
ITGA2B	MAPK1	0.916
SYK	JAK1	0.916
HRAS	TLN1	0.916
TLN1	MAPK1	0.916
IL2RG	MAPK3	0.915
FYN	JAK1	0.915
HDAC1	THBS1	0.915
IL2RG	MAP2K1	0.915
JAK3	FYN	0.915
SRC	ARAF	0.915
PRMT1	GATA1	0.915
MARK3	ITGA2B	0.915
PXN	PIK3CA	0.915
CBFB	MAPK3	0.915
CBFB	MAPK1	0.915
JAK1	LCK	0.915
PIK3CA	VCL	0.915
IL2RG	MAPK1	0.915
AKT1	CBFB	0.915
RAP1A	ITGA2B	0.915
NRAS	LMNA	0.914
RAP1A	PTK2	0.914
ITGB3	SHC1	0.914
SYK	RAP1A	0.913
ITGB3	CSK	0.913
ZFPM1	EP300	0.913
TLN1	CSK	0.913
VWF	KRAS	0.912
MARK3	VWF	0.912
JAK3	MAP2K1	0.912
KMT2A	GATA1	0.912
JAK3	JAK1	0.912
MAP2K1	VWF	0.912
APBB1IP	MAPK3	0.911
PTPN1	PIK3CA	0.911
PTPN1	TLN1	0.911
KMT2A	H2AFX	0.911
LMNA	VWF	0.911
HIST2H2BE	ITGA2B	0.911
FGG	THBS1	0.911
IL2RG	ITGA2B	0.91
FGA	KRAS	0.91
PTK2	LCK	0.91
LMNA	ITGA2B	0.91
LMNA	TLN1	0.91
GATA1	THBS1	0.91
ITGB3	MAP2K1	0.91
NRAS	CD47	0.909
TLN1	PIK3CA	0.909
MAP2K1	ITGA2B	0.909
HRAS	APBB1IP	0.909
SHC1	RAP1A	0.909
MARK3	ARAF	0.909
SHC1	TLN1	0.909
LMNA	FGB	0.909
STAT5A	STAT5B	0.908
FGB	VCL	0.908
PRMT1	ITGA2B	0.908
RAP1A	CSK	0.908
SHC1	APBB1IP	0.908
JAK3	ITGA2B	0.908
PTPN1	RAP1A	0.908
MARK3	MAP2K1	0.908
FYN	ITGA2B	0.908
ARAF	CSK	0.907
RAP1A	NRAS	0.907
FYN	LCK	0.907
SHC1	ITGA2B	0.907
HRAS	FGA	0.907
IL2RG	KRAS	0.907
HRAS	RAP1B	0.907
HRAS	RAP1A	0.907
FN1	ARAF	0.907
MARK3	FN1	0.907
MARK3	SRC	0.907
PTPN1	ITGA2B	0.907
KMT2A	CBFB	0.907
SRC	FGB	0.906
SRC	FGG	0.906
CBFB	KRAS	0.906
PIK3CA	CSK	0.906
ITGB3	NRAS	0.906
NRAS	ITGA2B	0.906
BCL2L11	ITGA2B	0.906
KMT2A	ITGA2B	0.906
IL2RG	FYN	0.906
PRMT1	RUNX1	0.906
NRAS	RAP1B	0.906
RAP1A	KRAS	0.906
SRC	LCK	0.906
MARK3	VCL	0.906
CBFB	HDAC1	0.906
JAK1	ITGA2B	0.906
RAP1A	PIK3CA	0.906
MARK3	MAPK3	0.906
HDAC1	ITGA2B	0.906
ITGB3	LMNA	0.906
APBB1IP	FGA	0.906
H2AFX	ITGA2B	0.906
KRAS	RAP1B	0.906
HIST2H2BE	THBS1	0.905
APBB1IP	MAPK1	0.905
SHC1	RAP1B	0.905
RAP1B	CSK	0.905
MARK3	LMNA	0.905
ITGB3	PTPN1	0.905
APBB1IP	PTPN1	0.905
ITGA2B	KRAS	0.905
TLN1	KRAS	0.905
FGG	VCL	0.905
APBB1IP	MAP2K1	0.905
NRAS	FGG	0.905
BCL2L11	CSK	0.905
SRC	RUNX1	0.905
FGA	VCL	0.904
CBFB	PRMT1	0.904
ARAF	ITGA2B	0.904
BCL2L11	VWF	0.904
PRMT1	ZFPM1	0.904
NRAS	KRAS	0.904
MARK3	MAPK1	0.904
ITGA2B	CSK	0.904
RAP1A	VWF	0.904
APBB1IP	KRAS	0.904
LMNA	FGA	0.904
TLN1	MAP2K1	0.904
ITGB3	MARK3	0.904
LMNA	FGG	0.903
TLN1	ARAF	0.903
SRC	FYN	0.903
MARK3	RAP1B	0.903
RUNX1	THBS1	0.903
CBFB	SRC	0.903
H2AFX	ZFPM1	0.903
PTPN1	VWF	0.903
NRAS	FGA	0.903
ITGB3	BCL2L11	0.903
MARK3	RAP1A	0.903
MARK3	CSK	0.903
SYK	FGB	0.902
KMT2A	THBS1	0.902
PTPN1	RAP1B	0.902
APBB1IP	FGG	0.902
APBB1IP	FGB	0.902
VWF	CSK	0.902
MAPK3	MAPK1	0.902
HRAS	KRAS	0.902
RAP1A	CD47	0.902
HRAS	NRAS	0.902
APBB1IP	NRAS	0.902
IL2RG	PIK3CA	0.902
MARK3	TLN1	0.902
FGB	KRAS	0.901
ARAF	VCL	0.901
BCL2L11	TLN1	0.901
KMT2A	ZFPM1	0.901
ITGB3	ARAF	0.901
LMNA	CSK	0.901
FGG	KRAS	0.901
NRAS	TLN1	0.901
MARK3	KRAS	0.901
LMNA	ARAF	0.901
CBFB	ZFPM1	0.9
PTPN1	FGB	0.9
FGG	MAP2K1	0.9
PTPN1	FGA	0.9
FGB	CSK	0.9
HIST2H2BE	RUNX1	0.9
FGA	ARAF	0.9
ARAF	VWF	0.9
H2AFX	CBFB	0.9
NRAS	FGB	0.9
PTPN1	FGG	0.9
MARK3	FGG	0.9
HIST2H2BE	ZFPM1	0.9
FGG	ARAF	0.9
SYK	FGG	0.9
FGA	CSK	0.9
CBFB	THBS1	0.9
BCL2L11	RAP1B	0.9
MARK3	APBB1IP	0.9
MARK3	FGA	0.9
APBB1IP	LMNA	0.9
RAP1A	FGB	0.9
FGB	ARAF	0.9
PTK2	FGA	0.9
APBB1IP	ARAF	0.9
RAP1A	FGG	0.9
FGG	RAP1B	0.9
PTK2	FGG	0.9
FGB	MAP2K1	0.9
BCL2L11	FGA	0.9
RAP1A	LMNA	0.9
MARK3	NRAS	0.9
ZFPM1	THBS1	0.9
BCL2L11	APBB1IP	0.9
NRAS	VWF	0.9
H2AFX	RUNX1	0.9
FGG	CSK	0.9
BCL2L11	FGB	0.9
BCL2L11	FGG	0.9
BCL2L11	RAP1A	0.9
LMNA	RAP1B	0.9
PTK2	FGB	0.9
HRAS	FGB	0.9
MARK3	BCL2L11	0.9
FGA	MAP2K1	0.9
CBFB	HIST2H2BE	0.9
FGB	RAP1B	0.9
MARK3	FGB	0.9

Gene Ontology Semantic Similarity

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#	2266 (FGG)	2243 (FGA)	207 (AKT1)	5747 (PTK2)	5829 (PXN)	3265 (HRAS)	6714 (SRC)	3690 (ITGB3)	3718 (JAK3)	2623 (GATA1)	3716 (JAK1)	5290 (PIK3CA)	961 (CD47)	7094 (TLN1)	3674 (ITGA2B)	2335 (FN1)	3065 (HDAC1)	4893 (NRAS)	5595 (MAPK3)	5604 (MAP2K1)	7450 (VWF)	10018 (BCL2L11)	4297 (KMT2A)	6776 (STAT5A)	6464 (SHC1)	3845 (KRAS)	54518 (APBB1IP)	6777 (STAT5B)	3932 (LCK)	3014 (H2AFX)	2534 (FYN)	3561 (IL2RG)	5770 (PTPN1)	369 (ARAF)	865 (CBFB)	3276 (PRMT1)	8349 (HIST2H2BE)	5906 (RAP1A)	4000 (LMNA)	6850 (SYK)	5594 (MAPK1)	1445 (CSK)	2033 (EP300)	161882 (ZFPM1)	861 (RUNX1)	2244 (FGB)	5908 (RAP1B)	4140 (MARK3)	7414 (VCL)	7057 (THBS1)	7448 (VTN)
2266 (FGG)	1.00	1.00	0.50	0.54	0.72	0.55	0.63	0.67	0.59	0.45	0.56	0.47	0.64	0.78	0.72	0.77	0.53	0.69	0.57	0.54	0.80	0.68	0.47	0.56	0.64	0.69	1.00	0.58	0.62	0.69	0.60	0.51	0.63	0.57	0.53	0.43	0.37	0.59	1.00	0.51	0.54	0.62	0.45	0.55	0.49	0.98	0.53	0.57	0.72	0.69	0.88
2243 (FGA)	1.00	1.00	0.50	0.54	0.72	0.55	0.63	0.67	0.59	0.45	0.56	0.47	0.64	0.78	0.72	0.77	0.53	0.69	0.57	0.54	0.80	0.68	0.47	0.56	0.64	0.69	1.00	0.58	0.62	0.69	0.60	0.51	0.63	0.57	0.53	0.43	0.37	0.59	1.00	0.51	0.54	0.62	0.45	0.55	0.49	0.98	0.53	0.57	0.72	0.69	0.88
207 (AKT1)	0.50	0.50	1.00	0.71	0.53	0.54	0.74	0.58	0.66	0.40	0.67	0.68	0.47	0.49	0.52	0.58	0.50	0.48	0.77	0.75	0.59	0.47	0.47	0.62	0.56	0.48	1.00	0.62	0.72	0.53	0.69	0.43	0.52	0.73	0.42	0.51	0.37	0.46	1.00	0.72	0.77	0.74	0.47	0.44	0.40	0.52	0.53	0.70	0.55	0.54	0.46
5747 (PTK2)	0.54	0.54	0.71	1.00	0.62	0.47	0.80	0.59	0.88	0.41	0.86	0.67	0.51	0.54	0.55	0.57	0.51	0.53	0.75	0.75	0.57	0.52	0.44	0.69	0.62	0.53	1.00	0.67	0.81	0.58	0.78	0.53	0.60	0.76	0.44	0.48	0.37	0.57	1.00	0.78	0.75	0.79	0.46	0.47	0.42	0.56	0.45	0.73	0.62	0.53	0.50
5829 (PXN)	0.72	0.72	0.53	0.62	1.00	0.61	0.62	0.67	0.73	0.47	0.65	0.50	0.70	0.75	0.80	0.68	0.55	0.77	0.65	0.56	0.71	0.76	0.49	0.60	0.62	0.77	1.00	0.60	0.65	0.77	0.60	0.54	0.65	0.63	0.56	0.44	0.37	0.64	1.00	0.54	0.61	0.66	0.47	0.58	0.53	0.73	0.58	0.63	0.79	0.61	0.70
3265 (HRAS)	0.55	0.55	0.54	0.47	0.61	1.00	0.57	0.59	0.47	0.40	0.46	0.36	0.53	0.55	0.58	0.62	0.51	0.55	0.48	0.48	0.60	0.54	0.41	0.43	0.54	0.55	1.00	0.47	0.56	0.60	0.50	0.42	0.55	0.44	0.44	0.39	0.37	0.47	1.00	0.41	0.45	0.56	0.42	0.46	0.39	0.58	0.94	0.44	0.63	0.56	0.50
6714 (SRC)	0.63	0.63	0.74	0.80	0.62	0.57	1.00	0.67	0.74	0.52	0.75	0.77	0.58	0.65	0.60	0.68	0.58	0.59	0.77	0.78	0.65	0.59	0.53	0.72	0.64	0.59	1.00	0.71	0.85	0.64	0.81	0.52	0.66	0.77	0.55	0.58	0.55	0.56	1.00	0.83	0.77	0.80	0.56	0.55	0.53	0.64	0.55	0.75	0.65	0.60	0.62
3690 (ITGB3)	0.67	0.67	0.58	0.59	0.67	0.59	0.67	1.00	0.61	0.51	0.59	0.55	0.68	0.68	0.68	0.72	0.58	0.65	0.63	0.58	0.74	0.65	0.54	0.59	0.63	0.65	1.00	0.59	0.64	0.68	0.63	0.65	0.64	0.60	0.57	0.53	0.37	0.60	1.00	0.60	0.61	0.64	0.50	0.58	0.55	0.68	0.58	0.60	0.68	0.70	0.67
3718 (JAK3)	0.59	0.59	0.66	0.88	0.73	0.47	0.74	0.61	1.00	0.39	0.91	0.65	0.55	0.58	0.63	0.60	0.50	0.59	0.76	0.73	0.62	0.58	0.42	0.66	0.64	0.59	1.00	0.64	0.74	0.63	0.77	0.56	0.55	0.77	0.43	0.42	0.37	0.65	1.00	0.77	0.75	0.77	0.43	0.47	0.40	0.61	0.44	0.74	0.65	0.55	0.53
2623 (GATA1)	0.45	0.45	0.40	0.41	0.47	0.40	0.52	0.51	0.39	1.00	0.40	0.34	0.42	0.45	0.44	0.49	0.72	0.43	0.40	0.40	0.50	0.42	0.76	0.59	0.45	0.43	1.00	0.61	0.48	0.65	0.44	0.38	0.54	0.37	0.80	0.44	1.00	0.41	1.00	0.37	0.39	0.43	0.57	0.81	0.87	0.47	0.40	0.37	0.50	0.47	0.41
3716 (JAK1)	0.56	0.56	0.67	0.86	0.65	0.46	0.75	0.59	0.91	0.40	1.00	0.63	0.52	0.54	0.56	0.58	0.50	0.53	0.72	0.71	0.59	0.52	0.42	0.67	0.60	0.53	1.00	0.65	0.75	0.59	0.78	0.53	0.54	0.73	0.43	0.43	0.37	0.59	1.00	0.77	0.72	0.75	0.45	0.46	0.40	0.58	0.44	0.70	0.66	0.53	0.50
5290 (PIK3CA)	0.47	0.47	0.68	0.67	0.50	0.36	0.77	0.55	0.65	0.34	0.63	1.00	0.42	0.46	0.44	0.51	0.47	0.41	0.79	0.71	0.53	0.40	0.38	0.61	0.46	0.41	1.00	0.61	0.75	0.47	0.70	0.35	0.46	0.76	0.34	0.45	0.37	0.37	1.00	0.71	0.78	0.80	0.46	0.38	0.31	0.49	0.34	0.71	0.53	0.48	0.38
961 (CD47)	0.64	0.64	0.47	0.51	0.70	0.53	0.58	0.68	0.55	0.42	0.52	0.42	1.00	0.63	0.71	0.62	0.51	0.68	0.55	0.52	0.66	0.66	0.44	0.51	0.57	0.68	1.00	0.53	0.57	0.68	0.54	0.65	0.58	0.53	0.48	0.39	0.37	0.56	1.00	0.46	0.51	0.59	0.42	0.52	0.45	0.66	0.50	0.53	0.70	0.58	0.60
7094 (TLN1)	0.78	0.78	0.49	0.54	0.75	0.55	0.65	0.68	0.58	0.45	0.54	0.46	0.63	1.00	0.71	0.72	0.52	0.68	0.56	0.53	0.77	0.68	0.47	0.54	0.61	0.68	1.00	0.56	0.60	0.68	0.56	0.50	0.64	0.57	0.52	0.42	0.37	0.58	1.00	0.57	0.53	0.61	0.44	0.54	0.49	0.79	0.53	0.57	0.75	0.66	0.81
3674 (ITGA2B)	0.72	0.72	0.52	0.55	0.80	0.58	0.60	0.68	0.63	0.44	0.56	0.44	0.71	0.71	1.00	0.69	0.53	0.85	0.64	0.54	0.76	0.83	0.49	0.57	0.61	0.85	1.00	0.58	0.61	0.80	0.59	0.50	0.63	0.62	0.52	0.42	0.37	0.63	1.00	0.49	0.58	0.71	0.43	0.56	0.48	0.73	0.55	0.61	0.78	0.63	0.72
2335 (FN1)	0.77	0.77	0.58	0.57	0.68	0.62	0.68	0.72	0.60	0.49	0.58	0.51	0.62	0.72	0.69	1.00	0.56	0.65	0.61	0.57	0.87	0.65	0.52	0.57	0.66	0.65	1.00	0.58	0.66	0.69	0.71	0.53	0.65	0.58	0.55	0.50	0.37	0.59	1.00	0.58	0.58	0.65	0.49	0.56	0.53	0.79	0.58	0.58	0.68	0.78	0.78
3065 (HDAC1)	0.53	0.53	0.50	0.51	0.55	0.51	0.58	0.58	0.50	0.72	0.50	0.47	0.51	0.52	0.53	0.56	1.00	0.52	0.52	0.51	0.57	0.52	0.62	0.48	0.52	0.52	1.00	0.50	0.56	0.64	0.52	0.46	0.60	0.49	0.61	0.52	0.73	0.49	1.00	0.48	0.51	0.53	0.63	0.67	0.67	0.54	0.50	0.49	0.56	0.52	0.50
4893 (NRAS)	0.69	0.69	0.48	0.53	0.77	0.55	0.59	0.65	0.59	0.43	0.53	0.41	0.68	0.68	0.85	0.65	0.52	1.00	0.57	0.52	0.70	0.77	0.44	0.53	0.59	1.00	1.00	0.62	0.58	0.76	0.55	0.48	0.61	0.57	0.49	0.39	0.37	0.73	1.00	0.47	0.52	0.63	0.44	0.53	0.45	0.71	0.64	0.57	0.76	0.61	0.67
5595 (MAPK3)	0.57	0.57	0.77	0.75	0.65	0.48	0.77	0.63	0.76	0.40	0.72	0.79	0.55	0.56	0.64	0.61	0.52	0.57	1.00	0.79	0.64	0.56	0.47	0.68	0.53	0.57	1.00	0.66	0.76	0.61	0.70	0.45	0.55	0.88	0.44	0.51	0.37	0.49	1.00	0.81	0.99	0.85	0.48	0.47	0.41	0.59	0.46	0.86	0.63	0.56	0.52
5604 (MAP2K1)	0.54	0.54	0.75	0.75	0.56	0.48	0.78	0.58	0.73	0.40	0.71	0.71	0.52	0.53	0.54	0.57	0.51	0.52	0.79	1.00	0.59	0.51	0.43	0.69	0.52	0.52	1.00	0.67	0.73	0.55	0.69	0.45	0.51	0.85	0.43	0.45	0.37	0.47	1.00	0.81	0.80	0.79	0.47	0.46	0.41	0.55	0.44	0.81	0.58	0.52	0.49
7450 (VWF)	0.80	0.80	0.59	0.57	0.71	0.60	0.65	0.74	0.62	0.50	0.59	0.53	0.66	0.77	0.76	0.87	0.57	0.70	0.64	0.59	1.00	0.71	0.56	0.60	0.64	0.70	1.00	0.61	0.64	0.71	0.61	0.55	0.63	0.62	0.57	0.49	0.37	0.63	1.00	0.61	0.61	0.67	0.48	0.59	0.55	0.82	0.59	0.62	0.71	0.76	0.85
10018 (BCL2L11)	0.68	0.68	0.47	0.52	0.76	0.54	0.59	0.65	0.58	0.42	0.52	0.40	0.66	0.68	0.83	0.65	0.52	0.77	0.56	0.51	0.71	1.00	0.44	0.52	0.59	0.77	1.00	0.54	0.58	0.75	0.55	0.47	0.60	0.56	0.48	0.38	0.37	0.58	1.00	0.47	0.51	0.62	0.42	0.52	0.44	0.69	0.51	0.55	0.75	0.60	0.67
4297 (KMT2A)	0.47	0.47	0.47	0.44	0.49	0.41	0.53	0.54	0.42	0.76	0.42	0.38	0.44	0.47	0.49	0.52	0.62	0.44	0.47	0.43	0.56	0.44	1.00	0.58	0.47	0.44	1.00	0.59	0.52	0.61	0.48	0.39	0.58	0.41	0.70	0.62	0.79	0.42	1.00	0.40	0.45	0.50	0.49	0.67	0.73	0.49	0.40	0.41	0.52	0.52	0.43
6776 (STAT5A)	0.56	0.56	0.62	0.69	0.60	0.43	0.72	0.59	0.66	0.59	0.67	0.61	0.51	0.54	0.57	0.57	0.48	0.53	0.68	0.69	0.60	0.52	0.58	1.00	0.51	0.53	1.00	0.89	0.69	0.58	0.65	0.40	0.52	0.72	0.70	0.40	0.37	0.45	1.00	0.74	0.68	0.73	0.42	0.74	0.64	0.58	0.41	0.69	0.62	0.53	0.48
6464 (SHC1)	0.64	0.64	0.56	0.62	0.62	0.54	0.64	0.63	0.64	0.45	0.60	0.46	0.57	0.61	0.61	0.66	0.52	0.59	0.53	0.52	0.64	0.59	0.47	0.51	1.00	0.59	1.00	0.53	0.64	0.61	0.66	0.57	0.67	0.53	0.50	0.43	0.37	0.62	1.00	0.55	0.51	0.58	0.44	0.52	0.48	0.65	0.52	0.52	0.63	0.61	0.59
3845 (KRAS)	0.69	0.69	0.48	0.53	0.77	0.55	0.59	0.65	0.59	0.43	0.53	0.41	0.68	0.68	0.85	0.65	0.52	1.00	0.57	0.52	0.70	0.77	0.44	0.53	0.59	1.00	1.00	0.62	0.58	0.76	0.55	0.48	0.61	0.57	0.49	0.39	0.37	0.73	1.00	0.47	0.52	0.63	0.44	0.53	0.45	0.71	0.64	0.57	0.76	0.61	0.67
54518 (APBB1IP)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.37	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
6777 (STAT5B)	0.58	0.58	0.62	0.67	0.60	0.47	0.71	0.59	0.64	0.61	0.65	0.61	0.53	0.56	0.58	0.58	0.50	0.62	0.66	0.67	0.61	0.54	0.59	0.89	0.53	0.62	1.00	1.00	0.68	0.58	0.65	0.44	0.53	0.68	0.68	0.42	0.37	0.54	1.00	0.71	0.66	0.70	0.50	0.71	0.63	0.59	0.50	0.66	0.62	0.55	0.52
3932 (LCK)	0.62	0.62	0.72	0.81	0.65	0.56	0.85	0.64	0.74	0.48	0.75	0.75	0.57	0.60	0.61	0.66	0.56	0.58	0.76	0.73	0.64	0.58	0.52	0.69	0.64	0.58	1.00	0.68	1.00	0.61	0.78	0.51	0.67	0.73	0.52	0.56	0.37	0.55	1.00	0.80	0.76	0.81	0.54	0.53	0.50	0.63	0.53	0.71	0.61	0.59	0.58
3014 (H2AFX)	0.69	0.69	0.53	0.58	0.77	0.60	0.64	0.68	0.63	0.65	0.59	0.47	0.68	0.68	0.80	0.69	0.64	0.76	0.61	0.55	0.71	0.75	0.61	0.58	0.61	0.76	1.00	0.58	0.61	1.00	0.59	0.51	0.73	0.61	0.72	0.50	1.00	0.62	1.00	0.51	0.57	0.65	0.52	0.59	0.64	0.70	0.58	0.61	0.76	0.60	0.68
2534 (FYN)	0.60	0.60	0.69	0.78	0.60	0.50	0.81	0.63	0.77	0.44	0.78	0.70	0.54	0.56	0.59	0.71	0.52	0.55	0.70	0.69	0.61	0.55	0.48	0.65	0.66	0.55	1.00	0.65	0.78	0.59	1.00	0.54	0.59	0.70	0.48	0.49	0.37	0.58	1.00	0.73	0.70	0.73	0.48	0.49	0.46	0.61	0.49	0.67	0.60	0.56	0.53
3561 (IL2RG)	0.51	0.51	0.43	0.53	0.54	0.42	0.52	0.65	0.56	0.38	0.53	0.35	0.65	0.50	0.50	0.53	0.46	0.48	0.45	0.45	0.55	0.47	0.39	0.40	0.57	0.48	1.00	0.44	0.51	0.51	0.54	1.00	0.49	0.40	0.39	0.36	0.37	0.54	1.00	0.39	0.42	0.47	0.39	0.43	0.37	0.53	0.40	0.40	0.56	0.52	0.45
5770 (PTPN1)	0.63	0.63	0.52	0.60	0.65	0.55	0.66	0.64	0.55	0.54	0.54	0.46	0.58	0.64	0.63	0.65	0.60	0.61	0.55	0.51	0.63	0.60	0.58	0.52	0.67	0.61	1.00	0.53	0.67	0.73	0.59	0.49	1.00	0.53	0.57	0.52	0.75	0.55	1.00	0.49	0.53	0.61	0.48	0.53	0.53	0.65	0.53	0.53	0.69	0.59	0.57
369 (ARAF)	0.57	0.57	0.73	0.76	0.63	0.44	0.77	0.60	0.77	0.37	0.73	0.76	0.53	0.57	0.62	0.58	0.49	0.57	0.88	0.85	0.62	0.56	0.41	0.72	0.53	0.57	1.00	0.68	0.73	0.61	0.70	0.40	0.53	1.00	0.40	0.43	0.37	0.47	1.00	0.88	0.88	0.83	0.44	0.45	0.36	0.60	0.41	0.96	0.65	0.54	0.51
865 (CBFB)	0.53	0.53	0.42	0.44	0.56	0.44	0.55	0.57	0.43	0.80	0.43	0.34	0.48	0.52	0.52	0.55	0.61	0.49	0.44	0.43	0.57	0.48	0.70	0.70	0.50	0.49	1.00	0.68	0.52	0.72	0.48	0.39	0.57	0.40	1.00	0.43	1.00	0.43	1.00	0.38	0.42	0.48	0.54	0.72	0.75	0.55	0.42	0.40	0.58	0.51	0.46
3276 (PRMT1)	0.43	0.43	0.51	0.48	0.44	0.39	0.58	0.53	0.42	0.44	0.43	0.45	0.39	0.42	0.42	0.50	0.52	0.39	0.51	0.45	0.49	0.38	0.62	0.40	0.43	0.39	1.00	0.42	0.56	0.50	0.49	0.36	0.52	0.43	0.43	1.00	0.75	0.37	1.00	0.43	0.50	0.53	0.50	0.39	0.39	0.44	0.38	0.41	0.47	0.46	0.38
8349 (HIST2H2BE)	0.37	0.37	0.37	0.37	0.37	0.37	0.55	0.37	0.37	1.00	0.37	0.37	0.37	0.37	0.37	0.37	0.73	0.37	0.37	0.37	0.37	0.37	0.79	0.37	0.37	0.37	0.37	0.37	0.37	1.00	0.37	0.37	0.75	0.37	1.00	0.75	1.00	0.37	0.37	0.37	0.37	0.37	1.00	0.43	0.73	0.37	0.37	0.37	0.37	0.37	0.37
5906 (RAP1A)	0.59	0.59	0.46	0.57	0.64	0.47	0.56	0.60	0.65	0.41	0.59	0.37	0.56	0.58	0.63	0.59	0.49	0.73	0.49	0.47	0.63	0.58	0.42	0.45	0.62	0.73	1.00	0.54	0.55	0.62	0.58	0.54	0.55	0.47	0.43	0.37	0.37	1.00	1.00	0.42	0.46	0.54	0.42	0.47	0.40	0.62	0.54	0.46	0.66	0.56	0.54
4000 (LMNA)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.37	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
6850 (SYK)	0.51	0.51	0.72	0.78	0.54	0.41	0.83	0.60	0.77	0.37	0.77	0.71	0.46	0.57	0.49	0.58	0.48	0.47	0.81	0.81	0.61	0.47	0.40	0.74	0.55	0.47	1.00	0.71	0.80	0.51	0.73	0.39	0.49	0.88	0.38	0.43	0.37	0.42	1.00	1.00	0.81	0.81	0.44	0.42	0.36	0.53	0.39	0.84	0.56	0.55	0.54
5594 (MAPK1)	0.54	0.54	0.77	0.75	0.61	0.45	0.77	0.61	0.75	0.39	0.72	0.78	0.51	0.53	0.58	0.58	0.51	0.52	0.99	0.80	0.61	0.51	0.45	0.68	0.51	0.52	1.00	0.66	0.76	0.57	0.70	0.42	0.53	0.88	0.42	0.50	0.37	0.46	1.00	0.81	1.00	0.84	0.48	0.45	0.39	0.56	0.43	0.86	0.59	0.54	0.48
1445 (CSK)	0.62	0.62	0.74	0.79	0.66	0.56	0.80	0.64	0.77	0.43	0.75	0.80	0.59	0.61	0.71	0.65	0.53	0.63	0.85	0.79	0.67	0.62	0.50	0.73	0.58	0.63	1.00	0.70	0.81	0.65	0.73	0.47	0.61	0.83	0.48	0.53	0.37	0.54	1.00	0.81	0.84	1.00	0.50	0.51	0.46	0.63	0.51	0.80	0.67	0.58	0.58
2033 (EP300)	0.45	0.45	0.47	0.46	0.47	0.42	0.56	0.50	0.43	0.57	0.45	0.46	0.42	0.44	0.43	0.49	0.63	0.44	0.48	0.47	0.48	0.42	0.49	0.42	0.44	0.44	1.00	0.50	0.54	0.52	0.48	0.39	0.48	0.44	0.54	0.50	1.00	0.42	1.00	0.44	0.48	0.50	1.00	0.49	0.50	0.47	0.42	0.43	0.48	0.46	0.41
161882 (ZFPM1)	0.55	0.55	0.44	0.47	0.58	0.46	0.55	0.58	0.47	0.81	0.46	0.38	0.52	0.54	0.56	0.56	0.67	0.53	0.47	0.46	0.59	0.52	0.67	0.74	0.52	0.53	1.00	0.71	0.53	0.59	0.49	0.43	0.53	0.45	0.72	0.39	0.43	0.47	1.00	0.42	0.45	0.51	0.49	1.00	0.87	0.57	0.44	0.45	0.60	0.53	0.50
861 (RUNX1)	0.49	0.49	0.40	0.42	0.53	0.39	0.53	0.55	0.40	0.87	0.40	0.31	0.45	0.49	0.48	0.53	0.67	0.45	0.41	0.41	0.55	0.44	0.73	0.64	0.48	0.45	1.00	0.63	0.50	0.64	0.46	0.37	0.53	0.36	0.75	0.39	0.73	0.40	1.00	0.36	0.39	0.46	0.50	0.87	1.00	0.51	0.37	0.36	0.56	0.50	0.42
2244 (FGB)	0.98	0.98	0.52	0.56	0.73	0.58	0.64	0.68	0.61	0.47	0.58	0.49	0.66	0.79	0.73	0.79	0.54	0.71	0.59	0.55	0.82	0.69	0.49	0.58	0.65	0.71	1.00	0.59	0.63	0.70	0.61	0.53	0.65	0.60	0.55	0.44	0.37	0.62	1.00	0.53	0.56	0.63	0.47	0.57	0.51	1.00	0.56	0.60	0.73	0.69	0.87
5908 (RAP1B)	0.53	0.53	0.53	0.45	0.58	0.94	0.55	0.58	0.44	0.40	0.44	0.34	0.50	0.53	0.55	0.58	0.50	0.64	0.46	0.44	0.59	0.51	0.40	0.41	0.52	0.64	1.00	0.50	0.53	0.58	0.49	0.40	0.53	0.41	0.42	0.38	0.37	0.54	1.00	0.39	0.43	0.51	0.42	0.44	0.37	0.56	1.00	0.41	0.61	0.56	0.48
4140 (MARK3)	0.57	0.57	0.70	0.73	0.63	0.44	0.75	0.60	0.74	0.37	0.70	0.71	0.53	0.57	0.61	0.58	0.49	0.57	0.86	0.81	0.62	0.55	0.41	0.69	0.52	0.57	1.00	0.66	0.71	0.61	0.67	0.40	0.53	0.96	0.40	0.41	0.37	0.46	1.00	0.84	0.86	0.80	0.43	0.45	0.36	0.60	0.41	1.00	0.65	0.54	0.50
7414 (VCL)	0.72	0.72	0.55	0.62	0.79	0.63	0.65	0.68	0.65	0.50	0.66	0.53	0.70	0.75	0.78	0.68	0.56	0.76	0.63	0.58	0.71	0.75	0.52	0.62	0.63	0.76	1.00	0.62	0.61	0.76	0.60	0.56	0.69	0.65	0.58	0.47	0.37	0.66	1.00	0.56	0.59	0.67	0.48	0.60	0.56	0.73	0.61	0.65	1.00	0.64	0.70
7057 (THBS1)	0.69	0.69	0.54	0.53	0.61	0.56	0.60	0.70	0.55	0.47	0.53	0.48	0.58	0.66	0.63	0.78	0.52	0.61	0.56	0.52	0.76	0.60	0.52	0.53	0.61	0.61	1.00	0.55	0.59	0.60	0.56	0.52	0.59	0.54	0.51	0.46	0.37	0.56	1.00	0.55	0.54	0.58	0.46	0.53	0.50	0.69	0.56	0.54	0.64	1.00	0.71
7448 (VTN)	0.88	0.88	0.46	0.50	0.70	0.50	0.62	0.67	0.53	0.41	0.50	0.38	0.60	0.81	0.72	0.78	0.50	0.67	0.52	0.49	0.85	0.67	0.43	0.48	0.59	0.67	1.00	0.52	0.58	0.68	0.53	0.45	0.57	0.51	0.46	0.38	0.37	0.54	1.00	0.54	0.48	0.58	0.41	0.50	0.42	0.87	0.48	0.50	0.70	0.71	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
ITGA2B	Human	Blood	-	3600 m	Native	upregulated	-	TMT-based proteomic analysis/LC-MS	Central Asia	Tibetans	-	High altitude native vs. low Lander	30908922

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
TAL1	6886	ITGA2B	3674	proximal_filtered	22955619	TRANSFAC
GATA2	2624	ITGA2B	3674	proximal_filtered	22955619	TRANSFAC
FLI1	2313	ITGA2B	3674	Unknown	12836278	TRUSST
GATA1	2623	ITGA2B	3674	Unknown	12836278	TRUSST
SPI1	6688	ITGA2B	3674	Activation	17407192	TRUSST
RUNX1	100506403861	ITGA2B	3674	Unknown	7565758	TRUSST
STAT6	6778	ITGA2B	3674	Unknown	21243522	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)

Gene Ontology

ID	GO ID	GO Term	GO Type
3674	GO:0009897	external side of plasma membrane	GOTERM_CC_DIRECT
3674	GO:0072562	blood microparticle	GOTERM_CC_DIRECT
3674	GO:0005887	integral component of plasma membrane	GOTERM_CC_DIRECT
3674	GO:0007229	integrin-mediated signaling pathway	GOTERM_BP_DIRECT
3674	GO:0002576	platelet degranulation	GOTERM_BP_DIRECT
3674	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
3674	GO:0042802	identical protein binding	GOTERM_MF_DIRECT
3674	GO:0005925	focal adhesion	GOTERM_CC_DIRECT
3674	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
3674	GO:0007160	cell-matrix adhesion	GOTERM_BP_DIRECT
3674	GO:0070527	platelet aggregation	GOTERM_BP_DIRECT
3674	GO:0046872	metal ion binding	GOTERM_MF_DIRECT
3674	GO:0050840	extracellular matrix binding	GOTERM_MF_DIRECT
3674	GO:0030198	extracellular matrix organization	GOTERM_BP_DIRECT
3674	GO:0008305	integrin complex	GOTERM_CC_DIRECT
3674	GO:0070051	serine-type aminopeptidase activity	GOTERM_MF_DIRECT
3674	GO:0031092	platelet alpha granule membrane	GOTERM_CC_DIRECT
3674	GO:0009986	cell surface	GOTERM_CC_DIRECT
3674	GO:0002687	positive regulation of leukocyte migration	GOTERM_BP_DIRECT
3674	GO:0007155	cell adhesion	GOTERM_BP_DIRECT
3674	GO:0005515	protein binding	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
3674	hsa04015	Rap1 signaling pathway
3674	hsa04151	PI3K-Akt signaling pathway
3674	hsa04611	Platelet activation
3674	hsa04640	Hematopoietic cell lineage
3674	hsa04512	ECM-receptor interaction
3674	hsa04510	Focal adhesion
3674	hsa04810	Regulation of actin cytoskeleton
3674	hsa05200	Pathways in cancer
3674	hsa05222	Small cell lung cancer
3674	hsa05414	Dilated cardiomyopathy
3674	hsa05412	Arrhythmogenic right ventricular cardiomyopathy
3674	hsa05410	Hypertrophic cardiomyopathy

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
ITGA2B	3674	Juvenile-Onset Still Disease	C0087031	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Acute Cerebrovascular Accidents	C0751956	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Juvenile psoriatic arthritis	C3714758	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Juvenile arthritis	C3495559	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Glanzmann Thrombasthenia, Type A	C3179396	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Internal Carotid Artery Thrombosis	C0750990	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Carotid Artery Thrombosis	C0007274	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.548	0.517	disease
ITGA2B	3674	Cerebral Hemorrhage	C2937358	Pathologic Function	0.3	0.548	0.517	phenotype
ITGA2B	3674	Cerebrovascular accident	C0038454	Disease or Syndrome	0.36	0.548	0.517	group
ITGA2B	3674	Thrombocytopenia	C0040034	Disease or Syndrome	0.34	0.548	0.517	phenotype
ITGA2B	3674	Common Carotid Artery Thrombosis	C0750988	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	External Carotid Artery Thrombosis	C0750989	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Thrombasthenia	C0040015	Disease or Syndrome	0.8	0.548	0.517	disease
ITGA2B	3674	Glanzmann Thrombasthenia, Autosomal Dominant	C1861195	Disease or Syndrome	0.8	0.548	0.517	disease
ITGA2B	3674	Congenital anemia	C0158995	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Cytopenia	C0010828	Pathologic Function	0.3	0.548	0.517	phenotype
ITGA2B	3674	Autosomal dominant macrothrombocytopenia	C4304021	Disease or Syndrome	0.3	0.548	0.517	disease
ITGA2B	3674	Neonatal Alloimmune Thrombocytopenia	C3853779	Disease or Syndrome	0.31	0.548	0.517	disease
ITGA2B	3674	FNAITP	C3854603	Disease or Syndrome	0.3	0.548	0.517	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
ITGA2B	3674	ABCIXIMAB	ABCIXIMAB	CHEMBL1201584	None
ITGA2B	3674	ABCIXIMAB	ABCIXIMAB	CHEMBL1201584	None
ITGA2B	3674	ABCIXIMAB	ABCIXIMAB	CHEMBL1201584	inhibitor
ITGA2B	3674	ANTIANGIOGENIC	None	None	None
ITGA2B	3674	ASPIRIN	ASPIRIN	CHEMBL25	None
ITGA2B	3674	ENOXAPARIN	ENOXAPARIN	CHEMBL1201685	None
ITGA2B	3674	EPTIFIBATIDE	EPTIFIBATIDE	CHEMBL1174	inhibitor
ITGA2B	3674	EPTIFIBATIDE	EPTIFIBATIDE	CHEMBL1174	None
ITGA2B	3674	GANTOFIBAN	GANTOFIBAN	CHEMBL78871	None
ITGA2B	3674	RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR	PHORBOL MYRISTATE ACETATE	CHEMBL279115	None
ITGA2B	3674	TADOCIZUMAB	TADOCIZUMAB	CHEMBL1743076	antagonist
ITGA2B	3674	THROMBIN	THROMBIN	CHEMBL2108110	None
ITGA2B	3674	TIROFIBAN HYDROCHLORIDE	TIROFIBAN HYDROCHLORIDE	CHEMBL1704	inhibitor
ITGA2B	3674	TIROFIBAN	TIROFIBAN	CHEMBL916	None
ITGA2B	3674	TIROFIBAN	TIROFIBAN	CHEMBL916	None