ALTITUDEOMICSDB

Serum paraoxonase/arylesterase

AltitudeomicsDB

Protein Official symbol	PON1
Aliases	PON1 PON
Chromosomal Location	7
Length	355
Uniprot ID	P27169
EC number	3.1.1.2; 3.1.1.81; 3.1.8.1
Protein family Information(Pfam)	PF01731;
PDB id	1V04;1XHR;
InterPro ID	IPR011042;IPR002640;IPR008363;
dbSNP	rs854560 rs72552787 rs13306698 rs662

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
APOA1	APOC3	0.9990000000000001
APOA2	APOA1	0.9990000000000001
APOA1	APOB	0.9990000000000001
ABCA1	APOA1	0.998
APOA2	APOB	0.997
APOA2	APOC3	0.996
APOE	APOB	0.996
LDLR	APOE	0.996
LDLR	APOB	0.996
APOB	APOC3	0.996
APP	APOE	0.995
LPA	APOB	0.9940000000000001
APOC2	APOE	0.993
APOC2	APOC3	0.993
LCAT	APOA1	0.992
APOC2	LPL	0.992
APOC1	APOE	0.992
APOE	APOA1	0.991
ALB	APOA1	0.991
APOC2	APOA1	0.991
APOA5	APOC3	0.991
APOA4	APOC3	0.99
APOB	CETP	0.9890000000000001
APOA1	CETP	0.9890000000000001
APOC2	APOA2	0.988
APOC2	APOB	0.988
APOA4	APOB	0.988
CLU	APP	0.987
ALB	APOB	0.986
LPL	APOB	0.986
APOA2	APOE	0.985
LPA	APOA1	0.985
LPL	APOC3	0.985
APOE	APOC3	0.9840000000000001
IL6	ALB	0.983
APOL1	APOA1	0.982
APOA5	LPL	0.982
LIPC	APOB	0.982
APOA5	APOB	0.981
APOA2	ALB	0.981
APOA2	LPA	0.981
APOA1	APOH	0.981
LPL	APOE	0.98
APOC2	APOA5	0.98
HP	APOA1	0.9790000000000001
ALB	APOE	0.9790000000000001
APOF	CETP	0.9790000000000001
APOC3	APOH	0.978
APOC2	APOC1	0.975
APOC2	APOA4	0.975
APOB	APOH	0.973
APOC1	APOB	0.973
LCAT	CETP	0.972
LPL	APOA1	0.971
IL6	APOA1	0.971
LDLR	APOA1	0.97
APOA2	APOH	0.97
APOA5	APOE	0.97
APOA5	APOA2	0.9690000000000001
LPA	LCAT	0.9690000000000001
IL6	APOE	0.9690000000000001
LPA	APOC3	0.9670000000000001
LIPC	APOE	0.966
APOA2	LPL	0.966
APOA2	LCAT	0.966
PLTP	APOE	0.965
ALB	APP	0.965
APOA2	APOA4	0.9640000000000001
APOC1	APOC3	0.9640000000000001
APOA5	ALB	0.963
LPA	APOE	0.961
APOM	LPA	0.96
LPA	CETP	0.96
PLTP	LCAT	0.96
LDLR	LIPC	0.9590000000000001
LDLR	APOC3	0.9590000000000001
CLU	ALB	0.958
APOC1	APOA2	0.9570000000000001
IL6	APP	0.9570000000000001
IL6	APOB	0.9570000000000001
APP	APOA1	0.956
APOA1	PON1	0.956
APOA4	APOA1	0.956
APOA4	LPL	0.9540000000000001
APOC4	APOC1	0.9540000000000001
CLU	APOE	0.953
HP	APOE	0.953
SAA1	APOA1	0.953
APOA5	APOA1	0.953
APOA4	LPA	0.953
APOC2	LDLR	0.953
ALB	LCAT	0.953
APOC2	LPA	0.9520000000000001
LCAT	APOB	0.9520000000000001
LCAT	APOE	0.951
APOL1	APOE	0.9490000000000001
APOA2	APOL1	0.9490000000000001
APOF	APOB	0.9470000000000001
PLTP	APOA1	0.946
APOA2	PON1	0.946
LDLR	APOA4	0.9440000000000001
HPR	HP	0.943
APOC1	APOA1	0.943
PLTP	APOA2	0.943
APOL1	ALB	0.9420000000000001
LDLR	APOA2	0.9420000000000001
APOE	CETP	0.9420000000000001
APOC2	APOM	0.9420000000000001
APOA4	APOE	0.94
PON3	PON1	0.9390000000000001
LPL	CETP	0.938
APOC3	CETP	0.938
SAA1	APOB	0.937
APOA5	APOA4	0.937
APOL1	APOB	0.937
LCAT	PON1	0.935
APOC1	CETP	0.932
LPA	PON1	0.93
LPA	APOH	0.93
APOA5	APOL1	0.927
APP	APOB	0.927
APOA2	HP	0.927
IL6	APOA2	0.9259999999999999
APOC1	LCAT	0.9259999999999999
SAA1	APP	0.9259999999999999
LIPC	CETP	0.925
APOA5	CETP	0.924
APOA2	CETP	0.9229999999999999
CLU	PON1	0.922
HPR	APOA1	0.9209999999999999
ABCA1	APOE	0.9209999999999999
PLTP	APOB	0.92
APOA4	APP	0.92
HPR	APOL1	0.919
APOA2	APP	0.9179999999999999
IL6	APOL1	0.9179999999999999
APOA5	IL6	0.9179999999999999
PLTP	ABCA1	0.9179999999999999
APOA5	LPA	0.917
APOC4	APOC2	0.917
APOB	PON1	0.915
PLTP	LPA	0.914
APOE	PON1	0.914
PON1	CETP	0.9129999999999999
APOM	APOA1	0.912
APOC1	LPA	0.91
APOC4	APOB	0.91
APOC1	APOA5	0.909
PLA2G7	APOC3	0.9079999999999999
LCAT	APOC3	0.9079999999999999
LPL	LIPC	0.9079999999999999
APOM	APOA2	0.9059999999999999
HP	APOL1	0.9059999999999999
CLU	APOA1	0.9059999999999999
APOC2	LCAT	0.905
LPA	PLA2G7	0.905
APOL1	APP	0.905
LPL	LCAT	0.904
APOM	APOB	0.903
APOA5	APP	0.903
PLA2G7	APOB	0.903
APOA5	PEX3	0.9
HP	APOH	0.9
APOC1	APOA4	0.9
APOA4	HP	0.899
APOC3	PON1	0.894
APOC2	CETP	0.893
APOA4	APOH	0.893
PLTP	PON1	0.893
APOM	APOC3	0.8909999999999999
HP	CLU	0.889
APOA2	CLU	0.888
ALB	APOH	0.888
APOM	PON1	0.885
HP	APOB	0.885
APOM	APOA4	0.885
APOM	LCAT	0.884
APOF	APOA2	0.884
APOA4	LCAT	0.883
HP	APP	0.8809999999999999
APOM	APOL1	0.88
APOC2	PLTP	0.88
APOA5	LCAT	0.88
HP	ALB	0.879
APOE	APOH	0.879
APOC1	APOM	0.879
APOM	APOE	0.879
APOA5	APOH	0.878
APOC1	APOH	0.877
APOC2	APOH	0.875
HP	APOC3	0.875
HP	PON1	0.8740000000000001
PLTP	APOC3	0.8740000000000001
APOC4	APOC3	0.872
APOA4	CETP	0.872
APOC1	PON1	0.872
LPA	CLU	0.871
LPA	LPL	0.871
APOC1	PLTP	0.87
APOA5	LIPC	0.8690000000000001
APOA4	PON1	0.868
HP	LCAT	0.867
APOA5	APOM	0.866
APOA4	CLU	0.866
APOM	CETP	0.866
PLTP	APOM	0.866
HPR	APOA2	0.865
CLU	APOC3	0.865
APOC1	CLU	0.865
LDLR	CETP	0.863
PLA2G7	CETP	0.863
PLA2G7	LCAT	0.862
PLA2G7	PON1	0.862
APOA5	PLTP	0.862
LPA	APOL1	0.861
CLU	APOH	0.86
APOA5	PON1	0.86
LDLR	LPL	0.8590000000000001
APOC2	CLU	0.8590000000000001
APOL1	PON1	0.858
ALB	APOC3	0.858
APOC1	APOL1	0.858
APOL1	APOC3	0.858
LPL	APOH	0.856
PLA2G7	APOE	0.8540000000000001
PLTP	LPL	0.853
APOC2	APOL1	0.853
HPR	PON1	0.853
APOC2	PON1	0.852
LIPC	APOA1	0.851
ABCA1	APOB	0.851
PLA2G7	APOA1	0.851
CLU	LCAT	0.851
ABCA1	LCAT	0.85
APOF	APOA1	0.8490000000000001
CLU	APOB	0.848
LIPC	LCAT	0.848
APOC1	HP	0.848
APOM	APOH	0.847
APOL1	LCAT	0.846
LDLR	LCAT	0.845
PON1	APOH	0.845
PLTP	PCYOX1	0.845
PLTP	CLU	0.843
LDLR	APOA5	0.841
LDLR	LPA	0.841
NFYC	PON3	0.84
SAA1	HP	0.84
HPR	APOC3	0.8370000000000001
APOM	CLU	0.836
APOA4	APOL1	0.836
APOC4	APOA4	0.836
PCYOX1	APOM	0.8320000000000001
APOA5	VIMP	0.8320000000000001
PLTP	PLA2G7	0.831
PLTP	APOL1	0.831
PCYOX1	PON1	0.83
PLTP	APOA4	0.828
SAA4	APOC3	0.826
PCYOX1	APOL1	0.8240000000000001
ABCA1	CETP	0.8240000000000001
APOC4	APOA1	0.8240000000000001
APOL1	CLU	0.8240000000000001
CLU	CETP	0.8240000000000001
APOA2	PLA2G7	0.8240000000000001
LIPC	APOC3	0.8220000000000001
APOL1	APOH	0.8220000000000001
PLTP	CETP	0.821
HPR	PLTP	0.821
NFYC	PON1	0.82
LDLR	ABCA1	0.8190000000000001
APOF	APOM	0.8190000000000001
APOC1	PLA2G7	0.8190000000000001
APOL1	CETP	0.818
APOC1	LPL	0.818
APOC1	APOF	0.8170000000000001
APOC2	HP	0.815
APOC2	PLA2G7	0.8140000000000001
LDLR	APP	0.8140000000000001
APOC4	PCYOX1	0.813
APOC4	APOE	0.812
HPR	LCAT	0.8079999999999999
PLTP	LIPC	0.807
LCAT	APOH	0.805
IL6	SAA1	0.805
ABCA1	LPA	0.805
PLTP	APOF	0.805
VIMP	APOB	0.804
APP	PON1	0.802
APOF	APOC3	0.8
LDLR	PLTP	0.8
APOC4	APOA2	0.8
IL6	HP	0.799
APOF	APOL1	0.799
SAA1	VIMP	0.797
HPR	APOM	0.797
HP	CETP	0.797
HP	LPA	0.7959999999999999
APOM	HP	0.7959999999999999
PCYOX1	CLU	0.7959999999999999
HPR	APOH	0.7959999999999999
LPA	ALB	0.795
APOC4	APOM	0.795
APOF	PON1	0.794
HPR	CETP	0.7929999999999999
APOC4	PON1	0.7929999999999999
APOH	CETP	0.7909999999999999
HPR	CLU	0.7909999999999999
PLTP	HP	0.7909999999999999
HPR	APOB	0.7909999999999999
APOF	LCAT	0.7909999999999999
HPR	APOA4	0.7909999999999999
PCYOX1	APOC3	0.7909999999999999
LDLR	APOH	0.79
PCYOX1	LCAT	0.789
APOF	APOH	0.789
PLTP	APOH	0.789
APOA5	HPR	0.7879999999999999
APOA4	LIPC	0.7879999999999999
APOC1	LDLR	0.787
APOA2	SAA4	0.7859999999999999
PCYOX1	APOA2	0.7859999999999999
SAA1	APOA2	0.785
APOA5	PLA2G7	0.785
APOM	PLA2G7	0.785
PCYOX1	LPA	0.785
APOC1	HPR	0.784
HPR	APP	0.784
APOC1	APP	0.7829999999999999
APOF	APOE	0.7829999999999999
APOC2	HPR	0.7829999999999999
LPA	APP	0.7829999999999999
HPR	APOE	0.782
APOC2	APOF	0.782
PCYOX1	APOA1	0.78
HPR	LPA	0.78
LPA	LIPC	0.779
APOA4	PLA2G7	0.779
PCYOX1	APOE	0.778
APOC2	APP	0.777
LDLR	APOM	0.773
APOC4	PLTP	0.773
APOF	LPA	0.7709999999999999
SAA4	APOA1	0.77
APOC2	LIPC	0.77
PCYOX1	CETP	0.77
APOC2	PCYOX1	0.769
CLU	PLA2G7	0.769
APOC4	CETP	0.769
LDLR	CLU	0.768
APOC4	LCAT	0.7659999999999999
APOC4	APOA5	0.764
APP	APOH	0.763
APOA5	HP	0.763
APOC4	PLA2G7	0.762
APOC4	APOH	0.7609999999999999
APP	LCAT	0.76
APOA5	APOF	0.759
APOL1	SAA4	0.759
APOC4	LPA	0.758
APOA5	CLU	0.757
HPR	PCYOX1	0.757
ALB	BCHE	0.757
SAA1	APOE	0.7559999999999999
APOF	CLU	0.755
APOC4	APOL1	0.755
APOC1	LIPC	0.755
HP	PLA2G7	0.755
SAA1	LPA	0.753
APOF	APOA4	0.753
APOM	SAA4	0.753
ABCA1	PON1	0.753
PCYOX1	APOA4	0.752
APOC4	CLU	0.7509999999999999
APOA2	LIPC	0.7509999999999999
PCYOX1	APOB	0.75
LPL	PON1	0.75
APP	CETP	0.747
PCYOX1	PLA2G7	0.746
PCYOX1	APOH	0.745
APOL1	PLA2G7	0.7440000000000001
APP	APOC3	0.743
LIPC	PON1	0.742
APOC1	PCYOX1	0.741
APOA5	PCYOX1	0.741
PCYOX1	HP	0.738
APOC2	SAA4	0.738
PLA2G7	APOH	0.738
SAA1	PON1	0.737
APOC1	SAA4	0.737
PLTP	APP	0.736
APOM	APP	0.736
SAA4	APOB	0.736
APOC4	HPR	0.733
APOC4	HP	0.733
APOF	SAA4	0.732
PCYOX1	APOF	0.732
LDLR	PON1	0.731
SAA1	APOC3	0.731
HPR	PLA2G7	0.73
VIMP	APOE	0.7290000000000001
VIMP	PON1	0.727
PCYOX1	APP	0.727
APOC2	SAA1	0.727
SAA1	LCAT	0.727
SAA1	APOA4	0.726
VIMP	APP	0.726
APOC4	APP	0.725
PEX3	LCAT	0.725
APOC4	APOF	0.723
APOC1	SAA1	0.721
APP	PLA2G7	0.721
VIMP	CETP	0.72
PEX3	APOE	0.72
VIMP	PEX3	0.72
PEX3	APOA4	0.72
PLTP	PEX3	0.72
VIMP	LCAT	0.72
PEX3	CETP	0.72
PCYOX1	PEX3	0.72
PEX3	APOB	0.72
VIMP	APOL1	0.72
APOC1	VIMP	0.72
PEX3	CLU	0.72
APOC4	PEX3	0.72
VIMP	APOC3	0.72
BCHE	PON1	0.72
PCYOX1	VIMP	0.72
APOC2	PEX3	0.72
PEX3	PLA2G7	0.72
PEX3	APOC3	0.72
VIMP	APOA1	0.72
APOA2	PEX3	0.72
VIMP	LPA	0.72
APOC1	PEX3	0.72
APOM	PEX3	0.72
VIMP	PLA2G7	0.72
HPR	PEX3	0.72
VIMP	APOA4	0.72
VIMP	CLU	0.72
PEX3	APP	0.72
VIMP	APOM	0.72
HPR	VIMP	0.72
VIMP	APOH	0.72
PEX3	PON1	0.72
VIMP	HP	0.72
PEX3	APOL1	0.72
APOC4	VIMP	0.72
PEX3	HP	0.72
PEX3	LPA	0.72
PLTP	VIMP	0.72
VIMP	APOA2	0.72
PEX3	APOH	0.72
APOC2	VIMP	0.72
PEX3	APOA1	0.72
HPR	APOF	0.7190000000000001
SAA1	CLU	0.7120000000000001
APP	BCHE	0.7090000000000001
IL6	PON1	0.708
ALB	PON1	0.7070000000000001
SAA4	PON1	0.706
APOA4	SAA4	0.706
APOF	HP	0.703
HP	SAA4	0.701
PLTP	SAA1	0.701
APOA5	SAA4	0.701
PLTP	SAA4	0.701

Gene Ontology Semantic Similarity

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#	335 (APOA1)	336 (APOA2)	19 (ABCA1)	348 (APOE)	3949 (LDLR)	338 (APOB)	351 (APP)	4018 (LPA)	3931 (LCAT)	341 (APOC1)	213 (ALB)	116519 (APOA5)	337 (APOA4)	1191 (CLU)	4023 (LPL)	3569 (IL6)	8542 (APOL1)	3990 (LIPC)	3240 (HP)	319 (APOF)	345 (APOC3)	55937 (APOM)	346 (APOC4)	6288 (SAA1)	3250 (HPR)	5446 (PON3)	5444 (PON1)	7941 (PLA2G7)	4802 (NFYC)	51449 (PCYOX1)	6291 (SAA4)	55829 (VIMP)	350 (APOH)	8504 (PEX3)	590 (BCHE)	1071 (CETP)
335 (APOA1)	1.00	0.88	0.66	0.81	0.57	0.72	0.64	0.57	0.54	0.46	0.60	0.81	0.78	0.59	0.56	0.57	0.58	0.42	0.57	0.64	0.65	0.46	0.73	0.45	0.82	0.33	0.43	0.36	0.50	0.21	0.44	0.60	0.71	0.61	0.56	0.63
336 (APOA2)	0.88	1.00	0.67	0.82	0.52	0.71	0.59	0.55	0.50	0.56	0.56	0.83	0.86	0.55	0.51	0.53	0.59	0.38	0.53	0.66	0.71	0.52	1.00	0.40	0.82	0.36	0.46	0.36	0.46	0.16	0.34	0.53	0.71	0.63	0.42	0.73
19 (ABCA1)	0.66	0.67	1.00	0.65	0.47	0.62	0.50	0.49	0.46	0.23	0.50	0.59	0.62	0.47	0.50	0.48	0.49	0.40	0.45	0.58	0.43	0.44	0.84	0.35	0.82	0.27	0.35	0.32	0.41	0.16	0.34	0.52	0.52	0.48	0.43	0.58
348 (APOE)	0.81	0.82	0.65	1.00	0.53	0.75	0.58	0.57	0.50	0.40	0.63	0.81	0.85	0.54	0.56	0.52	0.56	0.38	0.52	0.61	0.59	0.57	1.00	0.40	0.82	0.35	0.48	0.36	0.47	0.21	0.44	0.58	0.68	0.60	0.51	0.66
3949 (LDLR)	0.57	0.52	0.47	0.53	1.00	0.56	0.65	0.56	0.58	0.21	0.58	0.44	0.49	0.65	0.54	0.62	0.57	0.55	0.64	0.46	0.35	0.28	0.21	0.43	0.82	0.36	0.35	0.24	0.51	0.16	0.34	0.71	0.66	0.63	0.51	0.34
338 (APOB)	0.72	0.71	0.62	0.75	0.56	1.00	0.62	0.65	0.55	0.33	0.59	0.74	0.63	0.64	0.63	0.61	0.58	0.40	0.62	0.59	0.54	0.58	0.73	0.44	0.82	0.30	0.44	0.40	0.48	0.16	0.34	0.59	0.69	0.65	0.45	0.60
351 (APP)	0.64	0.59	0.50	0.58	0.65	0.62	1.00	0.72	0.65	0.30	0.70	0.54	0.53	0.73	0.60	0.73	0.63	0.47	0.72	0.56	0.48	0.29	0.21	0.52	0.82	0.40	0.37	0.26	0.70	0.16	0.34	0.69	0.68	0.70	0.55	0.36
4018 (LPA)	0.57	0.55	0.49	0.57	0.56	0.65	0.72	1.00	0.58	0.34	0.57	0.53	0.48	0.64	0.67	0.61	0.54	0.50	0.63	0.43	0.46	0.32	0.21	0.42	0.82	0.34	0.37	0.34	0.48	0.16	0.34	0.58	0.62	0.62	0.48	0.34
3931 (LCAT)	0.54	0.50	0.46	0.50	0.58	0.55	0.65	0.58	1.00	0.21	0.57	0.41	0.45	0.72	0.55	0.68	0.58	0.48	0.73	0.47	0.36	0.29	0.21	0.47	0.82	0.33	0.32	0.26	0.49	0.17	0.34	0.62	0.61	0.71	0.48	0.33
341 (APOC1)	0.46	0.56	0.23	0.40	0.21	0.33	0.30	0.34	0.21	1.00	0.37	0.56	0.51	0.23	0.23	0.22	0.28	0.17	0.23	0.25	0.67	0.36	0.15	0.22	0.25	0.12	0.27	0.29	0.20	0.11	0.23	0.24	0.46	0.31	0.20	0.40
213 (ALB)	0.60	0.56	0.50	0.63	0.58	0.59	0.70	0.57	0.57	0.37	1.00	0.50	0.64	0.64	0.55	0.60	0.57	0.43	0.60	0.46	0.43	0.48	0.28	0.42	0.82	0.35	0.44	0.35	0.64	0.21	0.44	0.66	0.64	0.62	0.49	0.43
116519 (APOA5)	0.81	0.83	0.59	0.81	0.44	0.74	0.54	0.53	0.41	0.56	0.50	1.00	0.78	0.46	0.50	0.46	0.50	0.32	0.44	0.54	0.71	0.47	0.73	0.36	0.66	0.24	0.38	0.36	0.39	0.16	0.34	0.50	0.74	0.53	0.40	0.64
337 (APOA4)	0.78	0.86	0.62	0.85	0.49	0.63	0.53	0.48	0.45	0.51	0.64	0.78	1.00	0.51	0.44	0.49	0.54	0.34	0.48	0.65	0.56	0.63	1.00	0.37	0.82	0.33	0.44	0.33	0.41	0.21	0.44	0.58	0.64	0.59	0.41	0.79
1191 (CLU)	0.59	0.55	0.47	0.54	0.65	0.64	0.73	0.64	0.72	0.23	0.64	0.46	0.51	1.00	0.60	0.77	0.70	0.51	0.84	0.56	0.40	0.31	0.21	0.54	0.82	0.39	0.36	0.26	0.59	0.16	0.34	0.71	0.69	0.81	0.52	0.37
4023 (LPL)	0.56	0.51	0.50	0.56	0.54	0.63	0.60	0.67	0.55	0.23	0.55	0.50	0.44	0.60	1.00	0.61	0.50	0.82	0.58	0.46	0.39	0.31	0.21	0.45	0.82	0.48	0.49	0.56	0.45	0.20	0.34	0.55	0.57	0.58	0.63	0.33
3569 (IL6)	0.57	0.53	0.48	0.52	0.62	0.61	0.73	0.61	0.68	0.22	0.60	0.46	0.49	0.77	0.61	1.00	0.66	0.48	0.79	0.64	0.44	0.29	0.21	0.61	0.82	0.36	0.34	0.25	0.56	0.16	0.34	0.66	0.66	0.76	0.48	0.35
8542 (APOL1)	0.58	0.59	0.49	0.56	0.57	0.58	0.63	0.54	0.58	0.28	0.57	0.50	0.54	0.70	0.50	0.66	1.00	0.40	0.70	0.52	0.44	0.42	0.26	0.45	0.82	0.30	0.36	0.32	0.47	0.16	0.34	0.60	0.71	0.82	0.43	0.52
3990 (LIPC)	0.42	0.38	0.40	0.38	0.55	0.40	0.47	0.50	0.48	0.17	0.43	0.32	0.34	0.51	0.82	0.48	0.40	1.00	0.49	0.32	0.27	0.24	0.17	0.34	0.66	0.43	0.41	0.55	0.35	0.20	0.28	0.46	0.45	0.49	0.58	0.26
3240 (HP)	0.57	0.53	0.45	0.52	0.64	0.62	0.72	0.63	0.73	0.23	0.60	0.44	0.48	0.84	0.58	0.79	0.70	0.49	1.00	0.56	0.40	0.33	0.21	0.57	1.00	0.37	0.34	0.26	0.56	0.16	0.34	0.69	0.68	0.84	0.49	0.36
319 (APOF)	0.64	0.66	0.58	0.61	0.46	0.59	0.56	0.43	0.47	0.25	0.46	0.54	0.65	0.56	0.46	0.64	0.52	0.32	0.56	1.00	0.55	0.54	1.00	0.49	0.66	0.24	0.26	0.22	0.38	0.13	0.28	0.49	0.50	0.58	0.35	0.73
345 (APOC3)	0.65	0.71	0.43	0.59	0.35	0.54	0.48	0.46	0.36	0.67	0.43	0.71	0.56	0.40	0.39	0.44	0.44	0.27	0.40	0.55	1.00	0.46	0.21	0.37	0.48	0.20	0.36	0.38	0.33	0.16	0.34	0.39	0.62	0.49	0.31	0.48
55937 (APOM)	0.46	0.52	0.44	0.57	0.28	0.58	0.29	0.32	0.29	0.36	0.48	0.47	0.63	0.31	0.31	0.29	0.42	0.24	0.33	0.54	0.46	1.00	1.00	0.34	0.31	0.17	0.37	0.44	0.29	0.21	0.44	0.47	0.49	0.42	0.30	0.67
346 (APOC4)	0.73	1.00	0.84	1.00	0.21	0.73	0.21	0.21	0.21	0.15	0.28	0.73	1.00	0.21	0.21	0.21	0.26	0.17	0.21	1.00	0.21	1.00	1.00	0.28	0.17	0.13	0.14	0.17	0.21	0.13	0.28	0.28	0.21	0.21	0.28	1.00
6288 (SAA1)	0.45	0.40	0.35	0.40	0.43	0.44	0.52	0.42	0.47	0.22	0.42	0.36	0.37	0.54	0.45	0.61	0.45	0.34	0.57	0.49	0.37	0.34	0.28	1.00	0.56	0.25	0.24	0.24	0.39	0.21	1.00	0.50	0.46	0.54	0.39	0.29
3250 (HPR)	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.82	0.25	0.82	0.66	0.82	0.82	0.82	0.82	0.82	0.66	1.00	0.66	0.48	0.31	0.17	0.56	1.00	0.49	0.49	0.31	0.82	0.13	0.28	0.82	0.82	0.82	0.66	0.48
5446 (PON3)	0.33	0.36	0.27	0.35	0.36	0.30	0.40	0.34	0.33	0.12	0.35	0.24	0.33	0.39	0.48	0.36	0.30	0.43	0.37	0.24	0.20	0.17	0.13	0.25	0.49	1.00	0.77	0.46	0.25	0.20	0.21	0.34	0.38	0.44	0.55	0.18
5444 (PON1)	0.43	0.46	0.35	0.48	0.35	0.44	0.37	0.37	0.32	0.27	0.44	0.38	0.44	0.36	0.49	0.34	0.36	0.41	0.34	0.26	0.36	0.37	0.14	0.24	0.49	0.77	1.00	0.60	0.27	0.20	0.21	0.33	0.50	0.45	0.52	0.32
7941 (PLA2G7)	0.36	0.36	0.32	0.36	0.24	0.40	0.26	0.34	0.26	0.29	0.35	0.36	0.33	0.26	0.56	0.25	0.32	0.55	0.26	0.22	0.38	0.44	0.17	0.24	0.31	0.46	0.60	1.00	0.23	0.28	0.28	0.27	0.42	0.35	0.59	0.34
4802 (NFYC)	0.50	0.46	0.41	0.47	0.51	0.48	0.70	0.48	0.49	0.20	0.64	0.39	0.41	0.59	0.45	0.56	0.47	0.35	0.56	0.38	0.33	0.29	0.21	0.39	0.82	0.25	0.27	0.23	1.00	0.16	0.34	0.54	0.52	0.56	0.40	0.32
51449 (PCYOX1)	0.21	0.16	0.16	0.21	0.16	0.16	0.16	0.16	0.17	0.11	0.21	0.16	0.21	0.16	0.20	0.16	0.16	0.20	0.16	0.13	0.16	0.21	0.13	0.21	0.13	0.20	0.20	0.28	0.16	1.00	0.21	0.21	0.16	0.16	0.46	0.16
6291 (SAA4)	0.44	0.34	0.34	0.44	0.34	0.34	0.34	0.34	0.34	0.23	0.44	0.34	0.44	0.34	0.34	0.34	0.34	0.28	0.34	0.28	0.34	0.44	0.28	1.00	0.28	0.21	0.21	0.28	0.34	0.21	1.00	0.44	0.34	0.34	0.44	0.34
55829 (VIMP)	0.60	0.53	0.52	0.58	0.71	0.59	0.69	0.58	0.62	0.24	0.66	0.50	0.58	0.71	0.55	0.66	0.60	0.46	0.69	0.49	0.39	0.47	0.28	0.50	0.82	0.34	0.33	0.27	0.54	0.21	0.44	1.00	0.62	0.68	0.58	0.37
350 (APOH)	0.71	0.71	0.52	0.68	0.66	0.69	0.68	0.62	0.61	0.46	0.64	0.74	0.64	0.69	0.57	0.66	0.71	0.45	0.68	0.50	0.62	0.49	0.21	0.46	0.82	0.38	0.50	0.42	0.52	0.16	0.34	0.62	1.00	0.79	0.50	0.52
8504 (PEX3)	0.61	0.63	0.48	0.60	0.63	0.65	0.70	0.62	0.71	0.31	0.62	0.53	0.59	0.81	0.58	0.76	0.82	0.49	0.84	0.58	0.49	0.42	0.21	0.54	0.82	0.44	0.45	0.35	0.56	0.16	0.34	0.68	0.79	1.00	0.48	0.53
590 (BCHE)	0.56	0.42	0.43	0.51	0.51	0.45	0.55	0.48	0.48	0.20	0.49	0.40	0.41	0.52	0.63	0.48	0.43	0.58	0.49	0.35	0.31	0.30	0.28	0.39	0.66	0.55	0.52	0.59	0.40	0.46	0.44	0.58	0.50	0.48	1.00	0.30
1071 (CETP)	0.63	0.73	0.58	0.66	0.34	0.60	0.36	0.34	0.33	0.40	0.43	0.64	0.79	0.37	0.33	0.35	0.52	0.26	0.36	0.73	0.48	0.67	1.00	0.29	0.48	0.18	0.32	0.34	0.32	0.16	0.34	0.37	0.52	0.53	0.30	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
PON1	Rat	Plasma	-	9754 m	0.5 hours	downregulated	0.31	2-DE	Northern indo-australian plate	Male Sprague-Dawley (SD)	1	Male Sprague-Dawley (SD) rats of weight 150 ± 10 g kept at standard conditions	24067188

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
SP1	6667	PON1	5444	Activation	20618946	TRUSST
SREBF2	6721	PON1	5444	Repression	19411072	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT007325	hsa-miR-616-3p	Homo sapiens	PON1	5444	Homo sapiens	Luciferase reporter assay	Functional MTI	23497787
MIRT540909	hsa-miR-5189-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540914	hsa-miR-939-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540918	hsa-miR-508-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540915	hsa-miR-6849-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540917	hsa-miR-759	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540918	hsa-miR-508-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540904	hsa-miR-6512-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540911	hsa-miR-3187-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540912	hsa-miR-1285-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540906	hsa-miR-661	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540913	hsa-miR-766-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540917	hsa-miR-759	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540919	hsa-miR-4797-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540903	hsa-miR-6720-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540908	hsa-miR-6860	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540905	hsa-miR-196a-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540909	hsa-miR-5189-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540910	hsa-miR-612	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540912	hsa-miR-1285-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540913	hsa-miR-766-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540914	hsa-miR-939-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540915	hsa-miR-6849-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540911	hsa-miR-3187-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540916	hsa-miR-5586-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540904	hsa-miR-6512-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540907	hsa-miR-5186	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540907	hsa-miR-5186	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540910	hsa-miR-612	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540906	hsa-miR-661	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540903	hsa-miR-6720-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540905	hsa-miR-196a-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	21572407
MIRT540908	hsa-miR-6860	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540919	hsa-miR-4797-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT540916	hsa-miR-5586-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT761972	hsa-miR-1273g-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT765731	hsa-miR-340-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT771010	hsa-miR-4684-5p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT772418	hsa-miR-4793-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT774330	hsa-miR-548c-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT778641	hsa-miR-6771-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT779929	hsa-miR-6827-3p	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025
MIRT782041	hsa-miR-7703	Homo sapiens	PON1	5444	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	27292025

Gene Ontology

ID	GO ID	GO Term	GO Type
5444	GO:0019439	aromatic compound catabolic process	GOTERM_BP_DIRECT
5444	GO:0072562	blood microparticle	GOTERM_CC_DIRECT
5444	GO:0031667	response to nutrient levels	GOTERM_BP_DIRECT
5444	GO:0005543	phospholipid binding	GOTERM_MF_DIRECT
5444	GO:0070542	response to fatty acid	GOTERM_BP_DIRECT
5444	GO:0034445	negative regulation of plasma lipoprotein particle oxidation	GOTERM_BP_DIRECT
5444	GO:0016311	dephosphorylation	GOTERM_BP_DIRECT
5444	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
5444	GO:0004064	aryldialkylphosphatase activity	GOTERM_MF_DIRECT
5444	GO:0034366	spherical high-density lipoprotein particle	GOTERM_CC_DIRECT
5444	GO:0009605	response to external stimulus	GOTERM_BP_DIRECT
5444	GO:0046470	phosphatidylcholine metabolic process	GOTERM_BP_DIRECT
5444	GO:0005576	extracellular region	GOTERM_CC_DIRECT
5444	GO:0051099	positive regulation of binding	GOTERM_BP_DIRECT
5444	GO:0005509	calcium ion binding	GOTERM_MF_DIRECT
5444	GO:0042803	protein homodimerization activity	GOTERM_MF_DIRECT
5444	GO:0005615	extracellular space	GOTERM_CC_DIRECT
5444	GO:0034364	high-density lipoprotein particle	GOTERM_CC_DIRECT
5444	GO:0102007	cadherin binding involved in cell-cell adhesion	GOTERM_MF_DIRECT
5444	GO:0010875	positive regulation of cholesterol efflux	GOTERM_BP_DIRECT
5444	GO:0046434	organophosphate catabolic process	GOTERM_BP_DIRECT
5444	GO:0009636	response to toxic substance	GOTERM_BP_DIRECT
5444	GO:1902617	response to fluoride	GOTERM_BP_DIRECT
5444	GO:0046395	carboxylic acid catabolic process	GOTERM_BP_DIRECT
5444	GO:0004063	aminoacylase activity	GOTERM_MF_DIRECT
5444	GO:0008203	cholesterol metabolic process	GOTERM_BP_DIRECT
5444	GO:0032411	positive regulation of transporter activity	GOTERM_BP_DIRECT
5444	GO:0043231	intracellular membrane-bounded organelle	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
PON1	5444	Metabolic Diseases	C0025517	Disease or Syndrome	0.3	0.443	0.828	group
PON1	5444	Heart Failure, Right-Sided	C0235527	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Constipation	C0009806	Sign or Symptom	0.3	0.443	0.828	phenotype
PON1	5444	Coronary heart disease	C0010068	Disease or Syndrome	0.4	0.443	0.828	disease
PON1	5444	Lung Neoplasms	C0024121	Neoplastic Process	0.3	0.443	0.828	group
PON1	5444	Prenatal Exposure Delayed Effects	C0033054	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Membranoproliferative Glomerulonephritis, Type I	C0268742	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Depressive disorder	C0011581	Mental or Behavioral Dysfunction	0.44	0.443	0.828	disease
PON1	5444	Depressive Syndrome	C0086133	Mental or Behavioral Dysfunction	0.3	0.443	0.828	disease
PON1	5444	Persian Gulf Syndrome	C0282550	Disease or Syndrome	0.33	0.443	0.828	disease
PON1	5444	Arteritis	C0003860	Pathologic Function	0.3	0.443	0.828	phenotype
PON1	5444	Coronary Artery Vasospasm	C0010073	Disease or Syndrome	0.32	0.443	0.828	disease
PON1	5444	Toxic Encephalitis	C0154659	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Diabetic Nephropathy	C0011881	Disease or Syndrome	0.32	0.443	0.828	disease
PON1	5444	Heart failure	C0018801	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Left-Sided Heart Failure	C0023212	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Prostatic Neoplasms	C0033578	Neoplastic Process	0.32	0.443	0.828	group
PON1	5444	Diabetic Retinopathy	C0011884	Disease or Syndrome	0.32	0.443	0.828	disease
PON1	5444	Unipolar Depression	C0041696	Mental or Behavioral Dysfunction	0.31	0.443	0.828	disease
PON1	5444	Spina Bifida	C0080178	Congenital Abnormality	0.31	0.443	0.828	disease
PON1	5444	Birth Weight	C0005612	Organism Attribute	0.3	0.443	0.828	phenotype
PON1	5444	Brain Neoplasms	C0006118	Neoplastic Process	0.32	0.443	0.828	group
PON1	5444	Diabetes Mellitus	C0011849	Disease or Syndrome	0.4	0.443	0.828	group
PON1	5444	Nodular glomerulosclerosis	C0017667	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Hypercholesterolemia	C0020443	Disease or Syndrome	0.34	0.443	0.828	disease
PON1	5444	Rachischisis	C0266508	Congenital Abnormality	0.3	0.443	0.828	disease
PON1	5444	Cholestasis	C0008370	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Autistic Disorder	C0004352	Mental or Behavioral Dysfunction	0.32	0.443	0.828	group
PON1	5444	Glomerulonephritis, Membranoproliferative	C0017662	Disease or Syndrome	0.31	0.443	0.828	disease
PON1	5444	Hepatitis, Toxic	C0019193	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Hyperlipoproteinemias	C0020476	Disease or Syndrome	0.3	0.443	0.828	group
PON1	5444	Malignant neoplasm of lung	C0242379	Neoplastic Process	0.33	0.443	0.828	disease
PON1	5444	Melancholia	C0025193	Mental or Behavioral Dysfunction	0.3	0.443	0.828	disease
PON1	5444	Neuroectodermal Tumor, Primitive	C0206663	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Hypercholesterolemia, Familial	C0020445	Disease or Syndrome	0.35	0.443	0.828	disease
PON1	5444	Hyperthyroidism	C0020550	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Status Dysraphicus	C0038219	Congenital Abnormality	0.3	0.443	0.828	disease
PON1	5444	Encephalopathy, Toxic	C0149504	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Depression, Neurotic	C0282126	Mental or Behavioral Dysfunction	0.3	0.443	0.828	disease
PON1	5444	Agricultural Workers' Diseases	C0001828	Disease or Syndrome	0.3	0.443	0.828	group
PON1	5444	Hemorrhoids	C0019112	Disease or Syndrome	0.31	0.443	0.828	disease
PON1	5444	Dyschezia	C0237326	Sign or Symptom	0.3	0.443	0.828	phenotype
PON1	5444	Chemical and Drug Induced Liver Injury	C4277682	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Membranoproliferative Glomerulonephritis, Type III	C1720821	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Cardiovascular Diseases	C0007222	Disease or Syndrome	0.4	0.443	0.828	group
PON1	5444	Congestive heart failure	C0018802	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Occupational Diseases	C0028797	Disease or Syndrome	0.3	0.443	0.828	group
PON1	5444	Secondary Parkinson Disease	C0030569	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Brain Tumor, Primary	C0750974	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Heart Decompensation	C1961112	Pathologic Function	0.3	0.443	0.828	phenotype
PON1	5444	Complications of Diabetes Mellitus	C0342257	Disease or Syndrome	0.31	0.443	0.828	group
PON1	5444	Metabolic Syndrome X	C0524620	Disease or Syndrome	0.38	0.443	0.828	disease
PON1	5444	Neoplasms, Intracranial	C1527390	Neoplastic Process	0.3	0.443	0.828	group
PON1	5444	Drug-Induced Acute Liver Injury	C3658290	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Amyotrophic Lateral Sclerosis With Dementia	C0393554	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Rheumatoid Arthritis	C0003873	Disease or Syndrome	0.34	0.443	0.828	disease
PON1	5444	Atherosclerosis	C0004153	Disease or Syndrome	0.4	0.443	0.828	disease
PON1	5444	Endogenous depression	C0011573	Mental or Behavioral Dysfunction	0.3	0.443	0.828	disease
PON1	5444	Lymphoma	C0024299	Neoplastic Process	0.31	0.443	0.828	group
PON1	5444	Periodontal Diseases	C0031090	Disease or Syndrome	0.3	0.443	0.828	group
PON1	5444	Alveolar pyorrhea	C0034219	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Malignant neoplasm of brain	C0153633	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Neurotoxicity Syndromes	C0235032	Injury or Poisoning	0.3	0.443	0.828	group
PON1	5444	Membranoproliferative Glomerulonephritis, Type II	C0268743	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Amyotrophic Lateral Sclerosis, Guam Form	C0543859	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Recurrent Brain Neoplasm	C0750977	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Primary malignant neoplasm of brain	C0750979	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Cerebral Primitive Neuroectodermal Tumor	C0751675	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Drug-Induced Liver Disease	C0860207	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Male sterility	C0917731	Finding	0.3	0.443	0.828	phenotype
PON1	5444	Colonic Inertia	C1257861	Sign or Symptom	0.3	0.443	0.828	phenotype
PON1	5444	Coronary Arteriosclerosis	C0010054	Disease or Syndrome	0.4	0.443	0.828	disease
PON1	5444	Fatty Liver	C0015695	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Heart Diseases	C0018799	Disease or Syndrome	0.3	0.443	0.828	group
PON1	5444	Male infertility	C0021364	Disease or Syndrome	0.33	0.443	0.828	disease
PON1	5444	Spongioblastoma	C0334584	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.34	0.443	0.828	disease
PON1	5444	Organophosphate poisoning	C0700359	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Hepatitis, Drug-Induced	C1262760	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Medulloepithelioma	C0334596	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Benign neoplasm of brain, unspecified	C0496899	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Acute Coronary Syndrome	C0948089	Disease or Syndrome	0.36	0.443	0.828	disease
PON1	5444	Atherogenesis	C1563937	Pathologic Function	0.3	0.443	0.828	phenotype
PON1	5444	Hyperlipoproteinemia Type IIb	C1704417	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5 (finding)	C2674665	Finding	0.4	0.443	0.828	phenotype
PON1	5444	Hematopoietic Neoplasms	C0376544	Neoplastic Process	0.3	0.443	0.828	group
PON1	5444	Atherosclerotic Parkinsonism	C0751415	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Steatohepatitis	C2711227	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Primary Hyperthyroidism	C3714618	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Organophosphorus Poisoning	C0353676	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Parkinson Disease, Secondary Vascular	C0751414	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Subfertility, Male	C0848676	Sign or Symptom	0.3	0.443	0.828	phenotype
PON1	5444	Myocardial Failure	C1959583	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Organothiophosphonate Poisoning	C3494247	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Chemically-Induced Liver Toxicity	C4279912	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	AMYOTROPHIC LATERAL SCLEROSIS 1	C1862939	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Amyotrophic Lateral Sclerosis, Sporadic	C1862941	Disease or Syndrome	0.34	0.443	0.828	disease
PON1	5444	Organothiophosphate Poisoning	C3494248	Injury or Poisoning	0.3	0.443	0.828	disease
PON1	5444	Hematologic Neoplasms	C0376545	Neoplastic Process	0.3	0.443	0.828	group
PON1	5444	Hyperlipoproteinemia Type IIa	C0745103	Disease or Syndrome	0.35	0.443	0.828	disease
PON1	5444	Coronary Artery Disease	C1956346	Disease or Syndrome	0.4	0.443	0.828	disease
PON1	5444	Hyperhomocysteinemia	C0598608	Disease or Syndrome	0.34	0.443	0.828	disease
PON1	5444	Ependymoblastoma	C0700367	Neoplastic Process	0.3	0.443	0.828	disease
PON1	5444	Amyotrophic Lateral Sclerosis	C0002736	Disease or Syndrome	0.7	0.443	0.828	disease
PON1	5444	Familial Ménière disease	C4302111	Disease or Syndrome	0.3	0.443	0.828	disease
PON1	5444	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.32	0.443	0.828	disease
PON1	5444	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.32	0.443	0.828	disease
PON1	5444	Bipolar I disorder	C0853193	Mental or Behavioral Dysfunction	0.31	0.443	0.828	disease
PON1	5444	Alcoholic Intoxication	C0001969	Mental or Behavioral Dysfunction	0.3	0.443	0.828	disease
PON1	5444	heavy drinking	C0687132	Mental or Behavioral Dysfunction	0.32	0.443	0.828	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types