ALTITUDEOMICSDB

Cholinesterase

AltitudeomicsDB

Protein Official symbol	BCHE
Aliases	BCHE CHE1
Chromosomal Location	3
Length	602
Uniprot ID	P06276
EC number	3.1.1.8
Protein family Information(Pfam)	PF08674;PF00135;
PDB id	1EHO;1EHQ;1KCJ;1P0I;1P0M;1P0P;1P0Q;1XLU;1XLV;1XLW;2J4C;2PM8;2WID;2WIF;2WIG;2WIJ;2WIK;2WIL;2WSL;2XMB;2XMC;2XMD;2XMG;2XQF;2XQG;2XQI;2XQJ;2XQK;2Y1K;3DJY;3DKK;3O9M;4AQD;4AXB;4B0O;4B0P;4BBZ;4BDS;4TPK;4XII;5DYT;5DYW;5DYY;5K5E;5LKR;5NN0;6EMI;6EP4;6EQP;6EQQ;6ESJ;6ESY;6EUL;6EYF;6EZ2;6F7Q;6I0B;6I0C;6I2T;6QAA;6QAB;6QAC;6QAD;6QAE;6R6V;6R6W;6RUA;
InterPro ID	IPR029058;IPR014788;IPR002018;IPR019826;IPR019819;IPR000997;
dbSNP	rs116047990 rs56309853 rs531738678 rs116097205 rs1553778274 rs148170012 rs1799807 rs979653503 rs1339128583 rs755600722 rs3732880 rs201820739 rs747598704 rs121918558 rs527843566 rs781368801 rs370077923 rs28933389 rs892642457 rs16849700 rs115624085 rs754644618 rs104893684 rs770337031 rs121918557 rs115129687 rs745364489 rs28933390 rs200998515 rs115017300 rs769316835 rs121918556 rs199660374 rs1803274

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
PSEN1	APP	0.998
AHSG	ALB	0.998
BACE1	APP	0.997
MUSK	RAPSN	0.997
AHSG	AFP	0.997
APOE	APOB	0.996
APP	APOE	0.995
MUSK	DOK7	0.99
AHSG	APOB	0.987
ALB	APOB	0.986
SNCA	APP	0.985
AFP	APOB	0.9840000000000001
ALB	APOE	0.9790000000000001
AHSG	F2	0.973
APP	TTR	0.97
COLQ	MUSK	0.966
ALB	APP	0.965
INS	APP	0.965
ENAM	FBN1	0.961
F2	ALB	0.96
PSEN1	BACE1	0.958
INS	ALB	0.9570000000000001
AFP	ALB	0.956
SLC18A3	CHAT	0.956
CYP2D6	MAOA	0.951
MAPT	APP	0.9490000000000001
MAOB	CYP2D6	0.946
MAOB	MAOA	0.945
F2	APP	0.9440000000000001
ADRB2	APOB	0.943
AFP	F2	0.9420000000000001
AHSG	APOE	0.9420000000000001
ENAM	APOB	0.937
ALB	TTR	0.93
ADRB1	ADRB2	0.93
FBN1	APP	0.93
FBN1	APOE	0.9279999999999999
ALB	CRP	0.927
FBN1	ALB	0.927
APP	APOB	0.927
CYP2B6	HPGDS	0.925
GPT	ALB	0.924
HPGDS	CAT	0.924
FBN1	APOB	0.924
INS	CRP	0.922
ADRB1	HTR7	0.9209999999999999
HTR7	ADRB2	0.9209999999999999
AFP	APOE	0.92
ENAM	APP	0.919
AFP	APP	0.919
AHSG	ENAM	0.919
ENAM	ALB	0.9179999999999999
APOB	PON1	0.915
APOE	PON1	0.914
AHSG	APP	0.9129999999999999
SLC18A3	ADRB2	0.9129999999999999
TRIO	APP	0.912
F2	ADRB2	0.91
COLQ	RAPSN	0.91
MAPT	APOE	0.907
ENAM	APOE	0.903
AFP	FBN1	0.903
AHSG	FBN1	0.903
GPT	F2	0.902
DOK7	RAPSN	0.9009999999999999
TRIO	F2	0.9009999999999999
INS	APOB	0.9
ENAM	AFP	0.9
SLC18A3	APOB	0.9
GPT	CRP	0.8959999999999999
MAPT	PSEN1	0.885
PSEN1	APOE	0.866
ALB	CAT	0.865
COLQ	BCHE	0.86
AHSG	TTR	0.858
GPT	CAT	0.855
MAPT	SNCA	0.853
INS	APOE	0.848
CHAT	BCHE	0.843
CRP	APOB	0.843
AFP	GPT	0.8420000000000001
INS	GPT	0.8390000000000001
COLQ	DOK7	0.8290000000000001
BDNF	APP	0.828
F2	APOB	0.825
CHRNA4	RIC3	0.8240000000000001
F2	CRP	0.813
BDNF	APOE	0.81
APP	PON1	0.802
AFP	TYR	0.7979999999999999
GABRR3	HTR7	0.789
BDNF	PSEN1	0.7809999999999999
COCH	BCHE	0.774
MAOA	HTR7	0.768
ALB	BCHE	0.757
CRP	TTR	0.757
HTR7	RIC3	0.7490000000000001
INS	CAT	0.74
GPT	BCHE	0.736
AFP	TTR	0.736
PRIMA1	COLQ	0.7340000000000001
BCHE	PON1	0.72
GABRR3	CHAT	0.7190000000000001
MAPT	BCHE	0.7170000000000001
PNPLA6	TRIO	0.716
BDNF	INS	0.715
BDNF	CHAT	0.713
MAOB	BCHE	0.71
BCHE	CAT	0.71
APP	BCHE	0.7090000000000001
BDNF	ALB	0.708
BDNF	SNCA	0.708
ALB	PON1	0.7070000000000001
ALB	HPGDS	0.706
SMUG1	APOE	0.7040000000000001
MAOB	HTR7	0.701
F2	BCHE	0.701
SMUG1	CRP	0.7
CHRNA4	BCHE	0.6970000000000001
CYP2B6	CAT	0.695
MAPT	BACE1	0.693
BCHE	APOE	0.693
AHSG	CRP	0.693
ALB	TYR	0.691
CHRNA4	CHAT	0.6859999999999999
BACE1	APOE	0.6859999999999999
APP	CAT	0.682
PNPLA6	BCHE	0.6809999999999999
AHSG	TYR	0.6809999999999999
CRP	APOE	0.68
CHRNA4	RAPSN	0.679
INS	TTR	0.6729999999999999
GPT	HPGDS	0.6709999999999999
SLC18A3	BCHE	0.6709999999999999
BDNF	CRP	0.6709999999999999
GABRR3	BDNF	0.67
CRP	PON1	0.669
SMUG1	INS	0.669
INS	ADRB2	0.6679999999999999
F2	TTR	0.667
F2	TYR	0.665
MUSK	CHRNA4	0.664
INS	CHAT	0.6609999999999999
BRCA2	FBN1	0.6609999999999999
AHSG	INS	0.659
GPT	APOB	0.655
DOK7	BCHE	0.653
GPT	CYP2B6	0.652
INS	ADRB1	0.6509999999999999
SMUG1	AFP	0.6509999999999999
BDNF	MAOA	0.649
MUSK	BCHE	0.648
CYP2B6	ALB	0.648
APOE	TTR	0.648
CRP	CAT	0.6459999999999999
BDNF	ADRB2	0.639
TTR	APOB	0.638
BDNF	HTR7	0.638
CHRNA4	APOE	0.634
BDNF	ENAM	0.634
FBN1	ADRB2	0.634
BRCA2	BCHE	0.632
ENAM	ADRB2	0.628
MAPRE2	BCHE	0.624
TRIO	BCHE	0.622
COCH	ALB	0.618
MAOA	BCHE	0.613
CHAT	APP	0.611
SLC18A3	CHRNA4	0.605
ADRB1	BCHE	0.602
BACE1	BCHE	0.601
CAT	PON1	0.6
BDNF	MAPT	0.598
INS	F2	0.597
AFP	CRP	0.597
BDNF	BACE1	0.594
RIC3	BCHE	0.59
ADRB2	BCHE	0.59
INS	HPGDS	0.589
SNCA	APOE	0.589
SMUG1	MAPT	0.589
SMUG1	ALB	0.585
MAOB	PSEN1	0.581
MAOB	CAT	0.58
GABRR3	INS	0.5770000000000001
INS	AFP	0.573
RIC8A	BCHE	0.5710000000000001
PSEN1	BCHE	0.5710000000000001
CHRNA4	HTR7	0.569
TYR	APOB	0.569
AHSG	BCHE	0.565
CYP2D6	HPGDS	0.564
RAPSN	BCHE	0.563
MAPT	ALB	0.563
SNCA	BCHE	0.563
INS	MAPT	0.56
BCHE	CRP	0.5589999999999999
INS	PON1	0.5589999999999999
SMUG1	APP	0.5589999999999999
BCHE	TYR	0.556
SNCA	PSEN1	0.555
PRIMA1	BCHE	0.555
CHAT	RAPSN	0.555
TYR	CAT	0.5529999999999999
HTR7	CHAT	0.552
BCHE	TTR	0.5489999999999999
PPCS	BCHE	0.544
SMUG1	PSEN1	0.5429999999999999
INS	BCHE	0.54
ENAM	BCHE	0.54
HTR7	BCHE	0.539
CHAT	ALB	0.537
FBN1	BCHE	0.536
INS	HTR7	0.5329999999999999
GPT	TTR	0.531
MAOB	SNCA	0.531
HPGDS	BCHE	0.53
GABRR3	ADRB1	0.53
INS	PSEN1	0.53
CYP2D6	HTR7	0.528
AFP	BCHE	0.527
GABRR3	BCHE	0.527
COLQ	CHAT	0.526
ADRB1	FBN1	0.525
NOP10	BCHE	0.524
GPT	CYP2D6	0.523
LMO1	BCHE	0.522
BDNF	MAOB	0.521
CYP2D6	BCHE	0.52
F2	CAT	0.519
INS	BACE1	0.519
BCHE	APOB	0.518
BDNF	BCHE	0.518
INS	CYP2B6	0.515
CYP2B6	BCHE	0.513
HTR7	ALB	0.513
GABRR3	ADRB2	0.512
SMUG1	BCHE	0.511
GJA8	BCHE	0.511
DOK7	CHAT	0.511
APOE	CAT	0.509
F2	APOE	0.507
PSEN1	ALB	0.505
BACE1	ALB	0.503
BDNF	CHRNA4	0.501
BRCA2	ADRB2	0.499
CHAT	APOE	0.493
BDNF	CAT	0.491
MAOA	CAT	0.49
BDNF	FBN1	0.485
CHRNA4	APP	0.484
CYP2D6	ALB	0.483
CHAT	PSEN1	0.481
CHAT	CAT	0.475
MAOA	ADRB2	0.473
GABRR3	MAOA	0.473
ADRB1	MAOA	0.473
GABRR3	ALB	0.473
SMUG1	GPT	0.473
MAPT	CHAT	0.473
INS	SNCA	0.473
RIC3	RAPSN	0.463
BDNF	BRCA2	0.461
MAOB	APP	0.46
MUSK	CHAT	0.459
SNCA	ALB	0.459
CHRNA4	MAOA	0.455
ENAM	BRCA2	0.454
ENAM	ADRB1	0.453
GABRR3	MAPT	0.453
HPGDS	PON1	0.452
APP	CRP	0.45
ADRB1	CYP2D6	0.448
CAT	APOB	0.447
CHRNA4	ADRB2	0.444
CHRNA4	ADRB1	0.4429999999999999
GABRR3	MAOB	0.442
BDNF	SLC18A3	0.442
CHRNA4	DOK7	0.435
MAOB	MAPT	0.429
BACE1	CAT	0.429
BDNF	APOB	0.426
AFP	CYP2B6	0.423
GPT	APOE	0.42
CYP2B6	PON1	0.42
LMO1	RIC3	0.42
MUSK	SLC18A3	0.42
GABRR3	CAT	0.418
AHSG	SNCA	0.418
CYP2D6	PON1	0.418
SMUG1	BRCA2	0.417
ADRB2	ALB	0.416
GABRR3	APP	0.416
SNCA	BACE1	0.416
SLC18A3	DOK7	0.413
CYP2D6	APOE	0.413
MAOB	CHRNA4	0.413
BDNF	MUSK	0.412
GABRR3	SLC18A3	0.411
MAOB	CYP2B6	0.41
CHAT	BACE1	0.408
INS	TYR	0.405
BRCA2	ADRB1	0.4

Gene Ontology Semantic Similarity

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#	5663 (PSEN1)	197 (AHSG)	23621 (BACE1)	4593 (MUSK)	348 (APOE)	351 (APP)	213 (ALB)	6622 (SNCA)	174 (AFP)	8292 (COLQ)	3630 (INS)	10117 (ENAM)	2147 (F2)	6572 (SLC18A3)	1565 (CYP2D6)	4137 (MAPT)	4129 (MAOB)	154 (ADRB2)	153 (ADRB1)	2200 (FBN1)	1555 (CYP2B6)	2875 (GPT)	27306 (HPGDS)	3363 (HTR7)	338 (APOB)	7204 (TRIO)	285489 (DOK7)	1103 (CHAT)	1401 (CRP)	627 (BDNF)	1137 (CHRNA4)	200959 (GABRR3)	1690 (COCH)	4128 (MAOA)	590 (BCHE)	10908 (PNPLA6)	23583 (SMUG1)	675 (BRCA2)	7276 (TTR)	10982 (MAPRE2)	847 (CAT)	79608 (RIC3)	60626 (RIC8A)	7299 (TYR)	5913 (RAPSN)	79717 (PPCS)	55505 (NOP10)	4004 (LMO1)	2703 (GJA8)	5444 (PON1)
5663 (PSEN1)	1.00	0.11	0.72	0.52	0.49	0.59	0.54	0.53	1.00	1.00	0.61	1.00	0.66	0.26	0.38	0.60	0.23	0.48	0.51	0.49	0.35	0.17	0.50	0.18	0.52	0.50	0.60	0.14	0.52	0.40	0.52	0.13	0.57	0.20	0.51	0.28	0.49	0.52	0.58	0.60	0.46	0.69	0.52	0.53	0.69	0.20	0.52	1.00	0.40	0.35
197 (AHSG)	0.11	1.00	0.12	0.13	0.16	0.33	0.14	0.18	0.16	0.16	0.12	0.16	0.12	0.09	0.14	0.12	0.17	0.17	0.15	0.12	0.13	0.08	0.12	0.09	0.12	0.28	0.09	0.07	0.11	0.10	0.10	0.08	0.14	0.09	0.14	0.08	0.11	0.11	0.14	0.14	0.13	0.11	0.27	0.12	0.11	0.09	0.12	0.16	0.11	0.08
23621 (BACE1)	0.72	0.12	1.00	0.49	0.53	0.59	0.52	0.53	1.00	1.00	0.61	1.00	0.64	0.19	0.44	0.61	0.26	0.45	0.45	0.46	0.39	0.25	0.49	0.18	0.50	0.46	0.73	0.21	0.49	0.38	0.39	0.13	0.54	0.28	0.71	0.40	0.52	0.51	0.55	0.56	0.50	0.69	0.49	0.53	0.69	0.28	0.48	1.00	0.18	0.39
4593 (MUSK)	0.52	0.13	0.49	1.00	0.48	0.64	0.55	0.52	1.00	1.00	0.70	1.00	0.56	0.21	0.39	0.63	0.25	0.48	0.46	0.50	0.36	0.23	0.52	0.19	0.53	0.51	0.60	0.19	0.54	0.49	0.39	0.13	0.69	0.16	0.46	0.14	0.38	0.54	0.69	0.74	0.47	0.69	0.56	0.53	0.69	0.16	0.55	1.00	0.18	0.30
348 (APOE)	0.49	0.16	0.53	0.48	1.00	0.58	0.63	0.65	1.00	1.00	0.57	1.00	0.51	0.27	0.37	0.59	0.26	0.52	0.48	0.58	0.36	0.19	0.56	0.24	0.75	0.50	0.60	0.15	0.58	0.37	0.46	0.17	0.51	0.21	0.51	0.16	0.44	0.49	0.54	0.55	0.56	0.69	0.54	0.55	0.69	0.21	0.48	1.00	0.33	0.48
351 (APP)	0.59	0.33	0.59	0.64	0.58	1.00	0.70	0.64	1.00	1.00	0.78	1.00	0.66	0.23	0.42	0.76	0.25	0.59	0.55	0.58	0.42	0.14	0.57	0.25	0.62	0.62	0.73	0.12	0.61	0.54	0.52	0.13	0.69	0.16	0.55	0.13	0.51	0.68	0.73	0.76	0.62	0.84	0.65	0.60	0.84	0.16	0.72	1.00	0.18	0.37
213 (ALB)	0.54	0.14	0.52	0.55	0.63	0.70	1.00	0.70	1.00	1.00	0.64	1.00	0.56	0.28	0.56	0.68	0.29	0.54	0.52	0.58	0.52	0.19	0.58	0.31	0.59	0.54	0.60	0.15	0.59	0.41	0.49	0.17	0.59	0.21	0.49	0.16	0.48	0.61	0.62	0.63	0.60	0.69	0.56	0.62	0.69	0.21	0.62	1.00	0.23	0.44
6622 (SNCA)	0.53	0.18	0.53	0.52	0.65	0.64	0.70	1.00	1.00	1.00	0.59	1.00	0.53	0.28	0.47	0.62	0.26	0.51	0.49	0.64	0.43	0.32	0.68	0.27	0.58	0.51	0.60	0.26	0.64	0.37	0.50	0.13	0.55	0.60	0.50	0.29	0.50	0.56	0.56	0.57	0.50	0.69	0.53	0.71	0.69	0.36	0.54	1.00	0.18	0.54
174 (AFP)	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.32	0.59	1.00	0.34	1.00	1.00	1.00	0.59	0.14	1.00	0.29	1.00	1.00	0.60	0.12	1.00	0.69	1.00	0.13	1.00	0.16	0.82	0.13	1.00	1.00	1.00	1.00	0.82	0.69	1.00	1.00	0.69	0.16	1.00	1.00	0.18	0.61
8292 (COLQ)	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.32	0.59	1.00	0.34	1.00	1.00	1.00	0.59	0.14	1.00	0.29	1.00	1.00	0.60	0.12	1.00	0.69	1.00	0.13	1.00	0.16	0.82	0.13	1.00	1.00	1.00	1.00	0.82	0.69	1.00	1.00	0.69	0.16	1.00	1.00	0.18	0.61
3630 (INS)	0.61	0.12	0.61	0.70	0.57	0.78	0.64	0.59	1.00	1.00	1.00	1.00	0.70	0.24	0.40	0.71	0.25	0.61	0.55	0.64	0.39	0.14	0.61	0.21	0.63	0.65	0.60	0.12	0.64	0.61	0.55	0.13	0.78	0.16	0.56	0.13	0.54	0.67	0.79	0.83	0.61	0.70	0.67	0.63	0.70	0.16	0.67	1.00	0.18	0.39
10117 (ENAM)	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.32	0.59	1.00	0.34	1.00	1.00	1.00	0.59	0.14	1.00	0.29	1.00	1.00	0.60	0.12	1.00	0.69	1.00	0.13	1.00	0.16	0.82	0.13	1.00	1.00	1.00	1.00	0.82	0.69	1.00	1.00	0.69	0.16	1.00	1.00	0.18	0.61
2147 (F2)	0.66	0.12	0.64	0.56	0.51	0.66	0.56	0.53	1.00	1.00	0.70	1.00	1.00	0.20	0.38	0.63	0.25	0.56	0.57	0.52	0.36	0.14	0.51	0.39	0.55	0.53	0.60	0.12	0.56	0.62	0.56	0.56	0.63	0.16	0.49	0.23	0.48	0.54	0.64	0.66	0.53	0.84	0.56	0.54	0.84	0.16	0.55	1.00	0.18	0.34
6572 (SLC18A3)	0.26	0.09	0.19	0.21	0.27	0.23	0.28	0.28	0.32	0.32	0.24	0.32	0.20	1.00	0.21	0.23	0.15	0.20	0.19	0.26	0.20	0.08	0.27	0.26	0.28	0.20	0.20	0.07	0.35	0.18	0.47	0.08	0.24	0.09	0.18	0.08	0.15	0.20	0.26	0.25	0.19	0.23	0.21	0.23	0.23	0.09	0.22	0.32	0.31	0.21
1565 (CYP2D6)	0.38	0.14	0.44	0.39	0.37	0.42	0.56	0.47	0.59	0.59	0.40	0.59	0.38	0.21	1.00	0.41	0.41	0.36	0.34	0.35	0.88	0.32	0.42	0.25	0.37	0.36	0.36	0.26	0.37	0.28	0.31	0.13	0.39	0.60	0.49	0.29	0.37	0.39	0.42	0.41	0.60	0.41	0.37	0.62	0.41	0.36	0.42	0.59	0.18	0.30
4137 (MAPT)	0.60	0.12	0.61	0.63	0.59	0.76	0.68	0.62	1.00	1.00	0.71	1.00	0.63	0.23	0.41	1.00	0.23	0.63	0.57	0.61	0.40	0.14	0.62	0.24	0.62	0.62	0.73	0.12	0.66	0.46	0.57	0.19	0.68	0.16	0.55	0.13	0.55	0.67	0.69	0.70	0.60	0.69	0.63	0.64	0.69	0.16	0.67	1.00	0.18	0.42
4129 (MAOB)	0.23	0.17	0.26	0.25	0.26	0.25	0.29	0.26	0.34	0.34	0.25	0.34	0.25	0.15	0.41	0.23	1.00	0.24	0.24	0.24	0.36	0.19	0.25	0.17	0.23	0.28	0.21	0.15	0.23	0.19	0.20	0.17	0.26	1.00	0.31	0.17	0.22	0.22	0.28	0.28	0.33	0.23	0.27	0.32	0.23	0.21	0.24	0.34	0.23	0.18
154 (ADRB2)	0.48	0.17	0.45	0.48	0.52	0.59	0.54	0.51	1.00	1.00	0.61	1.00	0.56	0.20	0.36	0.63	0.24	1.00	0.76	0.47	0.35	0.14	0.52	0.38	0.49	0.54	0.60	0.12	0.50	0.38	0.50	0.48	0.55	0.16	0.43	0.13	0.39	0.49	0.58	0.59	0.51	0.69	0.56	0.54	0.69	0.16	0.49	1.00	0.18	0.37
153 (ADRB1)	0.51	0.15	0.45	0.46	0.48	0.55	0.52	0.49	1.00	1.00	0.55	1.00	0.57	0.19	0.34	0.57	0.24	0.76	1.00	0.46	0.33	0.14	0.45	0.38	0.47	0.59	0.60	0.12	0.48	0.36	0.51	0.52	0.50	0.16	0.40	0.13	0.40	0.48	0.52	0.52	0.45	0.69	0.57	0.50	0.69	0.16	0.47	1.00	0.18	0.29
2200 (FBN1)	0.49	0.12	0.46	0.50	0.58	0.58	0.58	0.64	1.00	1.00	0.64	1.00	0.52	0.26	0.35	0.61	0.24	0.47	0.46	1.00	0.34	0.14	0.59	0.24	0.61	0.48	0.60	0.12	0.62	0.41	0.43	0.13	0.61	0.16	0.42	0.13	0.40	0.50	0.56	0.57	0.45	0.69	0.50	0.53	0.69	0.16	0.50	1.00	0.18	0.43
1555 (CYP2B6)	0.35	0.13	0.39	0.36	0.36	0.42	0.52	0.43	0.59	0.59	0.39	0.59	0.36	0.20	0.88	0.40	0.36	0.35	0.33	0.34	1.00	0.25	0.38	0.25	0.35	0.34	0.36	0.21	0.36	0.27	0.28	0.13	0.38	0.48	0.43	0.23	0.32	0.37	0.41	0.40	0.56	0.41	0.35	0.60	0.41	0.28	0.42	0.59	0.18	0.27
2875 (GPT)	0.17	0.08	0.25	0.23	0.19	0.14	0.19	0.32	0.14	0.14	0.14	0.14	0.14	0.08	0.32	0.14	0.19	0.14	0.14	0.14	0.25	1.00	0.35	0.10	0.14	0.14	0.08	0.21	0.14	0.09	0.14	0.07	0.14	0.17	0.42	0.15	0.17	0.16	0.14	0.14	0.25	0.09	0.14	0.25	0.09	0.17	0.14	0.14	0.09	0.17
27306 (HPGDS)	0.50	0.12	0.49	0.52	0.56	0.57	0.58	0.68	1.00	1.00	0.61	1.00	0.51	0.27	0.42	0.62	0.25	0.52	0.45	0.59	0.38	0.35	1.00	0.25	0.49	0.46	0.60	0.29	0.64	0.38	0.42	0.13	0.54	0.24	0.50	0.20	0.41	0.51	0.57	0.58	0.52	0.69	0.49	0.65	0.69	0.24	0.48	1.00	0.18	0.55
3363 (HTR7)	0.18	0.09	0.18	0.19	0.24	0.25	0.31	0.27	0.29	0.29	0.21	0.29	0.39	0.26	0.25	0.24	0.17	0.38	0.38	0.24	0.25	0.10	0.25	1.00	0.22	0.19	0.19	0.08	0.28	0.15	0.51	0.56	0.21	0.11	0.19	0.09	0.15	0.22	0.23	0.22	0.26	0.21	0.20	0.22	0.21	0.11	0.30	0.29	0.12	0.19
338 (APOB)	0.52	0.12	0.50	0.53	0.75	0.62	0.59	0.58	1.00	1.00	0.63	1.00	0.55	0.28	0.37	0.62	0.23	0.49	0.47	0.61	0.35	0.14	0.49	0.22	1.00	0.51	0.60	0.12	0.60	0.44	0.45	0.13	0.60	0.16	0.45	0.13	0.42	0.52	0.60	0.62	0.48	0.69	0.54	0.51	0.69	0.16	0.53	1.00	0.24	0.44
7204 (TRIO)	0.50	0.28	0.46	0.51	0.50	0.62	0.54	0.51	1.00	1.00	0.65	1.00	0.53	0.20	0.36	0.62	0.28	0.54	0.59	0.48	0.34	0.14	0.46	0.19	0.51	1.00	0.60	0.12	0.52	0.44	0.38	0.13	0.61	0.16	0.43	0.13	0.37	0.51	0.62	0.65	0.45	0.69	0.83	0.49	0.69	0.16	0.51	1.00	0.18	0.28
285489 (DOK7)	0.60	0.09	0.73	0.60	0.60	0.73	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.20	0.36	0.73	0.21	0.60	0.60	0.60	0.36	0.08	0.60	0.19	0.60	0.60	1.00	0.06	0.60	0.40	0.60	0.08	0.60	0.09	0.73	0.07	0.60	0.60	0.60	0.60	0.73	0.40	0.60	0.60	0.40	0.09	0.60	0.60	0.11	0.36
1103 (CHAT)	0.14	0.07	0.21	0.19	0.15	0.12	0.15	0.26	0.12	0.12	0.12	0.12	0.12	0.07	0.26	0.12	0.15	0.12	0.12	0.12	0.21	0.21	0.29	0.08	0.12	0.12	0.06	1.00	0.12	0.08	0.12	0.06	0.12	0.14	0.34	0.12	0.14	0.37	0.12	0.12	0.21	0.08	0.12	0.21	0.08	0.14	0.12	0.12	0.08	0.14
1401 (CRP)	0.52	0.11	0.49	0.54	0.58	0.61	0.59	0.64	1.00	1.00	0.64	1.00	0.56	0.35	0.37	0.66	0.23	0.50	0.48	0.62	0.36	0.14	0.64	0.28	0.60	0.52	0.60	0.12	1.00	0.45	0.51	0.13	0.61	0.16	0.42	0.13	0.43	0.53	0.61	0.63	0.46	0.69	0.54	0.57	0.69	0.16	0.54	1.00	0.18	0.44
627 (BDNF)	0.40	0.10	0.38	0.49	0.37	0.54	0.41	0.37	0.69	0.69	0.61	0.69	0.62	0.18	0.28	0.46	0.19	0.38	0.36	0.41	0.27	0.09	0.38	0.15	0.44	0.44	0.40	0.08	0.45	1.00	0.33	0.09	0.57	0.11	0.32	0.09	0.31	0.40	0.55	0.61	0.42	0.70	0.45	0.40	0.70	0.11	0.46	0.69	0.12	0.23
1137 (CHRNA4)	0.52	0.10	0.39	0.39	0.46	0.52	0.49	0.50	1.00	1.00	0.55	1.00	0.56	0.47	0.31	0.57	0.20	0.50	0.51	0.43	0.28	0.14	0.42	0.51	0.45	0.38	0.60	0.12	0.51	0.33	1.00	0.66	0.46	0.16	0.36	0.13	0.31	0.44	0.49	0.49	0.39	0.69	0.43	0.43	0.69	0.16	0.40	1.00	0.43	0.27
200959 (GABRR3)	0.13	0.08	0.13	0.13	0.17	0.13	0.17	0.13	0.13	0.13	0.13	0.13	0.56	0.08	0.13	0.19	0.17	0.48	0.52	0.13	0.13	0.07	0.13	0.56	0.13	0.13	0.08	0.06	0.13	0.09	0.66	1.00	0.13	0.08	0.17	0.07	0.13	0.13	0.13	0.13	0.17	0.09	0.13	0.13	0.09	0.08	0.13	0.13	0.09	0.09
1690 (COCH)	0.57	0.14	0.54	0.69	0.51	0.69	0.59	0.55	1.00	1.00	0.78	1.00	0.63	0.24	0.39	0.68	0.26	0.55	0.50	0.61	0.38	0.14	0.54	0.21	0.60	0.61	0.60	0.12	0.61	0.57	0.46	0.13	1.00	0.16	0.47	0.13	0.45	0.58	0.78	0.86	0.49	0.69	0.64	0.57	0.69	0.16	0.65	1.00	0.18	0.33
4128 (MAOA)	0.20	0.09	0.28	0.16	0.21	0.16	0.21	0.60	0.16	0.16	0.16	0.16	0.16	0.09	0.60	0.16	1.00	0.16	0.16	0.16	0.48	0.17	0.24	0.11	0.16	0.16	0.09	0.14	0.16	0.11	0.16	0.08	0.16	1.00	0.46	0.17	0.20	0.16	0.16	0.16	0.48	0.11	0.16	0.48	0.11	0.20	0.16	0.16	0.11	0.20
590 (BCHE)	0.51	0.14	0.71	0.46	0.51	0.55	0.49	0.50	0.82	0.82	0.56	0.82	0.49	0.18	0.49	0.55	0.31	0.43	0.40	0.42	0.43	0.42	0.50	0.19	0.45	0.43	0.73	0.34	0.42	0.32	0.36	0.17	0.47	0.46	1.00	0.61	0.50	0.47	0.53	0.54	0.54	0.56	0.44	0.54	0.56	0.46	0.42	0.82	0.23	0.52
10908 (PNPLA6)	0.28	0.08	0.40	0.14	0.16	0.13	0.16	0.29	0.13	0.13	0.13	0.13	0.23	0.08	0.29	0.13	0.17	0.13	0.13	0.13	0.23	0.15	0.20	0.09	0.13	0.13	0.07	0.12	0.13	0.09	0.13	0.07	0.13	0.17	0.61	1.00	0.28	0.13	0.13	0.13	0.23	0.09	0.13	0.23	0.09	0.17	0.13	0.13	0.09	0.61
23583 (SMUG1)	0.49	0.11	0.52	0.38	0.44	0.51	0.48	0.50	1.00	1.00	0.54	1.00	0.48	0.15	0.37	0.55	0.22	0.39	0.40	0.40	0.32	0.17	0.41	0.15	0.42	0.37	0.60	0.14	0.43	0.31	0.31	0.13	0.45	0.20	0.50	0.28	1.00	0.43	0.47	0.47	0.42	0.69	0.41	0.45	0.69	0.20	0.39	1.00	0.18	0.33
675 (BRCA2)	0.52	0.11	0.51	0.54	0.49	0.68	0.61	0.56	1.00	1.00	0.67	1.00	0.54	0.20	0.39	0.67	0.22	0.49	0.48	0.50	0.37	0.16	0.51	0.22	0.52	0.51	0.60	0.37	0.53	0.40	0.44	0.13	0.58	0.16	0.47	0.13	0.43	1.00	0.59	0.61	0.50	0.69	0.53	0.52	0.69	0.16	0.60	1.00	0.18	0.31
7276 (TTR)	0.58	0.14	0.55	0.69	0.54	0.73	0.62	0.56	1.00	1.00	0.79	1.00	0.64	0.26	0.42	0.69	0.28	0.58	0.52	0.56	0.41	0.14	0.57	0.23	0.60	0.62	0.60	0.12	0.61	0.55	0.49	0.13	0.78	0.16	0.53	0.13	0.47	0.59	1.00	0.90	0.52	0.69	0.65	0.60	0.69	0.16	0.65	1.00	0.18	0.38
10982 (MAPRE2)	0.60	0.14	0.56	0.74	0.55	0.76	0.63	0.57	1.00	1.00	0.83	1.00	0.66	0.25	0.41	0.70	0.28	0.59	0.52	0.57	0.40	0.14	0.58	0.22	0.62	0.65	0.60	0.12	0.63	0.61	0.49	0.13	0.86	0.16	0.54	0.13	0.47	0.61	0.90	1.00	0.53	0.69	0.67	0.62	0.69	0.16	0.69	1.00	0.18	0.39
847 (CAT)	0.46	0.13	0.50	0.47	0.56	0.62	0.60	0.50	0.82	0.82	0.61	0.82	0.53	0.19	0.60	0.60	0.33	0.51	0.45	0.45	0.56	0.25	0.52	0.26	0.48	0.45	0.73	0.21	0.46	0.42	0.39	0.17	0.49	0.48	0.54	0.23	0.42	0.50	0.52	0.53	1.00	0.84	0.47	0.61	0.84	0.28	0.50	0.82	0.23	0.38
79608 (RIC3)	0.69	0.11	0.69	0.69	0.69	0.84	0.69	0.69	0.69	0.69	0.70	0.69	0.84	0.23	0.41	0.69	0.23	0.69	0.69	0.69	0.41	0.09	0.69	0.21	0.69	0.69	0.40	0.08	0.69	0.70	0.69	0.09	0.69	0.11	0.56	0.09	0.69	0.69	0.69	0.69	0.84	1.00	0.69	0.69	1.00	0.11	0.69	0.69	0.12	0.42
60626 (RIC8A)	0.52	0.27	0.49	0.56	0.54	0.65	0.56	0.53	1.00	1.00	0.67	1.00	0.56	0.21	0.37	0.63	0.27	0.56	0.57	0.50	0.35	0.14	0.49	0.20	0.54	0.83	0.60	0.12	0.54	0.45	0.43	0.13	0.64	0.16	0.44	0.13	0.41	0.53	0.65	0.67	0.47	0.69	1.00	0.52	0.69	0.16	0.55	1.00	0.18	0.30
7299 (TYR)	0.53	0.12	0.53	0.53	0.55	0.60	0.62	0.71	1.00	1.00	0.63	1.00	0.54	0.23	0.62	0.64	0.32	0.54	0.50	0.53	0.60	0.25	0.65	0.22	0.51	0.49	0.60	0.21	0.57	0.40	0.43	0.13	0.57	0.48	0.54	0.23	0.45	0.52	0.60	0.62	0.61	0.69	0.52	1.00	0.69	0.28	0.51	1.00	0.18	0.49
5913 (RAPSN)	0.69	0.11	0.69	0.69	0.69	0.84	0.69	0.69	0.69	0.69	0.70	0.69	0.84	0.23	0.41	0.69	0.23	0.69	0.69	0.69	0.41	0.09	0.69	0.21	0.69	0.69	0.40	0.08	0.69	0.70	0.69	0.09	0.69	0.11	0.56	0.09	0.69	0.69	0.69	0.69	0.84	1.00	0.69	0.69	1.00	0.11	0.69	0.69	0.12	0.42
79717 (PPCS)	0.20	0.09	0.28	0.16	0.21	0.16	0.21	0.36	0.16	0.16	0.16	0.16	0.16	0.09	0.36	0.16	0.21	0.16	0.16	0.16	0.28	0.17	0.24	0.11	0.16	0.16	0.09	0.14	0.16	0.11	0.16	0.08	0.16	0.20	0.46	0.17	0.20	0.16	0.16	0.16	0.28	0.11	0.16	0.28	0.11	1.00	0.16	0.16	0.11	0.20
55505 (NOP10)	0.52	0.12	0.48	0.55	0.48	0.72	0.62	0.54	1.00	1.00	0.67	1.00	0.55	0.22	0.42	0.67	0.24	0.49	0.47	0.50	0.42	0.14	0.48	0.30	0.53	0.51	0.60	0.12	0.54	0.46	0.40	0.13	0.65	0.16	0.42	0.13	0.39	0.60	0.65	0.69	0.50	0.69	0.55	0.51	0.69	0.16	1.00	1.00	0.18	0.30
4004 (LMO1)	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.32	0.59	1.00	0.34	1.00	1.00	1.00	0.59	0.14	1.00	0.29	1.00	1.00	0.60	0.12	1.00	0.69	1.00	0.13	1.00	0.16	0.82	0.13	1.00	1.00	1.00	1.00	0.82	0.69	1.00	1.00	0.69	0.16	1.00	1.00	0.18	0.61
2703 (GJA8)	0.40	0.11	0.18	0.18	0.33	0.18	0.23	0.18	0.18	0.18	0.18	0.18	0.18	0.31	0.18	0.18	0.23	0.18	0.18	0.18	0.18	0.09	0.18	0.12	0.24	0.18	0.11	0.08	0.18	0.12	0.43	0.09	0.18	0.11	0.23	0.09	0.18	0.18	0.18	0.18	0.23	0.12	0.18	0.18	0.12	0.11	0.18	0.18	1.00	0.12
5444 (PON1)	0.35	0.08	0.39	0.30	0.48	0.37	0.44	0.54	0.61	0.61	0.39	0.61	0.34	0.21	0.30	0.42	0.18	0.37	0.29	0.43	0.27	0.17	0.55	0.19	0.44	0.28	0.36	0.14	0.44	0.23	0.27	0.09	0.33	0.20	0.52	0.61	0.33	0.31	0.38	0.39	0.38	0.42	0.30	0.49	0.42	0.20	0.30	0.61	0.12	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
BCHE	Human	Peripheral venous blood	-	4875 m	9 hours	upregulated	1.6	LTQ-XL Mass Spectrometry	Western US	Americans	1	Men and women living near Denver, Colorado (1,609 m)	24265281

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
EP300	2033	BCHE	590	distal	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT018332	hsa-miR-335-5p	Homo sapiens	BCHE	590	Homo sapiens	Microarray	Functional MTI (Weak)	18185580
MIRT029814	hsa-miR-26b-5p	Homo sapiens	BCHE	590	Homo sapiens	Microarray	Functional MTI (Weak)	19088304

Gene Ontology

ID	GO ID	GO Term	GO Type
590	GO:0008285	negative regulation of cell proliferation	GOTERM_BP_DIRECT
590	GO:0014016	neuroblast differentiation	GOTERM_BP_DIRECT
590	GO:0042493	response to drug	GOTERM_BP_DIRECT
590	GO:0050805	negative regulation of synaptic transmission	GOTERM_BP_DIRECT
590	GO:0016788	hydrolase activity	GOTERM_MF_DIRECT
590	GO:0042802	identical protein binding	GOTERM_MF_DIRECT
590	GO:0050783	cocaine metabolic process	GOTERM_BP_DIRECT
590	GO:0001540	lipopolysaccharide binding	GOTERM_MF_DIRECT
590	GO:0019899	enzyme binding	GOTERM_MF_DIRECT
590	GO:0005576	extracellular region	GOTERM_CC_DIRECT
590	GO:0005788	endoplasmic reticulum lumen	GOTERM_CC_DIRECT
590	GO:0007612	learning	GOTERM_BP_DIRECT
590	GO:0051384	response to glucocorticoid	GOTERM_BP_DIRECT
590	GO:0003824	catalytic activity	GOTERM_MF_DIRECT
590	GO:0004104	carnitine O-acetyltransferase activity	GOTERM_MF_DIRECT
590	GO:0019695	choline metabolic process	GOTERM_BP_DIRECT
590	GO:0043279	response to alkaloid	GOTERM_BP_DIRECT
590	GO:0051593	response to folic acid	GOTERM_BP_DIRECT
590	GO:0003990	acetyl-CoA C-acetyltransferase activity	GOTERM_MF_DIRECT
590	GO:0033265	progesterone receptor binding	GOTERM_MF_DIRECT
590	GO:0005641	nuclear envelope lumen	GOTERM_CC_DIRECT
590	GO:0016020	membrane	GOTERM_CC_DIRECT
590	GO:0016021	integral component of membrane	GOTERM_CC_DIRECT
590	GO:0072562	blood microparticle	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
BCHE	590	Apnea	C0003578	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Tonic-Clonic Epilepsy	C0014549	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Muscular fasciculation	C0015644	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Hemiparesis	C0018989	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Hypersomnia with Periodic Respiration	C0020529	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Obesity	C0028754	Disease or Syndrome	0.39	0.503	0.793	disease
BCHE	590	Paresis	C0030552	Disease or Syndrome	0.3	0.503	0.793	phenotype
BCHE	590	Sleep Apnea Syndromes	C0037315	Disease or Syndrome	0.3	0.503	0.793	group
BCHE	590	Trismus	C0041105	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Tachyarrhythmia	C0080203	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Toxic Encephalitis	C0154659	Injury or Poisoning	0.3	0.503	0.793	disease
BCHE	590	Seizures, Clonic	C0234535	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Neurotoxicity Syndromes	C0235032	Injury or Poisoning	0.3	0.503	0.793	group
BCHE	590	Epileptic drop attack	C0270846	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Organophosphorus Poisoning	C0353676	Injury or Poisoning	0.3	0.503	0.793	disease
BCHE	590	Seizures, Somatosensory	C0422850	Pathologic Function	0.3	0.503	0.793	phenotype
BCHE	590	Olfactory seizure	C0422853	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Malignant neoplasm of breast	C0006142	Neoplastic Process	0.32	0.503	0.793	disease
BCHE	590	Cognition Disorders	C0009241	Mental or Behavioral Dysfunction	0.32	0.503	0.793	group
BCHE	590	Jacksonian Seizure	C0022333	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Tonic Seizures	C0270844	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Giant Cell Glioblastoma	C0334588	Neoplastic Process	0.3	0.503	0.793	disease
BCHE	590	Seizures, Auditory	C0422852	Pathologic Function	0.3	0.503	0.793	phenotype
BCHE	590	Gustatory seizure	C0422854	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Cocaine Abuse	C0009171	Mental or Behavioral Dysfunction	0.34	0.503	0.793	disease
BCHE	590	Presenile dementia	C0011265	Mental or Behavioral Dysfunction	0.36	0.503	0.793	disease
BCHE	590	Drug toxicity	C0013221	Injury or Poisoning	0.3	0.503	0.793	group
BCHE	590	Glioblastoma	C0017636	Neoplastic Process	0.31	0.503	0.793	disease
BCHE	590	Hypertriglyceridemia	C0020557	Disease or Syndrome	0.32	0.503	0.793	phenotype
BCHE	590	Poisoning	C0032343	Injury or Poisoning	0.3	0.503	0.793	group
BCHE	590	Postoperative Complications	C0032787	Pathologic Function	0.3	0.503	0.793	group
BCHE	590	Tachycardia	C0039231	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Todd Paralysis	C0234544	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Cocaine-Related Disorders	C0236736	Mental or Behavioral Dysfunction	0.3	0.503	0.793	group
BCHE	590	Fasciculation, Tongue	C0239548	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Familial Alzheimer Disease (FAD)	C0276496	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Sleep Apnea, Mixed Central and Obstructive	C0338495	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Alzheimer's Disease	C0002395	Disease or Syndrome	0.4	0.503	0.793	disease
BCHE	590	Renal Cell Carcinoma	C0007134	Neoplastic Process	0.31	0.503	0.793	disease
BCHE	590	Multiple Sclerosis	C0026769	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Muscular Dystrophy	C0026850	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Neuroblastoma	C0027819	Neoplastic Process	0.31	0.503	0.793	group
BCHE	590	Seizures	C0036572	Sign or Symptom	0.32	0.503	0.793	phenotype
BCHE	590	Adverse reaction to drug	C0041755	Pathologic Function	0.3	0.503	0.793	group
BCHE	590	Encephalopathy, Toxic	C0149504	Injury or Poisoning	0.3	0.503	0.793	disease
BCHE	590	Complex partial seizures	C0149958	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Generalized seizures	C0234533	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Masseter Muscle Spasm	C0240302	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Monoparesis	C0270795	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Visual seizure	C0270824	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Conventional (Clear Cell) Renal Cell Carcinoma	C0279702	Neoplastic Process	0.3	0.503	0.793	disease
BCHE	590	Lockjaw	C0343495	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Cardiac Death	C0376297	Pathologic Function	0.3	0.503	0.793	phenotype
BCHE	590	Vertiginous seizure	C0422855	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Organophosphate poisoning	C0700359	Injury or Poisoning	0.3	0.503	0.793	disease
BCHE	590	Tonic - clonic seizures	C0494475	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Epilepsy, Tonic-Clonic, Familial	C0751118	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Fasciculation, Benign	C0751144	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Lower Extremity Paresis	C0751410	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Seizures, Focal	C0751495	Disease or Syndrome	0.3	0.503	0.793	phenotype
BCHE	590	Cardiotoxicity	C0876994	Injury or Poisoning	0.3	0.503	0.793	disease
BCHE	590	Mammary Neoplasms, Human	C1257931	Neoplastic Process	0.3	0.503	0.793	group
BCHE	590	Glioblastoma Multiforme	C1621958	Neoplastic Process	0.3	0.503	0.793	disease
BCHE	590	Bamforth syndrome	C1855794	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Absence Seizures	C4316903	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Generalized Absence Seizures	C4505436	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Paralysed	C0522224	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Acute Confusional Senile Dementia	C0546126	Mental or Behavioral Dysfunction	0.3	0.503	0.793	disease
BCHE	590	Cocaine Dependence	C0600427	Mental or Behavioral Dysfunction	0.33	0.503	0.793	disease
BCHE	590	Hyperkinesia, Generalized	C0751217	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Mammary Neoplasms	C1458155	Neoplastic Process	0.31	0.503	0.793	group
BCHE	590	Hypothyroidism, Thyroidal, With Spiky Hair And Cleft Palate	C1968699	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Organothiophosphonate Poisoning	C3494247	Injury or Poisoning	0.3	0.503	0.793	disease
BCHE	590	Nonepileptic Seizures	C3495874	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Convulsions	C4048158	Sign or Symptom	0.32	0.503	0.793	phenotype
BCHE	590	Hyperactive behavior	C0424295	Mental or Behavioral Dysfunction	0.31	0.503	0.793	phenotype
BCHE	590	Fasciculation, Skeletal Muscle	C0541957	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Breast Carcinoma	C0678222	Neoplastic Process	0.32	0.503	0.793	disease
BCHE	590	Alzheimer Disease, Early Onset	C0750901	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Single Seizure	C0751110	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Cryptogenic Tonic-Clonic Epilepsy	C0751117	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Epilepsy, Tonic-Clonic, Symptomatic	C0751119	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Multiple Sclerosis, Acute Fulminating	C0751324	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Seizures, Sensory	C0751496	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Chromophobe Renal Cell Carcinoma	C1266042	Neoplastic Process	0.3	0.503	0.793	disease
BCHE	590	Organothiophosphate Poisoning	C3494248	Injury or Poisoning	0.3	0.503	0.793	disease
BCHE	590	Alzheimer Disease, Late Onset	C0494463	Mental or Behavioral Dysfunction	0.34	0.503	0.793	disease
BCHE	590	Alzheimer's Disease, Focal Onset	C0750900	Mental or Behavioral Dysfunction	0.3	0.503	0.793	disease
BCHE	590	Non-epileptic convulsion	C0751056	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Atonic Absence Seizures	C0751123	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Upper Extremity Paresis	C0751409	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Convulsive Seizures	C0751494	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Sarcomatoid Renal Cell Carcinoma	C1266043	Neoplastic Process	0.3	0.503	0.793	disease
BCHE	590	Collecting Duct Carcinoma of the Kidney	C1266044	Neoplastic Process	0.3	0.503	0.793	disease
BCHE	590	Papillary Renal Cell Carcinoma	C1306837	Neoplastic Process	0.3	0.503	0.793	disease
BCHE	590	Epileptic Seizures	C4317109	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Myoclonic Seizures	C4317123	Sign or Symptom	0.3	0.503	0.793	phenotype
BCHE	590	Butyrylcholinesterase deficiency	C1283400	Disease or Syndrome	0.72	0.503	0.793	disease
BCHE	590	Pseudocholinesterase deficiency	C0268379	Disease or Syndrome	0.5	0.503	0.793	disease
BCHE	590	Suxamethonium sensitivity	C1622434	Pathologic Function	0.5	0.503	0.793	phenotype
BCHE	590	Apnea, Postanesthetic	C1867468	Pathologic Function	0.6	0.503	0.793	phenotype
BCHE	590	Alcoholic Intoxication	C0001969	Mental or Behavioral Dysfunction	0.3	0.503	0.793	disease
BCHE	590	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.31	0.503	0.793	disease
BCHE	590	Hypocholinesterasemia, Fluoride-Resistant, Japanese Type	C1867470	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	BCHE, H VARIANT PHENOTYPE	C3889592	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE NEWFOUNDLAND PHENOTYPE	C3889596	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, SILENT 1 PHENOTYPE	C3889604	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, DIBUCAINE-RESISTANT I PHENOTYPE	C4017543	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE*70G PHENOTYPE	C4017545	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, FLUORIDE-RESISTANT II PHENOTYPE	C4017552	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, QUANTITATIVE K POLYMORPHISM PHENOTYPE	C4017555	Finding	0.3	0.503	0.793	phenotype
BCHE	590	Acholinesterasemia	C1867467	Disease or Syndrome	0.3	0.503	0.793	disease
BCHE	590	Butyrylcholinesterase Deficiency, Fluoride-Resistant, Japanese Type	C1867469	Disease or Syndrome	0.4	0.503	0.793	disease
BCHE	590	BCHE, FLUORIDE 2 PHENOTYPE	C3889588	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, J VARIANT PHENOTYPE	C3889591	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE CYNTHIANA PHENOTYPE	C3889605	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE JOHANNESBURG PHENOTYPE	C3889606	Finding	0.3	0.503	0.793	phenotype
BCHE	590	CHE*70G PHENOTYPE	C4017544	Finding	0.3	0.503	0.793	phenotype
BCHE	590	CHE*243M PHENOTYPE	C4017550	Finding	0.4	0.503	0.793	phenotype
BCHE	590	BCHE*390V PHENOTYPE	C4017554	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE*FS126 PHENOTYPE	C4017560	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, K VARIANT PHENOTYPE	C3889589	Finding	0.3	0.503	0.793	phenotype
BCHE	590	APNEA, POSTANESTHETIC, DUE TO BCHE, ATYPICAL-1	C4016356	Finding	0.3	0.503	0.793	phenotype
BCHE	590	CHE*FS117 PHENOTYPE	C4017547	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, FLUORIDE-RESISTANT I PHENOTYPE	C4017549	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE*243M PHENOTYPE	C4017551	Finding	0.3	0.503	0.793	phenotype
BCHE	590	CHE*390V PHENOTYPE	C4017553	Finding	0.3	0.503	0.793	phenotype
BCHE	590	CHE*539T PHENOTYPE	C4017556	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE*539T PHENOTYPE	C4017557	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, QUANTITATIVE J VARIANT PHENOTYPE	C4017558	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, FLUORIDE 1 PHENOTYPE	C3889586	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE ANN ARBOR PHENOTYPE	C4017546	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE*FS117 PHENOTYPE	C4017548	Finding	0.3	0.503	0.793	phenotype
BCHE	590	BCHE, QUANTITATIVE H VARIANT PHENOTYPE	C4017559	Finding	0.3	0.503	0.793	phenotype

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
BCHE	590	ANESTHETICS	None	None	None
BCHE	590	BAMBUTEROL	BAMBUTEROL	CHEMBL521589	inhibitor
BCHE	590	BUPIVACAINE	BUPIVACAINE	CHEMBL1098	None
BCHE	590	DEMECARIUM BROMIDE	DEMECARIUM BROMIDE	CHEMBL1200514	None
BCHE	590	DEMECARIUM BROMIDE	DEMECARIUM BROMIDE	CHEMBL1200514	None
BCHE	590	DONEPEZIL	DONEPEZIL	CHEMBL502	None
BCHE	590	ECHOTHIOPHATE IODIDE	ECHOTHIOPHATE IODIDE	CHEMBL1200367	None
BCHE	590	ECHOTHIOPHATE IODIDE	ECHOTHIOPHATE IODIDE	CHEMBL1200367	None
BCHE	590	ECHOTHIOPHATE IODIDE	ECHOTHIOPHATE IODIDE	CHEMBL1200367	inhibitor
BCHE	590	HEXAFLURONIUM BROMIDE	None	None	inhibitor
BCHE	590	HEXAFLURONIUM BROMIDE	HEXAFLUORENIUM BROMIDE	CHEMBL1200933	None
BCHE	590	HEXAFLURONIUM BROMIDE	HEXAFLUORENIUM BROMIDE	CHEMBL1200933	None
BCHE	590	IRINOTECAN	IRINOTECAN	CHEMBL481	None
BCHE	590	IMMUNOTOXIN	None	None	None
BCHE	590	ISOFLUROPHATE	ISOFLUROPHATE	CHEMBL1025	None
BCHE	590	ISOFLUROPHATE	ISOFLUROPHATE	CHEMBL1025	None
BCHE	590	OPIOIDS	None	None	None
BCHE	590	PHYSOSTIGMINE	PHYSOSTIGMINE	CHEMBL94	inhibitor
BCHE	590	PHENOTHIAZINE	PHENOTHIAZINE	CHEMBL828	None
BCHE	590	PYRIDOSTIGMINE	PYRIDOSTIGMINE	CHEMBL1115	inhibitor
BCHE	590	RIVASTIGMINE	RIVASTIGMINE	CHEMBL636	None
BCHE	590	RIVASTIGMINE	RIVASTIGMINE	CHEMBL636	inhibitor
BCHE	590	RIVASTIGMINE	RIVASTIGMINE	CHEMBL636	None
BCHE	590	RIVASTIGMINE	RIVASTIGMINE	CHEMBL636	inhibitor
BCHE	590	RIVASTIGMINE TARTRATE	RIVASTIGMINE TARTRATE	CHEMBL215645	inhibitor
BCHE	590	Succinylcholine	SUXAMETHONIUM	CHEMBL703	None
BCHE	590	TACRINE	TACRINE	CHEMBL95	inhibitor
BCHE	590	TACRINE HYDROCHLORIDE	TACRINE HYDROCHLORIDE	CHEMBL1677	inhibitor
BCHE	590	TRIAMCINOLONE	TRIAMCINOLONE	CHEMBL1451	None